serine has been researched along with Melanoma in 47 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The outside-in signaling of the ectopically expressed alphaIIbbeta3 integrin was studied in B16a murine melanoma cells using a monoclonal antibody, specifically directed to the activated conformation of alphaIIbbeta3, PAC-1 and the physiological ligand, fibrinogen." | 7.71 | Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. ( Honn, KV; Paku, S; Rásó, E; Tímár, J; Tóth, K; Tóvári, J; Trikha, M, 2001) |
| "Binding of the CXC chemokine, melanoma growth stimulatory activity (MGSA), to the class II IL-8 receptor on cells which overexpress this G-protein coupled receptor results in enhanced phosphorylation on serine residues." | 7.69 | Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein. ( Richmond, A; Schraw, W, 1995) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 5.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| "These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets." | 5.37 | Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011) |
| " Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples." | 4.02 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021) |
| "Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas." | 3.91 | Increased PHGDH expression promotes aberrant melanin accumulation. ( Bronson, RT; Fiske, BP; Lau, AN; Mattaini, KR; Sullivan, MR; Vander Heiden, MG, 2019) |
| " The outside-in signaling of the ectopically expressed alphaIIbbeta3 integrin was studied in B16a murine melanoma cells using a monoclonal antibody, specifically directed to the activated conformation of alphaIIbbeta3, PAC-1 and the physiological ligand, fibrinogen." | 3.71 | Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. ( Honn, KV; Paku, S; Rásó, E; Tímár, J; Tóth, K; Tóvári, J; Trikha, M, 2001) |
| "Binding of the CXC chemokine, melanoma growth stimulatory activity (MGSA), to the class II IL-8 receptor on cells which overexpress this G-protein coupled receptor results in enhanced phosphorylation on serine residues." | 3.69 | Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein. ( Richmond, A; Schraw, W, 1995) |
| "Melanoma is a kind of aggressive skin neoplasms with high mortality." | 1.72 | LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis. ( Ji, G; Luo, B; Shen, G; Tian, T, 2022) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 1.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| "These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets." | 1.37 | Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011) |
| "Uveal melanoma is the most common malignancy of the eye, but little is known about its underlying genetic defects." | 1.31 | Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region. ( Brantley, MA; Harbour, JW, 2000) |
| "The putative metastasis suppressor genes, NME1(nm23-1) and NME2(nm23-2), were examined in a model system we developed to approximate the dissemination of melanoma from a primary skin tumor." | 1.29 | Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials. ( Backer, JM; Hamby, CV; Mendola, CE; Potla, L; Stafford, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.38) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 15 (31.91) | 29.6817 |
