serine has been researched along with Nervous System Disorders in 21 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Investigation of a 15-year old boy with progressive optic atrophy and spinocerebellar degeneration revealed elevated plasma, cerebrospinal fluid, and urine glycine concentrations." | 3.66 | Late-onset nonketotic hyperglycinemia and spinocerebellar degeneration. ( Berman, PH; Blazer-Yost, B; Segal, S; Steiman, GS; Yudkoff, M, 1979) |
| "Furthermore, in neurological disorders, such as traumatic brain injury and Alzheimer's disease, hyperactivation of NMDARs leads to synaptic damage." | 3.01 | Cross species review of the physiological role of D-serine in translationally relevant behaviors. ( Arizanovska, D; Emodogo, JA; Folorunso, OO; Lally, AP; Liebl, DJ; Palavicino-Maggio, CB, 2023) |
| " Dosing of animals with L-serine and human clinical trials investigating the therapeutic effects of L-serine support the FDA's determination that L-serine is generally regarded as safe (GRAS); it also appears to be neuroprotective." | 2.58 | L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential. ( Banack, SA; Cox, PA; Dunlop, RA; Metcalf, JS; Powell, JT, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Arizanovska, D | 1 |
| Emodogo, JA | 1 |
| Lally, AP | 1 |
| Palavicino-Maggio, CB | 1 |
| Liebl, DJ | 1 |
| Folorunso, OO | 1 |
| Tang, W | 1 |
| Liu, D | 1 |
| Traynelis, SF | 1 |
| Yuan, H | 1 |
| Metcalf, JS | 1 |
| Dunlop, RA | 1 |
| Powell, JT | 1 |
| Banack, SA | 1 |
| Cox, PA | 1 |
| Sasabe, J | 1 |
| Suzuki, M | 1 |
| Nishikawa, T | 3 |
| Fukui, K | 1 |
| Hashimoto, K | 1 |
| Halassa, MM | 1 |
| Haydon, PG | 1 |
| Jirásková-Vaníčková, J | 1 |
| Ettrich, R | 1 |
| Vorlová, B | 1 |
| Hoffman, HE | 1 |
| Lepšík, M | 1 |
| Jansa, P | 1 |
| Konvalinka, J | 1 |
| Fuchs, SA | 1 |
| Berger, R | 1 |
| de Koning, TJ | 1 |
| Henneberger, C | 1 |
| Bard, L | 1 |
| Rusakov, DA | 1 |
| Billard, JM | 1 |
| SCHWARTZ, JH | 1 |
| MAAS, WK | 1 |
| SIMON, EJ | 1 |
| Suzuki, T | 3 |
| Higa, S | 2 |
| Tsuge, I | 1 |
| Sakoda, S | 2 |
| Hayashi, A | 2 |
| Yamamura, Y | 1 |
| Takaba, Y | 2 |
| Nakajima, A | 2 |
| Ueji, M | 1 |
| Kumashiro, S | 1 |
| Hashimoto, A | 1 |
| Montini, M | 1 |
| Ongaro, A | 1 |
| Simonutti, M | 1 |
| Steiman, GS | 1 |
| Yudkoff, M | 1 |
| Berman, PH | 1 |
| Blazer-Yost, B | 1 |
| Segal, S | 1 |
| van der Westhuyzen, J | 1 |
| Davis, RE | 1 |
| Icke, GC | 1 |
| Metz, J | 1 |
| Azuma, T | 1 |
| Mizuno, R | 1 |
| Tsujino, S | 1 |
| Kishimoto, S | 1 |
| Mizuta, E | 1 |
| Ichikawa, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study[NCT03580616] | Phase 2 | 43 participants (Actual) | Interventional | 2018-10-24 | Terminated (stopped due to Study was terminated by the IRB due to continued noncompliance.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for serine and Nervous System Disorders
| Article | Year |
|---|---|
Cross species review of the physiological role of D-serine in translationally relevant behaviors.
Topics: Animals; Autism Spectrum Disorder; Genome-Wide Association Study; Humans; Nervous System Diseases; N | 2023 |
L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential.
