serine has been researched along with Obesity in 64 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 7.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 7.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| " We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels." | 7.77 | Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011) |
| "Obesity, a state of apparent "leptin resistance" is well known to be associated with insulin resistance." | 7.73 | Hepatic leptin signaling in obesity. ( Anderwald, C; Brabant, G; Horn, R; Müller, G; Nave, H; Roden, M, 2005) |
| "Obesity is associated with the development of leptin resistance." | 7.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 7.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 3.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 3.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| " We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels." | 3.77 | Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011) |
| "IRS-1 serine phosphorylation is often elevated in insulin resistance models, but confirmation in vivo in humans is lacking." | 3.77 | Global IRS-1 phosphorylation analysis in insulin resistance. ( De Filippis, E; Finlayson, J; Langlais, P; Luo, M; Mandarino, LJ; Mapes, R; Mattern, M; Meyer, C; Plummer, E; Tongchinsub, P; Yi, Z, 2011) |
| "Obesity, a state of apparent "leptin resistance" is well known to be associated with insulin resistance." | 3.73 | Hepatic leptin signaling in obesity. ( Anderwald, C; Brabant, G; Horn, R; Müller, G; Nave, H; Roden, M, 2005) |
| "Obesity is associated with the development of leptin resistance." | 3.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 3.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| "Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell loss in T1D." | 1.91 | Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation. ( Arroba, EN; Bertrand, MJ; Cardozo, AK; Franchimont, M; Gilglioni, EH; Gurzov, EN; Takiishi, T; Xiao, P, 2023) |
| "Obesity is linked to the development of major metabolic disorders such as type 2 diabetes, cardiovascular disease, and cancer." | 1.91 | Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model. ( , 2023) |
| "Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is becoming one of the most common liver diseases worldwide." | 1.72 | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice. ( Araujo, LCC; Carvalho, CRO; Matos, SL; Moreira, GV; Murata, GM, 2022) |
| "These effects were mediated by the breast cancer oncogene IKKε and its downstream target-the serine biosynthesis pathway as demonstrated by genetic or pharmacological tools." | 1.56 | Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. ( Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R, 2020) |
