serine has been researched along with Kidney Tubular Necrosis, Acute in 7 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Kidney Tubular Necrosis, Acute: Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of D-serine to rats induced acute necrosis of the proximal straight tubules, proteinuria, glucosuria, and aminoaciduria." | 7.65 | D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. ( Carone, FA; Ganote, CE, 1975) |
| "Administration of D-serine to rats induced acute necrosis of the proximal straight tubules, proteinuria, glucosuria, and aminoaciduria." | 3.65 | D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. ( Carone, FA; Ganote, CE, 1975) |
| " Alderely Park (Wistar-derived) rats were dosed with either D-serine (250 mg/kg ip) or vehicle (deionised water) and urine was collected at 0-12, 12-24, 24-36 and 36-48 h post-dosing." | 1.33 | D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach. ( Lenz, EM; Lock, EA; Major, H; Williams, RE; Wilson, ID, 2005) |
| "In similarly treated rats, proteinuria and glucosuria developed at the onset of tubular necrosis and disappeared when the tubules were completely relined by epithelium suggesting that they are due to diffusion of protein and glucose from interstitium into tubular fluid across the denuded basement membranes and that epithelial cells, under normal conditions, act as a barrier to diffusion of certain substances between the interstitium and tubular fluid." | 1.25 | The nature of D-serine--induced nephrotoxicity. ( Carone, FA; Ganote, CE; Peterson, DR, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levine, S | 1 |
| Saltzman, A | 1 |
| Williams, RE | 1 |
| Major, H | 1 |
| Lock, EA | 1 |
| Lenz, EM | 1 |
| Wilson, ID | 1 |
| Kaltenbach, JP | 2 |
| Carone, FA | 5 |
| Ganote, CE | 4 |
| Peterson, DR | 2 |
7 other studies available for serine and Kidney Tubular Necrosis, Acute
| Article | Year |
|---|---|
Hydropic degeneration of the anterior pituitary gland (adenohypophysis) in uremic rats.
Topics: Animals; Body Water; Body Weight; Diet; Hyponatremia; Kidney Tubular Necrosis, Acute; Male; Mercuric | 2004 |
D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.
Topics: Animals; Chromatography, High Pressure Liquid; Glycosuria; Kidney; Kidney Tubular Necrosis, Acute; M | 2005 |
Compounds protective against renal tubular necrosis induced by D-serine and D-2,3-diaminopropionic acid in the rat.
Topics: Acute Kidney Injury; Alanine; Amino Acids; Animals; beta-Alanine; Kidney Tubular Necrosis, Acute; Ra | 1982 |
Renal tubular necrosis induced by compounds structurally related to D-serine.
Topics: Acute Kidney Injury; Animals; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Necros | 1979 |
Renal regeneration following d-serine induced acute tubular necrosis.
Topics: Acute Kidney Injury; Animals; Basement Membrane; Cell Differentiation; Cell Membrane; Cytoplasm; Kid | 1979 |
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis.
Topics: Acute Kidney Injury; Animals; Glycosuria; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Pota | 1975 |
The nature of D-serine--induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Cytoplasm; Diffusion; Epithelial Cells; Epithelium; Glycosuria; Kidney | 1974 |