| 2010's | 14 (29.79) | 24.3611 |
| 2020's | 9 (19.15) | 2.80 |
| Authors | Studies |
|---|---|
| Csomós, I | 1 |
| Nagy, P | 1 |
| Filep, C | 1 |
| Rebenku, I | 1 |
| Nizsalóczki, E | 1 |
| Kovács, T | 1 |
| Vámosi, G | 1 |
| Mátyus, L | 1 |
| Bodnár, A | 1 |
| Hirata, AS | 1 |
| Rezende-Teixeira, P | 1 |
| Machado-Neto, JA | 1 |
| Jimenez, PC | 1 |
| Clair, JJ | 1 |
| Fenical, W | 1 |
| Costa-Lotufo, LV | 1 |
| Tian, T | 1 |
| Luo, B | 1 |
| Shen, G | 1 |
| Ji, G | 1 |
| Lee, CJ | 1 |
| An, HJ | 1 |
| Kim, SM | 1 |
| Yoo, SM | 1 |
| Park, J | 1 |
| Lee, GE | 1 |
| Kim, WY | 1 |
| Kim, DJ | 1 |
| Kang, HC | 1 |
| Lee, JY | 1 |
| Lee, HS | 1 |
| Cho, SJ | 1 |
| Cho, YY | 1 |
| Najjar, S | 1 |
| Homan, S | 1 |
| Sheehan, C | 1 |
| Carlson, JA | 1 |
| Nguyen, MQ | 1 |
| Teh, JLF | 1 |
| Purwin, TJ | 1 |
| Chervoneva, I | 1 |
| Davies, MA | 1 |
| Nathanson, KL | 1 |
| Cheng, PF | 1 |
| Levesque, MP | 1 |
| Dummer, R | 1 |
| Aplin, AE | 2 |
| Vido, MJ | 1 |
| Rock, J | 1 |
| Doepner, M | 1 |
| Lee, IY | 1 |
| Ridky, TW | 1 |
| Rawat, V | 1 |
| Malvi, P | 1 |
| Della Manna, D | 1 |
| Yang, ES | 1 |
| Bugide, S | 1 |
| Zhang, X | 1 |
| Gupta, R | 1 |
| Wajapeyee, N | 1 |
| Pathria, G | 1 |
| Scott, DA | 1 |
| Feng, Y | 1 |
| Sang Lee, J | 1 |
| Fujita, Y | 1 |
| Zhang, G | 1 |
| Sahu, AD | 1 |
| Ruppin, E | 1 |
| Herlyn, M | 2 |
| Osterman, AL | 1 |
| Ronai, ZA | 1 |
| Mattaini, KR | 1 |
| Sullivan, MR | 1 |
| Lau, AN | 1 |
| Fiske, BP | 1 |
| Bronson, RT | 1 |
| Vander Heiden, MG | 1 |
| Krishnan, H | 1 |
| Ochoa-Alvarez, JA | 1 |
| Shen, Y | 1 |
| Nevel, E | 1 |
| Lakshminarayanan, M | 1 |
| Williams, MC | 1 |
| Ramirez, MI | 1 |
| Miller, WT | 1 |
| Goldberg, GS | 1 |
| Wang, Q | 1 |
| Beaumont, KA | 1 |
| Otte, NJ | 1 |
| Font, J | 1 |
| Bailey, CG | 1 |
| van Geldermalsen, M | 1 |
| Sharp, DM | 1 |
| Tiffen, JC | 1 |
| Ryan, RM | 1 |
| Jormakka, M | 1 |
| Haass, NK | 1 |
| Rasko, JE | 1 |
| Holst, J | 1 |
| Iyengar, AS | 1 |
| Miller, PJ | 1 |
| Loupe, JM | 1 |
| Hollenbach, AD | 1 |
| Zajkowicz, A | 1 |
| Gdowicz-Kłosok, A | 1 |
| Krześniak, M | 1 |
| Ścieglińska, D | 1 |
| Rusin, M | 1 |
| Carter, JH | 1 |
| Deddens, JA | 1 |
| Spaulding, NR | 1 |
| Lucas, D | 1 |
| Colligan, BM | 1 |
| Lewis, TG | 1 |
| Hawkins, E | 1 |
| Jones, J | 1 |
| Pemberton, JO | 1 |
| Douglass, LE | 1 |
| Graff, JR | 1 |
| El Sayed, SM | 1 |
| Baghdadi, H | 1 |
| Zolaly, M | 1 |
| Almaramhy, HH | 1 |
| Ayat, M | 1 |
| Donki, JG | 1 |
| Sheridan, C | 1 |
| Brumatti, G | 1 |
| Martin, SJ | 1 |
| Li, Y | 1 |
| Depontieu, FR | 1 |
| Sidney, J | 1 |
| Salay, TM | 1 |
| Engelhard, VH | 2 |
| Hunt, DF | 2 |
| Sette, A | 1 |
| Topalian, SL | 1 |
| Mariuzza, RA | 1 |
| Zykova, TA | 1 |
| Zhu, F | 1 |
| Vakorina, TI | 1 |
| Zhang, J | 1 |
| Higgins, LA | 1 |
| Urusova, DV | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Liu, F | 1 |
| Singh, A | 1 |
| Yang, Z | 1 |
| Garcia, A | 1 |
