serine has been researched along with Seizures in 64 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 7.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 7.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice." | 7.67 | Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984) |
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 5.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| " In the present study, we found that pyridoxal-5'-phosphate phosphatase/chronophin (PLPP/CIN) transiently dephosphorylated DARPP-32 serine (S) 97 site in the early time window, and casein kinase 2 (CK2) subsequently phosphorylated this site in the later time points after kainic acid (KA) injection, which increased the latency of seizure onset in response to KA, but exacerbated the intensity (severity), duration and progression of seizures." | 4.12 | PLPP/CIN-mediated DARPP-32 serine 97 dephosphorylation delays the seizure onset in response to kainic acid in the mouse hippocampus. ( Kang, TC; Kim, JE; Kim, MJ; Kim, TH; Lee, DS; Park, H, 2022) |
| "A woman with ichthyosis, contractures, and progressive neuropathy represents the first case of phosphoserine aminotransferase deficiency diagnosed and treated in an adult." | 4.02 | Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy. ( Brown, LH; Cowen, EW; Debs, S; Ferreira, CR; Gahl, WA; Groden, C; Kim, HJ; King, KA; King, MC; Lehky, T; Macnamara, E; Merideth, M; Owen, CM; Soldatos, A; Toro, C, 2021) |
| "Serine biosynthesis defects can present in a broad phenotypic spectrum ranging from Neu-Laxova syndrome, a lethal disease with multiple congenital anomalies at the severe end, to an infantile disease with severe psychomotor retardation and seizures as an intermediate phenotype, to a childhood disease with intellectual disability at the mild end." | 3.85 | Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges. ( Benke, PJ; Braffman, BH; El-Hattab, AW; Gassen, KLIV; Hidalgo, RJ; Jans, J; Sunbul, R, 2017) |
| "We report on two new cases of serine deficiency due respectively to 3-phosphoglycerate dehydrogenase (PHGDH) deficiency (Patient 1) and phosphoserine aminotransferase (PSAT1) deficiency (Patient 2), presenting with congenital microcephaly (<3rd centile at birth) and encephalopathy with spasticity." | 3.83 | Two new cases of serine deficiency disorders treated with l-serine. ( Bahi-Buisson, N; Boddaert, N; Brassier, A; de Lonlay, P; Desguerre, I; Habarou, F; Hubert, L; Kaminska, A; Ottolenghi, C; Valayannopoulos, V; Van Schaftingen, E; Wiame, E, 2016) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 3.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "(R)-Lacosamide ((R)-2, (R)-N-benzyl 2-acetamido-3-methoxypropionamide) has recently gained regulatory approval for the treatment of partial-onset seizures in adults." | 3.75 | Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. ( Cotten, SW; Eyers, C; Gaskell, SJ; Kohn, H; Liu, R; Morieux, P; Park, KD; Reamtong, O; Salomé, C; Stables, JP, 2009) |
