serine has been researched along with Leukemia, Myeloid in 20 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a serine-deficient medium, cells from humangt chronic granulocytic leukemia and normal human bone marrow exhibited a marked inhibition of incorporation of-radioactive precursors of DNA, RNA, and protein into an acid insoluble cell fraction." | 3.65 | Serine requirement in leukemic and normal blood cells. ( Faulcon, FM; Lee, WH; Regan, JD; Takeda, S; Vodopick, N, 1969) |
| "The t(4;11) chromosomal translocation marks a subset of acute lymphoblastic and secondary myeloid leukemias." | 1.30 | The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations. ( Cleary, ML; Morrissey, JJ; Raney, S, 1997) |
| "Transforming growth factor beta (TGF-beta) has been shown to be a specific inhibitor of early human myeloid progenitors." | 1.30 | Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795. ( Hu, X; Moscinski, LC; Zuckerman, KS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, Y | 1 |
| Zhou, H | 1 |
| Gan, Y | 1 |
| Zhang, J | 1 |
| Chen, J | 1 |
| Gan, X | 1 |
| Li, H | 1 |
| Zheng, W | 1 |
| Meng, Z | 1 |
| Ma, X | 1 |
| Wang, X | 1 |
| Xu, X | 1 |
| Xu, G | 1 |
| Lu, X | 2 |
| Liang, Y | 1 |
| Zhang, X | 1 |
| Huang, W | 1 |
| Xu, R | 1 |
| Vijapurkar, U | 1 |
| Fischbach, N | 1 |
| Shen, W | 1 |
| Brandts, C | 1 |
| Stokoe, D | 1 |
| Lawrence, HJ | 1 |
| Largman, C | 1 |
| Tazzari, PL | 1 |
| Cappellini, A | 1 |
| Grafone, T | 1 |
| Mantovani, I | 1 |
| Ricci, F | 1 |
| Billi, AM | 1 |
| Ottaviani, E | 1 |
| Conte, R | 1 |
| Martinelli, G | 1 |
| Martelli, AM | 1 |
| Guthridge, MA | 1 |
| Powell, JA | 1 |
| Barry, EF | 1 |
| Stomski, FC | 1 |
| McClure, BJ | 1 |
| Ramshaw, H | 1 |
| Felquer, FA | 1 |
| Dottore, M | 1 |
| Thomas, DT | 1 |
| To, B | 1 |
| Begley, CG | 1 |
| Lopez, AF | 1 |
| Morotti, A | 1 |
| Parvis, G | 1 |
| Cilloni, D | 1 |
| Familiari, U | 1 |
| Pautasso, M | 1 |
| Bosa, M | 1 |
| Messa, F | 1 |
| Arruga, F | 1 |
| Defilippi, I | 1 |
| Catalano, R | 1 |
| Rosso, V | 1 |
| Carturan, S | 1 |
| Bracco, E | 1 |
| Guerrasio, A | 1 |
| Saglio, G | 1 |
| Morrissey, JJ | 1 |
| Raney, S | 1 |
| Cleary, ML | 1 |
| Hu, X | 2 |
| Moscinski, LC | 1 |
| Zuckerman, KS | 2 |
| Cress, WD | 1 |
| Zhong, Q | 1 |
| Houser, S | 1 |
| Koshlatyi, S | 1 |
| Lu, T | 1 |
| Gopen, T | 1 |
| Bargonetti, J | 1 |
| Behre, G | 1 |
| Singh, SM | 1 |
| Liu, H | 1 |
| Bortolin, LT | 1 |
| Christopeit, M | 1 |
| Radomska, HS | 1 |
| Rangatia, J | 1 |
| Hiddemann, W | 1 |
| Friedman, AD | 1 |
| Tenen, DG | 1 |
| Sato, H | 1 |
| Ishii, T | 1 |
| Sugita, Y | 1 |
| Bannai, S | 1 |
| Abou-Khalil, S | 1 |
| Abou-Khalil, WH | 1 |
| Whitney, PL | 1 |
| Yunis, AA | 1 |
| Armstrong, CA | 1 |
| Klostergaard, J | 1 |
| Granger, GA | 1 |
| Pizer, LI | 1 |
| Regan, JD | 3 |
| Höcker, P | 1 |
| Stacher, A | 1 |
| Weiser, M | 1 |
| Pazmiño, N | 1 |
| Doherty, DG | 1 |
| Vodopick, N | 1 |
| Takeda, S | 1 |
| Lee, WH | 1 |
| Faulcon, FM | 1 |
| Zozuliakova, SV | 1 |
| Kolosova, NN | 1 |
| Sergeev, AV | 1 |
| Bukin, IuV | 1 |
| Raushenbakh, MO | 1 |
| Dimitrov, NV | 1 |
| Hansz, J | 1 |
| Toth, MA | 1 |
| Bartolotta, B | 1 |
20 other studies available for serine and Leukemia, Myeloid
| Article | Year |
|---|---|
Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.
