serine has been researched along with Multiple Myeloma in 13 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteasome inhibitors such as bortezomib are highly active in multiple myeloma by affecting signaling cascades and leading to a toxic buildup of misfolded proteins." | 7.83 | Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation. ( Bahlis, NJ; Boise, LH; Jaye, DL; Lonial, S; Nooka, AK; Shah, SP, 2016) |
| "Proteasome inhibitors such as bortezomib are highly active in multiple myeloma by affecting signaling cascades and leading to a toxic buildup of misfolded proteins." | 3.83 | Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation. ( Bahlis, NJ; Boise, LH; Jaye, DL; Lonial, S; Nooka, AK; Shah, SP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Vega, M | 1 |
| Chen, Y | 1 |
| Shi, Y | 1 |
| Gera, J | 1 |
| Lichtenstein, A | 1 |
| Huang, QL | 1 |
| Zhao, RR | 1 |
| Yang, BY | 1 |
| Jiang, RY | 1 |
| Yang, LL | 1 |
| Yan, S | 1 |
| Fu, ZZ | 1 |
| Wu, DP | 1 |
| Wu, XJ | 1 |
| Abdollahi, P | 1 |
| Vandsemb, EN | 1 |
| Elsaadi, S | 1 |
| Røst, LM | 1 |
| Yang, R | 1 |
| Hjort, MA | 1 |
| Andreassen, T | 1 |
| Misund, K | 1 |
| Slørdahl, TS | 1 |
| Rø, TB | 1 |
| Sponaas, AM | 1 |
| Moestue, S | 1 |
| Bruheim, P | 1 |
| Børset, M | 1 |
| Shah, SP | 1 |
| Nooka, AK | 1 |
| Jaye, DL | 1 |
| Bahlis, NJ | 1 |
| Lonial, S | 1 |
| Boise, LH | 1 |
| Chauhan, D | 1 |
| Li, G | 1 |
| Hideshima, T | 1 |
| Podar, K | 1 |
| Mitsiades, C | 1 |
| Mitsiades, N | 1 |
| Munshi, N | 1 |
| Kharbanda, S | 1 |
| Anderson, KC | 1 |
| ANDERSON, EP | 1 |
| JACQUEZ, JA | 1 |
| Filippovich, IV | 1 |
| Sorokina, NI | 1 |
| Lisbona, A | 1 |
| Chérel, M | 1 |
| Chatal, JF | 1 |
| Dawson, G | 1 |
| Clamp, JR | 1 |
| Chen, BL | 1 |
| Poljak, RJ | 1 |
| Fujioka, S | 1 |
| Gallo, RC | 1 |
| Mushinski, JF | 1 |
| Skinner, M | 1 |
| Cohen, AS | 1 |
| Edmundson, AB | 1 |
| Simonds, NB | 1 |
| Sheber, FA | 1 |
| Johnson, T | 1 |
| Bangs, B | 1 |
13 other studies available for serine and Multiple Myeloma
| Article | Year |
|---|---|
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
Topics: Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 3; MTOR Inhi | 2022 |
[Preliminary exploration of the metabolic profile and metabolic pathways in newly diagnosed multiple myeloma].
Topics: Adult; Aged; Biomarkers; Cysteine; Female; Humans; Male; Metabolic Networks and Pathways; Metabolome | 2022 |
Phosphatase of regenerating liver-3 regulates cancer cell metabolism in multiple myeloma.
Topics: Adenosine Triphosphate; Cell Line, Tumor; Cell Proliferation; Glycine; Glycine Dehydrogenase (Decarb | 2021 |
Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation.
Topics: Adult; Aged; Antineoplastic Agents; Blotting, Western; Bortezomib; Cell Line, Tumor; Heat Shock Tran | 2016 |
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Cell Lin | 2003 |
Azaserine resistance in a plasma-cell neoplasm without change in active transport of the inhibitor.
Topics: Animals; Antineoplastic Agents; Azaserine; Biological Transport, Active; Multiple Myeloma; Neoplasms | 1962 |
Radiation-induced apoptosis in human myeloma cell line increases BCL-2/BAX dimer formation and does not result in BAX/BAX homodimerization.
Topics: Apoptosis; bcl-2-Associated X Protein; Cytosol; Dimerization; Humans; Mitochondria; Multiple Myeloma | 2001 |
The presence of two types of carbohydrate-amino acid linkage in the same glycoprotein.
Topics: Aspartic Acid; Chromatography, Paper; Galactose; gamma-Globulins; Glycoproteins; Hexoses; Mannose; M | 1967 |
Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).
Topics: Alkylation; Amino Acid Sequence; Amino Acids; Chromatography, Gel; Chymotrypsin; Dansyl Compounds; E | 1974 |
Aminoacyl transfer RNA profiles in human myeloma cells.
Topics: Acyltransferases; Aspartic Acid; Carbon Isotopes; Cell Line; Chromatography; Culture Techniques; Hum | 1971 |
Stability of chromatographic patterns of aminoacyl transfer ribonucleic acid from individual mouse plasmacytomas and variability among different immunoglobulin A producing plasmacytomas and normal organs.
Topics: Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography; Drug Stability; Immunoglobuli | 1971 |
N-terminal amino acid analysis of the amyloid fibril protein.
Topics: Amino Acids; Amyloid; Amyloidosis; Aspartic Acid; Chromatography, Paper; Electrophoresis; Fluorine; | 1971 |
Use of carboxypeptidase A for simultaneous assessment of purity and assignment of human Bence Jones proteins and light chains to K and L classes.
Topics: Amino Acids; Antigens; Bence Jones Protein; Carboxypeptidases; Chromatography, Gel; Humans; Immunogl | 1969 |