serine has been researched along with Neoplasm Metastasis in 38 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 9.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 5.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 5.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| " Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples." | 4.02 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021) |
| " We investigated the effect of LB1, a small molecule inhibitor of serine/threonine protein phosphatase 2A (PP2A), on its ability to inhibit a low growth fraction and highly drug-resistant solid neuroendocrine tumor, such as metastatic pheochromocytoma (PHEO)." | 3.77 | Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy. ( Bernardo, M; Chiang, J; Lonser, R; Lu, J; Martiniova, L; Pacak, K; Zhuang, Z, 2011) |
| "In this study, FBXO31 inhibits gastric cancer progression by suppressing the epithelial-mesenchymal transition (EMT)." | 1.48 | FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation. ( Jia, J; Liu, Z; Ma, C; Xu, X; Yang, F; Zou, S, 2018) |
| "The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide in recent decades." | 1.48 | Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin. ( Dong, QZ; Gao, XM; Jia, HL; Luo, Q; Qin, LX; Sheng, YY; Wang, CQ; Wei, JW; Wu, C; Yang, JM; Yu, XX; Zhang, Y; Zheng, Y; Zhou, C; Zhu, Y, 2018) |
| "Using cellular progression models of metastasis, we observed a signature high level of Akt2, p-Akt2 and p-hnRNP E1 protein expression, coupled to a significantly reduced level of total hnRNP E1 in metastatic cells." | 1.43 | Identification and characterization of an hnRNP E1 translational silencing motif. ( Brown, AS; Howe, PH; Mohanty, BK, 2016) |
| " One way is to improve the bioavailability and efficacy by synthesizing derivatives that reversibly bind to carbonic anhydrase II (CAII) in red blood cells followed by a slow release into the blood circulation system." | 1.38 | In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. ( Joubert, AM; Joubert, F; McKenna, R; Sippel, KH; Stander, BA; Tu, C, 2012) |
| "We studied Akt-FAK interaction in colon cancer cells under 15 mmHg increased extracellular pressure." | 1.37 | Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. ( Basson, MD; Wang, S, 2011) |
| "Finally we show that human breast cancers lacking Wnt-5a protein have a significantly lower level of membrane-associated beta-catenin." | 1.35 | Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. ( Andersson, T; Landberg, G; Leandersson, K; Medrek, C, 2009) |
| "The putative metastasis suppressor genes, NME1(nm23-1) and NME2(nm23-2), were examined in a model system we developed to approximate the dissemination of melanoma from a primary skin tumor." | 1.29 | Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials. ( Backer, JM; Hamby, CV; Mendola, CE; Potla, L; Stafford, G, 1995) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 1.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 11 (28.95) | 29.6817 |
| 2010's | 20 (52.63) | 24.3611 |
| 2020's | 3 (7.89) | 2.80 |
| Authors | Studies |
|---|---|
| Rossi, M | 1 |
| Altea-Manzano, P | 1 |
| Demicco, M | 1 |
| Doglioni, G | 1 |