| " The phosphorylation of SNAP-25 was regulated in a neuronal activity-dependent manner and, in the rat hippocampus, decreased by introducing seizures with kainic acid." | 3.73 | Development- and activity-dependent regulation of SNAP-25 phosphorylation in rat brain. ( Inokuchi, K; Kataoka, M; Kuwahara, R; Matsuo, R; Sekiguchi, M; Takahashi, M, 2006) |
| "Congenital microcephaly, intractable seizures and severe psychomotor retardation characterize 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, a disorder of L-serine biosynthesis." | 3.71 | Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids. ( De Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Pineda, M; Poll-The, BT; Van Maldergem, L, 2002) |
| "The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model." | 3.69 | Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 3.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice." | 3.67 | Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984) |
| "Its typical features are congenital microcephaly, epileptic seizures, and psychomotor developmental delay." | 3.01 | Mild phenotypes of phosphoglycerate dehydrogenase deficiency by a novel mutation of PHGDH gene: Case report and literature review. ( Chen, L; Fu, J; Liu, Y; Su, T; Xu, S, 2023) |
| "Neonatal seizures disrupt normal synaptic maturation and often lead to later-life epilepsy and cognitive deficits." | 1.48 | Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain. ( Folweiler, K; Handy, M; Hilario-Gomez, C; Jacobs, L; Jensen, FE; Lippman-Bell, JJ; Rakhade, S; Rosenberg, EC; Soldan, SS, 2018) |
| "Prolonged seizures cause significant damage to the brain, and cellular damage due to status epilepticus may be related to the pathogenesis of epilepsy." | 1.36 | Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death. ( Cho, GJ; Choi, MY; Choi, WS; Jeon, BT; Kang, SS; Kim, HJ; Kim, YH; Kim, YS; Lee, DH; Roh, GS, 2010) |
| "Treatment with oral L-serine abolished seizures and improved psychomotor development, hyperexcitability, head growth, cortical and subcortical hypotrophy, and hypomyelination of the brain on MRI scans." | 1.31 | 3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome. ( Aracil, A; Artuch, R; García González, MM; Jaeken, J; Pineda, M; Santos, S; Van Schaftingen, E; Vilaseca, MA, 2000) |
| "They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures." | 1.31 | Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. ( de Koning, TJ; Jaeken, J; Pineda, M; Poll-The, BT; van der Knaap, MS; Van Maldergem, L, 2000) |
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 1.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| "Choline treatment did not change brain choline content, and was not associated with clinical or radiological improvement." | 1.30 | One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. ( Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH, 1998) |
