serine has been researched along with Malignant Melanoma in 47 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The outside-in signaling of the ectopically expressed alphaIIbbeta3 integrin was studied in B16a murine melanoma cells using a monoclonal antibody, specifically directed to the activated conformation of alphaIIbbeta3, PAC-1 and the physiological ligand, fibrinogen." | 7.71 | Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. ( Honn, KV; Paku, S; Rásó, E; Tímár, J; Tóth, K; Tóvári, J; Trikha, M, 2001) |
| "Binding of the CXC chemokine, melanoma growth stimulatory activity (MGSA), to the class II IL-8 receptor on cells which overexpress this G-protein coupled receptor results in enhanced phosphorylation on serine residues." | 7.69 | Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein. ( Richmond, A; Schraw, W, 1995) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 5.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| "These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets." | 5.37 | Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011) |
| " Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples." | 4.02 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021) |
| "Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas." | 3.91 | Increased PHGDH expression promotes aberrant melanin accumulation. ( Bronson, RT; Fiske, BP; Lau, AN; Mattaini, KR; Sullivan, MR; Vander Heiden, MG, 2019) |
| " The outside-in signaling of the ectopically expressed alphaIIbbeta3 integrin was studied in B16a murine melanoma cells using a monoclonal antibody, specifically directed to the activated conformation of alphaIIbbeta3, PAC-1 and the physiological ligand, fibrinogen." | 3.71 | Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. ( Honn, KV; Paku, S; Rásó, E; Tímár, J; Tóth, K; Tóvári, J; Trikha, M, 2001) |
| "Binding of the CXC chemokine, melanoma growth stimulatory activity (MGSA), to the class II IL-8 receptor on cells which overexpress this G-protein coupled receptor results in enhanced phosphorylation on serine residues." | 3.69 | Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein. ( Richmond, A; Schraw, W, 1995) |
| "Melanoma is a kind of aggressive skin neoplasms with high mortality." | 1.72 | LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis. ( Ji, G; Luo, B; Shen, G; Tian, T, 2022) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 1.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| "These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets." | 1.37 | Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011) |
| "Uveal melanoma is the most common malignancy of the eye, but little is known about its underlying genetic defects." | 1.31 | Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region. ( Brantley, MA; Harbour, JW, 2000) |
| "The putative metastasis suppressor genes, NME1(nm23-1) and NME2(nm23-2), were examined in a model system we developed to approximate the dissemination of melanoma from a primary skin tumor." | 1.29 | Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials. ( Backer, JM; Hamby, CV; Mendola, CE; Potla, L; Stafford, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.38) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 15 (31.91) | 29.6817 |