| " It is well established that reduced vascular endothelial nitric oxide (NO) bioavailability promotes arterial inflammation; however, the role of NO in modulating inflammation in AT remains disputed." | 1.43 | Ablation of eNOS does not promote adipose tissue inflammation. ( Gastecki, ML; Jurrissen, TJ; Padilla, J; Rector, RS; Sheldon, RD; Vieira-Potter, VJ; Woodford, ML; Zidon, TM, 2016) |
| "Obesity is often associated with an alter lipid profile, e." | 1.42 | The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals. ( Avan, A; Emamian, M; Ferns, GA; Ghayour-Mobarhan, M; Mirhafez, SR; Moghadam, MS; Parizadeh, SM; Pasdar, A; Sadeghzadeh, M, 2015) |
| "Metformin is a first-line, anti-diabetic agent prescribed to over 150 million people worldwide." | 1.40 | Potential biomarker of metformin action. ( Germain-Lee, EL; He, L; Meng, S; Radovick, S; Wondisford, FE, 2014) |
| " The role of p66shc in adverse effects of OA was determined using knockdown, p66shc serine36 phosphorylation and cytochrome c binding-deficient cells." | 1.39 | Role of p66shc in renal toxicity of oleic acid. ( Arany, I; Clark, JS; Dixit, M; Juncos, LA; Reed, DK, 2013) |
| "Obesity is a health hazard that is associated with a number of diseases and metabolic abnormalities, such as type-2 diabetes, hypertension, dyslipidemia, and coronary heart disease." | 1.38 | Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. ( Cho, JH; Kim, CH; Kim, GS; Kim, MK; Ko, YG; Koh, PO; Min, W; Park, HJ; Won, CK; Woo, JH, 2012) |
| "On leptin treatment, mitochondrial permeability transition pore opening was delayed by 43% (P < 0." | 1.35 | The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat. ( Davidson, SM; Dixon, RA; Smith, CC; Wynne, AM; Yellon, DM, 2009) |
| "Obesity and type 2 diabetes mellitus are characterized by insulin resistance, reduced bioavailability of the antiatherosclerotic signaling molecule nitric oxide (NO), and accelerated atherosclerosis." | 1.35 | Vascular insulin-like growth factor-I resistance and diet-induced obesity. ( Abbas, A; Ajjan, R; Cubbon, RM; Duncan, ER; Ezzat, VA; Gage, M; Grant, PJ; Imrie, H; Kahn, M; Kearney, MT; Rajwani, A; Viswambharan, H; Wheatcroft, SB, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.56) | 18.7374 |
| 1990's | 3 (4.69) | 18.2507 |
| 2000's | 22 (34.38) | 29.6817 |
| 2010's | 26 (40.63) | 24.3611 |
| 2020's | 12 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| López-Gonzales, E | 1 |
| Lehmann, L | 1 |
| Ruiz-Ojeda, FJ | 1 |
| Hernández-Bautista, R | 1 |
| Altun, I | 1 |
| Onogi, Y | 1 |
| Khalil, AE | 1 |
| Liu, X | 1 |
| Israel, A | 2 |
| Ussar, S | 2 |
| Du, M | 1 |
| Li, X | 1 |
| Xiao, F | 1 |
| Fu, Y | 1 |
| Shi, Y | 1 |
| Guo, S | 1 |
| Chen, L | 2 |
| Shen, L | 1 |
| Wang, L | 1 |
| Cheng, H | 1 |
| Li, H | 1 |
| Xie, A | 1 |
| Zhou, Y | 1 |
| Yang, K | 1 |
| Fang, H | 1 |
| Lyu, J | 1 |
| Zhao, Q | 1 |
| Chen, H | 1 |
| Liu, C | 2 |
| Wang, Q | 2 |
| Xiong, M | 1 |
| Zeng, X | 1 |
| Yang, D | 1 |
| Xie, Y | 1 |
| Su, H | 1 |
| Zhang, Y | 2 |
| Huang, Y | 1 |
| Chen, Y | 1 |
| Yue, J | 1 |
| Wang, S | 1 |
| Huang, K | 1 |
| Zheng, L | 1 |
| Pileggi, CA | 1 |
| Blondin, DP | 1 |