| "Cavernous angiomas are vascular malformations that cause neurodegeneration and symptoms including epileptiform seizures, headache, and motor deficits." | 1.29 | High levels of glycine and serine as a cause of the seizure symptoms of cavernous angiomas? ( Hamberger, A; Mozzi, R; Nyström, B; Rydenhag, B; van Gelder, N; von Essen, C, 1996) |
| "7CKA did not affect NMDA-induced convulsions but reduced the D-serine potentiation of NMDA responses." | 1.28 | In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. ( Peeters, BW; Vanderheyden, PM, 1992) |
| "Limbic seizure-activity was induced by injecting kainic acid into the amygdala of rats." | 1.28 | Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats. ( Berg, M; Bruhn, T; Cobo, M; Diemer, NH, 1992) |
| "The patient developed a series of partial seizures during an 8 min period." | 1.28 | Seizure related elevations of extracellular amino acids in human focal epilepsy. ( Carlson, H; Hillered, L; Ronne-Engström, E; Ungerstedt, U, 1992) |
| "Minimal electroshock seizure threshold (EST) was not significantly altered by L-DOPS at a dose of 200 or 400 mg/kg." | 1.28 | [Inhibitory effects of L-threo-DOPS on electroshock seizure in mice]. ( Nakanishi, T; Yoshida, M, 1989) |
| "To clarify the biochemical mechanism of convulsions from a view point of the amino acid metabolism, the free amino acid patterns in brains of El mice were investigated." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure. ( Honda, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (15.63) | 18.7374 |
| 1990's | 12 (18.75) | 18.2507 |
| 2000's | 14 (21.88) | 29.6817 |
| 2010's | 18 (28.13) | 24.3611 |
| 2020's | 10 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Krey, I | 1 |
| von Spiczak, S | 1 |
| Johannesen, KM | 1 |
| Hikel, C | 1 |
| Kurlemann, G | 1 |
| Muhle, H | 1 |
| Beysen, D | 1 |
| Dietel, T | 1 |
| Møller, RS | 1 |
| Lemke, JR | 1 |
| Syrbe, S | 1 |
| Adhikari, A | 1 |
| Buchanan, FKB | 1 |
| Fenton, TA | 1 |
| Cameron, DL | 1 |
| Halmai, JANM | 1 |
| Copping, NA | 1 |
| Fink, KD | 1 |
| Silverman, JL | 1 |
| Sarigecili, E | 1 |
| Bulut, FD | 1 |
| Anlas, O | 1 |
| Kim, JE | 3 |
| Lee, DS | 2 |
| Kim, TH | 1 |
| Park, H | 1 |
| Kim, MJ | 1 |
| Kang, TC | 2 |
| Fu, J | 1 |
| Chen, L | 1 |
| Su, T | 1 |
| Xu, S | 1 |
| Liu, Y | 1 |
| Dhanawat, M | 1 |
| Gupta, S | 1 |
| Mehta, DK | 1 |
| Das, R | 1 |
| Ali, A | 1 |
| Dhahouri, NA | 1 |
| Almesmari, FSA | 1 |
| Fathalla, WM | 1 |
| Jasmi, FA | 1 |
| Debs, S | 1 |
| Ferreira, CR | 1 |
| Groden, C | 1 |
| Kim, HJ | 2 |
| King, KA | 1 |
| King, MC | 1 |
| Lehky, T | 1 |
| Cowen, EW | 1 |
| Brown, LH | 1 |
| Merideth, M | 1 |
| Owen, CM | 1 |
| Macnamara, E | 1 |
| Toro, C | 1 |
| Gahl, WA | 1 |
| Soldatos, A | 1 |
| Glinton, KE | 1 |
| Benke, PJ | 2 |
| Lines, MA | 1 |
| Geraghty, MT | 1 |
| Chakraborty, P | 1 |
| Al-Dirbashi, OY | 1 |
| Jiang, Y | 1 |
| Kennedy, AD | 1 |
| Grotewiel, MS | 1 |
| Sutton, VR | 1 |
| Elsea, SH | 1 |
| El-Hattab, AW | 2 |