| 2010's | 14 (29.79) | 24.3611 |
| 2020's | 9 (19.15) | 2.80 |
| Authors | Studies |
|---|---|
| Csomós, I | 1 |
| Nagy, P | 1 |
| Filep, C | 1 |
| Rebenku, I | 1 |
| Nizsalóczki, E | 1 |
| Kovács, T | 1 |
| Vámosi, G | 1 |
| Mátyus, L | 1 |
| Bodnár, A | 1 |
| Hirata, AS | 1 |
| Rezende-Teixeira, P | 1 |
| Machado-Neto, JA | 1 |
| Jimenez, PC | 1 |
| Clair, JJ | 1 |
| Fenical, W | 1 |
| Costa-Lotufo, LV | 1 |
| Tian, T | 1 |
| Luo, B | 1 |
| Shen, G | 1 |
| Ji, G | 1 |
| Lee, CJ | 1 |
| An, HJ | 1 |
| Kim, SM | 1 |
| Yoo, SM | 1 |
| Park, J | 1 |
| Lee, GE | 1 |
| Kim, WY | 1 |
| Kim, DJ | 1 |
| Kang, HC | 1 |
| Lee, JY | 1 |
| Lee, HS | 1 |
| Cho, SJ | 1 |
| Cho, YY | 1 |
| Najjar, S | 1 |
| Homan, S | 1 |
| Sheehan, C | 1 |
| Carlson, JA | 1 |
| Nguyen, MQ | 1 |
| Teh, JLF | 1 |
| Purwin, TJ | 1 |
| Chervoneva, I | 1 |
| Davies, MA | 1 |
| Nathanson, KL | 1 |
| Cheng, PF | 1 |
| Levesque, MP | 1 |
| Dummer, R | 1 |
| Aplin, AE | 2 |
| Vido, MJ | 1 |
| Rock, J | 1 |
| Doepner, M | 1 |
| Lee, IY | 1 |
| Ridky, TW | 1 |
| Rawat, V | 1 |
| Malvi, P | 1 |
| Della Manna, D | 1 |
| Yang, ES | 1 |
| Bugide, S | 1 |
| Zhang, X | 1 |
| Gupta, R | 1 |
| Wajapeyee, N | 1 |
| Pathria, G | 1 |
| Scott, DA | 1 |
| Feng, Y | 1 |
| Sang Lee, J | 1 |
| Fujita, Y | 1 |
| Zhang, G | 1 |
| Sahu, AD | 1 |
| Ruppin, E | 1 |
| Herlyn, M | 2 |
| Osterman, AL | 1 |
| Ronai, ZA | 1 |
| Mattaini, KR | 1 |
| Sullivan, MR | 1 |
| Lau, AN | 1 |
| Fiske, BP | 1 |
| Bronson, RT | 1 |
| Vander Heiden, MG | 1 |
| Krishnan, H | 1 |
| Ochoa-Alvarez, JA | 1 |
| Shen, Y | 1 |
| Nevel, E | 1 |
| Lakshminarayanan, M | 1 |
| Williams, MC | 1 |
| Ramirez, MI | 1 |
| Miller, WT | 1 |
| Goldberg, GS | 1 |
| Wang, Q | 1 |
| Beaumont, KA | 1 |
| Otte, NJ | 1 |
| Font, J | 1 |
| Bailey, CG | 1 |
| van Geldermalsen, M | 1 |
| Sharp, DM | 1 |
| Tiffen, JC | 1 |
| Ryan, RM | 1 |
| Jormakka, M | 1 |
| Haass, NK | 1 |
| Rasko, JE | 1 |
| Holst, J | 1 |
| Iyengar, AS | 1 |
| Miller, PJ | 1 |
| Loupe, JM | 1 |
| Hollenbach, AD | 1 |
| Zajkowicz, A | 1 |
| Gdowicz-Kłosok, A | 1 |
| Krześniak, M | 1 |
| Ścieglińska, D | 1 |
| Rusin, M | 1 |
| Carter, JH | 1 |
| Deddens, JA | 1 |
| Spaulding, NR | 1 |
| Lucas, D | 1 |
| Colligan, BM | 1 |
| Lewis, TG | 1 |
| Hawkins, E | 1 |
| Jones, J | 1 |
| Pemberton, JO | 1 |
| Douglass, LE | 1 |
| Graff, JR | 1 |
| El Sayed, SM | 1 |
| Baghdadi, H | 1 |
| Zolaly, M | 1 |
| Almaramhy, HH | 1 |
| Ayat, M | 1 |
| Donki, JG | 1 |
| Sheridan, C | 1 |
| Brumatti, G | 1 |
| Martin, SJ | 1 |
| Li, Y | 1 |
| Depontieu, FR | 1 |
| Sidney, J | 1 |
| Salay, TM | 1 |
| Engelhard, VH | 2 |
| Hunt, DF | 2 |
| Sette, A | 1 |
| Topalian, SL | 1 |
| Mariuzza, RA | 1 |
| Zykova, TA | 1 |
| Zhu, F | 1 |
| Vakorina, TI | 1 |
| Zhang, J | 1 |
| Higgins, LA | 1 |
| Urusova, DV | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Liu, F | 1 |
| Singh, A | 1 |
| Yang, Z | 1 |
| Garcia, A | 1 |
