serine has been researched along with Intellectual Disability in 23 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 5.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| "Acrodysostosis is a very rare congenital multisystem condition characterized by skeletal dysplasia with severe brachydactyly, midfacial hypoplasia, and short stature, varying degrees of intellectual disability, and possible resistance to multiple G protein-coupled receptor signalling hormones." | 1.46 | Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation. ( Bertsche, A; Gesing, J; Hirsch, FW; Hoppmann, J; Kiess, W; Leroy, C; Pfäffle, R; Schuster, V; Silve, C, 2017) |
| "Fragile X syndrome is caused by loss of FMR1 protein expression." | 1.31 | Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties. ( Higashijima, K; Ishizuka, A; Siomi, H; Siomi, MC, 2002) |
| "They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures." | 1.31 | Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. ( de Koning, TJ; Jaeken, J; Pineda, M; Poll-The, BT; van der Knaap, MS; Van Maldergem, L, 2000) |
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 1.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| den Hollander, B | 1 |
| Veenvliet, ARJ | 1 |
| Rothuizen-Lindenschot, M | 1 |
| van Essen, P | 1 |
| Peters, G | 1 |
| Santos-Gómez, A | 1 |
| Olivella, M | 1 |
| Altafaj, X | 1 |
| Brands, MM | 1 |
| Jacobs, BAW | 1 |
| van Karnebeek, CD | 1 |
| Hoppmann, J | 1 |
| Gesing, J | 1 |
| Silve, C | 1 |
| Leroy, C | 1 |
| Bertsche, A | 1 |
| Hirsch, FW | 1 |
| Kiess, W | 1 |
| Pfäffle, R | 1 |
| Schuster, V | 1 |
| Kraoua, I | 1 |
| Wiame, E | 1 |
| Kraoua, L | 1 |
| Nasrallah, F | 1 |
| Benrhouma, H | 1 |
| Rouissi, A | 1 |
| Turki, I | 1 |
| Chaabouni, H | 1 |
| Briand, G | 1 |
| Kaabachi, N | 1 |
| Van Schaftingen, E | 2 |
| Gouider-Khouja, N | 1 |
| Siomi, MC | 1 |
| Higashijima, K | 1 |
| Ishizuka, A | 1 |
| Siomi, H | 1 |
| DINGMAN, HF | 1 |
| WRIGHT, SW | 1 |
| NYHAN, WL | 2 |
| CHILDS, B | 1 |
| Kang, ES | 1 |
| Seyer, J | 1 |
| Todd, TA | 1 |
| Herrera, C | 1 |
| Lejeune, J | 1 |
| de Koning, TJ | 2 |
| Duran, M | 1 |
| Dorland, L | 1 |
| Gooskens, R | 1 |
| Jaeken, J | 2 |
| Blau, N | 1 |
| Berger, R | 1 |
| Poll-The, BT | 2 |
| Pineda, M | 1 |
| Van Maldergem, L | 1 |
| van der Knaap, MS | 1 |
| Hultberg, B | 1 |
| Ockerman, PA | 1 |
| Eriksson, O | 1 |
| Shaw, KN | 1 |
| Lieberman, E | 1 |
| Koch, R | 1 |
| Donnell, GN | 1 |
| Ionasescu, V | 1 |
| Stegink, L | 1 |
| Mueller, S | 1 |
| Weinstein, M | 1 |
| Reploh, H | 1 |
| Gröbe, H | 1 |
| Diekmann, L | 1 |
| Palm, D | 1 |
| von Bassewitz, DB | 1 |
| Jenett, W | 1 |
| Tippett, P | 1 |
| Danks, DM | 1 |
| Kerr, GR | 1 |
| Chamove, AS | 1 |
| Harlow, HF | 1 |
| Waisman, HA | 1 |
| Sabater, J | 1 |
| Ferre, C | 1 |
| Antich, J | 1 |
| Baumgartner, R | 1 |
| Ando, T | 1 |
| De Groot, CJ | 1 |
| Troelstra, JA | 1 |
| Hommes, FA | 1 |
| McKean, CM | 1 |
| Peterson, NA | 1 |
| Wong, PW | 1 |
| Komrower, GM | 1 |
| Schwarz, V | 1 |
| Bieber, G | 1 |
| Cesario, S | 1 |
| Mann, TP | 1 |
1 review available for serine and Intellectual Disability
| Article | Year |
|---|---|
3-Phosphoglycerate dehydrogenase deficiency: description of two new cases in Tunisia and review of the literature.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Humans; Intellectual Disability; Mal | 2013 |
22 other studies available for serine and Intellectual Disability
| Article | Year |
|---|---|
Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.
