serine has been researched along with Osteogenic Sarcoma in 22 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteosarcoma is the major malignant primary bone cancer in children and adolescents, which is highly aggressive with frequent acquisition of chemoresistance phenotypes." | 5.46 | A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development. ( Bi, ZG; Cao, Y; E, XQ; Ji, G; Liu, W; Wang, DW; Wu, L; Yang, L, 2017) |
| "We revealed that expression of miR-659-3p was significantly downregulated in osteosarcoma compared with normal bone cells and was inversely correlated with serine-arginine protein kinase 1 (SRPK1) expression." | 4.12 | MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1. ( Gong, Y; Wei, ZR, 2022) |
| "Ascochlorin, a prenylphenol antitumor antibiotic, profoundly increases the expression of endogenous p53 by increasing protein stability in the human osteosarcoma cells and human colon cancer cells." | 3.75 | Ascochlorin activates p53 in a manner distinct from DNA damaging agents. ( Chang, HW; Chang, YC; Furukawa, C; Jeong, JH; Kim, CH; Lee, IS; Magae, J; Min, KS; Nakajima, H; Otsuka, K; Park, KK; Taki, K; Tomita, M, 2009) |
| "Previous results have shown that 1,25-dihydroxycholecalciferol [1,25(OH)2D3] enhances the synthesis of phosphatidylserine (PS) and suppresses the synthesis of phosphatidylethanolamine (PE) in osteoblast-like rat osteogenic sarcoma UMR 106 cells [Matsumoto, Kawanobe, Morita & Ogata (1985) J." | 3.67 | Effect of parathyroid hormone on phospholipid metabolism in osteoblast-like rat osteogenic sarcoma cells. ( Kawanobe, Y; Matsumoto, T; Morita, K; Ogata, E, 1986) |
| "Osteosarcoma is the major malignant primary bone cancer in children and adolescents, which is highly aggressive with frequent acquisition of chemoresistance phenotypes." | 1.46 | A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development. ( Bi, ZG; Cao, Y; E, XQ; Ji, G; Liu, W; Wang, DW; Wu, L; Yang, L, 2017) |
| "ERα is critical in many breast tumors and is inhibited by antiestrogens such as tamoxifen in cancer therapy." | 1.38 | Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen. ( de Leeuw, R; Houtman, R; Martens, JW; Melchers, D; Michalides, R; Neefjes, J; Rondaij, M; Ruijtenbeek, R; Verwoerd, D, 2012) |
| "Here, we have examined three different Burkitt's lymphoma mutant c-Myc proteins found in primary Burkitt's lymphomas and one mutant c-Myc protein detected in a Burkitt's lymphoma cell line." | 1.29 | Functional analysis of Burkitt's lymphoma mutant c-Myc proteins. ( Beijersbergen, RL; Bernards, R; Hijmans, EM; Smith-Sørensen, B, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, Y | 1 |
| Wei, ZR | 1 |
| Wu, Q | 1 |
| Paul, A | 1 |
| Su, D | 1 |
| Mehmood, S | 1 |
| Foo, TK | 1 |
| Ochi, T | 1 |
| Bunting, EL | 1 |
| Xia, B | 1 |
| Robinson, CV | 1 |
| Wang, B | 1 |
| Blundell, TL | 1 |
| Wang, DW | 1 |
| Wu, L | 1 |
| Cao, Y | 1 |
| Yang, L | 1 |
| Liu, W | 1 |
| E, XQ | 1 |
| Ji, G | 1 |
| Bi, ZG | 1 |
| Gorska-Ponikowska, M | 1 |
| Perricone, U | 1 |
| Kuban-Jankowska, A | 1 |
| Lo Bosco, G | 1 |
| Barone, G | 1 |
| Jeong, JH | 1 |
| Nakajima, H | 1 |
| Magae, J | 1 |
| Furukawa, C | 1 |
| Taki, K | 1 |
| Otsuka, K | 1 |
| Tomita, M | 1 |
| Lee, IS | 1 |
| Kim, CH | 1 |
| Chang, HW | 1 |
| Min, KS | 1 |
| Park, KK | 2 |
| Chang, YC | 1 |
| Houtman, R | 1 |
| de Leeuw, R | 1 |
| Rondaij, M | 1 |
| Melchers, D | 1 |
| Verwoerd, D | 1 |
| Ruijtenbeek, R | 1 |
| Martens, JW | 1 |
| Neefjes, J | 1 |
| Michalides, R | 1 |
| Yap, DB | 1 |
| Hsieh, JK | 1 |
| Zhong, S | 1 |
| Heath, V | 1 |
| Gusterson, B | 1 |
| Crook, T | 1 |
| Lu, X | 2 |
| Götz, C | 1 |
| Kartarius, S | 1 |
| Schwär, G | 1 |
| Montenarh, M | 1 |
| Canton, DA | 1 |
| Olsten, ME | 1 |
| Kim, K | 1 |
| Doherty-Kirby, A | 1 |
| Lajoie, G | 1 |
| Cooper, JA | 1 |
| Litchfield, DW | 1 |
| Berger, M | 1 |
| Stahl, N | 1 |
| Del Sal, G | 1 |
| Haupt, Y | 1 |
| Tanaka, H | 1 |
| Yoshida, K | 1 |
| Okamura, H | 1 |
| Morimoto, H | 1 |
| Nagata, T | 1 |
| Haneji, T | 1 |
| Ma, O | 1 |
| Nguyen, TA | 1 |
| Jones, SN | 1 |
| Oren, M | 1 |
| Donehower, LA | 1 |
| Katayama, H | 1 |
| Sasai, K | 1 |
| Czerniak, BA | 1 |
| Carter, JL | 1 |
| Sen, S | 1 |
| Ghebranious, N | 1 |
| Knoll, BJ | 1 |
| Wu, H | 1 |
| Lozano, G | 1 |
| Sell, S | 1 |
| Smith-Sørensen, B | 1 |