| Hooks, BG | 1 |
| Parmar, G | 1 |
| Alecu, I | 1 |
| Patten, DA | 1 |
| Cuillerier, A | 1 |
| O'Dwyer, C | 1 |
| Thrush, AB | 1 |
| Fullerton, MD | 1 |
| Bennett, SA | 1 |
| Doucet, É | 1 |
| Haman, F | 1 |
| Cuperlovic-Culf, M | 1 |
| McPherson, R | 1 |
| Dent, RRM | 1 |
| Harper, ME | 1 |
| Moreira, GV | 1 |
| Araujo, LCC | 1 |
| Murata, GM | 1 |
| Matos, SL | 1 |
| Carvalho, CRO | 1 |
| Nichenametla, SN | 3 |
| Mattocks, DAL | 3 |
| Cooke, D | 3 |
| Midya, V | 3 |
| Malloy, VL | 3 |
| Mansilla, W | 3 |
| Øvrebø, B | 3 |
| Turner, C | 3 |
| Bastani, NE | 3 |
| Sokolová, J | 3 |
| Pavlíková, M | 3 |
| Richie, JP | 3 |
| Shoveller, AK | 3 |
| Refsum, H | 3 |
| Olsen, T | 3 |
| Vinknes, KJ | 3 |
| Kožich, V | 3 |
| Ables, GP | 3 |
| Takiishi, T | 1 |
| Xiao, P | 1 |
| Franchimont, M | 1 |
| Gilglioni, EH | 1 |
| Arroba, EN | 1 |
| Gurzov, EN | 1 |
| Bertrand, MJ | 1 |
| Cardozo, AK | 1 |
| Ramírez-Orozco, RE | 1 |
| Malacara, JM | 1 |
| Figueroa-Vega, N | 1 |
| Wilcz-Villega, E | 1 |
| Carter, E | 1 |
| Ironside, A | 1 |
| Xu, R | 1 |
| Mataloni, I | 1 |
| Holdsworth, J | 1 |
| Jones, W | 1 |
| Moreno Béjar, R | 1 |
| Uhlik, L | 1 |
| Bentham, RB | 1 |
| Godinho, SA | 1 |
| Dalli, J | 1 |
| Grose, R | 1 |
| Szabadkai, G | 1 |
| Jones, L | 1 |
| Hodivala-Dilke, K | 1 |
| Bianchi, K | 1 |
| Fridman, V | 1 |
| Zarini, S | 1 |
| Sillau, S | 1 |
| Harrison, K | 1 |
| Bergman, BC | 1 |
| Feldman, EL | 1 |
| Reusch, JEB | 1 |
| Callaghan, BC | 1 |
| Broadfield, LA | 1 |
| Duarte, JAG | 1 |
| Schmieder, R | 1 |
| Broekaert, D | 1 |
| Veys, K | 1 |
| Planque, M | 1 |
| Vriens, K | 1 |
| Karasawa, Y | 1 |
| Napolitano, F | 1 |
| Fujita, S | 1 |
| Fujii, M | 1 |
| Eto, M | 1 |
| Holvoet, B | 1 |
| Vangoitsenhoven, R | 1 |
| Fernandez-Garcia, J | 1 |
| Van Elsen, J | 1 |
| Dehairs, J | 1 |
| Zeng, J | 1 |
| Dooley, J | 1 |
| Rubio, RA | 1 |
| van Pelt, J | 1 |
| Grünewald, TGP | 1 |
| Liston, A | 1 |
| Mathieu, C | 1 |
| Deroose, CM | 1 |
| Swinnen, JV | 1 |
| Lambrechts, D | 1 |
| di Bernardo, D | 1 |
| Kuroda, S | 1 |
| De Bock, K | 1 |
| Fendt, SM | 1 |
| Riedlinger, T | 1 |
| Dommerholt, MB | 1 |
| Wijshake, T | 1 |
| Kruit, JK | 1 |
| Huijkman, N | 1 |
| Dekker, D | 1 |
| Koster, M | 1 |
| Kloosterhuis, N | 1 |
| Koonen, DPY | 1 |
| de Bruin, A | 1 |
| Baker, D | 1 |
| Hofker, MH | 1 |
| van Deursen, J | 1 |
| Jonker, JW | 1 |
| Schmitz, ML | 1 |
| van de Sluis, B | 1 |
| Vandenbeek, R | 1 |
| Khan, NP | 1 |
| Estall, JL | 1 |
| Hernández-Alonso, P | 1 |
| Giardina, S | 1 |
| Cañueto, D | 1 |
| Salas-Salvadó, J | 1 |
| Cañellas, N | 1 |
| Bulló, M | 1 |
| Hong, S | 1 |
| Song, W | 1 |
| Zushin, PH | 1 |
| Liu, B | 1 |
| Jedrychowski, MP | 1 |
| Mina, AI | 1 |
| Deng, Z | 1 |
| Cabarkapa, D | 1 |
| Hall, JA | 1 |
| Palmer, CJ | 1 |
| Aliakbarian, H | 1 |
| Szpyt, J | 1 |
| Gygi, SP | 1 |
| Tavakkoli, A | 1 |
| Lynch, L | 1 |
| Perrimon, N | 1 |
| Banks, AS | 1 |
| Jin, X | 1 |
| Qiao, A | 1 |
| Moskophidis, D | 1 |
| Mivechi, NF | 1 |