| Kong, Y | 1 |
| Meyskens, FL | 1 |
| Possemato, R | 1 |
| Marks, KM | 1 |
| Shaul, YD | 1 |
| Pacold, ME | 1 |
| Kim, D | 1 |
| Birsoy, K | 1 |
| Sethumadhavan, S | 1 |
| Woo, HK | 1 |
| Jang, HG | 1 |
| Jha, AK | 1 |
| Chen, WW | 1 |
| Barrett, FG | 1 |
| Stransky, N | 1 |
| Tsun, ZY | 1 |
| Cowley, GS | 1 |
| Barretina, J | 1 |
| Kalaany, NY | 1 |
| Hsu, PP | 1 |
| Ottina, K | 1 |
| Chan, AM | 1 |
| Yuan, B | 1 |
| Garraway, LA | 1 |
| Root, DE | 1 |
| Mino-Kenudson, M | 1 |
| Brachtel, EF | 1 |
| Driggers, EM | 1 |
| Sabatini, DM | 1 |
| Sakaguchi, M | 1 |
| Oka, M | 1 |
| Iwasaki, T | 1 |
| Fukami, Y | 1 |
| Nishigori, C | 1 |
| Lee, BR | 1 |
| Matsuo, Y | 1 |
| Cashikar, AG | 1 |
| Kamitani, T | 1 |
| Shonukan, O | 1 |
| Bagayogo, I | 1 |
| McCrea, P | 1 |
| Chao, M | 1 |
| Hempstead, B | 1 |
| Woo, MS | 1 |
| Ohta, Y | 1 |
| Rabinovitz, I | 1 |
| Stossel, TP | 1 |
| Blenis, J | 1 |
| Ramirez-Montagut, T | 1 |
| Blachere, NE | 1 |
| Sviderskaya, EV | 1 |
| Bennett, DC | 1 |
| Rettig, WJ | 1 |
| Garin-Chesa, P | 1 |
| Houghton, AN | 1 |
| Roesch, A | 2 |
| Becker, B | 2 |
| Meyer, S | 1 |
| Hafner, C | 1 |
| Wild, PJ | 1 |
| Landthaler, M | 2 |
| Vogt, T | 2 |
| Posen, Y | 1 |
| Kalchenko, V | 1 |
| Seger, R | 1 |
| Brandis, A | 1 |
| Scherz, A | 1 |
| Salomon, Y | 1 |
| Schneider-Brachert, W | 1 |
| Hagen, I | 1 |
| Mo, JS | 1 |
| Kim, MY | 1 |
| Han, SO | 1 |
| Kim, IS | 1 |
| Ann, EJ | 1 |
| Lee, KS | 1 |
| Seo, MS | 1 |
| Kim, JY | 1 |
| Lee, SC | 1 |
| Park, JW | 1 |
| Choi, EJ | 1 |
| Seong, JY | 1 |
| Joe, CO | 1 |
| Faessler, R | 1 |
| Park, HS | 1 |
| Garate, M | 1 |
| Campos, EI | 1 |
| Bush, JA | 1 |
| Xiao, H | 1 |
| Li, G | 1 |
| Pohl, G | 1 |
| Källström, M | 1 |
| Bergsdorf, N | 1 |
| Wallén, P | 1 |
| Jörnvall, H | 1 |
| Schraw, W | 1 |
| Richmond, A | 1 |
| Hamby, CV | 1 |
| Mendola, CE | 1 |
| Potla, L | 1 |
| Stafford, G | 1 |
| Backer, JM | 1 |
| Guldberg, P | 1 |
| Kirkin, AF | 1 |
| Gronbaek, K | 1 |
| thor Straten, P | 1 |
| Ahrenkiel, V | 1 |
| Zeuthen, J | 1 |
| Kittlesen, DJ | 1 |
| Thompson, LW | 1 |
| Gulden, PH | 1 |
| Skipper, JC | 1 |
| Colella, TA | 1 |
| Shabanowitz, J | 1 |
| Slingluff, CL | 1 |
| Shabanowitz, JA | 1 |
| Kurian, MS | 1 |
| de la Cuesta, RS | 1 |
| Waneck, GL | 1 |
| MacLaughlin, DT | 1 |
| Manganaro, TF | 1 |
| Donahoe, PK | 1 |
| Blaydes, JP | 1 |
| Craig, AL | 1 |
| Wallace, M | 1 |
| Ball, HM | 1 |
| Traynor, NJ | 1 |
| Gibbs, NK | 1 |
| Hupp, TR | 1 |
| Brantley, MA | 1 |
| Harbour, JW | 1 |
| Satyamoorthy, K | 1 |
| Chehab, NH | 1 |
| Waterman, MJ | 1 |
| Lien, MC | 1 |
| El-Deiry, WS | 1 |
| Halazonetis, TD | 1 |
| Timár, J | 2 |
| Tóth, S | 1 |
| Tóvári, J | 2 |
| Paku, S | 2 |
| Raz, A | 1 |
| Omholt, K | 1 |
| Platz, A | 1 |
| Ringborg, U | 1 |
| Hansson, J | 1 |
| Rásó, E | 1 |
| Tóth, K | 1 |
| Trikha, M | 1 |
| Honn, KV | 1 |
| Legg, JW | 1 |
| Lewis, CA | 1 |
| Parsons, M | 1 |
| Ng, T | 1 |
| Isacke, CM | 1 |
| Spiro, RC | 1 |
| Quaranta, V | 1 |
| Schulman, JD | 1 |
| Wrathall, JR | 1 |
| Silagi, S | 1 |
| Doores, L | 1 |
47 other studies available for serine and Melanoma