| Hijmans, EM | 1 |
| Beijersbergen, RL | 1 |
| Bernards, R | 1 |
| Whitfield, JF | 1 |
| Morley, P | 1 |
| Willick, G | 1 |
| Langille, R | 1 |
| Ross, V | 1 |
| MacLean, S | 1 |
| Barbier, JR | 1 |
| Rogatsky, I | 1 |
| Logan, SK | 1 |
| Garabedian, MJ | 1 |
| Barrientes, S | 1 |
| Cooke, C | 1 |
| Goodrich, DW | 1 |
| Oda, K | 1 |
| Arakawa, H | 1 |
| Tanaka, T | 1 |
| Matsuda, K | 1 |
| Tanikawa, C | 1 |
| Mori, T | 1 |
| Nishimori, H | 1 |
| Tamai, K | 1 |
| Tokino, T | 1 |
| Nakamura, Y | 1 |
| Taya, Y | 1 |
| Matsumoto, T | 1 |
| Morita, K | 1 |
| Kawanobe, Y | 1 |
| Ogata, E | 1 |
| Knox, WE | 1 |
| Herzfeld, A | 1 |
| Hudson, J | 1 |
| Meienhofer, J | 1 |
| Patel, RP | 1 |
22 other studies available for serine and Osteogenic Sarcoma
| Article | Year |
|---|---|
MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1.
Topics: 3' Untranslated Regions; Animals; Arginine; Arginine Kinase; Bone Neoplasms; Cell Line, Tumor; Cell | 2022 |
Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Topics: Amino Acid Sequence; Ataxia Telangiectasia Mutated Proteins; Bone Neoplasms; BRCA1 Protein; Carrier | 2016 |
A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development.
Topics: Apoptosis; Carbon; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycine; Humans; Mechanisti | 2017 |
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Binding Sites; Bone Neoplasms; Breast Neoplasms; Cell Mov | 2017 |
Ascochlorin activates p53 in a manner distinct from DNA damaging agents.
Topics: Adenosine Triphosphate; Alkenes; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins | 2009 |
Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen.
Topics: Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Estrogen Recept | 2012 |
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; | 2004 |
Phosphorylation of mdm2 at serine 269 impairs its interaction with the retinoblastoma protein.
Topics: Casein Kinase II; Humans; Nuclear Proteins; Osteosarcoma; Phosphorylation; Proto-Oncogene Proteins; | 2005 |
The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein.
Topics: Actin Capping Proteins; Actin Cytoskeleton; Actin Depolymerizing Factors; Actins; Amino Acid Sequenc | 2005 |
Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.
Topics: Animals; Cell Line; Cell Line, Tumor; Checkpoint Kinase 2; DNA Damage; Embryo, Mammalian; Fibroblast | 2005 |
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells.
Topics: Apoptosis; Binding Sites; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans | 2007 |
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; | 2007 |
Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.
Topics: Aurora Kinase B; Aurora Kinases; Cell Cycle; Cell Line, Tumor; DNA, Complementary; Enzyme Stability; | 2007 |
Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Arginine; Base Sequence; Carcinoma, Hepatocellular; Codo | 1995 |
Functional analysis of Burkitt's lymphoma mutant c-Myc proteins.
Topics: Amino Acid Sequence; Base Sequence; Burkitt Lymphoma; Cell Line; Genes, myc; Humans; Molecular Seque | 1996 |
Cyclization by a specific lactam increases the ability of human parathyroid hormone (hPTH)-(1-31)NH2 to stimulate bone growth in ovariectomized rats.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bone Development; Bone Neoplasms; Disease Models, | 1997 |
Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; HeLa Cells; Humans; JNK Mitoge | 1998 |
Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function.
Topics: Bone Neoplasms; Cell Cycle; Cell Line; Cyclin-Dependent Kinases; Genes, Retinoblastoma; Glutamic Aci | 2000 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non- | 2000 |
Effect of parathyroid hormone on phospholipid metabolism in osteoblast-like rat osteogenic sarcoma cells.
Topics: Animals; Calcitriol; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Ethanolamine; Ethanola | 1986 |
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues.
Topics: Adenocarcinoma; Animals; Brain; Carcinoma, Hepatocellular; Female; Fetus; Fibrosarcoma; Kidney; Kine | 1969 |
Synthesis of an actinomycin analog with substituted lactone oxygens (1',1'-bis(L-,-diaminopropionic acid))-actinomycin C (C 1).
Topics: Amino Acids; Animals; Antineoplastic Agents; Benzyl Compounds; Chemical Phenomena; Chemistry; Dactin | 1971 |