serine has been researched along with Parkinsonian Disorders in 24 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For those greater than 60 years old, parkinsonism was present in 38." | 1.39 | Greater risk of parkinsonism associated with non-N370S GBA1 mutations. ( Alfonso, P; Barrett, MJ; Capablo, JL; Garcia-Rodriguez, B; Giraldo, P; Irun, P; Pastores, GM; Pocovi, M, 2013) |
| "Parkinsonism is one of the phenotypic features associated also with the W748S mutation." | 1.35 | Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene. ( Hinttala, R; Kärppä, M; Majamaa, K; Remes, AM; Soini, H; Takalo, R; Uusimaa, J, 2008) |
| "The mean age at onset for parkinsonism was 60 years, range 30-79 years; fewer than 20% of the patients had symptoms before the age 50 years, while by 75 years >90% of them had developed symptoms." | 1.35 | Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. ( Benecke, R; Berg, D; Bonifati, V; Brown, L; Cras, P; De Deyn, PP; Engelborghs, S; Farrer, MJ; Foroud, T; Gaig, C; Gasser, T; Gibson, JM; Goldwurm, S; Guidi, M; Hagenah, J; Haugarvoll, K; Kachergus, JM; Klein, C; Nichols, WC; Nuytemans, K; Pals, P; Pickut, B; Rademakers, R; Riboldazzi, G; Ross, OA; Samii, A; Tan, EK; Theuns, J; Tolosa, E; Uitti, RJ; Van Broeckhoven, C; Walter, U; Wszolek, ZK; Zabetian, CP, 2008) |
| "Frontotemporal dementia with parkinsonism linked to chromosome 17q21-22 (FTDP-17) is an autosomal dominant tauopathy manifested by a variable combination of personality changes, cognitive decline and hypokinetic-rigid movement disorder." | 1.32 | Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family. ( Abramsky, O; Biran, I; Boher, M; Ekstein, D; Gal, A; Gomori, JM; Lossos, A; Meiner, Z; Newman, JP; Reches, A; Rosenmann, H; Soffer, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (58.33) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nakahara, K | 3 |
| Okuda, H | 3 |
| Isonishi, A | 3 |
| Kawabe, Y | 3 |
| Tanaka, T | 3 |
| Tatsumi, K | 3 |
| Wanaka, A | 3 |
| Vieweg, S | 1 |
| Mulholland, K | 1 |
| Bräuning, B | 1 |
| Kachariya, N | 1 |
| Lai, YC | 1 |
| Toth, R | 1 |
| Singh, PK | 1 |
| Volpi, I | 1 |
| Sattler, M | 1 |
| Groll, M | 1 |
| Itzen, A | 1 |
| Muqit, MMK | 1 |
| Salvatore, MF | 1 |
| El Arfani, A | 1 |
| Albertini, G | 1 |
| Bentea, E | 1 |
| Demuyser, T | 1 |
| Van Eeckhaut, A | 1 |
| Smolders, I | 1 |
| Massie, A | 1 |
| Morris, JK | 1 |
| Zhang, H | 1 |
| Gupte, AA | 1 |
| Bomhoff, GL | 1 |
| Stanford, JA | 1 |
| Geiger, PC | 1 |
| Munhoz, RP | 1 |
| Teive, HA | 1 |
| Francisco, AN | 1 |
| Raskin, S | 1 |
| Rogaeva, E | 1 |
| Chalimoniuk, M | 1 |
| Stolecka, A | 1 |
| Ziemińska, E | 1 |
| Stepień, A | 1 |
| Langfort, J | 1 |
| Strosznajder, JB | 1 |
| Nguyen, XV | 1 |
| Liu, M | 1 |
| Kim, HC | 1 |
| Bing, G | 1 |
| Wider, C | 1 |
| Dachsel, JC | 2 |
| Farrer, MJ | 4 |
| Dickson, DW | 2 |
| Tsuboi, Y | 1 |
| Wszolek, ZK | 2 |
| Morissette, M | 1 |