| Article | Year |
|---|---|
Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells.
Topics: Apoptosis; Benzophenanthridines; Berberine Alkaloids; Cell Line, Tumor; Humans; Interleukin-6; Melan | 2021 |
Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Discovery; GTP Phosphohydrolases | 2021 |
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Gene Expression Regulation, | 2022 |
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation.
Topics: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Proliferation; F-Box-WD Repeat-Containing Pro | 2020 |
SERINE-910 Phosphorylated Focal Adhesion Kinase Expression Predicts Better Overall and Disease-free Survival in Melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Disease-Free Su | 2020 |
Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition.
Topics: Animals; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Glutathione; | 2020 |
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
Topics: Binding Sites; Cell Line, Tumor; Humans; Indoles; Melanoma; Mutation; Protein Kinase Inhibitors; Pro | 2021 |
Drug Resistant Melanoma May Be Vulnerable to Inhibitors of Serine Synthesis.
Topics: Glutathione; GTP Phosphohydrolases; Humans; Melanoma; Membrane Proteins; Mitogen-Activated Protein K | 2020 |
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow | 2021 |
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
Topics: Activating Transcription Factor 4; Amino Acid Transport System ASC; Aspartic Acid; Cell Line, Tumor; | 2018 |
Increased PHGDH expression promotes aberrant melanin accumulation.
Topics: Alleles; Animals; Cell Line; Doxycycline; Gene Expression; Hair Follicle; Humans; Melanins; Melanocy | 2019 |
Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility.
Topics: Animals; Cell Line, Tumor; Cell Movement; Coculture Techniques; Cyclic AMP-Dependent Protein Kinases | 2013 |
Targeting glutamine transport to suppress melanoma cell growth.
Topics: Amino Acid Transport System ASC; Amino Acids, Cyclic; Benzyl Compounds; Biological Transport; Carrie | 2014 |
Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Melanocytes; Melanoma | 2014 |
Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
Topics: Cell Line, Tumor; Dactinomycin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma | 2015 |
Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.
Topics: Adult; Biomarkers, Tumor; Disease Progression; Eukaryotic Initiation Factor-4E; Female; Humans; Immu | 2016 |
The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view.
Topics: Acetaminophen; Administration, Oral; Albumins; Alkylating Agents; Animals; Antineoplastic Agents; Ci | 2017 |
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-Ass | 2008 |
Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells.
Topics: Amino Acid Sequence; Antigen Presentation; Antigens, Neoplasm; Binding Sites; CD4-Positive T-Lymphoc | 2010 |
T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Circular Dichroism; Flow Cytometry; Humans; Hydrogen | 2010 |
MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells.