| Bornes, L | 1 |
| Fukano, M | 1 |
| Vandekeere, A | 1 |
| Cuadros, AM | 1 |
| Fernández-García, J | 1 |
| Riera-Domingo, C | 1 |
| Jauset, C | 1 |
| Planque, M | 1 |
| Alkan, HF | 1 |
| Nittner, D | 1 |
| Zuo, D | 1 |
| Broadfield, LA | 1 |
| Parik, S | 1 |
| Pane, AA | 1 |
| Rizzollo, F | 1 |
| Rinaldi, G | 1 |
| Zhang, T | 1 |
| Teoh, ST | 1 |
| Aurora, AB | 1 |
| Karras, P | 1 |
| Vermeire, I | 1 |
| Broekaert, D | 1 |
| Elsen, JV | 1 |
| Knott, MML | 1 |
| Orth, MF | 1 |
| Demeyer, S | 1 |
| Eelen, G | 1 |
| Dobrolecki, LE | 1 |
| Bassez, A | 1 |
| Brussel, TV | 1 |
| Sotlar, K | 1 |
| Lewis, MT | 1 |
| Bartsch, H | 1 |
| Wuhrer, M | 1 |
| Veelen, PV | 1 |
| Carmeliet, P | 1 |
| Cools, J | 1 |
| Morrison, SJ | 1 |
| Marine, JC | 1 |
| Lambrechts, D | 1 |
| Mazzone, M | 1 |
| Hannon, GJ | 1 |
| Lunt, SY | 1 |
| Grünewald, TGP | 1 |
| Park, M | 1 |
| Rheenen, JV | 1 |
| Fendt, SM | 1 |
| Volz, C | 1 |
| Breid, S | 1 |
| Selenz, C | 1 |
| Zaplatina, A | 1 |
| Golfmann, K | 1 |
| Meder, L | 1 |
| Dietlein, F | 1 |
| Borchmann, S | 1 |
| Chatterjee, S | 1 |
| Siobal, M | 1 |
| Schöttle, J | 1 |
| Florin, A | 1 |
| Koker, M | 1 |
| Nill, M | 1 |
| Ozretić, L | 1 |
| Uhlenbrock, N | 1 |
| Smith, S | 1 |
| Büttner, R | 1 |
| Miao, H | 1 |
| Wang, B | 1 |
| Reinhardt, HC | 1 |
| Rauh, D | 1 |
| Hallek, M | 1 |
| Acker-Palmer, A | 1 |
| Heukamp, LC | 1 |
| Ullrich, RT | 1 |
| Rawat, V | 1 |
| Malvi, P | 1 |
| Della Manna, D | 1 |
| Yang, ES | 1 |
| Bugide, S | 1 |
| Zhang, X | 1 |
| Gupta, R | 1 |
| Wajapeyee, N | 1 |
| Chen, T | 1 |
| Li, J | 1 |
| Xu, M | 1 |
| Zhao, Q | 1 |
| Hou, Y | 1 |
| Yao, L | 1 |
| Zhong, Y | 1 |
| Chou, PC | 1 |
| Zhang, W | 1 |
| Zhou, P | 1 |
| Jiang, Y | 1 |
| Zou, S | 1 |
| Ma, C | 1 |
| Yang, F | 1 |
| Xu, X | 1 |
| Jia, J | 1 |
| Liu, Z | 1 |
| Zheng, Y | 2 |
| Zhou, C | 1 |
| Yu, XX | 1 |
| Wu, C | 1 |
| Jia, HL | 1 |
| Gao, XM | 1 |
| Yang, JM | 1 |
| Wang, CQ | 1 |
| Luo, Q | 1 |
| Zhu, Y | 1 |
| Zhang, Y | 2 |
| Wei, JW | 1 |
| Sheng, YY | 1 |
| Dong, QZ | 1 |
| Qin, LX | 1 |
| Haiping, C | 1 |
| Qi, X | 1 |
| Dawei, L | 1 |
| Qiang, W | 1 |
| Guo, Q | 1 |
| Su, N | 1 |
| Zhang, J | 2 |
| Li, X | 1 |
| Miao, Z | 1 |
| Wang, G | 2 |
| Cheng, M | 1 |
| Xu, H | 1 |
| Cao, L | 1 |
| Li, F | 1 |
| von Pawel, J | 1 |
| Gorbounova, V | 1 |
| Reck, M | 1 |
| Kowalski, DM | 1 |
| Allard, A | 1 |
| Chadjaa, M | 1 |
| Rey, A | 1 |
| Bennouna, J | 1 |
| Grossi, F | 1 |
| Iyengar, AS | 1 |
| Miller, PJ | 1 |
| Loupe, JM | 1 |
| Hollenbach, AD | 1 |
| Thuringer, D | 1 |
| Berthenet, K | 1 |
| Cronier, L | 1 |
| Solary, E | 1 |
| Garrido, C | 1 |
| Brown, AS | 1 |
| Mohanty, BK | 1 |
| Howe, PH | 1 |
| Werden, SJ | 1 |
| Sphyris, N | 1 |
| Sarkar, TR | 1 |
| Paranjape, AN | 1 |
| LaBaff, AM | 1 |
| Taube, JH | 1 |
| Hollier, BG | 1 |
| Ramirez-Peña, EQ | 1 |
| Soundararajan, R | 1 |
| den Hollander, P | 1 |
| Powell, E | 1 |
| Echeverria, GV | 1 |
| Miura, N | 1 |
| Chang, JT | 1 |
| Piwnica-Worms, H | 1 |
| Rosen, JM | 1 |
| Mani, SA | 1 |
| Xu, HT | 1 |
| Lai, WL | 1 |
| Liu, HF | 1 |
| Wong, LL | 1 |
| Ng, IO | 1 |
| Ching, YP | 1 |
| Graboń, W | 1 |
| Otto-Ślusarczyk, D | 1 |
| Chrzanowska, A | 1 |
| Mielczarek-Puta, M | 1 |