| Suwandhi, L | 1 |
| Hausmann, S | 1 |
| Braun, A | 1 |
| Gruber, T | 1 |
| Heinzmann, SS | 1 |
| Gálvez, EJC | 1 |
| Buck, A | 1 |
| Legutko, B | 1 |
| Feuchtinger, A | 1 |
| Haythorne, E | 1 |
| Staiger, H | 1 |
| Heni, M | 1 |
| Häring, HU | 2 |
| Schmitt-Kopplin, P | 1 |
| Walch, A | 1 |
| Cáceres, CG | 1 |
| Tschöp, MH | 1 |
| Rutter, GA | 1 |
| Strowig, T | 1 |
| Elsner, M | 1 |
| Leifheit-Nestler, M | 1 |
| Wagner, NM | 1 |
| Gogiraju, R | 1 |
| Didié, M | 1 |
| Konstantinides, S | 1 |
| Hasenfuss, G | 1 |
| Schäfer, K | 1 |
| Arany, I | 1 |
| Clark, JS | 1 |
| Reed, DK | 1 |
| Juncos, LA | 1 |
| Dixit, M | 1 |
| He, L | 1 |
| Meng, S | 1 |
| Germain-Lee, EL | 1 |
| Radovick, S | 1 |
| Wondisford, FE | 1 |
| Kim, H | 1 |
| Park, M | 1 |
| Lee, SK | 1 |
| Jeong, J | 1 |
| Namkoong, K | 1 |
| Cho, HS | 1 |
| Park, JY | 1 |
| Lee, BI | 1 |
| Kim, E | 1 |
| Lima-Leopoldo, AP | 1 |
| Leopoldo, AS | 1 |
| da Silva, DC | 1 |
| do Nascimento, AF | 1 |
| de Campos, DH | 1 |
| Luvizotto, RA | 1 |
| de Deus, AF | 1 |
| Freire, PP | 1 |
| Medeiros, A | 1 |
| Okoshi, K | 1 |
| Cicogna, AC | 1 |
| Li, J | 2 |
| Bi, L | 1 |
| Hulke, M | 1 |
| Li, T | 1 |
| Emamian, M | 1 |
| Avan, A | 1 |
| Pasdar, A | 1 |
| Mirhafez, SR | 1 |
| Sadeghzadeh, M | 1 |
| Moghadam, MS | 1 |
| Parizadeh, SM | 1 |
| Ferns, GA | 1 |
| Ghayour-Mobarhan, M | 1 |
| Jung, J | 1 |
| Ha, TK | 1 |
| Lee, J | 2 |
| Lho, Y | 1 |
| Nam, M | 1 |
| Lee, D | 1 |
| le Roux, CW | 1 |
| Ryu, DH | 1 |
| Ha, E | 1 |
| Hwang, GS | 1 |
| Jurrissen, TJ | 1 |
| Sheldon, RD | 1 |
| Gastecki, ML | 1 |
| Woodford, ML | 1 |
| Zidon, TM | 1 |
| Rector, RS | 1 |
| Vieira-Potter, VJ | 1 |
| Padilla, J | 1 |
| Chen, Q | 1 |
| Xie, B | 1 |
| Quan, C | 1 |
| Sheng, Y | 1 |
| Zhu, S | 1 |
| Rong, P | 1 |
| Zhou, S | 1 |
| Sakamoto, K | 1 |
| MacKintosh, C | 1 |
| Wang, HY | 1 |
| Chen, S | 1 |
| Sasaki, T | 1 |
| Matsui, S | 1 |
| Kitamura, T | 1 |
| Wang, H | 1 |
| Liu, L | 1 |
| Lin, JZ | 1 |
| Aprahamian, TR | 1 |
| Farmer, SR | 1 |
| Muñoz, MC | 2 |
| Giani, JF | 1 |
| Mayer, MA | 1 |
| Toblli, JE | 2 |
| Turyn, D | 2 |
| Dominici, FP | 2 |
| Muraoka, M | 1 |
| Fukushima, A | 1 |
| Viengchareun, S | 1 |
| Lombès, M | 1 |
| Kishi, F | 1 |
| Miyauchi, A | 1 |
| Kanematsu, M | 1 |
| Doi, J | 1 |
| Kajimura, J | 1 |
| Nakai, R | 1 |
| Uebi, T | 1 |
| Okamoto, M | 1 |
| Takemori, H | 1 |
| Dixon, RA | 1 |
| Davidson, SM | 1 |
| Wynne, AM | 1 |
| Yellon, DM | 1 |
| Smith, CC | 1 |
| Imrie, H | 1 |
| Abbas, A | 1 |
| Viswambharan, H | 1 |
| Rajwani, A | 1 |
| Cubbon, RM | 1 |
| Gage, M | 1 |
| Kahn, M | 1 |
| Ezzat, VA | 1 |
| Duncan, ER | 1 |
| Grant, PJ | 1 |
| Ajjan, R | 1 |
| Wheatcroft, SB | 1 |
| Kearney, MT | 1 |
| Grillo, CA | 1 |
| Piroli, GG | 1 |
| Evans, AN | 1 |
| Macht, VA | 1 |
| Wilson, SP | 1 |
| Scott, KA | 1 |
| Sakai, RR | 1 |
| Mott, DD | 1 |
| Reagan, LP | 1 |
| Langlais, P | 1 |
| Yi, Z | 1 |
| Finlayson, J | 1 |
| Luo, M | 1 |
| Mapes, R | 1 |
| De Filippis, E | 1 |
