serine has been researched along with Nerve Degeneration in 38 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 5.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "The substitution of Proline with Serine at residue 56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) has been linked to an atypical autosomal dominant form of familial amyotrophic lateral sclerosis 8 (ALS8)." | 3.79 | Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. ( Aliaga, L; Cai, H; Chub, N; Lai, C; Lin, X; O'Donovan, MJ; Shim, H; Sun, L; Xie, C; Yang, WJ; Yu, J, 2013) |
| "The motor impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of α-synuclein (α-syn) called Lewy bodies." | 2.49 | The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models. ( Arawaka, S; Kato, T; Sato, H, 2013) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 1.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| " These data predict that the ability of cdk5 phosphorylation to protect against htt cleavage, aggregation, and toxicity is compromised in cells expressing toxic fragments of htt." | 1.33 | Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. ( Davies, JE; Luo, S; Rubinsztein, DC; Vacher, C, 2005) |
| "The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)." | 1.33 | Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006) |
| "Spinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion." | 1.32 | Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. ( Acevedo, SF; Aitken, A; Botas, J; Chen, HK; Fernandez, MH; Fernandez-Funez, P; Kaytor, MD; Lam, YC; Orr, HT; Skoulakis, EM; Zoghbi, HY, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.89) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 25 (65.79) | 29.6817 |
| 2010's | 7 (18.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dunlop, RA | 1 |
| Powell, JT | 1 |
| Metcalf, JS | 1 |
| Guillemin, GJ | 1 |
| Cox, PA | 1 |
| Aliaga, L | 1 |
| Lai, C | 1 |
| Yu, J | 1 |
| Chub, N | 1 |
| Shim, H | 1 |
| Sun, L | 1 |
| Xie, C | 1 |
| Yang, WJ | 1 |
| Lin, X | 1 |
| O'Donovan, MJ | 1 |
| Cai, H | 1 |
| Wolosker, H | 1 |
| Radzishevsky, I | 1 |
| Jeon, GS | 1 |
| Choi, DH | 1 |
| Lee, HN | 1 |
| Kim, DW | 1 |
| Chung, CK | 1 |
| Cho, SS | 1 |
| Liu, YH | 1 |
| Wang, L | 1 |
| Wei, LC | 1 |
| Huang, YG | 1 |
| Chen, LW | 1 |
| Tian, B | 1 |
| Yang, Q | 1 |
| Mao, Z | 1 |
| Aras, MA | 1 |
| Hara, H | 1 |
| Hartnett, KA | 1 |
| Kandler, K | 1 |
| Aizenman, E | 1 |
| Chalimoniuk, M | 1 |
| Stolecka, A | 1 |
| Ziemińska, E | 1 |
| Stepień, A | 1 |
| Langfort, J | 1 |
| Strosznajder, JB | 1 |
| Ng, CH | 1 |
| Mok, SZ | 1 |
| Koh, C | 1 |
| Ouyang, X | 1 |
| Fivaz, ML | 1 |
| Tan, EK | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Yu, F | 1 |
| Lim, KL | 1 |
| Gu, X | 1 |
| Greiner, ER | 1 |
| Mishra, R | 1 |
| Kodali, R | 1 |
| Osmand, A | 1 |
| Finkbeiner, S | 1 |
| Steffan, JS | 1 |
| Thompson, LM | 1 |
| Wetzel, R | 1 |
| Yang, XW | 1 |
| Lim, Y | 1 |
| Kehm, VM | 1 |
| Lee, EB | 1 |
| Soper, JH | 1 |
| Li, C | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| de Calignon, A | 1 |
| Polydoro, M | 1 |
