serine has been researched along with Leukemia in 27 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berger, A | 1 |
| Hoelbl-Kovacic, A | 1 |
| Bourgeais, J | 1 |
| Hoefling, L | 1 |
| Warsch, W | 1 |
| Grundschober, E | 1 |
| Uras, IZ | 1 |
| Menzl, I | 1 |
| Putz, EM | 1 |
| Hoermann, G | 1 |
| Schuster, C | 1 |
| Fajmann, S | 2 |
| Leitner, E | 1 |
| Kubicek, S | 1 |
| Moriggl, R | 2 |
| Gouilleux, F | 2 |
| Sexl, V | 2 |
| Kuželová, K | 1 |
| Grebeňová, D | 1 |
| Holoubek, A | 1 |
| Röselová, P | 1 |
| Obr, A | 1 |
| Yin, T | 1 |
| Lallena, MJ | 1 |
| Kreklau, EL | 1 |
| Fales, KR | 1 |
| Carballares, S | 1 |
| Torrres, R | 1 |
| Wishart, GN | 1 |
| Ajamie, RT | 1 |
| Cronier, DM | 1 |
| Iversen, PW | 1 |
| Meier, TI | 1 |
| Foreman, RT | 1 |
| Zeckner, D | 1 |
| Sissons, SE | 1 |
| Halstead, BW | 1 |
| Lin, AB | 1 |
| Donoho, GP | 1 |
| Qian, Y | 1 |
| Li, S | 1 |
| Wu, S | 1 |
| Aggarwal, A | 1 |
| Ye, XS | 1 |
| Starling, JJ | 1 |
| Gaynor, RB | 1 |
| de Dios, A | 1 |
| Du, J | 1 |
| Yamagishi, N | 1 |
| Nakao, R | 1 |
| Kondo, R | 1 |
| Nishitsuji, M | 1 |
| Saito, Y | 1 |
| Kuga, T | 1 |
| Hatayama, T | 1 |
| Nakayama, Y | 1 |
| Polet, F | 1 |
| Corbet, C | 1 |
| Pinto, A | 1 |
| Rubio, LI | 1 |
| Martherus, R | 1 |
| Bol, V | 1 |
| Drozak, X | 1 |
| Grégoire, V | 1 |
| Riant, O | 1 |
| Feron, O | 1 |
| Huang, Y | 1 |
| Thoms, JA | 1 |
| Tursky, ML | 1 |
| Knezevic, K | 1 |
| Beck, D | 1 |
| Chandrakanthan, V | 1 |
| Suryani, S | 1 |
| Olivier, J | 1 |
| Boulton, A | 1 |
| Glaros, EN | 1 |
| Thomas, SR | 1 |
| Lock, RB | 1 |
| MacKenzie, KL | 1 |
| Bushweller, JH | 1 |
| Wong, JW | 1 |
| Pimanda, JE | 1 |
| Jang, SW | 1 |
| Yang, SJ | 1 |
| Ehlén, A | 1 |
| Dong, S | 1 |
| Khoury, H | 1 |
| Chen, J | 1 |
| Persson, JL | 1 |
| Ye, K | 1 |
| Tichý, A | 1 |
| Záskodová, D | 1 |
| Zoelzer, F | 1 |
| Vávrová, J | 1 |
| Sinkorová, Z | 1 |
| Pejchal, J | 1 |
| Osterreicher, J | 1 |
| Rezácová, M | 1 |
| Cao, J | 1 |
| Xu, D | 1 |
| Wang, D | 1 |
| Wu, R | 1 |
| Zhang, L | 1 |
| Zhu, H | 1 |
| He, Q | 1 |
| Yang, B | 1 |
| Friedbichler, K | 1 |
| Kerenyi, MA | 1 |
| Kovacic, B | 1 |
| Li, G | 1 |
| Hoelbl, A | 1 |
| Yahiaoui, S | 1 |
| Müllner, EW | 1 |
| Cerny-Reiterer, S | 1 |
| Valent, P | 1 |
| Beug, H | 1 |
| Bunting, KD | 1 |
| Tamaichi, H | 1 |
| Sato, M | 1 |
| Porter, AC | 1 |
| Shimizu, T | 1 |
| Mizutani, S | 1 |
| Takagi, M | 1 |
| Azuma, H | 1 |
| Takao, R | 1 |
| Niiro, H | 1 |
| Shikata, K | 1 |
| Tamagaki, S | 1 |
| Tachibana, T | 1 |
| Ogino, K | 1 |
| Sgarra, R | 1 |
| Diana, F | 1 |
| Rustighi, A | 1 |
| Manfioletti, G | 1 |
| Giancotti, V | 1 |
| Wilson, GM | 1 |
| Lu, J | 1 |
| Sutphen, K | 1 |
| Sun, Y | 1 |
| Huynh, Y | 1 |
| Brewer, G | 1 |
| Ito, K | 1 |
| Nakazato, T | 1 |
| Yamato, K | 1 |
| Miyakawa, Y | 1 |
| Yamada, T | 1 |
| Hozumi, N | 1 |
| Segawa, K | 1 |
| Ikeda, Y | 1 |
| Kizaki, M | 1 |
| Hara, T | 1 |
| Suzuki, Y | 1 |
| Semba, T | 1 |
| Hatanaka, M | 1 |
| Matsumoto, M | 1 |
| Seya, T | 1 |
| Ruvolo, PP | 1 |
| Deng, X | 1 |
| May, WS | 1 |
| Thorndike, J | 1 |
| Pelliniemi, TT | 1 |
| Beck, WS | 1 |
| Wiseman, C | 1 |
| McGregor, RF | 1 |
| McCredie, KB | 1 |
| Adler, V | 1 |
| Polotskaya, A | 1 |
| Wagner, F | 1 |
| Kraft, AS | 1 |
| Amson, RB | 1 |
| Marcelle, C | 1 |
| Telerman, A | 1 |
| Pizer, LI | 1 |
| Regan, JD | 1 |
| Jones, C | 1 |
| Wuthier, P | 1 |
| Kao, FT | 1 |
| Puck, TT | 1 |
| Bertino, JR | 1 |
| Hillcoat, BL | 1 |
| Groth, DP | 1 |
| D'Angelo, JM | 1 |
| Vogler, WR | 1 |
| Mingioli, ES | 1 |
| Betz, B | 1 |
| Zozuliakova, SV | 1 |
| Kolosova, NN | 1 |
| Grignani, F | 1 |
| Martelli, M | 1 |
| Tonato, M | 1 |
| Colonna, A | 1 |
2 reviews available for serine and Leukemia
| Article | Year |
|---|---|
Phosphorylation of Bcl2 and regulation of apoptosis.