| Meyer, C | 1 |
| Plummer, E | 1 |
| Tongchinsub, P | 1 |
| Mattern, M | 1 |
| Mandarino, LJ | 1 |
| Mao, T | 1 |
| Shao, M | 1 |
| Qiu, Y | 1 |
| Huang, J | 1 |
| Song, B | 1 |
| Jiang, L | 1 |
| Liu, Y | 2 |
| Han, JD | 1 |
| Cao, P | 1 |
| Gao, X | 1 |
| Rui, L | 1 |
| Qi, L | 1 |
| Li, W | 1 |
| Lorente-Cebrián, S | 1 |
| Kulyté, A | 1 |
| Hedén, P | 1 |
| Näslund, E | 1 |
| Arner, P | 1 |
| Rydén, M | 1 |
| Kim, GS | 1 |
| Park, HJ | 1 |
| Woo, JH | 1 |
| Kim, MK | 1 |
| Koh, PO | 1 |
| Min, W | 1 |
| Ko, YG | 1 |
| Kim, CH | 1 |
| Won, CK | 1 |
| Cho, JH | 1 |
| Krawczyk, SA | 1 |
| Haller, JF | 1 |
| Ferrante, T | 1 |
| Zoeller, RA | 1 |
| Corkey, BE | 1 |
| Katta, A | 1 |
| Kakarla, SK | 1 |
| Manne, ND | 1 |
| Wu, M | 1 |
| Kundla, S | 1 |
| Kolli, MB | 1 |
| Nalabotu, SK | 1 |
| Blough, ER | 1 |
| Liu, M | 1 |
| Zhou, L | 1 |
| Wei, L | 1 |
| Villarreal, R | 1 |
| Yang, X | 1 |
| Hu, D | 1 |
| Riojas, RA | 1 |
| Holmes, BM | 1 |
| Langlais, PR | 1 |
| Lee, H | 1 |
| Dong, LQ | 1 |
| Gum, RJ | 1 |
| Gaede, LL | 1 |
| Koterski, SL | 1 |
| Heindel, M | 1 |
| Clampit, JE | 1 |
| Zinker, BA | 1 |
| Trevillyan, JM | 1 |
| Ulrich, RG | 1 |
| Jirousek, MR | 1 |
| Rondinone, CM | 1 |
| Muller, YL | 1 |
| Bogardus, C | 1 |
| Pedersen, O | 1 |
| Baier, L | 1 |
| Rangwala, SM | 1 |
| Rhoades, B | 1 |
| Shapiro, JS | 1 |
| Rich, AS | 1 |
| Kim, JK | 1 |
| Shulman, GI | 1 |
| Kaestner, KH | 1 |
| Lazar, MA | 1 |
| Santini, F | 1 |
| Maffei, M | 1 |
| Ceccarini, G | 1 |
| Pelosini, C | 1 |
| Scartabelli, G | 1 |
| Rosellini, V | 1 |
| Chiellini, C | 1 |
| Marsili, A | 1 |
| Lisi, S | 1 |
| Tonacchera, M | 1 |
| Agretti, P | 1 |
| Chiovato, L | 1 |
| Mammoli, C | 1 |
| Vitti, P | 1 |
| Pinchera, A | 1 |
| Huang, W | 1 |
| Dedousis, N | 1 |
| Bhatt, BA | 1 |
| O'Doherty, RM | 1 |
| Werner, ED | 1 |
| Hansen, L | 1 |
| Yuan, M | 1 |
| Shoelson, SE | 1 |
| Coba, MP | 1 |
| Peña, C | 1 |
| Bartke, A | 1 |
| Araújo, EP | 1 |
| De Souza, CT | 2 |
| Gasparetti, AL | 1 |
| Ueno, M | 1 |
| Boschero, AC | 1 |
| Saad, MJ | 2 |
| Velloso, LA | 2 |
| Khamzina, L | 1 |
| Veilleux, A | 1 |
| Bergeron, S | 1 |
| Marette, A | 2 |
| Brabant, G | 1 |
| Müller, G | 1 |
| Horn, R | 1 |
| Anderwald, C | 1 |
| Roden, M | 2 |
| Nave, H | 1 |
| Fanelli, M | 1 |
| Filippi, E | 1 |
| Sentinelli, F | 1 |
| Romeo, S | 1 |
| Fallarino, M | 1 |
| Buzzetti, R | 1 |
| Leonetti, F | 1 |
| Baroni, MG | 1 |
| Dallongeville, J | 1 |
| Delcroix, AG | 1 |
| Wagner, A | 1 |
| Ducimetière, P | 1 |
| Ruidavets, JB | 1 |
| Arveiler, D | 1 |
| Bingham, A | 1 |
| Ferrières, J | 1 |
| Amouyel, P | 1 |
| Meirhaeghe, A | 1 |
| Sutton, GM | 1 |
| Trevaskis, JL | 1 |
| Hulver, MW | 1 |
| McMillan, RP | 1 |
| Markward, NJ | 1 |
| Babin, MJ | 1 |
| Meyer, EA | 1 |
| Butler, AA | 1 |
| Ridderstråle, M | 1 |
| Johansson, LE | 1 |
| Rastam, L | 1 |
| Lindblad, U | 1 |
| Hennige, AM | 1 |
| Stefan, N | 1 |
| Kapp, K | 1 |
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| Weigert, C | 1 |
