serine has been researched along with Lymph Node Metastasis in 17 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen." | 9.14 | Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer. ( Hauptmann, M; Holm-Wigerup, C; Kok, M; Landberg, G; Linn, S; Michalides, R; Stål, O, 2009) |
| "We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial." | 9.14 | Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010) |
| "Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen." | 5.14 | Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer. ( Hauptmann, M; Holm-Wigerup, C; Kok, M; Landberg, G; Linn, S; Michalides, R; Stål, O, 2009) |
| "We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial." | 5.14 | Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010) |
| "Secretion of 12(S)-HETE by breast cancer emboli provokes "circular chemorepellent induced defects" (CCIDs) in the adjacent lymphatic vasculature facilitating their intravasation and lymph node metastasis which determines prognosis." | 1.43 | 12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply. ( Atanasov, AG; Brenner, S; Dirsch, VM; Dolznig, H; Fristiohardy, A; Giessrigl, B; Holzner, S; Huttary, N; Jäger, W; Krieger, S; Krupitza, G; Li, Y; Milovanovic, D; Nguyen, CH; Riha, J; Saiko, P; Simonitsch-Klupp, I; Stadler, S; Szekeres, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, LY | 1 |
| Xie, YH | 1 |
| Xie, YM | 1 |
| Liao, LD | 1 |
| Xu, XE | 1 |
| Zhang, Q | 1 |
| Zeng, FM | 1 |
| Tao, LH | 1 |
| Xie, WM | 1 |
| Xie, JJ | 1 |
| Xu, LY | 1 |
| Li, EM | 1 |
| Yoon, S | 1 |
| Kim, JG | 1 |
| Seo, AN | 1 |
| Park, SY | 1 |
| Kim, HJ | 1 |
| Park, JS | 1 |
| Choi, GS | 1 |
| Jeong, JY | 1 |
| Jun, do Y | 1 |
| Yoon, GS | 1 |
| Kang, BW | 1 |
| Nguyen, CH | 1 |
| Brenner, S | 1 |
| Huttary, N | 1 |
| Li, Y | 1 |
| Atanasov, AG | 1 |
| Dirsch, VM | 1 |
| Holzner, S | 1 |
| Stadler, S | 1 |
| Riha, J | 1 |
| Krieger, S | 1 |
| Milovanovic, D | 1 |
| Fristiohardy, A | 1 |
| Simonitsch-Klupp, I | 1 |
| Dolznig, H | 1 |
| Saiko, P | 1 |
| Szekeres, T | 1 |
| Giessrigl, B | 1 |
| Jäger, W | 1 |
| Krupitza, G | 1 |
| Kreager, DA | 1 |
| Ragan, DT | 1 |
| Nguyen, H | 1 |
| Staff, J | 1 |
| Bartosh, TJ | 1 |
| Ylostalo, JH | 1 |
| Dutta, NK | 1 |
| He, R | 1 |
| Pinn, ML | 1 |
| He, Y | 1 |
| Burrows, F | 1 |
| Zhang, ZY | 1 |
| Karakousis, PC | 1 |
| Jin, YJ | 1 |
| Wang, S | 1 |
| Cho, J | 1 |
| Selim, MA | 1 |
| Wright, T | 1 |
| Mosialos, G | 1 |
| Zhang, JY | 1 |
| Roy, S | 1 |
| Karmakar, T | 1 |
| Nagappa, LK | 1 |
| Prahlada Rao, VS | 1 |
| Balasubramanian, S | 1 |
| Balaram, H | 1 |
| Mazuquin, BF | 1 |
| Dela Bela, LF | 1 |
| Pelegrinelli, AR | 1 |
| Dias, JM | 1 |
| Carregaro, RL | 1 |
| Moura, FA | 1 |
| Selfe, J | 1 |
| Richards, J | 1 |
| Brown, LE | 1 |
| Cardoso, JR | 1 |
| Naeem, MA | 1 |
| Armutlulu, A | 1 |
| Broda, M | 1 |
| Lebedev, D | 1 |
| Müller, CR | 1 |
| Jin, X | 1 |
| Liang, N | 1 |
| Wang, M | 1 |
| Meng, Y | 1 |
| Jia, B | 1 |
| Shi, X | 1 |
| Li, S | 1 |
| Luo, J | 1 |
| Luo, Y | 1 |
| Cui, Q | 1 |
| Zheng, K | 1 |
| Liu, Z | 1 |
| Shi, J | 1 |
| Li, F | 1 |
| Wang, F | 1 |
| Zhu, Z | 1 |
| Gallo, S | 1 |
| Woolfrey, AE | 1 |
| Burroughs, LM | 1 |
| Storer, BE | 1 |
| Flowers, ME | 1 |
| Hari, P | 1 |
| Pulsipher, MA | 1 |
| Heimfeld, S | 1 |
| Kiem, HP | 1 |
| Sandmaier, BM | 1 |
| Storb, R | 1 |
| Lu, H | 1 |
| Cai, Y | 1 |
| Yu, YN | 1 |
| Yang, H | 1 |
| Kok, M | 1 |
| Holm-Wigerup, C | 1 |
| Hauptmann, M | 1 |
| Michalides, R | 1 |
| Stål, O | 1 |
| Linn, S | 1 |
| Landberg, G | 1 |
| Yang, SX | 1 |
| Costantino, JP | 1 |
| Kim, C | 1 |
| Mamounas, EP | 1 |
| Nguyen, D | 1 |
| Jeong, JH | 1 |
| Wolmark, N | 1 |
| Kidwell, K | 1 |
| Paik, S | 1 |
| Swain, SM | 1 |
| Wang, Z | 1 |