Topics: Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Humans; Melanocytes; Melanoma; Microphthalm | 2010 |
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycl | 2011 |
Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Survival; DNA; Humans; Melanocytes; Melanoma; | 2012 |
Role of Ser129 phosphorylation of α-synuclein in melanoma cells.
Topics: alpha-Synuclein; Amino Acid Sequence; Antibodies, Monoclonal; Cell Line, Tumor; Epitope Mapping; Hum | 2013 |
Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin.
Topics: Actins; Amino Acid Substitution; Aspartic Acid; Carrier Proteins; Cell Movement; Cytoskeleton; Human | 2003 |
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.
Topics: Amino Acid Sequence; Animals; Butadienes; Cell Line, Tumor; Cell Movement; Colforsin; Contractile Pr | 2004 |
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.
Topics: Animals; Apoptosis; Cell Cycle; Contact Inhibition; Dipeptidyl Peptidase 4; Endopeptidases; Gelatina | 2004 |
Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Topics: Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanocyt | 2005 |
Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species.
Topics: Animals; Bacteriochlorophylls; Cell Line, Tumor; Cell Survival; Cell-Free System; Cells, Cultured; D | 2005 |
Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.
Topics: Cell Division; Cell Line, Tumor; DNA-Binding Proteins; DNA, Complementary; G1 Phase; Gene Expression | 2006 |
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Nucleus; Down-Regulation; Humans; Mel | 2007 |
Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells.
Topics: Cell Line, Tumor; Cell Proliferation; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling | 2007 |
Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.
Topics: Amino Acid Sequence; Carbohydrates; Cell Line; Cyanogen Bromide; DNA; Endopeptidases; Genetic Variat | 1984 |
Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein.
Topics: Antigens, CD; Blotting, Western; Cell Line; Cell Membrane; Chemokine CXCL1; Chemokines, CXC; Chemota | 1995 |
Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Clone Cells; DNA Primers; Gene Expression; G | 1995 |
Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.
Topics: Asparagine; Biopsy; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; DNA Mutational Analysis; El | 1997 |
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cancer Vaccines; Cysteine; Cytotoxicity, Immu | 1998 |
Cleavage of Müllerian inhibiting substance activates antiproliferative effects in vivo.
Topics: Animals; Anti-Mullerian Hormone; Arginine; Cell Division; Eye Neoplasms; Female; Fibrinolysin; Glyco | 1995 |
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways.
Topics: Amino Acid Sequence; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; DNA Damage; Enzym | 2000 |
Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.
Topics: Cyclin D; Cyclins; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanoma; M | 2000 |
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Topics: 14-3-3 Proteins; Apoptosis; Base Sequence; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Ge | 2000 |
Autocrine motility factor (neuroleukin, phosphohexose isomerase) induces cell movement through 12-lipoxygenase-dependent tyrosine phosphorylation and serine dephosphorylation events.
Topics: Actins; Animals; Cell Movement; Enzyme Inhibitors; Glucose-6-Phosphate Isomerase; Isoenzymes; Lipoxy | 1999 |
Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.
Topics: beta Catenin; Cell Nucleus; Codon; Cytoplasm; Cytoskeletal Proteins; DNA Mutational Analysis; Exons; | 2001 |
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Antibodies, Monoclonal; Arachidonate 12-Lipoxyg | 2001 |
A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Movement; Cytoskeletal Proteins; Humans; | 2002 |
The invariant chain is a phosphorylated subunit of class II molecules.
Topics: Amino Acid Sequence; B-Lymphocytes; Cell Line; Cytoplasm; HLA-D Antigens; Humans; Lymphocyte Activat | 1989 |
Altered amino acid concentrations accompanying suppression of malignancy of mouse melanoma cells by 5-bromodeoxyuridine.
Topics: Alanine; Amino Acids; Animals; Asparagine; Bromodeoxyuridine; Cells, Cultured; Glutamates; Glutamine | 1974 |