serine has been researched along with Methemoglobinemia in 3 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hereditary methemoglobinemia is an autosomal recessive disorder characterized by NADH-cytochrome b5 reductase (b5R) deficiency." | 5.28 | Serine-proline replacement at residue 127 of NADH-cytochrome b5 reductase causes hereditary methemoglobinemia, generalized type. ( Fukumaki, Y; Inoue, J; Kobayashi, Y; Sakaki, Y; Yubisui, T, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bewley, MC | 1 |
| Davis, CA | 1 |
| Marohnic, CC | 1 |
| Taormina, D | 1 |
| Barber, MJ | 1 |
| Percy, MJ | 1 |
| Oren, H | 1 |
| Savage, G | 1 |
| Irken, G | 1 |
| Kobayashi, Y | 1 |
| Fukumaki, Y | 1 |
| Yubisui, T | 1 |
| Inoue, J | 1 |
| Sakaki, Y | 1 |
3 other studies available for serine and Methemoglobinemia
| Article | Year |
|---|---|
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
Topics: Adenosine Monophosphate; Amino Acid Substitution; Animals; Binding Sites; Crystallography, X-Ray; Cy | 2003 |
Congenital methaemoglobinaemia Type I in a Turkish infant due to a novel mutation, Pro144Ser, in NADH-cytochrome b5 reductase.
Topics: Amino Acid Substitution; Ascorbic Acid; Cytochrome-B(5) Reductase; Female; Humans; Infant; Methemogl | 2004 |
Serine-proline replacement at residue 127 of NADH-cytochrome b5 reductase causes hereditary methemoglobinemia, generalized type.
Topics: Adult; Alleles; Amino Acid Sequence; Base Sequence; Blood Platelets; Cytochrome Reductases; Cytochro | 1990 |