| Beck, A | 1 |
| Moeschel, K | 1 |
| Mushack, J | 1 |
| Schleicher, E | 1 |
| Ropelle, ER | 1 |
| Pauli, JR | 1 |
| Prada, PO | 1 |
| Picardi, PK | 1 |
| Faria, MC | 1 |
| Cintra, DE | 1 |
| Fernandes, MF | 1 |
| Flores, MB | 1 |
| Carvalheira, JB | 1 |
| Tremblay, F | 1 |
| Brûlé, S | 1 |
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| Li, Y | 1 |
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| Sun, XJ | 1 |
| Krebs, M | 1 |
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| Thomas, G | 1 |
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| Peraldi, P | 1 |
| Budavari, A | 1 |
| Ellis, R | 1 |
| White, MF | 1 |
| Spiegelman, BM | 1 |
| Ristow, M | 1 |
| Müller-Wieland, D | 1 |
| Pfeiffer, A | 1 |
| Krone, W | 1 |
| Kahn, CR | 1 |
| Shimabukuro, M | 1 |
| Higa, M | 1 |
| Zhou, YT | 1 |
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| Wahl, HG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 4 Study of the Effects of Pravastatin on Cholesterol Levels, Inflammation and Cognition in Schizophrenia[NCT01082588] | Phase 4 | 60 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/L (Mean) |
|---|---|
| Pravastatin | 0.8063 |
| Placebo | -0.5136 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/dl (Mean) |
|---|---|
| Pravastatin | -25.565 |
| Placebo | -2.913 |
"The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery measures cognitive functioning within 7 domains: speed of processing, attention/vigilance, working memory (non verbal and verbal), verbal learning, visual learning, reasoning and problem solving and social cognition.~The composite score is calculated by the MATRICS computer program, which equally weights each of the 7 domain scores. The range of composite scores is 20-80. Higher scores indicate higher levels or cognitive functioning, while lower scores indicate lower levels of cognitive functioning." (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | 4.0417 |
| Placebo | 4.125 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 15-105. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -5.625 |
| Placebo | -3.76 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -0.83 |
| Placebo | -0.28 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -2.9583 |
| Placebo | -2.44 |
The Positive and Negative Syndrome Scale (PANSS) is a scale used to rate severity of schizophrenia. All items are summed to calculate the total score. The scale range is 30-210. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -9.416 |
| Placebo | -6.48 |
2 reviews available for serine and Obesity
| Article | Year |
|---|---|
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea | 2018 |
Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.
Topics: Appetite; Dopamine; Food Preferences; Glutamic Acid; Humans; Obesity; Receptors, N-Methyl-D-Aspartat | 2016 |
1 trial available for serine and Obesity
| Article | Year |
|---|---|
Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention.
