serine has been researched along with Sarcoma, Ewing in 6 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Sarcoma, Ewing: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes." | 5.48 | Menin regulates the serine biosynthetic pathway in Ewing sarcoma. ( Bankhead, AR; Cierpicki, T; Grembecka, J; Halbrook, CJ; Kerk, S; Klossowski, S; Kremer, D; Lawlor, ER; Lee, HJ; Ljungman, M; Lyssiotis, CA; Magnuson, B; Sud, S; Svoboda, LK; Teh, SSK; Thomas, D; Treichel, S; Zebolsky, A; Zhang, L, 2018) |
| "Ewing sarcomas are driven by EWS-ETS fusions, most commonly EWS-FLI1, which promotes widespread metabolic reprogramming, including activation of serine biosynthesis." | 4.02 | EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma. ( Apfelbaum, AA; Bradin, J; Chen, D; Cierpicki, T; Garcia, AX; Grembecka, J; Haarer, E; Hawkins, AG; Jiménez, JA; Kumar, A; Lawlor, ER; Lyssiotis, CA; Nwosu, ZC; Purohit, T; Ruiz, RO; Svoboda, LK, 2021) |
| "We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes." | 1.48 | Menin regulates the serine biosynthetic pathway in Ewing sarcoma. ( Bankhead, AR; Cierpicki, T; Grembecka, J; Halbrook, CJ; Kerk, S; Klossowski, S; Kremer, D; Lawlor, ER; Lee, HJ; Ljungman, M; Lyssiotis, CA; Magnuson, B; Sud, S; Svoboda, LK; Teh, SSK; Thomas, D; Treichel, S; Zebolsky, A; Zhang, L, 2018) |
| "Four human cell lines derived from Ewing's sarcoma, EW-7, EW-1, COH and ORS, were investigated to establish the effects of human recombinant interferon-alpha2a and human recombinant interferon-beta on cell proliferation and apoptosis." | 1.31 | IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. ( Delattre, O; Hiscott, J; Sancéau, J; Wietzerbin, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Issaq, SH | 1 |
| Mendoza, A | 1 |
| Kidner, R | 1 |
| Rosales, TI | 1 |
| Duveau, DY | 1 |
| Heske, CM | 1 |
| Rohde, JM | 1 |
| Boxer, MB | 1 |
| Thomas, CJ | 1 |
| DeBerardinis, RJ | 1 |
| Helman, LJ | 1 |
| Jiménez, JA | 1 |
| Apfelbaum, AA | 1 |
| Hawkins, AG | 1 |
| Svoboda, LK | 2 |
| Kumar, A | 1 |
| Ruiz, RO | 1 |
| Garcia, AX | 1 |
| Haarer, E | 1 |
| Nwosu, ZC | 1 |
| Bradin, J | 1 |
| Purohit, T | 1 |
| Chen, D | 1 |
| Cierpicki, T | 2 |
| Grembecka, J | 2 |
| Lyssiotis, CA | 2 |
| Lawlor, ER | 2 |
| Teh, SSK | 1 |
| Sud, S | 1 |
| Kerk, S | 1 |
| Zebolsky, A | 1 |
| Treichel, S | 1 |
| Thomas, D | 1 |
| Halbrook, CJ | 1 |
| Lee, HJ | 1 |
| Kremer, D | 1 |
| Zhang, L | 1 |
| Klossowski, S | 1 |
| Bankhead, AR | 1 |
| Magnuson, B | 1 |
| Ljungman, M | 1 |
| Sen, N | 1 |
| Cross, AM | 1 |
| Lorenzi, PL | 1 |
| Khan, J | 1 |
| Gryder, BE | 1 |
| Kim, S | 1 |
| Caplen, NJ | 1 |
| Sancéau, J | 1 |
| Hiscott, J | 1 |
| Delattre, O | 1 |
| Wietzerbin, J | 1 |
| Olsen, RJ | 1 |
| Hinrichs, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients With Relapsed or Refractory Acute Myeloid Leukemia[NCT04067336] | Phase 1/Phase 2 | 199 participants (Anticipated) | Interventional | 2019-09-12 | Recruiting | ||
| A Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in Patients With Relapsed/Refractory Leukemias, Including Those Harboring an MLL/KMT2A Gene Rearrangement or Nucleophosmin 1 (NPM1) Mutation[NCT04065399] | Phase 1/Phase 2 | 440 participants (Anticipated) | Interventional | 2019-11-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for serine and Sarcoma, Ewing
| Article | Year |
|---|---|
EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplast | 2020 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Energy Metabol | 2018 |
EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
Topics: Amino Acid Transport System ASC; Aminohydrolases; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell | 2018 |
IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7.
Topics: 2',5'-Oligoadenylate Synthetase; Apoptosis; Caspase 7; Caspases; Cell Division; DNA-Binding Proteins | 2000 |
Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins.
Topics: 3T3 Cells; Animals; DNA; Exons; Heterogeneous-Nuclear Ribonucleoproteins; Mice; Oncogene Proteins, F | 2001 |