serine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 12 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The survival rate of childhood acute lymphoblastic leukemia (ALL) is approaching 90%, while the prognosis of adults remains poor due to the limited therapeutic approaches." | 1.46 | Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia. ( Chen, H; Hu, L; Jiang, M; Li, B; Li, Q; Liu, T; Ning, H; Wang, D; Zhang, B, 2017) |
| "We propose that patients whose tumors show this phenotype will be sensitive to folate antagonists targeting thymidylate or purine biosynthesis." | 1.39 | Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. ( Bertino, JR; Tedeschi, PM; Vazquez, A, 2013) |
| "We studied 170 patients with acute lymphoblastic leukemia (ALL), treated from 1988 to 1994 according to a protocol derived from BFM-83 studies, in order to evaluate the incidence and prognostic significance of mutations in this gene in childhood ALL." | 1.31 | Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia. ( Clementino, NC; Costa, FF; Figueiredo, MS; Kerbauy, J; Saad, ST; Viana, MB; Yamamoto, M, 2001) |
| "The t(4;11) chromosomal translocation marks a subset of acute lymphoblastic and secondary myeloid leukemias." | 1.30 | The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations. ( Cleary, ML; Morrissey, JJ; Raney, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fioretti, T | 1 |
| Cevenini, A | 1 |
| Zanobio, M | 1 |
| Raia, M | 1 |
| Sarnataro, D | 1 |
| Salvatore, F | 1 |
| Esposito, G | 1 |
| Li, Q | 1 |
| Li, B | 1 |
| Hu, L | 1 |
| Ning, H | 1 |
| Jiang, M | 1 |
| Wang, D | 1 |
| Liu, T | 1 |
| Zhang, B | 1 |
| Chen, H | 1 |
| Habib, T | 1 |
| Sadoun, A | 1 |
| Nader, N | 1 |
| Suzuki, S | 1 |
| Liu, W | 1 |
| Jithesh, PV | 1 |
| Kino, T | 1 |
| Uckun, FM | 1 |
| Ma, H | 1 |
| Zhang, J | 1 |
| Ozer, Z | 1 |
| Dovat, S | 1 |
| Mao, C | 1 |
| Ishkhanian, R | 1 |
| Goodman, P | 1 |
| Qazi, S | 1 |
| Jensen, RH | 1 |
| Johansen, HK | 1 |
| Arendrup, MC | 1 |
| Vazquez, A | 1 |
| Tedeschi, PM | 1 |
| Bertino, JR | 1 |
| Miller, AL | 1 |
| Webb, MS | 1 |
| Copik, AJ | 1 |
| Wang, Y | 1 |
| Johnson, BH | 1 |
| Kumar, R | 1 |
| Thompson, EB | 1 |
| Malempati, S | 1 |
| Tibbitts, D | 1 |
| Cunningham, M | 1 |
| Akkari, Y | 1 |
| Olson, S | 1 |
| Fan, G | 1 |
| Sears, RC | 1 |
| Morrissey, J | 1 |
| Tkachuk, DC | 1 |
| Milatovich, A | 1 |
| Francke, U | 1 |
| Link, M | 1 |
| Cleary, ML | 2 |
| Morrissey, JJ | 1 |
| Raney, S | 1 |
| Clementino, NC | 1 |
| Yamamoto, M | 1 |
| Viana, MB | 1 |
| Figueiredo, MS | 1 |
| Kerbauy, J | 1 |
| Saad, ST | 1 |
| Costa, FF | 1 |
| Sukemori, S | 1 |
| Sugimura, K | 1 |
12 other studies available for serine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation.
Topics: 14-3-3 Proteins; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; DNA-B | 2019 |
Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Animals; Cell Line, Tumor; Cell Proliferation; Exome Sequencing; Female; Genetic | 2017 |
AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.
Topics: 14-3-3 Proteins; Biomarkers, Tumor; Cell Nucleus; Chromatin; E1A-Associated p300 Protein; Exoribonuc | 2017 |
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.
Topics: Cell Nucleus; Humans; Ikaros Transcription Factor; Intracellular Signaling Peptides and Proteins; Mu | 2012 |
Stepwise development of a homozygous S80P substitution in Fks1p, conferring echinocandin resistance in Candida tropicalis.
Topics: Amino Acid Substitution; Antifungal Agents; Candida tropicalis; Candidiasis; Clone Cells; Drug Resis | 2013 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondri | 2013 |
p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.
Topics: Alanine; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Dexamethasone; DNA; Enzyme | 2005 |
Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line; Child; Enzyme Activation; Gene Amplification; Gly | 2006 |
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Topics: Amino Acid Sequence; Base Sequence; Child; Chromosome Mapping; Chromosomes, Human, Pair 11; Chromoso | 1993 |
The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations.
Topics: Adenoviridae; Adenovirus E1B Proteins; Amino Acid Sequence; Animals; Binding Sites; Chromosomes, Hum | 1997 |
Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia.
Topics: Amino Acid Substitution; Base Sequence; Bone Marrow Cells; Brazil; Child; Child, Preschool; Cloning, | 2001 |
Stimulation of amino acid efflux from cells by extracellular serine.
Topics: Amino Acids; Animals; Biological Transport, Active; Cell Division; Culture Media; Extracellular Spac | 1992 |