Topics: Child, Preschool; Cognition; Female; Humans; Infant; Intellectual Disability; Neurodevelopmental Dis | 2023 |
Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation.
Topics: Adult; Amino Acid Substitution; Child, Preschool; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucle | 2017 |
Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties.
Topics: Amino Acid Sequence; Animals; Casein Kinase II; Cell Fractionation; Cell Line; DNA-Binding Proteins; | 2002 |
A MULTIVARIATE ANALYSIS OF AMINO-ACID EXCRETIONS.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Biomedical Research; Child; Chromatograp | 1964 |
HYPERGLYCINEMIA. V. THE MISCIBLE POOL AND TURNOVER RATE OF GLYCINE AND THE FORMATION OF SERINE.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Blood; Child; Chromatography; Glycine; Humans; In | 1964 |
Variability in the phenotypic expression of abnormal sarcosine metabolism in a family.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Genetic Variation; Glycine; H | 1983 |
[Fragile site Xq27 and metabolism of monocarbons].
Topics: Amino Acids; Aminolevulinic Acid; Female; Formyltetrahydrofolates; Humans; Hydroxyproline; Intellect | 1980 |
Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Carbohydrate Dehydrogenases; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalogra | 1998 |
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Amino Acids; Carbohydrate Dehydrogenases; Cerebral Cortex; Child; Child, Preschool; Choline; Demyeli | 2000 |
Urinary amino acids in storage disorders: mucopolysaccharidosis, Gaucher's disease and metachromatic leucodystrophy.
Topics: Adolescent; Adult; Amino Acids; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Dif | 1969 |
Cystathioninuria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschoo | 1967 |
Amino acid abnormality in Sjögren-Larsson syndrome.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Dental Enamel Hypoplasia; Epilepsy; Ethylamines; G | 1973 |
The clinical findings in a patient with nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Diet Therapy; Glycine; Humans; Infant; Intellectual Disability | 1973 |
The clinical and biochemical findings in three cases of hypersarcosinemia and one case of transient hypersarcosinuria associated with folic acid deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anemia, Macrocytic; Electrophoresis; Female; Folic | 1974 |
"Fetal PKU:" the effect of maternal hyperphenylalaninemia during pregnancy in the rhesus monkey (Macaca mulatta).
Topics: Amino Acids; Animals; Animals, Newborn; Birth Weight; Diet; Female; Fetal Diseases; Haplorhini; Huma | 1968 |
Abnormal levels of aspartic acid, serine and cystine in the plasma in three cases of Rubinstein Taybi's syndrome.
Topics: Abnormalities, Multiple; Aspartic Acid; Chromatography, Ion Exchange; Cystine; Female; Humans; Intel | 1972 |
Nonketotic hyperglycinemia.
Topics: Agranulocytosis; Amino Acid Metabolism, Inborn Errors; Benzoates; Body Weight; Carbon Isotopes; Diet | 1969 |
Nonketotic hyperglycinemia: an in vitro study of the glycine-serine conversion in liver of three patients and the effect of dietary methionine.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Biopsy; Carbon Isotopes; Culture Techniques; Diet Th | 1970 |
Glutamine in the phenylketonuric central nervous system.
Topics: Adolescent; Adult; Amino Acids; Biological Transport, Active; Brain; Brain Chemistry; Child; Female; | 1970 |
The biosynthesis of cystathionine in patients with homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Child; Child, Preschool; Chromato | 1968 |
[Preliminary results of a drug therapy of a group of school-age mental retardates].
Topics: Adolescent; Amino Acids; Arginine; Child; Female; Glutamine; Humans; Intellectual Disability; Male; | 1969 |
Mental retardation, abnormal hair and mild aminoaciduria, all of unknown aetiology, in siblings.
Topics: Alanine; Child, Preschool; Female; Fluoroscopy; Glutamine; Glycine; Hair; Humans; Intellectual Disab | 1969 |