Page last updated: 2024-11-08

serine and Sarcoma

serine has been researched along with Sarcoma in 4 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Research Excerpts

ExcerptRelevanceReference
" Patients aged 18 years and older with metastatic soft-tissue sarcomas, an Eastern Cooperative Oncology Group performance status of 0-2, and who had previously received treatment with anthracycline and ifosfamide were randomly assigned (1:1) to intravenous infusion of ombrabulin 25 mg/m(2) plus cisplatin 75 mg/m(2) or intravenous infusion of placebo plus cisplatin 75 mg/m(2) every 3 weeks."9.20Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial. ( Babovic, N; Blay, JY; Bompas, E; Chawla, SP; Cohen, P; Cupissol, D; Demetri, GD; Franke, FA; Isambert, N; Italiano, A; Le-Guennec, S; López-Pousa, A; Pápai, Z; Penel, N; Saâda-Bouzid, E; Santoro, A; Staddon, AP; Tolcher, AW, 2015)
" Patients aged 18 years and older with metastatic soft-tissue sarcomas, an Eastern Cooperative Oncology Group performance status of 0-2, and who had previously received treatment with anthracycline and ifosfamide were randomly assigned (1:1) to intravenous infusion of ombrabulin 25 mg/m(2) plus cisplatin 75 mg/m(2) or intravenous infusion of placebo plus cisplatin 75 mg/m(2) every 3 weeks."5.20Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial. ( Babovic, N; Blay, JY; Bompas, E; Chawla, SP; Cohen, P; Cupissol, D; Demetri, GD; Franke, FA; Isambert, N; Italiano, A; Le-Guennec, S; López-Pousa, A; Pápai, Z; Penel, N; Saâda-Bouzid, E; Santoro, A; Staddon, AP; Tolcher, AW, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Wang, Y1
Ilyas, FZ1
Kheradmandi, M1
Tsilimigras, DI1
Grignol, VP1
Contreras, C1
Tsichlis, PN1
Pollock, RE1
Beane, JD1
Blay, JY1
Pápai, Z1
Tolcher, AW1
Italiano, A1
Cupissol, D1
López-Pousa, A1
Chawla, SP1
Bompas, E1
Babovic, N1
Penel, N1
Isambert, N1
Staddon, AP1
Saâda-Bouzid, E1
Santoro, A1
Franke, FA1
Cohen, P1
Le-Guennec, S1
Demetri, GD1
Quek, R1
Hori, K1
Saito, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multinational, Randomized, Double-blind Placebo Controlled Study of AVE8062 (25 mg/m2) Administered Every 3 Weeks in Patients With Advanced-stage Soft Tissue Sarcoma, Treated With Cisplatin (75 mg) After Failure of Anthracycline and Ifosfamide Chemother[NCT00699517]Phase 3355 participants (Actual)Interventional2008-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for serine and Sarcoma

ArticleYear
The Role of AKT in Soft Tissue Sarcoma: Review and Insights.
    Molecular cancer research : MCR, 2022, 10-04, Volume: 20, Issue:10

    Topics: Humans; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; S

2022

Trials

1 trial available for serine and Sarcoma

ArticleYear
Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial.
    The Lancet. Oncology, 2015, Volume: 16, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anthracyclines; Cisplatin; Disease-Free Survival; Double-Blind Metho

2015

Other Studies

2 other studies available for serine and Sarcoma

ArticleYear
Tumour vascular-disrupting agents in soft-tissue sarcoma.
    The Lancet. Oncology, 2015, Volume: 16, Issue:5

    Topics: Cisplatin; Female; Humans; Male; Sarcoma; Serine

2015
Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700).
    British journal of cancer, 2004, Jan-26, Volume: 90, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Catecholamines; Epinephrine; Necrosis; Neoplasms, Experi

2004