| Rosenberg, EC | 1 |
| Lippman-Bell, JJ | 1 |
| Handy, M | 1 |
| Soldan, SS | 1 |
| Rakhade, S | 1 |
| Hilario-Gomez, C | 1 |
| Folweiler, K | 1 |
| Jacobs, L | 1 |
| Jensen, FE | 2 |
| Leal, RB | 1 |
| Lopes, MW | 1 |
| Formolo, DA | 1 |
| de Carvalho, CR | 1 |
| Hoeller, AA | 1 |
| Latini, A | 1 |
| Sousa, DS | 1 |
| Wolf, P | 1 |
| Prediger, RD | 1 |
| Bortolotto, ZA | 1 |
| Linhares, MN | 1 |
| Lin, K | 1 |
| Walz, R | 1 |
| Vandekeere, S | 1 |
| Dubois, C | 1 |
| Kalucka, J | 1 |
| Sullivan, MR | 1 |
| García-Caballero, M | 1 |
| Goveia, J | 1 |
| Chen, R | 1 |
| Diehl, FF | 1 |
| Bar-Lev, L | 1 |
| Souffreau, J | 1 |
| Pircher, A | 1 |
| Kumar, S | 1 |
| Vinckier, S | 1 |
| Hirabayashi, Y | 1 |
| Furuya, S | 2 |
| Schoonjans, L | 1 |
| Eelen, G | 1 |
| Ghesquière, B | 1 |
| Keshet, E | 1 |
| Li, X | 1 |
| Vander Heiden, MG | 1 |
| Dewerchin, M | 1 |
| Carmeliet, P | 1 |
| van der Crabben, SN | 1 |
| Verhoeven-Duif, NM | 1 |
| Brilstra, EH | 1 |
| Van Maldergem, L | 3 |
| Coskun, T | 1 |
| Rubio-Gozalbo, E | 1 |
| Berger, R | 2 |
| de Koning, TJ | 4 |
| Kraoua, I | 1 |
| Wiame, E | 2 |
| Kraoua, L | 1 |
| Nasrallah, F | 1 |
| Benrhouma, H | 1 |
| Rouissi, A | 1 |
| Turki, I | 1 |
| Chaabouni, H | 1 |
| Briand, G | 1 |
| Kaabachi, N | 1 |
| Van Schaftingen, E | 4 |
| Gouider-Khouja, N | 1 |
| Marquezan, BP | 1 |
| Funck, VR | 1 |
| Oliveira, CV | 1 |
| Pereira, LM | 1 |
| Araújo, SM | 1 |
| Zarzecki, MS | 1 |
| Royes, LF | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Shaheen, R | 1 |
| Rahbeeni, Z | 1 |
| Alhashem, A | 1 |
| Faqeih, E | 1 |
| Zhao, Q | 1 |
| Xiong, Y | 1 |
| Almoisheer, A | 1 |
| Al-Qattan, SM | 1 |
| Almadani, HA | 1 |
| Al-Onazi, N | 1 |
| Al-Baqawi, BS | 1 |
| Saleh, MA | 1 |
| Alkuraya, FS | 1 |
| Lee, H | 1 |
| Park, KD | 4 |
| Torregrosa, R | 1 |
| Yang, XF | 1 |
| Dustrude, ET | 1 |
| Wang, Y | 1 |
| Wilson, SM | 1 |
| Barbosa, C | 1 |
| Xiao, Y | 1 |
| Cummins, TR | 1 |
| Khanna, R | 1 |
| Kohn, H | 4 |
| Sayano, T | 1 |
| Esaki, K | 1 |
| Brassier, A | 1 |
| Valayannopoulos, V | 1 |
| Bahi-Buisson, N | 1 |
| Hubert, L | 1 |
| Boddaert, N | 1 |
| Kaminska, A | 1 |
| Habarou, F | 1 |
| Desguerre, I | 1 |
| Ottolenghi, C | 1 |
| de Lonlay, P | 1 |
| Hidalgo, RJ | 1 |
| Braffman, BH | 1 |
| Jans, J | 1 |
| Gassen, KLIV | 1 |
| Sunbul, R | 1 |
| Min, WW | 1 |
| Yuskaitis, CJ | 1 |
| Yan, Q | 1 |
| Sikorski, C | 1 |
| Chen, S | 1 |
| Jope, RS | 1 |
| Bauchwitz, RP | 1 |
| Morieux, P | 2 |
| Salomé, C | 2 |
| Cotten, SW | 1 |
| Reamtong, O | 1 |
| Eyers, C | 1 |
| Gaskell, SJ | 1 |
| Stables, JP | 3 |
| Liu, R | 2 |
| Salomé-Grosjean, E | 1 |
| Swendiman, R | 1 |
| DeMarco, E | 1 |
| Ryu, HJ | 1 |
| Yeo, SI | 1 |
| Kim, DS | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Kim, YS | 1 |
| Choi, MY | 1 |
| Kim, YH | 1 |
| Jeon, BT | 1 |
| Lee, DH | 1 |
| Roh, GS | 1 |
| Kang, SS | 1 |
| Cho, GJ | 1 |
| Choi, WS | 1 |
| Dunleavy, M | 1 |
| Provenzano, G | 1 |
| Henshall, DC | 1 |