Topics: Adult; Biomarkers; Blood Glucose; Body Weight; Diet; Diet, Fat-Restricted; Female; Glycemic Index; H | 2019 |
61 other studies available for serine and Obesity
| Article | Year |
|---|---|
L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis.
Topics: Adipose Tissue, Brown; Animals; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Fasting; Mal | 2022 |
Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice.
Topics: Animals; Catalytic Domain; Cholesterol; Diet, High-Fat; Insulin Resistance; Lipid Metabolism; Liver; | 2022 |
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.
Topics: Diabetic Nephropathies; Histone Demethylases; Humans; Kidney; Liver; Metabolic Diseases; Obesity; Ph | 2022 |
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.
Topics: Adenosine Triphosphate; Canada; Diet, Reducing; Exercise; Female; Humans; Insulins; Mitochondria; Mu | 2022 |
Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice.
Topics: Animals; Bile Acids and Salts; Carbohydrates; Citrate (si)-Synthase; Collagen; Diet, High-Fat; Farne | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; M | 2022 |
Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation.
Topics: Animals; Diabetes Mellitus, Type 1; Humans; Inflammation; Mice; Obesity; Protein Kinases; Receptor-I | 2023 |
Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model.
Topics: Animals; Antioxidants; CCAAT-Enhancer-Binding Protein-alpha; Diabetes Mellitus, Type 2; Lipid Metabo | 2023 |
Obesity as a negative mediator of serine-118/serine-105 phosphorylation sites on ERα/ERβ through the ovarian cycle.
Topics: Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Menstrual Cycle; Obesity; Phosphorylation; | 2023 |
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Hum | 2020 |
Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Obesity; Serine; Tandem Mass Spectrometry | 2021 |
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F | 2021 |
NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.
Topics: Aging; Amino Acid Substitution; Animals; Gene Expression Regulation; Gene Knock-In Techniques; Human | 2017 |
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Topics: 3T3 Cells; Adipocytes, White; Animals; Drosophila melanogaster; Humans; Lipolysis; MAP Kinase Signal | 2018 |
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.
Topics: Aging; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Knock | 2018 |
Chronic d-serine supplementation impairs insulin secretion.
Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Glucose | 2018 |
Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity.
Topics: Animals; Cardiomegaly; Echocardiography; Immunohistochemistry; Leptin; Mice; Mice, Transgenic; Mutat | 2013 |
Role of p66shc in renal toxicity of oleic acid.
Topics: Animals; Cell Line; Cytochromes c; Dose-Response Relationship, Drug; Kidney; Kidney Tubules; Kidney | 2013 |
Potential biomarker of metformin action.
Topics: Adolescent; Adult; Animals; Biomarkers; Cells, Cultured; CREB-Binding Protein; Fasting; Female; Gluc | 2014 |
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antipsychotic Agents; Benzodiazepines; | 2014 |
Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling.
Topics: Animals; Blood Pressure; Calcium; Calcium Channels, L-Type; Calcium-Binding Proteins; Diastole; Hear | 2014 |
Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diabetes Mellitus, Type 2; Diet, Western; Fenofibrat | 2014 |
The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals.
Topics: Adult; Amino Acid Substitution; Case-Control Studies; Cholesterol Ester Transfer Proteins; Cholester | 2015 |
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aldehyde Dehydrogenase; AMP- | 2016 |
Ablation of eNOS does not promote adipose tissue inflammation.
Topics: Adipose Tissue, Brown; Adiposity; Animals; Diet, High-Fat; Disease Models, Animal; Genetic Predispos | 2016 |
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Topics: Adipocytes; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chondrocytes; G | 2016 |
Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diet; Energy Metabolism; Flow Cyt | 2016 |
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Insulin Resistance; Liver; Male; Mice; Mice, | 2009 |
Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.
Topics: Adipocytes, Brown; Animals; Gene Expression; Hypoglycemic Agents; Insulin; Ion Channels; Mice; Mice, | 2009 |
The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat.
Topics: Animals; Cardiotonic Agents; Heart Ventricles; Leptin; Male; Mitochondrial Membrane Transport Protei | 2009 |
Vascular insulin-like growth factor-I resistance and diet-induced obesity.
