serine has been researched along with Protein Aggregation, Pathological in 10 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)." | 4.12 | α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. ( Abdi, IY; Ardah, MT; Attems, J; Carloni, P; Dorn, A; El-Agnaf, OMA; Erskine, D; Fayyad, M; Ghanem, SS; Jensen, NM; Jensen, PH; Majbour, NK; McKeith, I; Melachroinou, K; Outeiro, TF; Poggiolini, I; Santos, P; Sudhakaran, IP; Vaikath, NN; Vasili, E; Vekrellis, K, 2022) |
| "Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is phosphorylated on serine 129 (Ser-129)." | 3.83 | Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization. ( Campbell, EM; Flavin, WP; Fraser, PE; Iqbal, S; Pacelli, C; Samuel, F; Sri Renganathan, SD; Tandon, A; Trudeau, LE, 2016) |
| " Here, we study the Alzheimer disease-related amyloid-β (Aβ) peptide and investigate how phosphorylation at serine 8 affects the structure of Aβ aggregates." | 3.83 | Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus. ( Kumar, S; Rezaei-Ghaleh, N; Walter, J; Zweckstetter, M, 2016) |
| "Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD)." | 1.56 | Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. ( Bell, BM; Chakrabarty, P; Davies, P; Giasson, BI; Gorion, KM; Kim, JD; Manaois, AN; Prokop, S; Sorrentino, ZA; Xia, Y, 2020) |
| "Parkinson's disease has become one of the most common neurodegenerative diseases." | 1.56 | Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry. ( Cao, X; Chen, C; Peng, Q; Tan, Y; Wang, J; Wu, Y; Xu, Y; Yang, X; Zeng, W, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghanem, SS | 1 |
| Majbour, NK | 1 |
| Vaikath, NN | 1 |
| Ardah, MT | 1 |
| Erskine, D | 1 |
| Jensen, NM | 1 |
| Fayyad, M | 1 |
| Sudhakaran, IP | 1 |
| Vasili, E | 1 |
| Melachroinou, K | 1 |
| Abdi, IY | 1 |
| Poggiolini, I | 1 |
| Santos, P | 1 |
| Dorn, A | 1 |
| Carloni, P | 1 |
| Vekrellis, K | 1 |
| Attems, J | 1 |
| McKeith, I | 1 |
| Outeiro, TF | 1 |
| Jensen, PH | 1 |
| El-Agnaf, OMA | 1 |
| Ding, J | 1 |
| Wang, Y | 1 |
| Huang, J | 1 |
| Lian, Y | 1 |
| Meng, Y | 1 |
| Li, C | 1 |
| He, Y | 1 |
| Qiu, P | 1 |
| Xia, Y | 1 |
| Prokop, S | 1 |
| Gorion, KM | 2 |
| Kim, JD | 1 |
| Sorrentino, ZA | 2 |
| Bell, BM | 1 |
| Manaois, AN | 1 |
| Chakrabarty, P | 1 |
| Davies, P | 1 |
| Giasson, BI | 2 |
| Wang, J | 1 |
| Tan, Y | 1 |
| Peng, Q | 1 |
| Zeng, W | 1 |
| Yang, X | 1 |
| Chen, C | 1 |
| Wu, Y | 1 |
| Xu, Y | 1 |
| Cao, X | 1 |
| Weston, LJ | 1 |
| Cook, ZT | 1 |
| Stackhouse, TL | 1 |
| Sal, MK | 1 |
| Schultz, BI | 1 |
| Tobias, ZJC | 1 |
| Osterberg, VR | 1 |
| Brockway, NL | 1 |
| Pizano, S | 1 |
| Glover, G | 1 |
| Weissman, TA | 1 |
| Unni, VK | 1 |
| Despres, C | 1 |
| Byrne, C | 1 |
| Qi, H | 1 |
| Cantrelle, FX | 1 |
| Huvent, I | 1 |
| Chambraud, B | 1 |
| Baulieu, EE | 1 |
| Jacquot, Y | 1 |
| Landrieu, I | 1 |
| Lippens, G | 1 |
| Smet-Nocca, C | 1 |
| van Ameijde, J | 1 |
| Crespo, R | 1 |
| Janson, R | 1 |
| Juraszek, J | 1 |
| Siregar, B | 1 |
| Verveen, H | 1 |
| Sprengers, I | 1 |
| Nahar, T | 1 |
| Hoozemans, JJ | 1 |
| Steinbacher, S | 1 |
| Willems, R | 1 |
| Delbroek, L | 1 |
| Borgers, M | 1 |
| Dockx, K | 1 |
| Van Kolen, K | 1 |
| Mercken, M | 1 |
| Pascual, G | 1 |
| Koudstaal, W | 1 |
| Apetri, A | 1 |
| Strang, KH | 1 |
| Riffe, CJ | 1 |
| Vijayaraghavan, N | 1 |
| Golde, TE | 1 |
| Samuel, F | 1 |
| Flavin, WP | 1 |
| Iqbal, S | 1 |
| Pacelli, C | 1 |
| Sri Renganathan, SD | 1 |
| Trudeau, LE | 1 |
| Campbell, EM | 1 |
| Fraser, PE | 1 |
| Tandon, A | 1 |
| Rezaei-Ghaleh, N | 1 |
| Kumar, S | 1 |
| Walter, J | 1 |
| Zweckstetter, M | 1 |
10 other studies available for serine and Protein Aggregation, Pathological
| Article | Year |
|---|---|
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Topics: alpha-Synuclein; Amyloid; Humans; Lewy Body Disease; Parkinson Disease; Phosphorylation; Protein Agg | 2022 |
Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo.
Topics: alpha-Synuclein; Animals; Cell Line; Central Nervous System Stimulants; Humans; Male; Methamphetamin | 2020 |
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies.
Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; HEK293 Cells; Humans; Mice, Inb | 2020 |
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Male; Medial Forebrain Bundle; Parkinson Di | 2020 |
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Humans; Parkinson D | 2021 |
Identification of the Tau phosphorylation pattern that drives its aggregation.
Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Magnetic Resonance Spectroscopy; Microscopy, El | 2017 |
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies; Antibody Affinity; Autopsy; Brain; | 2018 |
Phosphorylation of serine 305 in tau inhibits aggregation.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Cells, Cultured; HEK293 Cells; Humans; Mi | 2019 |
Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Animals, Newborn; Cell Line; Cells, Cultured; Dop | 2016 |
Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Deuterium Exchange Measurement; Humans; Nuclear Magnetic R | 2016 |