serine has been researched along with Retinoblastoma in 9 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endogenous pp60c-src from Y79 unsynchronized human retinoblastoma cells is phosphorylated at an additional N-terminal serine residue relative to unsynchronized fibroblast pp60c-src." | 3.69 | Novel phosphorylation at a mitotic site, serine 75, in human pp60c-src from unsynchronized human tumor cells having a spherical morphology. ( Kato, G; Maeda, S, 1995) |
| "Retinoblastoma is a malignant tumour of the retina which most often occurs in children." | 1.48 | Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases. ( Danda, R; Elchuri, SV; Gowda, H; Khetan, V; Krishnakumar, S; Krishnan, UM; Madugundu, AK; Pandey, A; Prasad, TSK; Puttamallesh, VN; Rishi, P; Sathe, GJ; Selvan, LDN, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Van Meenen, D | 1 |
| Doege, A | 1 |
| Alefeld, E | 1 |
| Haase, A | 1 |
| Beier, M | 1 |
| Kiefer, T | 1 |
| Biewald, E | 1 |
| Metz, K | 1 |
| Dräger, O | 1 |
| Busch, MA | 1 |
| Dünker, N | 1 |
| Zhu, X | 1 |
| Wang, K | 1 |
| Yao, Y | 1 |
| Zhang, K | 1 |
| Zhou, F | 1 |
| Zhu, L | 1 |
| Selvan, LDN | 1 |
| Danda, R | 1 |
| Madugundu, AK | 1 |
| Puttamallesh, VN | 1 |
| Sathe, GJ | 1 |
| Krishnan, UM | 1 |
| Khetan, V | 1 |
| Rishi, P | 1 |
| Prasad, TSK | 1 |
| Pandey, A | 1 |
| Krishnakumar, S | 1 |
| Gowda, H | 1 |
| Elchuri, SV | 1 |
| Kawano, T | 1 |
| Akiyama, M | 1 |
| Agawa-Ohta, M | 1 |
| Mikami-Terao, Y | 1 |
| Iwase, S | 1 |
| Yanagisawa, T | 1 |
| Ida, H | 1 |
| Agata, N | 1 |
| Yamada, H | 1 |
| Kato, G | 2 |
| Maeda, S | 2 |
| Wagner, LM | 1 |
| Saleh, SM | 1 |
| Boyle, DJ | 1 |
| Takemoto, DJ | 1 |
| Higa, HH | 1 |
| Diaz, S | 1 |
| Varki, A | 1 |
| Yorek, MA | 1 |
| Rosario, RT | 1 |
| Dudley, DT | 1 |
| Spector, AA | 1 |
9 other studies available for serine and Retinoblastoma
| Article | Year |
|---|---|
ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis.
Topics: ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; Carcinogenesis; Disintegrins; | 2022 |
Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
Topics: Acetylation; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Exp | 2018 |
Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases.
Topics: Adult; CDC2 Protein Kinase; Cell Cycle Proteins; Gene Regulatory Networks; Histones; Humans; Nuclear | 2018 |
Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation.
Topics: Acetylation; Apoptosis; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Depsipeptides; Dose-Respon | 2010 |
Novel phosphorylation at a mitotic site, serine 75, in human pp60c-src from unsynchronized human tumor cells having a spherical morphology.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Adhesion; Cell Cycle; Cell Line; Eye Neoplasms; Fibrob | 1995 |
Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells.
Topics: 4-Butyrolactone; Binding Sites; CSK Tyrosine-Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Depen | 1999 |
Effect of protein kinase Cgamma on gap junction disassembly in lens epithelial cells and retinal cells in culture.
Topics: Animals; Connexin 43; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epithelial Cells; Gap | 2002 |
Biochemical and genetic evidence for distinct membrane-bound and cytosolic sialic acid O-acetyl-esterases: serine-active-site enzymes.
Topics: Acetylesterase; Animals; Binding Sites; Carboxylic Ester Hydrolases; Cell Line; Cell Membrane; Cytos | 1987 |
The utilization of ethanolamine and serine for ethanolamine phosphoglyceride synthesis by human Y79 retinoblastoma cells.
Topics: Cell Line; Choline; Ethanolamine; Ethanolamines; Eye Neoplasms; Hemicholinium 3; Humans; Kinetics; P | 1985 |