serine has been researched along with Multiple System Atrophy in 4 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129." | 7.73 | alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy. ( Barrett, JM; Fontaine, D; Shults, CW, 2006) |
| "Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease." | 3.76 | Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. ( Aebischer, P; Chegini, F; Chiappe, D; Eliezer, D; Fernandez, CO; Gai, WP; Kim, HY; Lamberto, GR; Lashuel, HA; Masliah, E; Moniatte, M; Oueslati, A; Paleologou, KE; Rospigliosi, CC; Schmid, A; Schneider, BL; Shakked, G; Zweckstetter, M, 2010) |
| "Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129." | 3.73 | alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy. ( Barrett, JM; Fontaine, D; Shults, CW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagao, M | 1 |
| Hayashi, H | 1 |
| Paleologou, KE | 1 |
| Oueslati, A | 1 |
| Shakked, G | 1 |
| Rospigliosi, CC | 1 |
| Kim, HY | 1 |
| Lamberto, GR | 1 |
| Fernandez, CO | 1 |
| Schmid, A | 1 |
| Chegini, F | 1 |
| Gai, WP | 1 |
| Chiappe, D | 1 |
| Moniatte, M | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Eliezer, D | 1 |
| Zweckstetter, M | 1 |
| Masliah, E | 1 |
| Lashuel, HA | 1 |
| Hasegawa, T | 1 |
| Baba, T | 1 |
| Kobayashi, M | 1 |
| Konno, M | 1 |
| Sugeno, N | 1 |
| Kikuchi, A | 1 |
| Itoyama, Y | 1 |
| Takeda, A | 1 |
| Shults, CW | 1 |
| Barrett, JM | 1 |
| Fontaine, D | 1 |
4 other studies available for serine and Multiple System Atrophy
| Article | Year |
|---|---|
Glycogen synthase kinase-3beta is associated with Parkinson's disease.
Topics: Aged; Amino Acid Sequence; Biomarkers; Brain; Cytosol; Female; Glycogen Synthase Kinase 3; Glycogen | 2009 |
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cell Membrane; Creatine Kin | 2010 |
Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Topics: alpha-Synuclein; Apoptosis; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; HEK | 2010 |
alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.
Topics: Adult; Aged; alpha-Synuclein; Animals; Arabidopsis Proteins; Blood Platelets; Blotting, Western; Car | 2006 |