| Samadi, P | 1 |
| Hadj Tahar, A | 1 |
| Bélanger, N | 1 |
| Di Paolo, T | 1 |
| Malagelada, C | 1 |
| Jin, ZH | 1 |
| Jackson-Lewis, V | 1 |
| Przedborski, S | 1 |
| Greene, LA | 1 |
| Valldeoriola, F | 2 |
| Gaig, C | 3 |
| Muxí, A | 1 |
| Navales, I | 1 |
| Paredes, P | 1 |
| Lomeña, F | 1 |
| De la Cerda, A | 1 |
| Buongiorno, M | 1 |
| Ezquerra, M | 2 |
| Santacruz, P | 1 |
| Martí, MJ | 2 |
| Tolosa, E | 3 |
| Barrett, MJ | 1 |
| Giraldo, P | 1 |
| Capablo, JL | 1 |
| Alfonso, P | 1 |
| Irun, P | 1 |
| Garcia-Rodriguez, B | 1 |
| Pocovi, M | 1 |
| Pastores, GM | 1 |
| van Nuenen, BF | 1 |
| Helmich, RC | 1 |
| Ferraye, M | 1 |
| Thaler, A | 1 |
| Hendler, T | 1 |
| Orr-Urtreger, A | 1 |
| Mirelman, A | 1 |
| Bressman, S | 1 |
| Marder, KS | 1 |
| Giladi, N | 1 |
| van de Warrenburg, BP | 1 |
| Bloem, BR | 1 |
| Toni, I | 1 |
| Lossos, A | 1 |
| Reches, A | 1 |
| Gal, A | 1 |
| Newman, JP | 1 |
| Soffer, D | 1 |
| Gomori, JM | 1 |
| Boher, M | 1 |
| Ekstein, D | 1 |
| Biran, I | 1 |
| Meiner, Z | 1 |
| Abramsky, O | 1 |
| Rosenmann, H | 1 |
| Kobayashi, K | 2 |
| Kidani, T | 2 |
| Ujike, H | 2 |
| Hayashi, M | 2 |
| Ishihara, T | 2 |
| Miyazu, K | 1 |
| Kuroda, S | 2 |
| Koshino, Y | 2 |
| Iijima, M | 1 |
| Nakano, H | 1 |
| Sugimori, K | 1 |
| Shimazaki, M | 1 |
| Rajput, A | 1 |
| Robinson, CA | 1 |
| Ross, OA | 3 |
| Lincoln, SJ | 1 |
| Cobb, SA | 1 |
| Rajput, ML | 1 |
| Schüpbach, M | 1 |
| Lohmann, E | 1 |
| Anheim, M | 1 |
| Lesage, S | 1 |
| Czernecki, V | 1 |
| Yaici, S | 1 |
| Worbe, Y | 1 |
| Charles, P | 1 |
| Welter, ML | 1 |
| Pollak, P | 1 |
| Dürr, A | 1 |
| Agid, Y | 1 |
| Brice, A | 1 |
| González-Fernández, MC | 1 |
| Lezcano, E | 1 |
| Gómez-Esteban, JC | 1 |
| Gómez-Busto, F | 1 |
| Velasco, F | 1 |
| Alvarez-Alvarez, M | 1 |
| Rodríguez-Martínez, MB | 1 |
| Ciordia, R | 1 |
| Zarranz, JJ | 1 |
| Mata, IF | 1 |
| de Pancorbo, MM | 1 |
| Remes, AM | 1 |
| Hinttala, R | 1 |
| Kärppä, M | 1 |
| Soini, H | 1 |
| Takalo, R | 1 |
| Uusimaa, J | 1 |
| Majamaa, K | 1 |
| Haugarvoll, K | 1 |
| Rademakers, R | 1 |
| Kachergus, JM | 1 |
| Nuytemans, K | 1 |
| Gibson, JM | 1 |
| Tan, EK | 1 |
| Goldwurm, S | 1 |
| Guidi, M | 1 |
| Riboldazzi, G | 1 |
| Brown, L | 1 |
| Walter, U | 1 |
| Benecke, R | 1 |
| Berg, D | 1 |
| Gasser, T | 1 |
| Theuns, J | 1 |
| Pals, P | 1 |
| Cras, P | 1 |
| De Deyn, PP | 1 |
| Engelborghs, S | 1 |
| Pickut, B | 1 |
| Uitti, RJ | 1 |
| Foroud, T | 1 |
| Nichols, WC | 1 |
| Hagenah, J | 1 |
| Klein, C | 1 |
| Samii, A | 1 |
| Zabetian, CP | 1 |
| Bonifati, V | 1 |
| Van Broeckhoven, C | 1 |
| Muñoz, E | 1 |
| Lladó, A | 1 |
| Rey, MJ | 1 |
| Cardozo, A | 1 |
| Molinuevo, JL | 1 |
| Lavedan, C | 1 |
| Buchholtz, S | 1 |
| Nussbaum, RL | 1 |
| Albin, RL | 1 |
| Polymeropoulos, MH | 1 |
1 trial available for serine and Parkinsonian Disorders
| Article | Year |
|---|---|
Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.
