serine has been researched along with Multiple Sclerosis in 11 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple sclerosis is an immune-mediated brain disease ameliorated by interferon-beta therapy." | 1.31 | Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1. ( Boos, MD; Byskosh, PV; Chen, M; Feng, X; Petraglia, AL; Reder, AT, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, A | 1 |
| Sun, Y | 1 |
| Kiker, T | 1 |
| Zhou, Y | 1 |
| Ye, K | 1 |
| Myronovkij, S | 1 |
| Negrych, N | 1 |
| Nehrych, T | 1 |
| Tkachenko, V | 1 |
| Souchelnytskyi, S | 1 |
| Stoika, R | 1 |
| Kit, Y | 1 |
| Grecchi, S | 1 |
| Mazzini, G | 1 |
| Lisa, A | 1 |
| Armentero, MT | 1 |
| Bergamaschi, R | 1 |
| Romani, A | 1 |
| Blandini, F | 1 |
| Di Perri, C | 1 |
| Scovassi, AI | 1 |
| Feng, X | 1 |
| Petraglia, AL | 1 |
| Chen, M | 1 |
| Byskosh, PV | 1 |
| Boos, MD | 1 |
| Reder, AT | 1 |
| van Winsen, LL | 1 |
| Hooper-van Veen, T | 1 |
| van Rossum, EF | 1 |
| Polman, CH | 1 |
| van den Berg, TK | 1 |
| Koper, JW | 1 |
| Uitdehaag, BM | 1 |
| Curran, NM | 1 |
| Griffin, BD | 1 |
| O'Toole, D | 1 |
| Brady, KJ | 1 |
| Fitzgerald, SN | 1 |
| Moynagh, PN | 1 |
| D'Souza, CA | 1 |
| Wood, DD | 1 |
| She, YM | 1 |
| Moscarello, MA | 1 |
| Grant, JE | 1 |
| Hu, J | 1 |
| Liu, T | 1 |
| Jain, MR | 1 |
| Elkabes, S | 1 |
| Li, H | 1 |
| Bendahhou, S | 1 |
| Cummins, TR | 1 |
| Potts, JF | 1 |
| Tong, J | 1 |
| Agnew, WS | 1 |
| Poser, CM | 1 |
| Sylwester, DL | 1 |
| Ho, B | 1 |
| Alpert, A | 1 |
| Alling, C | 1 |
| Vanier, MT | 1 |
| Svennerholm, L | 1 |
1 trial available for serine and Multiple Sclerosis
| Article | Year |
|---|---|
Amino acid residues of serum and CSF protein in multiple sclerosis. Clinical application of statistical discriminant analysis.
Topics: Amino Acids; Autoanalysis; Blood Proteins; Cerebrospinal Fluid Proteins; Clinical Trials as Topic; D | 1975 |
10 other studies available for serine and Multiple Sclerosis
| Article | Year |
|---|---|
A metabolome-wide Mendelian randomization study prioritizes potential causal circulating metabolites for multiple sclerosis.
Topics: Acetoacetates; Acetone; Genome-Wide Association Study; Humans; Lysine; Mendelian Randomization Analy | 2023 |
Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients.
Topics: Adult; Amino Acid Sequence; Biomarkers; Cysteine; Female; Humans; Male; Middle Aged; Multiple Sclero | 2016 |
Search for cellular stress biomarkers in lymphocytes from patients with multiple sclerosis: a pilot study.
Topics: Adult; Apoptosis; Biomarkers; Case-Control Studies; DNA Breaks, Double-Stranded; Female; Follow-Up S | 2012 |
Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.
Topics: 2',5'-Oligoadenylate Synthetase; Adult; DNA-Binding Proteins; Down-Regulation; Female; Gene Expressi | 2002 |
The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis.
Topics: Analysis of Variance; Aspartic Acid; Blood Cells; Cells, Cultured; Cytokines; DNA Mutational Analysi | 2005 |
The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.
Topics: Active Transport, Cell Nucleus; Astrocytes; Astrocytoma; Benzoxazines; Blotting, Western; Calcium Ch | 2005 |
Autocatalytic cleavage of myelin basic protein: an alternative to molecular mimicry.
Topics: Animals; Catalysis; Humans; Hydrogen-Ion Concentration; Immunodominant Epitopes; Isoflurophate; Lipi | 2005 |
Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis.
Topics: Amino Acid Sequence; Animals; Arginine; Astrocytes; Citrulline; Encephalomyelitis, Autoimmune, Exper | 2007 |
Serine-1321-independent regulation of the mu 1 adult skeletal muscle Na+ channel by protein kinase C.
Topics: Adult; Alkaloids; Amino Acid Sequence; Base Sequence; Cell Line; Consensus Sequence; Conserved Seque | 1995 |
Lipid alterations in apparently normal white matter in multiple sclerosis.
Topics: Adult; Aged; Brain; Cerebrosides; Cholesterol; Choline; Fatty Acids; Female; Humans; Inositol; Lipid | 1971 |