| Joniec-Maciejak, I | 1 |
| Słabik, K | 1 |
| Barańczyk-Kuźma, A | 1 |
| Feng, J | 1 |
| Xu, G | 1 |
| Liu, J | 1 |
| Zhang, N | 1 |
| Li, L | 1 |
| Ji, J | 1 |
| Zhang, L | 1 |
| Wang, X | 1 |
| Tan, J | 1 |
| Huang, B | 1 |
| Lu, J | 2 |
| Sakurai, H | 1 |
| Medrek, C | 1 |
| Landberg, G | 1 |
| Andersson, T | 1 |
| Leandersson, K | 1 |
| Xia, Y | 1 |
| Hawke, D | 1 |
| Halle, M | 1 |
| Tremblay, ML | 1 |
| Gao, X | 1 |
| Zhou, XZ | 1 |
| Aldape, K | 1 |
| Cobb, MH | 1 |
| Xie, K | 1 |
| He, J | 1 |
| Lu, Z | 1 |
| Du, WW | 1 |
| Yang, BB | 1 |
| Shatseva, TA | 1 |
| Yang, BL | 1 |
| Deng, Z | 1 |
| Shan, SW | 1 |
| Lee, DY | 1 |
| Seth, A | 1 |
| Yee, AJ | 1 |
| Wang, S | 1 |
| Basson, MD | 1 |
| Martiniova, L | 1 |
| Chiang, J | 1 |
| Bernardo, M | 1 |
| Lonser, R | 1 |
| Zhuang, Z | 1 |
| Pacak, K | 1 |
| Bravo-Cordero, JJ | 1 |
| Oser, M | 1 |
| Chen, X | 1 |
| Eddy, R | 1 |
| Hodgson, L | 1 |
| Condeelis, J | 1 |
| Li, N | 1 |
| Jiang, P | 1 |
| Du, W | 1 |
| Wu, Z | 1 |
| Li, C | 2 |
| Qiao, M | 1 |
| Yang, X | 1 |
| Wu, M | 1 |
| Stander, BA | 1 |
| Joubert, F | 1 |
| Tu, C | 1 |
| Sippel, KH | 1 |
| McKenna, R | 1 |
| Joubert, AM | 1 |
| Roesch, A | 1 |
| Becker, B | 1 |
| Meyer, S | 1 |
| Hafner, C | 1 |
| Wild, PJ | 1 |
| Landthaler, M | 1 |
| Vogt, T | 1 |
| Yanagawa, T | 1 |
| Funasaka, T | 1 |
| Tsutsumi, S | 1 |
| Raz, T | 1 |
| Tanaka, N | 1 |
| Raz, A | 1 |
| Cardone, RA | 1 |
| Bagorda, A | 1 |
| Bellizzi, A | 1 |
| Busco, G | 1 |
| Guerra, L | 1 |
| Paradiso, A | 1 |
| Casavola, V | 1 |
| Zaccolo, M | 1 |
| Reshkin, SJ | 1 |
| Schmidt, AE | 1 |
| Chand, HS | 1 |
| Cascio, D | 1 |
| Kisiel, W | 1 |
| Bajaj, SP | 1 |
| Mackay, H | 1 |
| Hedley, D | 1 |
| Major, P | 1 |
| Townsley, C | 1 |
| Mackenzie, M | 1 |
| Vincent, M | 1 |
| Degendorfer, P | 1 |
| Tsao, MS | 1 |
| Nicklee, T | 1 |
| Birle, D | 1 |
| Wright, J | 1 |
| Siu, L | 1 |
| Moore, M | 1 |
| Oza, A | 1 |
| Alessandro, R | 1 |
| Seidita, G | 1 |
| Flugy, AM | 1 |
| Damiani, F | 1 |
| Russo, A | 1 |
| Corrado, C | 1 |
| Colomba, P | 1 |
| Gullotti, L | 1 |
| Buettner, R | 1 |
| Bruno, L | 1 |
| De Leo, G | 1 |
| Collier, ME | 1 |
| Frentzou, GA | 1 |
| Greenman, J | 1 |
| Ettelaie, C | 1 |
| Cardot-Bauters, C | 1 |
| Leteurtre, E | 1 |
| Leclerc, L | 1 |
| Vantyghem, MC | 1 |
| Do Cao, C | 1 |
| Wemeau, JL | 1 |
| d'Herbomez, M | 1 |
| Carnaille, B | 1 |
| Barbu, V | 1 |
| Pinson, S | 1 |
| Pigny, P | 1 |
| Hamby, CV | 1 |
| Mendola, CE | 1 |
| Potla, L | 1 |
| Stafford, G | 1 |
| Backer, JM | 1 |
| MacDonald, NJ | 1 |
| De la Rosa, A | 1 |
| Benedict, MA | 1 |
| Freije, JM | 1 |
| Krutsch, H | 1 |
| Steeg, PS | 2 |
| Hartsough, MT | 1 |
| Morrison, DK | 1 |
| Salerno, M | 1 |
| Palmieri, D | 1 |
| Ouatas, T | 1 |
| Mair, M | 1 |
| Patrick, J | 1 |
| Longnecker, DS | 1 |
| Curphey, TJ | 1 |
| Mönch, E | 1 |
| Stefan, H | 1 |
| Käser, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study Of PS-341 In Patients With Metastatic Colorectal Cancer[NCT00052507] | Phase 2 | 0 participants | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Neoplasm Metastasis
| Article | Year |
|---|---|
Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression.
Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Disease Progression; Drug Resistance, Neop | 2017 |
2 trials available for serine and Neoplasm Metastasis
| Article | Year |
|---|---|
DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compoun | 2014 |
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer.
Topics: Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomi | 2005 |
35 other studies available for serine and Neoplasm Metastasis
| Article | Year |
|---|---|
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; | 2022 |
Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; | 2020 |
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow | 2021 |
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
Topics: Acetylation; Animals; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Colorectal Neoplasms; Epider | 2017 |
FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation.
Topics: Animals; Cell Line, Tumor; Epithelial-Mesenchymal Transition; F-Box Proteins; Humans; Mice; Neoplasm | 2018 |
Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin.
Topics: Animals; beta Catenin; Bile Duct Neoplasms; Case-Control Studies; Cell Growth Processes; Cell Line, | 2018 |
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Movement; Cell Proliferation; Hippo Sig | 2019 |
PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Cell Line, Tumor; Cell Movement; Female; HEK293 Cells | 2014 |
Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Melanocytes; Melanoma | 2014 |
Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.
Topics: 14-3-3 Proteins; Adenosine Triphosphate; Capillaries; Cell Line, Tumor; Cell Movement; Coculture Tec | 2015 |
Identification and characterization of an hnRNP E1 translational silencing motif.
Topics: 3' Untranslated Regions; Base Sequence; Binding Sites; Caco-2 Cells; Cell Line, Tumor; DNA-Binding P | 2016 |
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Mode | 2016 |
PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis.
Topics: Cell Line, Tumor; Cell Movement; DNA; Humans; Liver Neoplasms; Neoplasm Metastasis; p21-Activated Ki | 2016 |
Lactate Formation in Primary and Metastatic Colon Cancer Cells at Hypoxia and Normoxia.
Topics: Aspartate Aminotransferases; Aspartic Acid; Cell Count; Cell Hypoxia; Cell Line, Tumor; Colonic Neop | 2016 |
Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.
Topics: Animals; Antigens, CD; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferat | 2016 |
Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells.
Topics: beta Catenin; Breast; Breast Neoplasms; Cadherins; Casein Kinase Ialpha; Cell Adhesion; Cell Line, T | 2009 |
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Topics: Animals; Binding Sites; Cell Line; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine | 2009 |
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cycl | 2010 |
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.
Topics: Adenocarcinoma; Amino Acid Sequence; Caco-2 Cells; Catalytic Domain; Colonic Neoplasms; Focal Adhesi | 2011 |
Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; | 2011 |
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.
Topics: Actin Depolymerizing Factors; Actins; Adenocarcinoma; Animals; Biosensing Techniques; Cell Movement; | 2011 |
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Topics: Animals; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Calcium-Calmodulin-Depe | 2011 |
In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity.
Topics: Antimitotic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Cycle; Cell Proliferati | 2012 |
Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Topics: Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanocyt | 2005 |
Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.
Topics: Amino Acid Sequence; Binding Sites; Casein Kinase II; Cell Line, Tumor; Cross-Linking Reagents; Cyto | 2005 |
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Topics: Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Collagen; Culture Media, Serum-Free; | 2005 |
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition.
Topics: Animals; Cattle; Chymotrypsin; Crystallography, X-Ray; Escherichia coli; Factor VIIa; Fibrinolysin; | 2005 |
Role of S128R polymorphism of E-selectin in colon metastasis formation.
Topics: Arginine; Cell Adhesion; Cell Movement; Colonic Neoplasms; E-Selectin; Female; Humans; Male; Middle | 2007 |
Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.
Topics: Alanine; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Immune System; Models, Bi | 2008 |
Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?
Topics: Adolescent; Adult; Age of Onset; Aged; Carcinoma, Medullary; Case-Control Studies; Female; Genetic V | 2008 |
Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Clone Cells; DNA Primers; Gene Expression; G | 1995 |
A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA Primers | 1993 |
Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.
Topics: Alanine; Amino Acid Substitution; Antigens, Neoplasm; Base Sequence; Breast Neoplasms; Cell Line; DN | 2002 |
Adenocarcinoma of the pancreas in azaserine-treated rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azaserine; Dipeptides; Disease Models, Animal; Hyperplasia; Inject | 1975 |
[Pepper type neuroblastoma with homocystinuria. Diagnosis, biochemistry and therapy].
Topics: Amino Acids; Catecholamines; Child, Preschool; Cyclophosphamide; Dopamine; Homocystinuria; Humans; L | 1970 |