| Bozzi, Y | 1 |
| Rakhade, SN | 1 |
| Fitzgerald, EF | 1 |
| Klein, PM | 1 |
| Zhou, C | 1 |
| Sun, H | 1 |
| Huganir, RL | 1 |
| Hunganir, RL | 1 |
| Cestèle, S | 1 |
| Labate, A | 1 |
| Rusconi, R | 1 |
| Tarantino, P | 1 |
| Mumoli, L | 1 |
| Franceschetti, S | 1 |
| Annesi, G | 1 |
| Mantegazza, M | 1 |
| Gambardella, A | 1 |
| Duran, M | 2 |
| Pineda, M | 3 |
| Dorland, L | 2 |
| Gooskens, R | 2 |
| Jaeken, J | 5 |
| Poll-The, BT | 3 |
| CREMER, JE | 1 |
| Morii, H | 1 |
| Yamada, T | 1 |
| Nakano, I | 1 |
| Coulson, JM | 1 |
| Mori, N | 1 |
| Chen, WF | 1 |
| Chang, H | 1 |
| Huang, LT | 1 |
| Lai, MC | 1 |
| Yang, CH | 1 |
| Wan, TH | 1 |
| Yang, SN | 1 |
| Long, KD | 2 |
| Mastropaolo, J | 2 |
| Rosse, RB | 2 |
| Deutsch, SI | 2 |
| Manaye, KF | 1 |
| Kataoka, M | 1 |
| Kuwahara, R | 1 |
| Matsuo, R | 1 |
| Sekiguchi, M | 1 |
| Inokuchi, K | 1 |
| Takahashi, M | 1 |
| Gargus, JJ | 1 |
| Tournay, A | 1 |
| Chan, YC | 1 |
| Burgunder, JM | 1 |
| Wilder-Smith, E | 1 |
| Chew, SE | 1 |
| Lam-Mok-Sing, KM | 1 |
| Sharma, V | 1 |
| Ong, BK | 1 |
| Honda, T | 1 |
| Wambebe, C | 1 |
| Osuide, G | 1 |
| Gamaniel, K | 1 |
| De Sarro, G | 1 |
| Ongini, E | 1 |
| Bertorelli, R | 1 |
| Aguglia, U | 1 |
| De Sarro, A | 1 |
| Chu, PJ | 1 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Saito, H | 1 |
| Abe, K | 1 |
| von Essen, C | 1 |
| Rydenhag, B | 1 |
| Nyström, B | 1 |
| Mozzi, R | 1 |
| van Gelder, N | 1 |
| Hamberger, A | 1 |
| Blau, N | 1 |
| Van Hove, JL | 1 |
| Lazeyras, F | 1 |
| Zeisel, SH | 1 |
| Bottiglieri, T | 1 |
| Hyland, K | 1 |
| Charles, HC | 1 |
| Gray, L | 1 |
| Kahler, SG | 1 |
| Feldman, JD | 1 |
| Vician, L | 1 |
| Crispino, M | 1 |
| Hoe, W | 1 |
| Baudry, M | 1 |
| Herschman, HR | 1 |
| Vilaseca, MA | 1 |
| Artuch, R | 1 |
| Santos, S | 1 |
| García González, MM | 1 |
| Aracil, A | 1 |
| van der Knaap, MS | 1 |
| Takao, M | 1 |
| Ghetti, B | 1 |
| Murrell, JR | 1 |
| Unverzagt, FW | 1 |
| Giaccone, G | 1 |
| Tagliavini, F | 1 |
| Bugiani, O | 1 |
| Piccardo, P | 1 |
| Hulette, CM | 1 |
| Crain, BJ | 1 |
| Farlow, MR | 1 |
| Heyman, A | 1 |
| Peeters, BW | 1 |
| Vanderheyden, PM | 1 |
| Bruhn, T | 1 |
| Cobo, M | 1 |
| Berg, M | 1 |
| Diemer, NH | 1 |
| Carlson, H | 1 |
| Ronne-Engström, E | 1 |
| Ungerstedt, U | 1 |
| Hillered, L | 1 |
| Croucher, MJ | 1 |
| Bradford, HF | 1 |
| Peterson, SL | 1 |
| Singh, L | 2 |
| Oles, RJ | 2 |
| Tricklebank, MD | 1 |
| Vass, CA | 1 |
| Woodruff, GN | 1 |
| Yoshida, M | 1 |
| Nakanishi, T | 1 |
| Gallagher, BB | 1 |
| Alimov, IIu | 1 |
| Iur'eva, EA | 1 |
| Marchenko, ZM | 1 |
| Stone, WE | 1 |
| Tews, JK | 2 |
| Whisler, KE | 1 |
| Brown, DJ | 1 |
| Boggan, WO | 1 |
| Seiden, LS | 1 |
| Sprince, H | 1 |
| Parker, CM | 1 |
| Josephs, JA | 1 |
4 reviews available for serine and Seizures
| Article | Year |
|---|---|
Mild phenotypes of phosphoglycerate dehydrogenase deficiency by a novel mutation of PHGDH gene: Case report and literature review.