Topics: Animals; Humans; Nervous System Diseases; Neuroprotective Agents; Serine | 2018 |
Distinctive Roles of D-Amino Acids in the Homochiral World: Chirality of Amino Acids Modulates Mammalian Physiology and Pathology.
Topics: Amino Acids; Animals; Archaea; Bacteria; D-Aspartic Acid; Endocrine System; Humans; Immunity, Innate | 2019 |
[Metabolism and functions of brain D-serine in mammals: relevance to neuropsychiatric disorders].
Topics: Animals; Brain; Drug Design; Glycine; Humans; Isomerism; Mental Disorders; Nervous System Diseases; | 2008 |
[Disease-oriented enzymology in D-amino acid metabolism].
Topics: Amino Acids; Animals; Antipsychotic Agents; Astrocytes; Cloning, Molecular; Crystallization; D-Amino | 2008 |
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Behavior, Animal; Calcium Signaling; Glutamic Acid; Hum | 2010 |
Inhibition of human serine racemase, an emerging target for medicinal chemistry.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Drug Delivery Systems; Drug Design; Enzyme Inhibitor | 2011 |
D-serine: the right or wrong isoform?
Topics: Animals; Central Nervous System; Humans; Nervous System Diseases; Protein Binding; Protein Isoforms; | 2011 |
D-Serine: a key to synaptic plasticity?
Topics: Animals; Gene Expression Regulation; Nervous System Diseases; Neuronal Plasticity; Serine; Synapses | 2012 |
D-Amino acids in brain neurotransmission and synaptic plasticity.
Topics: Animals; Brain; D-Amino-Acid Oxidase; D-Aspartic Acid; Humans; Nervous System Diseases; Neuronal Pla | 2012 |
Metabolism and functional roles of endogenous D-serine in mammalian brains.
Topics: Animals; Brain; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Receptors, N-Met | 2005 |
1 trial available for serine and Nervous System Disorders
| Article | Year |
|---|---|
[Controlled clinical study and clinico-psychological evaluation of a preparation with neurotrophic effects].
Topics: Aged; Arginine; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Glutamine; Hum | 1977 |
9 other studies available for serine and Nervous System Disorders
| Article | Year |
|---|---|
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.
Topics: Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Gen | 2020 |
CSF serine enantiomers and glycine in the study of neurologic and psychiatric disorders.
Topics: Animals; Cerebrospinal Fluid; Glycine; Humans; Mental Disorders; Nervous System Diseases; Serine; St | 2008 |
An impaired concentrating mechanism for amino acids in mutants of Escherichia coli resistant to L-canavanine and D-serine.
Topics: Amino Acids; Biochemical Phenomena; Canavanine; Escherichia coli; Nervous System Diseases; Serine | 1959 |
Effect of infused L-threo-3,4-dihydroxyphenylserine on adrenergic activity in patients with familial amyloid polyneuropathy.
Topics: Adult; Amyloidosis; Autonomic Nervous System; Blood Pressure; Dopamine beta-Hydroxylase; Droxidopa; | 1980 |
Pharmacokinetic studies of oral L-threo-3,4-dihydroxyphenylserine in normal subjects and patients with familial amyloid polyneuropathy.
Topics: Adult; Amyloidosis; Blood Pressure; Dopamine beta-Hydroxylase; Droxidopa; Female; Humans; Intestinal | 1982 |
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par | 1995 |
Late-onset nonketotic hyperglycinemia and spinocerebellar degeneration.
Topics: Adolescent; Diseases in Twins; Glycine; Humans; Male; Nervous System Diseases; Optic Atrophy; Serine | 1979 |
Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment.
Topics: Animals; Brain; Chiroptera; Folic Acid; Liver; Methionine; Nervous System Diseases; Nitrous Oxide; S | 1987 |
Studies of neurocirculatory effects of long-term L-threo-3,4-dihydroxyphenylserine administration in a patient with familial amyloidotic polyneuropathy.
Topics: Amyloidosis; Blood Circulation; Blood Pressure; Consciousness; Droxidopa; Female; Heart Rate; Humans | 1988 |