serine and Hypoxia
serine has been researched along with Hypoxia in 61 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 7.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "This study tested if the antidepressant imipramine or the mood stabilizers lithium and sodium valproate regulated pathophysiological serine-dephosphorylation of GSK3 caused by hypoxia in mouse brain in vivo." | 7.73 | Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine. ( De Sarno, P; Eom, TY; Jope, RS; Roh, MS; Roth, KA; Zmijewska, AA, 2005) |
| " The molecular mechanism(s) by which hypoxia/reoxygenation (H/R) regulates p56lck-dependent activation of NFkappaB through tyrosine phosphorylation of IkappaBalpha and modulates the expression of downstream genes that are involved in cell migration in human breast cancer cells are not well defined." | 7.72 | Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. ( Kundu, GC; Mahabeleshwar, GH, 2003) |
| " Overactivation of the N-methyl-D-aspartate receptor (NMDAr) plays a central role in the pathogenesis of cerebral hypoxia-ischemia, but the role of both endogenous NMDAr co-agonists D-serine and glycine remains largely elusive." | 3.78 | Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia. ( Berger, R; de Barse, MM; de Koning, TJ; Fuchs, SA; Klomp, LW; Peeters-Scholte, CM; Roeleveld, MW, 2012) |
| " Parallel experiments were performed in rat lung sections and PASMCs and in rodent PAH models induced by the HIF-1α activator, cobalt, chronic hypoxia, and monocrotaline." | 3.78 | Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. ( Archer, SL; Chen, Y; Fang, YH; Hong, Z; Marsboom, G; Morrow, E; Piao, L; Pogoriler, J; Rehman, J; Ryan, JJ; Thenappan, T; Toth, PT; Weir, EK; Wu, X; Zhang, HJ, 2012) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 3.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "This study tested if the antidepressant imipramine or the mood stabilizers lithium and sodium valproate regulated pathophysiological serine-dephosphorylation of GSK3 caused by hypoxia in mouse brain in vivo." | 3.73 | Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine. ( De Sarno, P; Eom, TY; Jope, RS; Roh, MS; Roth, KA; Zmijewska, AA, 2005) |
| " The molecular mechanism(s) by which hypoxia/reoxygenation (H/R) regulates p56lck-dependent activation of NFkappaB through tyrosine phosphorylation of IkappaBalpha and modulates the expression of downstream genes that are involved in cell migration in human breast cancer cells are not well defined." | 3.72 | Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. ( Kundu, GC; Mahabeleshwar, GH, 2003) |
| "In the pulmonary artery isolated from 1-week hypoxia-induced pulmonary hypertensive rats, endothelial NO production stimulated by carbachol was decreased significantly in in situ visualization using diaminofluorescein-2 diacetate and also in cGMP content." | 3.71 | Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. ( Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K, 2002) |
| " The cytosolic p53 x IkappaBalpha complex rapidly dissociated in response to apoptotic stress, etoposide- and UV-mediated DNA damage, hypoxia, and TGF-beta1-mediated growth suppression." | 3.71 | The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. ( Chang, NS, 2002) |
| "Pulmonary artery endothelial cells (PAEC) were exposed to normoxia or hypoxia (0% O(2)-95% N(2)-5% CO(2)) in the presence and absence of calpain inhibitor I or calpeptin, after which endothelial nitric oxide synthase (eNOS) activity and protein content were assayed." | 3.70 | Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells. ( Block, ER; Su, Y, 2000) |
| " By using this system of graded hypoxia a comparison was made between rates of gluconeogenesis from lactate, serine and aspartate in the whole animal and the concentrations of several liver metabolites." | 3.65 | Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions. ( Ballard, FJ, 1971) |
| "Sphingolipids have been implicated in anoxia injury, but the pathomechanism is unknown." | 1.51 | 1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding. ( Abegg, D; Adibekian, A; Gentina, S; Gomez, L; Guex, N; Hannich, JT; Haribowo, AG; Martinou, JC; Ovize, M; Paillard, M; Pillot, B; Riezman, H; Thibault, H; Zumbuehl, A, 2019) |
