serine has been researched along with Neuralgia in 12 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute intrathecal administration of the NMDA receptor antagonist d-AP5 as well as chronic administration of the glia metabolism inhibitor fluoroacetate significantly reduced mechanical allodynia in neuropathic rats." | 1.42 | Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats. ( Amadio, A; Dallel, R; Descheemaeker, A; Lefèvre, Y; Oliet, SH; Vincent, P; Voisin, DL, 2015) |
| "Mechanical allodynia and thermal hyperalgesia were assessed before, after chronic constriction injury, and every 2 days during substance application." | 1.40 | Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats. ( Aragon, C; Barthel, F; Bauer, I; Brandenburger, T; Eulenburg, V; Hermanns, H; Schlösser, L; Urban, A; Werdehausen, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 11 (91.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Khrasani, M | 1 |
| Mohammadzadeh, A | 1 |
| Balogh, M | 1 |
| Király, K | 1 |
| Barsi, S | 1 |
| Hajnal, B | 1 |
| Köles, L | 1 |
| Zádori, ZS | 1 |
| Harsing, LG | 1 |
| Hopkins, SC | 1 |
| Zhao, FY | 1 |
| Bowen, CA | 1 |
| Fang, X | 1 |
| Wei, H | 1 |
| Heffernan, ML | 1 |
| Spear, KL | 1 |
| Spanswick, DC | 1 |
| Varney, MA | 1 |
| Large, TH | 1 |
| Barthel, F | 1 |
| Urban, A | 1 |
| Schlösser, L | 1 |
| Eulenburg, V | 1 |
| Werdehausen, R | 1 |
| Brandenburger, T | 1 |
| Aragon, C | 1 |
| Bauer, I | 1 |
| Hermanns, H | 1 |
| Takahashi, Y | 1 |
| Hara, K | 1 |
| Haranishi, Y | 1 |
| Terada, T | 1 |
| Obara, G | 1 |
| Sata, T | 1 |
| Wang, XQ | 1 |
| Zhong, XL | 1 |
| Li, ZB | 1 |
| Wang, HT | 1 |
| Zhang, J | 1 |
| Li, F | 1 |
| Zhang, JY | 1 |
| Dai, RP | 1 |
| Xin-Fu, Z | 1 |
| Li, CQ | 1 |
| Li, ZY | 1 |
| Bi, FF | 1 |
| Lefèvre, Y | 1 |
| Amadio, A | 1 |
| Vincent, P | 1 |
| Descheemaeker, A | 1 |
| Oliet, SH | 1 |
| Dallel, R | 1 |
| Voisin, DL | 1 |
| Moon, JY | 2 |
| Choi, SR | 2 |
| Roh, DH | 2 |
| Yoon, SY | 2 |
| Kwon, SG | 2 |
| Choi, HS | 2 |
| Kang, SY | 2 |
| Han, HJ | 2 |
| Kim, HW | 1 |
| Beitz, AJ | 2 |
| Oh, SB | 1 |
| Lee, JH | 2 |
| Aira, Z | 1 |
| Barrenetxea, T | 1 |
| Buesa, I | 1 |
| Martínez, E | 1 |
| Azkue, JJ | 1 |
| Kato, E | 1 |
| Matsuzawa, R | 1 |
| Kobayashi, S | 1 |
| Fukushima, T | 1 |
| Maekawa, M | 1 |
| Hori, Y | 1 |
| Yan, X | 1 |
| Jiang, E | 1 |
| Gao, M | 1 |
| Weng, HR | 1 |
| Lu, Y | 1 |
| Sun, YN | 1 |
| Wu, X | 1 |
| Sun, Q | 1 |
| Liu, FY | 1 |
| Xing, GG | 1 |
| Wan, Y | 1 |
1 review available for serine and Neuralgia
| Article | Year |
|---|---|
Glycine transporter inhibitors: A new avenue for managing neuropathic pain.
Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuro | 2019 |
11 other studies available for serine and Neuralgia
| Article | Year |
|---|---|
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb | 2013 |
Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Constriction, Pathologic; Dose-Response Relationship, | 2014 |
Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine Plasma Membra | 2015 |
Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Anxiety; Dietary Sucrose; Disease Models, Animal; Hippocamp | 2015 |
Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats.
Topics: Animals; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Racem | 2015 |
Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
Topics: Animals; Astrocytes; Disease Models, Animal; Ethylenediamines; Hyperalgesia; Male; Mice; Mice, Inbre | 2015 |
Spinal D1-like dopamine receptors modulate NMDA receptor-induced hyperexcitability and NR1 subunit phosphorylation at serine 889.
Topics: Animals; Cycloleucine; Evoked Potentials; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neurons; Phos | 2016 |
Effects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Male; | 2017 |
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitato | 2017 |
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; Ligation; Male; N-Meth | 2013 |
Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat.
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; | 2008 |