Topics: Animals; Aorta; Dietary Fats; Endothelium, Vascular; Enzyme Activation; Humans; In Vitro Techniques; | 2009 |
Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction.
Topics: Adiposity; Animals; Area Under Curve; Autoradiography; Body Weight; Corticosterone; Disease Models, | 2011 |
Global IRS-1 phosphorylation analysis in insulin resistance.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2011 |
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.
Topics: Animals; Base Sequence; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Endoplasmic Reticulum; Endo | 2011 |
Relationship between site-specific HSL phosphorylation and adipocyte lipolysis in obese women.
Topics: Adipocytes; Adult; Cyclic AMP; Female; Humans; Lipase; Lipolysis; Middle Aged; Norepinephrine; Obesi | 2011 |
Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Protein | 2012 |
Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes.
Topics: Acetylcysteine; Adipocytes; Adipose Tissue; Adult; Antioxidants; Biphenyl Compounds; Colforsin; Fema | 2012 |
Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; eIF-2 Kinase; Extracellular Signal-Regulated MAP Kinases; In | 2012 |
Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Endoplasmic Reticulum Stress; Enzyme Activ | 2012 |
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 be | 2003 |
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.
Topics: Adipocytes; Adipose Tissue; Adult; Alleles; Blood Glucose; Body Composition; Body Mass Index; Cell S | 2003 |
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Alanine; Amino Acid Substitution; Animals; Blood | 2003 |
Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Animals; Child; Chlorocebus aethiops; Cohort Studies; | 2004 |
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.
Topics: Androstadienes; Animals; Chromones; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insul | 2004 |
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.
Topics: Animals; Hyperinsulinism; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Obese | 2004 |
Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats.
Topics: Animals; Cattle; Growth Hormone; Immunoblotting; Insulin Resistance; Liver; Male; Mice; Mice, Transg | 2004 |
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
Topics: Adipose Tissue; Animals; Body Weight; Epididymis; Glucose; Glucose Clamp Technique; Glucose Toleranc | 2005 |
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Activation; Food Deprivation; Humans; Immunoblott | 2005 |
Hepatic leptin signaling in obesity.
Topics: AMP-Activated Protein Kinases; Animals; Dietary Fats; Drug Resistance; Gene Expression; Glycogen Syn | 2005 |
The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.
Topics: Adult; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Glucose Intolerance; Glyc | 2005 |
The APOA4 Thr347->Ser347 polymorphism is not a major risk factor of obesity.
Topics: Adult; Alleles; Apolipoproteins A; Body Mass Index; Exercise; Female; France; Genotype; Humans; Lipi | 2005 |
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.
Topics: Adipose Tissue; Animal Feed; Animals; Calorimetry; Cell Proliferation; Diet; Energy Metabolism; Fatt | 2006 |
Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men.
Topics: Adult; Age Distribution; Aged; Alleles; Exercise; Female; Glycine; Heat-Shock Proteins; Humans; Leis | 2006 |
Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.
Topics: Adult; Animals; Biological Transport; Deoxyglucose; Down-Regulation; Female; Humans; Insulin; Insuli | 2006 |
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.
Topics: Animals; Dietary Fats; Dose-Response Relationship, Drug; I-kappa B Proteins; Insulin; Insulin Recept | 2006 |
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.
Topics: Animals; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Nutritional Status; | 2007 |
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Cells, Cultured; Insulin; Insulin Receptor Substrate Proteins; | 1996 |
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
Topics: Adipocytes; Animals; Base Sequence; Cell Differentiation; Cell Line; DNA Mutational Analysis; Female | 1998 |
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
Topics: Acyltransferases; Animals; Apoptosis; Ceramides; Diabetes Mellitus, Experimental; Fatty Acids; Gene | 1998 |
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
Topics: Adult; Alleles; Aspartic Acid; Blood Glucose; Exons; Fatty Acids, Nonesterified; Female; Glucose Cla | 2001 |
Erythrocyte-specific anti-nuclear factors in chickens of the obese strain (OS).
Topics: Absorption; Animals; Antibodies, Antinuclear; Autoantibodies; Cattle; Cell Nucleus; Chickens; Erythr | 1971 |