Topics: Humans; Microcephaly; Mutation; Phenotype; Phosphoglycerate Dehydrogenase; Seizures; Serine | 2023 |
3-Phosphoglycerate dehydrogenase deficiency: description of two new cases in Tunisia and review of the literature.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Humans; Intellectual Disability; Mal | 2013 |
[Essentiality of de novo L-serine synthesis for embryonic development and higher functions].
Topics: Animals; Brain; Carbohydrate Metabolism, Inborn Errors; Embryo, Mammalian; Gene Expression Regulatio | 2014 |
Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine.
Topics: Adolescent; Adult; Cell Line, Transformed; Computer Simulation; DNA Mutational Analysis; Electric St | 2013 |
60 other studies available for serine and Seizures
| Article | Year |
|---|---|
L-Serine Treatment is Associated with Improvements in Behavior, EEG, and Seizure Frequency in Individuals with GRIN-Related Disorders Due to Null Variants.
Topics: Electroencephalography; Humans; Receptors, N-Methyl-D-Aspartate; Retrospective Studies; Seizures; Se | 2022 |
Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency.
Topics: Animals; Cognition; Cyclin-Dependent Kinases; Epileptic Syndromes; Female; Humans; Male; Mice; Prote | 2022 |
A rare cause of microcephaly, thin corpus callosum and refractory epilepsy due to a novel SLC1A4 gene mutation.
Topics: Amino Acid Transport System ASC; Corpus Callosum; Drug Resistant Epilepsy; Humans; Microcephaly; Mut | 2022 |
PLPP/CIN-mediated DARPP-32 serine 97 dephosphorylation delays the seizure onset in response to kainic acid in the mouse hippocampus.
Topics: Animals; Casein Kinase II; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Hippocampus; Kai | 2022 |
P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures.
Topics: Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Autophagy; Carrier Proteins; Focal Adhesi | 2020 |
Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug.
Topics: Animals; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Esters; Hydrophobic and Hydroph | 2021 |
Characterization of
Topics: Carbohydrate Metabolism, Inborn Errors; Child, Preschool; Electron-Transferring Flavoproteins; Femal | 2021 |
Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy.
Topics: Adult; Child, Preschool; Congenital Abnormalities; Exome Sequencing; Female; Fetal Growth Retardatio | 2021 |
Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling.
Topics: Carbohydrate Metabolism, Inborn Errors; Cell Differentiation; Child; Child, Preschool; Dietary Suppl | 2018 |
Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Hippocampus; Male; Methyl-CpG-Binding Protein 2; Phosphor | 2018 |
Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Topics: Adult; Amygdala; Anxiety; Anxiety Disorders; Biomarkers; Fear; Female; Glutamic Acid; Hippocampus; H | 2020 |
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
Topics: Apoptosis; Carbohydrate Metabolism, Inborn Errors; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2018 |
An update on serine deficiency disorders.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Humans; Infant; In | 2013 |
Pentylenetetrazol-induced seizures are associated with Na⁺,K⁺-ATPase activity decrease and alpha subunit phosphorylation state in the mice cerebral cortex.
Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Mal | 2013 |
Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH.
Topics: Abnormalities, Multiple; Alleles; Amino Acid Sequence; Animals; Brain Diseases; Carbohydrate Metabol | 2014 |
Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.
Topics: Animals; Anticonvulsants; Biphenyl Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; HE | 2014 |
Two new cases of serine deficiency disorders treated with l-serine.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carbohydrate Metabolism, Inborn Errors; Ch | 2016 |
Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges.
Topics: Abnormalities, Multiple; Adolescent; Brain Diseases; Carbohydrate Metabolism, Inborn Errors; Child, | 2017 |
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antimanic Agents; Brain; Citrates; Disease Mode | 2009 |
Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.
Topics: Acetamides; Animals; Anticonvulsants; Brain; In Vitro Techniques; Intercellular Signaling Peptides a | 2009 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group.
