serine has been researched along with Motor Neuron Disease in 5 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| " UHPLC-MS/MS was used to confirm BMAA exposures in dosed vervets." | 1.56 | l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND. ( Banack, SA; Beierschmitt, A; Bradley, WG; Cox, PA; Davis, DA; Garamszegi, SP; Hagan, MJ; Lecusay, PD; Mash, DC; Metcalf, JS; Palmour, RM; Powell, JT, 2020) |
| "Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by upper and lower motor neuron damage." | 1.36 | Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease. ( Hirayama, T; Ikeda, K; Ito, H; Iwasaki, Y; Kano, O; Kawabe, K; Nakamura, Y; Sobue, G; Takazawa, T; Tanaka, F; Yoshii, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fiorillo, C | 1 |
| Capodivento, G | 1 |
| Geroldi, A | 1 |
| Tozza, S | 1 |
| Moroni, I | 1 |
| Mohassel, P | 1 |
| Cataldi, M | 1 |
| Campana, C | 1 |
| Morando, S | 1 |
| Panicucci, C | 1 |
| Pedemonte, M | 1 |
| Brolatti, N | 1 |
| Siliquini, S | 1 |
| Traverso, M | 1 |
| Baratto, S | 1 |
| Debellis, D | 1 |
| Magri, S | 1 |
| Prada, V | 1 |
| Bellone, E | 1 |
| Salpietro, V | 1 |
| Donkervoort, S | 1 |
| Gable, K | 1 |
| Gupta, SD | 1 |
| Dunn, TM | 1 |
| Bönnemann, CG | 1 |
| Taroni, F | 1 |
| Bruno, C | 1 |
| Schenone, A | 1 |
| Mandich, P | 1 |
| Nobbio, L | 1 |
| Nolano, M | 1 |
| Davis, DA | 1 |
| Cox, PA | 1 |
| Banack, SA | 1 |
| Lecusay, PD | 1 |
| Garamszegi, SP | 1 |
| Hagan, MJ | 1 |
| Powell, JT | 1 |
| Metcalf, JS | 1 |
| Palmour, RM | 1 |
| Beierschmitt, A | 1 |
| Bradley, WG | 1 |
| Mash, DC | 1 |
| Takazawa, T | 1 |
| Ikeda, K | 1 |
| Hirayama, T | 1 |
| Kawabe, K | 1 |
| Nakamura, Y | 1 |
| Ito, H | 1 |
| Kano, O | 1 |
| Yoshii, Y | 1 |
| Tanaka, F | 1 |
| Sobue, G | 1 |
| Iwasaki, Y | 1 |
| Maystadt, I | 1 |
| Rezsöhazy, R | 1 |
| Barkats, M | 1 |
| Duque, S | 1 |
| Vannuffel, P | 1 |
| Remacle, S | 1 |
| Lambert, B | 1 |
| Najimi, M | 1 |
| Sokal, E | 1 |
| Munnich, A | 1 |
| Viollet, L | 1 |
| Verellen-Dumoulin, C | 1 |
| Banerjee, P | 1 |
| Boyers, MJ | 1 |
| Berry-Kravis, E | 1 |
| Dawson, G | 1 |
5 other studies available for serine and Motor Neuron Disease
| Article | Year |
|---|---|
The SPTLC1 p.S331 mutation bridges sensory neuropathy and motor neuron disease and has implications for treatment.
Topics: Hereditary Sensory and Autonomic Neuropathies; Humans; Motor Neuron Disease; Mutation; Peripheral Ne | 2022 |
l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chlorocebus aethiops; Cyanobacteria To | 2020 |
Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease.
Topics: Adult; Amyotrophic Lateral Sclerosis; Fatal Outcome; Female; Glycine; Humans; Male; Motor Neuron Dis | 2010 |
The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset.
Topics: Age of Onset; Amino Acid Sequence; Animals; Cells, Cultured; Child; Genes, Recessive; Guanine Nucleo | 2007 |
Preferential beta-hexosaminidase (Hex) A (alpha beta) formation in the absence of beta-Hex B (beta beta) due to heterozygous point mutations present in beta-Hex beta-chain alleles of a motor neuron disease patient.
Topics: Adult; Alleles; Amino Acid Sequence; Animals; beta-N-Acetylhexosaminidases; Cell Line; Exons; Female | 1994 |