Topics: Adult; Aged; Deep Brain Stimulation; Female; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine P | 2007 |
23 other studies available for serine and Parkinsonian Disorders
| Article | Year |
|---|---|
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Topics: HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mitochondria; Parkinson | 2020 |
ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Male; O | 2014 |
Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Male; Motor Cortex; Oxidopamine; Pa | 2015 |
Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Blotting, Western; Chromatography, High Pressure Liquid; | 2008 |
Unilateral pallidotomy in a patient with parkinsonism and G2019S LRRK2 mutation.
Topics: Female; Functional Laterality; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase- | 2009 |
Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism--the possible key role of PKG.
Topics: Animals; Arachidonic Acid; Calcium; Catalytic Domain; Cell Death; Cyclic GMP; Cyclic GMP-Dependent P | 2009 |
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins; | 2009 |
Elucidating the genetics and pathology of Perry syndrome.
Topics: Adult; Age of Onset; Aged; Animals; Brain; Chlorocebus aethiops; COS Cells; Depression; DNA-Binding | 2010 |
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; D | 2010 |
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Death; Cycloheximi | 2010 |
123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations.
Topics: 3-Iodobenzylguanidine; Adult; Aged; Aged, 80 and over; Female; Glycine; Heart; Humans; Leucine-Rich | 2011 |
Greater risk of parkinsonism associated with non-N370S GBA1 mutations.
Topics: Adult; Aged; Amino Acid Substitution; beta-Glucosidase; Female; Genetic Association Studies; Genetic | 2013 |
Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.
Topics: Adult; Analysis of Variance; Biomechanical Phenomena; Brain; Cerebral Cortex; DNA Mutational Analysi | 2012 |
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family.
Topics: Adult; Algeria; Cerebral Cortex; Dementia; DNA Mutational Analysis; Family Health; Female; Humans; I | 2003 |
Another phenotype of frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17) with a missense mutation of S305N closely resembling Pick's disease.
Topics: Asparagine; Chromosomes, Human, Pair 17; Dementia; Dentate Gyrus; Genetic Linkage; Humans; Immunohis | 2003 |
Pick's disease pathology of a missense mutation of S305N of frontotemporal dementia and parkinsonism linked to chromosome 17: another phenotype of S305N.
Topics: Asparagine; Base Sequence; Brain; Dementia; DNA Mutational Analysis; Genetic Linkage; Heterozygote; | 2004 |
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.
Topics: Aged; alpha-Synuclein; Brain; Cell Line; Disability Evaluation; Disease Progression; Female; Glycine | 2006 |
Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
Topics: Adult; Aged; Arginine; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Dis | 2007 |
Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene.
Topics: Aged; Cocaine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Humans; Male; Mutation; Parkinsoni | 2008 |
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Cysteine; DNA Mutational Analysis | 2008 |
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Topics: Dementia; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Testing; Glyci | 2008 |
A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration.
Topics: Adult; Age of Onset; Brain; Cytoskeleton; DNA Mutational Analysis; Female; Genetic Testing; Glycine; | 2002 |