Topics: Acute Disease; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line, Tumor; Dose | 2015 |
Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.
Topics: Amino Acid Sequence; Animals; Bone Marrow Cells; Casein Kinase II; Cell Differentiation; Cell Line; | 2004 |
Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry.
Topics: Acute Disease; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Western; Flow Cyto | 2004 |
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Animals; Binding Sites; CD11b Antigen; Cell Differentiation; Cel | 2006 |
CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536.
Topics: Acute Disease; Antigens, CD7; CD56 Antigen; Humans; Leukemia, Myeloid; Phosphorylation; Serine; Tran | 2007 |
The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations.
Topics: Adenoviridae; Adenovirus E1B Proteins; Amino Acid Sequence; Animals; Binding Sites; Chromosomes, Hum | 1997 |
Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795.
Topics: Cell Differentiation; Cell Division; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Dose-Respo | 1999 |
Transforming growth factor beta inhibits the phosphorylation of pRB at multiple serine/threonine sites and differentially regulates the formation of pRB family-E2F complexes in human myeloid leukemia cells.
Topics: Blotting, Western; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; DNA; | 2000 |
Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Bleomycin; Camptothecin; Cell Cycle; | 2001 |
Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.
Topics: Acute Disease; Alanine; Amino Acid Substitution; CCAAT-Enhancer-Binding Protein-alpha; Cell Differen | 2002 |
Changes in neutral amino acid transport activity in myeloid leukemia cells differentiated by lipopolysaccharide.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Dif | 1989 |
Importance of the mitochondrial amino acid pool in the sensitivity of erythroid cells to chloramphenicol: role of glycine and serine.
Topics: Amino Acids; Animals; Cells, Cultured; Chloramphenicol; Erythrocytes; Female; Glycine; In Vitro Tech | 1987 |
Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1.
Topics: Alanine; Catalase; Cell Line; Cloning, Molecular; Cytotoxicity, Immunologic; Electrophoresis, Polyac | 1985 |
Basis for the serine requirement in leukemic and normal human leukocytes. Reduced levels of the enzymes in the phosphorylated pathway.
Topics: Carbon Isotopes; Carcinoma; Cell Line; Fibroblasts; Glycerolphosphate Dehydrogenase; HeLa Cells; Hum | 1972 |
[Amino acid concentration in plasma and blood cells during coli-L-asparaginase therapy].
Topics: Alanine; Amino Acids; Asparaginase; Asparagine; Autoanalysis; Erythrocytes; Glutamates; Humans; Leuk | 1972 |
Inhibition of DNA and RNA synthesis, but minimally of protein synthesis, in human leukemia cells by a serine antimetabolite.
Topics: Antimetabolites; Carbon Radioisotopes; Cyclohexanecarboxylic Acids; Depression, Chemical; DNA; Human | 1973 |
Serine requirement in leukemic and normal blood cells.
Topics: Alanine; Asparagine; Aspartic Acid; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Culture Media; | 1969 |
[Free serum amino acids in leukosis].
Topics: Adult; Amino Acids; Central Nervous System Diseases; Histidine; Humans; Leukemia; Leukemia, Lymphoid | 1969 |
[Study of serine hydroxymethyltransferase in experimental leukemias].
Topics: Animals; Ascitic Fluid; Cycloserine; Friend murine leukemia virus; Hydrazines; Hydroxylamines; In Vi | 1971 |
Serine and aspartic acid metabolism in leukemic leukocytes: correlation to effectiveness of therapy.
Topics: Adult; Aged; Aspartic Acid; Blood Proteins; Carbon Dioxide; Carbon Isotopes; Female; Glycine; Humans | 1971 |