| Trope, CG | 1 |
| Flørenes, VA | 1 |
| Suo, Z | 1 |
| Nesland, JM | 1 |
| Holm, R | 1 |
| Fan, CF | 1 |
| Mao, XY | 1 |
| Wang, EH | 1 |
| Murphy, L | 1 |
| Cherlet, T | 1 |
| Adeyinka, A | 1 |
| Niu, Y | 1 |
| Snell, L | 1 |
| Watson, P | 1 |
| Matsumoto, M | 1 |
| Furihata, M | 1 |
| Kurabayashi, A | 1 |
| Sasaguri, S | 1 |
| Araki, K | 1 |
| Hayashi, H | 1 |
| Ohtsuki, Y | 1 |
| Kondo, E | 1 |
| Miyake, T | 1 |
| Shibata, M | 1 |
| Kimura, T | 1 |
| Iwagaki, H | 1 |
| Nakamura, S | 1 |
| Tanaka, T | 1 |
| Ohara, N | 1 |
| Ichimura, K | 1 |
| Oka, T | 1 |
| Yanai, H | 1 |
| Shibasaki, F | 1 |
| Yoshino, T | 1 |
| Hashimoto, T | 1 |
| Uchida, K | 1 |
| Okayama, N | 1 |
| Imate, Y | 1 |
| Suehiro, Y | 1 |
| Hamanaka, Y | 1 |
| Ueyama, Y | 1 |
| Yamashita, H | 1 |
| Hinoda, Y | 1 |
| Zhang, D | 1 |
| Wong, LL | 1 |
| Koay, ES | 1 |
| Rabbani, F | 1 |
| Richon, VM | 1 |
| Orlow, I | 1 |
| Lu, ML | 1 |
| Drobnjak, M | 1 |
| Dudas, M | 1 |
| Charytonowicz, E | 1 |
| Dalbagni, G | 1 |
| Cordon-Cardo, C | 1 |
| Hori, K | 2 |
| Saito, S | 2 |
| Nihei, Y | 1 |
| Suzuki, M | 1 |
| Sato, Y | 1 |
| Kubota, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Levels of Phosphorylated AKT in Patients With Node-Positive Breast Cancer: Correlation With Disease-Free and Overall Survival[NCT00965276] | 2,500 participants (Actual) | Observational | 2004-01-13 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for serine and Lymph Node Metastasis
| Article | Year |
|---|---|
Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; F | 2009 |
Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adju | 2010 |
15 other studies available for serine and Lymph Node Metastasis
| Article | Year |
|---|---|
Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.
Topics: Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cytos | 2017 |
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biom | 2015 |
12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Breast Neoplasms; Calcium; Calcium Channel Blockers; Cal | 2016 |
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acid Substitution; Anemia, Aplastic; Athletes; Athletic | 2016 |
[The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis].
Topics: Aurora Kinase A; Carcinogenesis; Carcinoma, Squamous Cell; Humans; Immunohistochemistry; Lymphatic M | 2009 |
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Topics: Adult; Aged; Aged, 80 and over; Antibody Specificity; Blotting, Western; Carcinoma, Squamous Cell; c | 2010 |
Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma.
Topics: Activating Transcription Factor 4; Adolescent; Adult; Aged; Breast Neoplasms; Cell Line, Tumor; Fema | 2012 |
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.
Topics: Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line, Tum | 2004 |
Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Proli | 2004 |
Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.
Topics: Adenocarcinoma; Adenoma; Antibody Specificity; Apoptosis; Cell Cycle; Cell Line, Tumor; Colorectal N | 2005 |
Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Cysteine; DNA Glycosylas | 2006 |
Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Genes, erbB-2; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; H | 2007 |
Prognostic significance of transcription factor E2F-1 in bladder cancer: genotypic and phenotypic characterization.
Topics: Carcinoma; Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E | 1999 |
Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700.
Topics: Animals; Antineoplastic Agents; Blood Pressure; Body Weight; Disease Models, Animal; Drug Screening | 1999 |
A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Drug Screening Assays, Antitumor; Heart Neopl | 2002 |