| Kong, Y | 1 |
| Meyskens, FL | 1 |
| Possemato, R | 1 |
| Marks, KM | 1 |
| Shaul, YD | 1 |
| Pacold, ME | 1 |
| Kim, D | 1 |
| Birsoy, K | 1 |
| Sethumadhavan, S | 1 |
| Woo, HK | 1 |
| Jang, HG | 1 |
| Jha, AK | 1 |
| Chen, WW | 1 |
| Barrett, FG | 1 |
| Stransky, N | 1 |
| Tsun, ZY | 1 |
| Cowley, GS | 1 |
| Barretina, J | 1 |
| Kalaany, NY | 1 |
| Hsu, PP | 1 |
| Ottina, K | 1 |
| Chan, AM | 1 |
| Yuan, B | 1 |
| Garraway, LA | 1 |
| Root, DE | 1 |
| Mino-Kenudson, M | 1 |
| Brachtel, EF | 1 |
| Driggers, EM | 1 |
| Sabatini, DM | 1 |
| Sakaguchi, M | 1 |
| Oka, M | 1 |
| Iwasaki, T | 1 |
| Fukami, Y | 1 |
| Nishigori, C | 1 |
| Lee, BR | 1 |
| Matsuo, Y | 1 |
| Cashikar, AG | 1 |
| Kamitani, T | 1 |
| Shonukan, O | 1 |
| Bagayogo, I | 1 |
| McCrea, P | 1 |
| Chao, M | 1 |
| Hempstead, B | 1 |
| Woo, MS | 1 |
| Ohta, Y | 1 |
| Rabinovitz, I | 1 |
| Stossel, TP | 1 |
| Blenis, J | 1 |
| Ramirez-Montagut, T | 1 |
| Blachere, NE | 1 |
| Sviderskaya, EV | 1 |
| Bennett, DC | 1 |
| Rettig, WJ | 1 |
| Garin-Chesa, P | 1 |
| Houghton, AN | 1 |
| Roesch, A | 2 |
| Becker, B | 2 |
| Meyer, S | 1 |
| Hafner, C | 1 |
| Wild, PJ | 1 |
| Landthaler, M | 2 |
| Vogt, T | 2 |
| Posen, Y | 1 |
| Kalchenko, V | 1 |
| Seger, R | 1 |
| Brandis, A | 1 |
| Scherz, A | 1 |
| Salomon, Y | 1 |
| Schneider-Brachert, W | 1 |
| Hagen, I | 1 |
| Mo, JS | 1 |
| Kim, MY | 1 |
| Han, SO | 1 |
| Kim, IS | 1 |
| Ann, EJ | 1 |
| Lee, KS | 1 |
| Seo, MS | 1 |
| Kim, JY | 1 |
| Lee, SC | 1 |
| Park, JW | 1 |
| Choi, EJ | 1 |
| Seong, JY | 1 |
| Joe, CO | 1 |
| Faessler, R | 1 |
| Park, HS | 1 |
| Garate, M | 1 |
| Campos, EI | 1 |
| Bush, JA | 1 |
| Xiao, H | 1 |
| Li, G | 1 |
| Pohl, G | 1 |
| Källström, M | 1 |
| Bergsdorf, N | 1 |
| Wallén, P | 1 |
| Jörnvall, H | 1 |
| Schraw, W | 1 |
| Richmond, A | 1 |
| Hamby, CV | 1 |
| Mendola, CE | 1 |
| Potla, L | 1 |
| Stafford, G | 1 |
| Backer, JM | 1 |
| Guldberg, P | 1 |
| Kirkin, AF | 1 |
| Gronbaek, K | 1 |
| thor Straten, P | 1 |
| Ahrenkiel, V | 1 |
| Zeuthen, J | 1 |
| Kittlesen, DJ | 1 |
| Thompson, LW | 1 |
| Gulden, PH | 1 |
| Skipper, JC | 1 |
| Colella, TA | 1 |
| Shabanowitz, J | 1 |
| Slingluff, CL | 1 |
| Shabanowitz, JA | 1 |
| Kurian, MS | 1 |
| de la Cuesta, RS | 1 |
| Waneck, GL | 1 |
| MacLaughlin, DT | 1 |
| Manganaro, TF | 1 |
| Donahoe, PK | 1 |
| Blaydes, JP | 1 |
| Craig, AL | 1 |
| Wallace, M | 1 |
| Ball, HM | 1 |
| Traynor, NJ | 1 |
| Gibbs, NK | 1 |
| Hupp, TR | 1 |
| Brantley, MA | 1 |
| Harbour, JW | 1 |
| Satyamoorthy, K | 1 |
| Chehab, NH | 1 |
| Waterman, MJ | 1 |
| Lien, MC | 1 |
| El-Deiry, WS | 1 |
| Halazonetis, TD | 1 |
| Timár, J | 2 |
| Tóth, S | 1 |
| Tóvári, J | 2 |
| Paku, S | 2 |
| Raz, A | 1 |
| Omholt, K | 1 |
| Platz, A | 1 |
| Ringborg, U | 1 |
| Hansson, J | 1 |
| Rásó, E | 1 |
| Tóth, K | 1 |
| Trikha, M | 1 |
| Honn, KV | 1 |
| Legg, JW | 1 |
| Lewis, CA | 1 |
| Parsons, M | 1 |
| Ng, T | 1 |
| Isacke, CM | 1 |
| Spiro, RC | 1 |
| Quaranta, V | 1 |
| Schulman, JD | 1 |
| Wrathall, JR | 1 |
| Silagi, S | 1 |
| Doores, L | 1 |
47 other studies available for serine and Malignant Melanoma