| Suárez-Calvet, M | 1 |
| William, C | 1 |
| Adamowicz, DH | 1 |
| Kopeikina, KJ | 1 |
| Pitstick, R | 1 |
| Sahara, N | 1 |
| Ashe, KH | 1 |
| Carlson, GA | 1 |
| Spires-Jones, TL | 1 |
| Hyman, BT | 1 |
| Ma, S | 1 |
| Liu, S | 2 |
| Huang, Q | 1 |
| Xie, B | 1 |
| Lai, B | 1 |
| Wang, C | 1 |
| Song, B | 1 |
| Li, M | 1 |
| Sato, H | 1 |
| Kato, T | 1 |
| Arawaka, S | 1 |
| Maurage, CA | 1 |
| Sergeant, N | 1 |
| Ruchoux, MM | 1 |
| Hauw, JJ | 1 |
| Delacourte, A | 1 |
| Chen, HK | 1 |
| Fernandez-Funez, P | 1 |
| Acevedo, SF | 1 |
| Lam, YC | 1 |
| Kaytor, MD | 1 |
| Fernandez, MH | 1 |
| Aitken, A | 1 |
| Skoulakis, EM | 1 |
| Orr, HT | 1 |
| Botas, J | 1 |
| Zoghbi, HY | 1 |
| Wang, J | 1 |
| Fu, Y | 1 |
| Wang, JH | 1 |
| Lu, Y | 1 |
| Yang, L | 2 |
| Omori, K | 1 |
| Suzukawa, J | 1 |
| Inagaki, C | 1 |
| Chen, L | 1 |
| Feany, MB | 1 |
| Luo, S | 1 |
| Vacher, C | 1 |
| Davies, JE | 1 |
| Rubinsztein, DC | 1 |
| Feksa, LR | 1 |
| Cornelio, A | 1 |
| Dutra-Filho, CS | 1 |
| Wyse, AT | 1 |
| Wajner, M | 1 |
| Wannmacher, CM | 1 |
| Cripps, D | 1 |
| Thomas, SN | 1 |
| Jeng, Y | 1 |
| Yang, F | 1 |
| Davies, P | 1 |
| Yang, AJ | 1 |
| Guillozet-Bongaarts, AL | 1 |
| Cahill, ME | 1 |
| Cryns, VL | 1 |
| Reynolds, MR | 1 |
| Berry, RW | 1 |
| Binder, LI | 1 |
| Rickle, A | 1 |
| Behbahani, H | 1 |
| Ankarcrona, M | 1 |
| Winblad, B | 1 |
| Cowburn, RF | 1 |
| Lobsiger, CS | 1 |
| Boillée, S | 1 |
| Cleveland, DW | 1 |
| Morimoto, N | 1 |
| Nagai, M | 1 |
| Ohta, Y | 1 |
| Miyazaki, K | 1 |
| Kurata, T | 1 |
| Morimoto, M | 1 |
| Murakami, T | 1 |
| Takehisa, Y | 1 |
| Ikeda, Y | 1 |
| Kamiya, T | 1 |
| Abe, K | 1 |
| Wang, X | 1 |
| Fan, Z | 1 |
| Wang, B | 1 |
| Luo, J | 1 |
| Ke, ZJ | 1 |
| Hinners, I | 1 |
| Hill, A | 1 |
| Otto, U | 1 |
| Michalsky, A | 1 |
| Mack, TG | 1 |
| Striggow, F | 1 |
| Trauner, DA | 1 |
| Page, T | 1 |
| Greco, C | 1 |
| Sweetman, L | 1 |
| Kulovich, S | 1 |
| Nyhan, WL | 1 |
| Fedele, E | 1 |
| Foster, AC | 1 |
| Caputi, A | 1 |
| Gardoni, F | 1 |
| Cimino, M | 1 |
| Pastorino, L | 1 |
| Cattabeni, F | 1 |
| Di Luca, M | 1 |
| Oh, JD | 1 |
| Vaughan, CL | 1 |
| Chase, TN | 1 |
| Heese, K | 1 |
| Nagai, Y | 1 |
| Sawada, T | 1 |
| Zhang, B | 1 |
| Toku, K | 1 |
| Maeda, N | 1 |
| Sakanaka, M | 1 |
| Tanaka, J | 1 |
| Honda, K | 1 |
| Shimohama, S | 1 |
| Sawada, H | 1 |
| Kihara, T | 1 |
| Nakamizo, T | 1 |
| Shibasaki, H | 1 |
| Akaike, A | 1 |
| Kaneko, I | 1 |
| Morimoto, K | 1 |
| Kubo, T | 1 |
| Domonkos, J | 1 |
| Heiner, L | 1 |
| Roberts, PJ | 1 |
| Keen, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study[NCT03580616] | Phase 2 | 43 participants (Actual) | Interventional | 2018-10-24 | Terminated (stopped due to Study was terminated by the IRB due to continued noncompliance.) | ||
| Amyotrophic Lateral Sclerosis and the Innate Immune System[NCT02869048] | 375 participants (Anticipated) | Observational | 2016-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for serine and Nerve Degeneration
| Article | Year |
|---|---|
The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration.