Topics: Acetamides; Animals; Anticonvulsants; Azides; Brain; Cells, Cultured; Isothiocyanates; Lacosamide; L | 2010 |
Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Movement; Electrophysiology; Epilepsy, Temporal Lobe; Fluorescent Antibody | 2010 |
Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Animals; bcl-Associated Death Protein; Caspase 3; Cell Death; Disease Models, Anima | 2010 |
Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; beta Catenin; CA1 Region, Hippocampal; CA3 | 2013 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La | 2012 |
Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
Topics: Carbohydrate Dehydrogenases; Child; Child, Preschool; Female; Glycine; Humans; Infant; Male; Microce | 2002 |
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.
Topics: Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamates; Gl | 1964 |
Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Dizocilpine Maleate; Dose-Response | 2006 |
Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia.
Topics: Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease M | 2006 |
Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiatio | 2007 |
Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interacti | 2006 |
Development- and activity-dependent regulation of SNAP-25 phosphorylation in rat brain.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Female; Hippocampus; Kainic Acid; Male; Neurons; | 2006 |
Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3.
Topics: Adult; Child, Preschool; DNA Mutational Analysis; Family Health; Female; Humans; Male; Migraine with | 2007 |
Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation.
Topics: Adolescent; Adult; Calcium Channels; Child; DNA Mutational Analysis; Electroencephalography; Family | 2008 |
Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Cystathionine; gamma-Aminobutyric Acid; Glutami | 1984 |
Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice.
Topics: Animals; Apomorphine; Droxidopa; Levodopa; Mice; Phentolamine; Propranolol; Seizures; Serine; Strych | 1984 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1994 |
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred | 1994 |
High levels of glycine and serine as a cause of the seizure symptoms of cavernous angiomas?
Topics: Adult; Brain Chemistry; Ethanolamine; Ethanolamines; Female; Glycine; Hemangioma, Cavernous; Humans; | 1996 |
Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Carbohydrate Dehydrogenases; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalogra | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; | 1998 |
The salt-inducible kinase, SIK, is induced by depolarization in brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Colforsin; Cycloheximide; Epilepsy; Excitatory Amino A | 2000 |
3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.
Topics: Brain; Carbohydrate Dehydrogenases; Electroencephalography; Failure to Thrive; Female; Humans; Infan | 2000 |
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Amino Acids; Carbohydrate Dehydrogenases; Cerebral Cortex; Child; Child, Preschool; Choline; Demyeli | 2000 |
Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Brain; Choristoma | 2001 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; | 1992 |
Seizure related elevations of extracellular amino acids in human focal epilepsy.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cerebral Cortex; Dialysis; Electroencephalography; Epilepsie | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intra | 1991 |
[Inhibitory effects of L-threo-DOPS on electroshock seizure in mice].
Topics: Animals; Anticonvulsants; Desipramine; Droxidopa; Drug Therapy, Combination; Electroshock; Male; Map | 1989 |
Amino acids and cerebral excitability.
Topics: Amino Acids; Ammonia; Animals; Brain; Central Nervous System Stimulants; Diet; Glutamates; Glutamine | 1969 |
[Amino acid metabolism pathology in the convulsive syndrome in young children].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine | 1972 |
Incorporation of carbon from glucose into cerebral amino acids, proteins and lipids, and alterations during recovery from hypoglycaemia.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Cerebr | 1972 |
Dopa reversal of reserpine enhancement of audiogenic seizure susceptibility in mice.
Topics: Animals; Behavior, Animal; Benzyl Compounds; Brain Chemistry; Dihydroxyphenylalanine; Dopa Decarboxy | 1971 |
Pyridoxine deficiency and brain amino acids.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; G | 1969 |
Homocysteine-induced convulsions in the rat: protection by homoserine, serine, betaine, glycine and glucose.
Topics: Animals; Betaine; Glucose; Glycine; Homocysteine; Male; Rats; Seizures; Serine; Time Factors | 1969 |