| Article | Year |
|---|---|
Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells.
Topics: Apoptosis; Benzophenanthridines; Berberine Alkaloids; Cell Line, Tumor; Humans; Interleukin-6; Melan | 2021 |
Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Discovery; GTP Phosphohydrolases | 2021 |
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Gene Expression Regulation, | 2022 |
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation.
Topics: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Proliferation; F-Box-WD Repeat-Containing Pro | 2020 |
SERINE-910 Phosphorylated Focal Adhesion Kinase Expression Predicts Better Overall and Disease-free Survival in Melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Disease-Free Su | 2020 |
Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition.
Topics: Animals; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Glutathione; | 2020 |
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
Topics: Binding Sites; Cell Line, Tumor; Humans; Indoles; Melanoma; Mutation; Protein Kinase Inhibitors; Pro | 2021 |
Drug Resistant Melanoma May Be Vulnerable to Inhibitors of Serine Synthesis.
Topics: Glutathione; GTP Phosphohydrolases; Humans; Melanoma; Membrane Proteins; Mitogen-Activated Protein K | 2020 |
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow | 2021 |
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
Topics: Activating Transcription Factor 4; Amino Acid Transport System ASC; Aspartic Acid; Cell Line, Tumor; | 2018 |
Increased PHGDH expression promotes aberrant melanin accumulation.
Topics: Alleles; Animals; Cell Line; Doxycycline; Gene Expression; Hair Follicle; Humans; Melanins; Melanocy | 2019 |
Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility.
Topics: Animals; Cell Line, Tumor; Cell Movement; Coculture Techniques; Cyclic AMP-Dependent Protein Kinases | 2013 |
Targeting glutamine transport to suppress melanoma cell growth.
Topics: Amino Acid Transport System ASC; Amino Acids, Cyclic; Benzyl Compounds; Biological Transport; Carrie | 2014 |
Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Melanocytes; Melanoma | 2014 |
Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
Topics: Cell Line, Tumor; Dactinomycin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma | 2015 |
Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.
Topics: Adult; Biomarkers, Tumor; Disease Progression; Eukaryotic Initiation Factor-4E; Female; Humans; Immu | 2016 |
The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view.
Topics: Acetaminophen; Administration, Oral; Albumins; Alkylating Agents; Animals; Antineoplastic Agents; Ci | 2017 |
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-Ass | 2008 |
Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells.
Topics: Amino Acid Sequence; Antigen Presentation; Antigens, Neoplasm; Binding Sites; CD4-Positive T-Lymphoc | 2010 |
T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Circular Dichroism; Flow Cytometry; Humans; Hydrogen | 2010 |
MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells.
