serine has been researched along with Local Neoplasm Recurrence in 10 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine(345) (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence." | 5.43 | Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer. ( Abdel-Fatah, TM; Aleskandarany, MA; Alsubhi, N; Arora, A; Chan, SY; Curtin, NJ; Doherty, R; Ellis, IO; Green, AR; Madhusudan, S; Martin, SG; Middleton, F; Moseley, PM; Rakha, EA; Stephens, P, 2016) |
| "Resistance to platinum-based chemotherapy represents a major clinical challenge for many tumors, including epithelial ovarian cancer." | 4.12 | Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers. ( Agami, R; Amant, F; Annibali, D; Baiden-Amissah, REM; Berardi, E; Berkers, CR; Carmeliet, P; Davidson, B; De Wispelaere, W; Duarte, JAG; Eelen, G; Fendt, SM; Horlings, HM; Körner, PR; Lambrechts, D; Moens, S; Planque, M; Rizzotto, L; Rossi, M; Sonke, GS; Swinnen, JV; Talebi, A; Van Nyen, T; van Wagensveld, L; Zaal, EA, 2022) |
| "In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine(345) (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence." | 1.43 | Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer. ( Abdel-Fatah, TM; Aleskandarany, MA; Alsubhi, N; Arora, A; Chan, SY; Curtin, NJ; Doherty, R; Ellis, IO; Green, AR; Madhusudan, S; Martin, SG; Middleton, F; Moseley, PM; Rakha, EA; Stephens, P, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Ilyas, FZ | 1 |
| Kheradmandi, M | 1 |
| Tsilimigras, DI | 1 |
| Grignol, VP | 1 |
| Contreras, C | 1 |
| Tsichlis, PN | 1 |
| Pollock, RE | 1 |
| Beane, JD | 1 |
| Van Nyen, T | 1 |
| Planque, M | 1 |
| van Wagensveld, L | 1 |
| Duarte, JAG | 1 |
| Zaal, EA | 1 |
| Talebi, A | 1 |
| Rossi, M | 1 |
| Körner, PR | 1 |
| Rizzotto, L | 1 |
| Moens, S | 1 |
| De Wispelaere, W | 1 |
| Baiden-Amissah, REM | 1 |
| Sonke, GS | 1 |
| Horlings, HM | 1 |
| Eelen, G | 1 |
| Berardi, E | 1 |
| Swinnen, JV | 1 |
| Berkers, CR | 1 |
| Carmeliet, P | 1 |
| Lambrechts, D | 1 |
| Davidson, B | 1 |
| Agami, R | 1 |
| Fendt, SM | 1 |
| Annibali, D | 1 |
| Amant, F | 1 |
| Zhu, G | 1 |
| Xiong, Z | 1 |
| Chen, W | 1 |
| Zhu, Z | 1 |
| Wang, W | 1 |
| Gao, X | 1 |
| Locasale, JW | 1 |
| Reid, MA | 1 |
| von Pawel, J | 1 |
| Gorbounova, V | 1 |
| Reck, M | 1 |
| Kowalski, DM | 1 |
| Allard, A | 1 |
| Chadjaa, M | 1 |
| Rey, A | 1 |
| Bennouna, J | 1 |
| Grossi, F | 1 |
| Yoon, S | 1 |
| Kim, JG | 1 |
| Seo, AN | 1 |
| Park, SY | 1 |
| Kim, HJ | 1 |
| Park, JS | 1 |
| Choi, GS | 1 |
| Jeong, JY | 1 |
| Jun, do Y | 1 |
| Yoon, GS | 1 |
| Kang, BW | 1 |
| Alsubhi, N | 1 |
| Middleton, F | 1 |
| Abdel-Fatah, TM | 1 |
| Stephens, P | 1 |
| Doherty, R | 1 |
| Arora, A | 1 |
| Moseley, PM | 1 |
| Chan, SY | 1 |
| Aleskandarany, MA | 1 |
| Green, AR | 1 |
| Rakha, EA | 1 |
| Ellis, IO | 1 |
| Martin, SG | 1 |
| Curtin, NJ | 1 |
| Madhusudan, S | 1 |
| Bae, JS | 1 |
| Noh, SJ | 1 |
| Kim, KM | 1 |
| Jang, KY | 1 |
| Park, HS | 1 |
| Chung, MJ | 1 |
| Park, BH | 1 |
| Moon, WS | 1 |
| Holownia, A | 1 |
| Mroz, RM | 1 |
| Kozlowski, M | 1 |
| Chyczewska, E | 1 |
| Laudanski, J | 1 |
| Chyczewski, L | 1 |
| Braszko, JJ | 1 |
| Jordan, VC | 1 |
1 review available for serine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
The Role of AKT in Soft Tissue Sarcoma: Review and Insights.
Topics: Humans; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; S | 2022 |
1 trial available for serine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compoun | 2014 |
8 other studies available for serine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers.
Topics: Carcinoma, Ovarian Epithelial; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Recurrence, Local | 2022 |
Identification of key biomarkers and related immune cell infiltration in cervical cancer tissue based on bioinformatics analysis.
Topics: Biomarkers; Cell Cycle Proteins; Chemokines; Computational Biology; Female; Humans; Neoplasm Recurre | 2023 |
Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.
Topics: Carbon; Humans; Male; Methionine; Neoplasm Recurrence, Local; Prostatic Neoplasms; Serine | 2019 |
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biom | 2015 |
Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer.
Topics: Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Checkpoint Kinase 1; Cohort Studies; DNA R | 2016 |
PIN1 in hepatocellular carcinoma is associated with TP53 gene status.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Female; Gene Exp | 2016 |
Therapy increases poly-ADP-ribose and p53-Ser392-P levels in recurrent squamous cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma, Squamous Cell; Cisplatin; C | 2003 |
Pak up your breast tumor--and grow!
Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Drug | 2006 |