Topics: Animals; Apoptosis; Humans; Leukemia; Lymphoma; Phosphorylation; Protein Processing, Post-Translatio | 2001 |
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Foli | 1968 |
25 other studies available for serine and Leukemia
| Article | Year |
|---|---|
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Nucleus; Cells, Cultured; DNA Primers; Fusion Protein | 2014 |
Group I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cells.
Topics: Actin Depolymerizing Factors; Apoptosis; Blood Cells; Cell Adhesion; Cell Proliferation; Disulfides; | 2014 |
A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclohexylamines; Hum | 2014 |
Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2014 |
Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Electrophoresis, Gel, Two-Dimensional; | 2016 |
MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.
Topics: Binding Sites; Cell Line, Tumor; Cell Proliferation; Hematopoietic Stem Cells; Humans; Leukemia; Leu | 2016 |
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.
Topics: Bone Marrow; Cell Cycle; Cell Nucleus; Cell Proliferation; Cyclin A; Cyclin A1; Flow Cytometry; Fluo | 2008 |
Gamma-radiation-induced phosphorylation of p53 on serine 15 is dose-dependent in MOLT-4 leukaemia cells.
Topics: Cell Line, Tumor; Cell Proliferation; Gamma Rays; Humans; Leukemia; Phosphorylation; Serine; Tumor S | 2009 |
ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromones; Dose-Response Relationship, | 2009 |
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.
Topics: Adult; Aged; Animals; Blotting, Western; Bone Marrow Transplantation; Cell Lineage; Cell Proliferati | 2010 |
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Topics: Alanine; Antigens, Neoplasm; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, | 2013 |
Total syntheses of symbioramide derivatives from l-serine and their antileukemic activities.
Topics: Animals; Antineoplastic Agents; Catalysis; Combinatorial Chemistry Techniques; HL-60 Cells; Humans; | 2003 |
Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosis.
Topics: Apoptosis; Chromatin; Chromatography, High Pressure Liquid; HMGA1a Protein; Humans; Leukemia; Methyl | 2003 |
Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Adhesion; Cell Line; Cytoplasm; Dactinom | 2003 |
Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species.
Topics: Apoptosis; Capsaicin; Cell Division; Cell Line, Tumor; G1 Phase; Humans; Leukemia; Mitochondria; Oxi | 2004 |
High expression of membrane cofactor protein of complement (CD46) in human leukaemia cell lines: implication of an alternatively spliced form containing the STA domain in CD46 up-regulation.
Topics: Alternative Splicing; Amino Acid Sequence; Antibodies; Antibody Specificity; Antigens, CD; B-Lymphoc | 1995 |
Serine hydroxymethyltransferase activity and serine incorporation in leukocytes.
Topics: DNA; DNA, Neoplasm; Glycine Hydroxymethyltransferase; Granulocytes; Humans; Leukemia; Leukocytes; Ly | 1979 |
Urinary amino acid excretion in acute leukemia.
Topics: Amino Acids; Antineoplastic Agents; Aspartic Acid; Female; Humans; Leukemia; Male; Remission, Sponta | 1976 |
Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.
Topics: Cell Line; Chromatography, Affinity; Glutathione Transferase; Humans; Kinetics; Leukemia; Phosphopro | 1992 |
Identification of a 130 Kda bcr related gene product.
Topics: Amino Acids; Leukemia; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Pr | 1989 |
Basis for the serine requirement in leukemic and normal human leukocytes. Reduced levels of the enzymes in the phosphorylated pathway.
Topics: Carbon Isotopes; Carcinoma; Cell Line; Fibroblasts; Glycerolphosphate Dehydrogenase; HeLa Cells; Hum | 1972 |
Genetics of somatic mammalian cells. XV. Evidence for linkage between human genes for lactic dehydrogenase B and serine hydroxymethylase.
Topics: Amniotic Fluid; Animals; Bone Marrow; Bone Marrow Cells; Cell Line; Clone Cells; Cricetinae; Electro | 1972 |
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom | 1971 |
[Free serum amino acids in leukosis].
Topics: Adult; Amino Acids; Central Nervous System Diseases; Histidine; Humans; Leukemia; Leukemia, Lymphoid | 1969 |
Purification and properties of serine hydroxymethylase from human leukaemic leukocytes.
Topics: Humans; Leukemia; Leukocytes; Mixed Function Oxygenases; Pyridoxal Phosphate; Serine | 1965 |