Topics: Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Humans; Melanocytes; Melanoma; Microphthalm | 2010 |
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycl | 2011 |
Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Survival; DNA; Humans; Melanocytes; Melanoma; | 2012 |
Role of Ser129 phosphorylation of α-synuclein in melanoma cells.
Topics: alpha-Synuclein; Amino Acid Sequence; Antibodies, Monoclonal; Cell Line, Tumor; Epitope Mapping; Hum | 2013 |
Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin.
Topics: Actins; Amino Acid Substitution; Aspartic Acid; Carrier Proteins; Cell Movement; Cytoskeleton; Human | 2003 |
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.
Topics: Amino Acid Sequence; Animals; Butadienes; Cell Line, Tumor; Cell Movement; Colforsin; Contractile Pr | 2004 |
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.
Topics: Animals; Apoptosis; Cell Cycle; Contact Inhibition; Dipeptidyl Peptidase 4; Endopeptidases; Gelatina | 2004 |
Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Topics: Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanocyt | 2005 |
Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species.
Topics: Animals; Bacteriochlorophylls; Cell Line, Tumor; Cell Survival; Cell-Free System; Cells, Cultured; D | 2005 |
Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.
Topics: Cell Division; Cell Line, Tumor; DNA-Binding Proteins; DNA, Complementary; G1 Phase; Gene Expression | 2006 |
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Nucleus; Down-Regulation; Humans; Mel | 2007 |
Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells.
Topics: Cell Line, Tumor; Cell Proliferation; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling | 2007 |
Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.
Topics: Amino Acid Sequence; Carbohydrates; Cell Line; Cyanogen Bromide; DNA; Endopeptidases; Genetic Variat | 1984 |
Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein.
Topics: Antigens, CD; Blotting, Western; Cell Line; Cell Membrane; Chemokine CXCL1; Chemokines, CXC; Chemota | 1995 |
Differential expression and mutation of NME genes in autologous cultured human melanoma cells with different metastatic potentials.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Clone Cells; DNA Primers; Gene Expression; G | 1995 |
Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.
Topics: Asparagine; Biopsy; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; DNA Mutational Analysis; El | 1997 |
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cancer Vaccines; Cysteine; Cytotoxicity, Immu | 1998 |
Cleavage of Müllerian inhibiting substance activates antiproliferative effects in vivo.
Topics: Animals; Anti-Mullerian Hormone; Arginine; Cell Division; Eye Neoplasms; Female; Fibrinolysin; Glyco | 1995 |
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways.
Topics: Amino Acid Sequence; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; DNA Damage; Enzym | 2000 |
Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.
Topics: Cyclin D; Cyclins; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanoma; M | 2000 |
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Topics: 14-3-3 Proteins; Apoptosis; Base Sequence; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Ge | 2000 |
Autocrine motility factor (neuroleukin, phosphohexose isomerase) induces cell movement through 12-lipoxygenase-dependent tyrosine phosphorylation and serine dephosphorylation events.
Topics: Actins; Animals; Cell Movement; Enzyme Inhibitors; Glucose-6-Phosphate Isomerase; Isoenzymes; Lipoxy | 1999 |
Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.
Topics: beta Catenin; Cell Nucleus; Codon; Cytoplasm; Cytoskeletal Proteins; DNA Mutational Analysis; Exons; | 2001 |
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Antibodies, Monoclonal; Arachidonate 12-Lipoxyg | 2001 |
A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Movement; Cytoskeletal Proteins; Humans; | 2002 |
The invariant chain is a phosphorylated subunit of class II molecules.
Topics: Amino Acid Sequence; B-Lymphocytes; Cell Line; Cytoplasm; HLA-D Antigens; Humans; Lymphocyte Activat | 1989 |
Altered amino acid concentrations accompanying suppression of malignancy of mouse melanoma cells by 5-bromodeoxyuridine.
Topics: Alanine; Amino Acids; Animals; Asparagine; Bromodeoxyuridine; Cells, Cultured; Glutamates; Glutamine | 1974 |