Topics: Humans; Nerve Degeneration; Neuroglia; Neurons; Serine; Synaptic Transmission | 2013 |
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Humans; Nerve Degeneration; Parkinson Disease; Pho | 2013 |
36 other studies available for serine and Nerve Degeneration
| Article | Year |
|---|---|
L-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI).
Topics: Activating Transcription Factor 4; Amino Acids, Diamino; Apoptosis; Caspase 3; Cell Line, Tumor; Cel | 2018 |
Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Dendrites; Humans; M | 2013 |
Expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and neutral amino acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus.
Topics: Amino Acid Transport System ASC; Animals; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Mice | 2009 |
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner | 2009 |
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Ataxia Telangiectasia | 2009 |
Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.
Topics: Amino Acid Sequence; Animals; Brain Infarction; Cell Death; Cell Survival; Cells, Cultured; Cytoprot | 2009 |
Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism--the possible key role of PKG.
Topics: Animals; Arachidonic Acid; Calcium; Catalytic Domain; Cell Death; Cyclic GMP; Cyclic GMP-Dependent P | 2009 |
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Dopamine; Drosophila; Drosophila Pr | 2009 |
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode | 2009 |
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
Topics: Acoustic Stimulation; Age Factors; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; | 2011 |
Propagation of tau pathology in a model of early Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Entorhinal Cor | 2012 |
Site-specific phosphorylation protects glycogen synthase kinase-3β from calpain-mediated truncation of its N and C termini.
Topics: Animals; Apoptosis; Calpain; Cerebellum; Glutamine; Glycogen Synthase Kinase 3; Glycogen Synthase Ki | 2012 |
Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Child | 2003 |
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Amino Acid Sequence; Animals; Ataxin-1; Ataxins; Cell Nucleus; C | 2003 |
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Cell Death; Cyclin-Dependent Kinase 5; Cyclin-Dependen | 2003 |
Calcineurin-mediated BAD Ser155 dephosphorylation in ammonia-induced apoptosis of cultured rat hippocampal neurons.
Topics: Ammonia; Animals; Apoptosis; bcl-Associated Death Protein; Calcineurin; Calcineurin Inhibitors; Calc | 2004 |
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; bet | 2005 |
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
Topics: Amino Acid Sequence; Animals; Brain; Caspases; Cell Death; Cell Membrane; Cyclin-Dependent Kinase 5; | 2005 |
The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Binding Sites; Brain Diseases, Metabolic | 2005 |
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Topics: Algorithms; Alzheimer Disease; Amino Acid Sequence; Chromatography, Liquid; Humans; Immunoblotting; | 2006 |
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar | 2006 |
PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.
Topics: Aldehydes; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase | 2006 |
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.
Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Separation; Enzym | 2007 |
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Central Nervous System; Disease Models, Animal; F | 2007 |
Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Antioxidants; Brain; Cells, Cultured; eIF | 2007 |
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Topics: Animals; Animals, Newborn; Enzyme-Linked Immunosorbent Assay; Fluoresceins; Green Fluorescent Protei | 2008 |
Progressive neurodegenerative disorder in a patient with nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Central Nervous System Diseases; Cerebral Cortex; Female; Glyc | 1981 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glu | 1993 |
CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Ki | 1999 |
Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antibodies; Antiparkinson Agent | 1999 |
Induction of rat L-phosphoserine phosphatase by amyloid-beta (1-42) is inhibited by interleukin-11.
Topics: Amyloid beta-Peptides; Animals; Blotting, Southern; Cell Survival; Dose-Response Relationship, Drug; | 2000 |
Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Survival; Cells, Cultured; Cerebral Cortex; Coloring Agents; | 2000 |
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element | 2001 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptide | 2001 |
On the possibility of lysophosphatide formation during Wallerian degeneration.
Topics: Animals; Cerebrosides; Chromatography; Denervation; Fatty Acids; Nerve Degeneration; Phosphatidylcho | 1968 |
Effect of dorsal root section on amino acids of rat spinal cord.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Centrifugation, | 1974 |