| "703 patients with type 1 diabetes mellitus from one endocrine department were included in the study." | 1.51 | Protective Effect of the ( Catrina, SB; Chatzidionysiou, K; Ekberg, NR; Eliasson, S; Falhammar, H; Gu, HF; Li, YW; Zheng, X, 2019) |
| "These data imply that COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity." | 1.33 | Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. ( Kirschenbaum, A; Levine, AC; Liu, XH; Yao, S; Yu, K, 2005) |
| "However, hypoxia within tumors is often transient and is inevitably followed by reoxygenation." | 1.32 | ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. ( Dorie, MJ; Giaccia, AJ; Hammond, EM, 2003) |
| " The dose-response effects of glutamate and serine were studied on the population spikes evoked in the granular cell layer." | 1.29 | Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function. ( Hirai, H; Okada, Y, 1993) |
| "3." | 1.25 | Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967) |
Research
Studies (61)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.28) | 18.7374 |
| 1990's | 3 (4.92) | 18.2507 |
| 2000's | 30 (49.18) | 29.6817 |
| 2010's | 23 (37.70) | 24.3611 |
| 2020's | 3 (4.92) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Giacalone, D | 1 |
| Yap, RE | 1 |
| Ecker, AMV | 1 |
| Tan, S | 1 |
| Hu, L | 1 |
| Hu, J | 1 |
| Huang, Y | 1 |
| Zheng, S | 1 |
| Yin, J | 1 |
| Li, X | 2 |
| Li, D | 1 |
| Lv, C | 1 |
| Li, S | 1 |
| Hu, W | 1 |
| Sliusar, MY | 1 |
| Minchenko, DO | 1 |
| Khita, OO | 1 |
| Tsymbal, DO | 1 |
| Viletska, YM | 1 |
| Luzina, OY | 1 |
| Danilovskyi, SV | 1 |
| Ratushna, OO | 1 |
| Minchenko, OH | 1 |
| Hannich, JT | 1 |
| Haribowo, AG | 1 |
| Gentina, S | 1 |
| Paillard, M | 1 |
| Gomez, L | 1 |
| Pillot, B | 1 |
| Thibault, H | 1 |
| Abegg, D | 1 |
| Guex, N | 1 |
| Zumbuehl, A | 1 |
| Adibekian, A | 1 |
| Ovize, M | 1 |
| Martinou, JC | 1 |
| Riezman, H | 1 |
| Park, J | 1 |
| Lee, Y | 1 |
| Mavroeidi, P | 1 |
| Mavrofrydi, O | 1 |
| Pappa, E | 1 |
| Panopoulou, M | 1 |
| Papazafiri, P | 1 |
| Haralambous, S | 1 |
| Efthimiopoulos, S | 1 |
| Ghosh, D | 1 |
| Bhargava, K | 1 |
| Sethy, NK | 1 |
| Zhan, L | 1 |
| Lu, Z | 1 |
| Zhu, X | 1 |
| Xu, W | 1 |
| Li, L | 1 |
| Chen, S | 1 |
| Sun, W | 1 |
| Xu, E | 1 |
| Ekberg, NR | 1 |
| Eliasson, S | 1 |
| Li, YW | 1 |
| Zheng, X | 1 |
| Chatzidionysiou, K | 1 |
| Falhammar, H | 1 |
| Gu, HF | 1 |
| Catrina, SB | 1 |
| Arlier, Z | 1 |
| Basar, M | 1 |
| Kocamaz, E | 1 |
| Kiraz, K | 1 |
| Tanriover, G | 1 |
| Kocer, G | 1 |
| Arlier, S | 1 |
| Giray, S | 1 |
| Nasırcılar, S | 1 |
| Gunduz, F | 1 |
| Senturk, UK | 1 |
| Demir, N | 1 |
| Ye, J | 1 |
| Fan, J | 1 |
| Venneti, S | 1 |
| Wan, YW | 1 |
| Pawel, BR | 1 |
| Zhang, J | 1 |
| Finley, LW | 1 |
| Lu, C | 1 |
| Lindsten, T | 1 |
| Cross, JR | 1 |
| Qing, G | 1 |
| Liu, Z | 1 |
| Simon, MC | 1 |
| Rabinowitz, JD | 1 |
| Thompson, CB | 1 |
| Martínez-Reyes, I | 1 |
| Chandel, NS | 1 |
| Jakubauskiene, E | 1 |
| Vilys, L | 1 |
| Makino, Y | 1 |
| Poellinger, L | 1 |
| Kanopka, A | 1 |
| Lu, W | 1 |
| Ai, H | 1 |
| Peng, L | 1 |
| Wang, JJ | 1 |
| Zhang, B | 1 |
| Liu, X | 1 |
| Luo, JH | 1 |
| Liu, JR | 1 |
| Liu, Q | 1 |
| Khoury, J | 1 |
| Li, YJ | 1 |
| Han, XH | 1 |
| Li, J | 1 |
| Ibla, JC | 1 |
| García-Bermúdez, J | 1 |
| Cuezva, JM | 1 |
| An, YM | 1 |
| Feng, H | 1 |
| Zhang, XZ | 1 |
| Cong, X | 1 |
| Zhao, Q | 1 |
| Wu, LL | 1 |
| Dou, D | 1 |
| Ignacak, ML | 1 |
| Harbaugh, SV | 1 |
| Dayyat, E | 1 |
| Row, BW | 1 |
| Gozal, D | 2 |
| Czyzyk-Krzeska, MF | 1 |
| Deck, KM | 1 |
| Vasanthakumar, A | 1 |
| Anderson, SA | 1 |
| Goforth, JB | 1 |
| Kennedy, MC | 1 |
| Antholine, WE | 1 |
| Eisenstein, RS | 1 |
| Thevenet, J | 1 |
| Angelillo-Scherrer, A | 1 |
| Price, M | 1 |
| Hirt, L | 1 |
| Lee, HT | 1 |
| Chang, YC | 1 |
| Tu, YF | 1 |
| Huang, CC | 1 |
| Anupriya, G | 1 |
| Roopa, K | 1 |
| Basappa, S | 1 |
| Chong, YS | 1 |
| Annamalai, L | 1 |
| Tsuchimoto, T | 1 |
| Sakata, K | 1 |
| Someya, M | 1 |
| Yamamoto, H | 1 |
| Hirayama, R | 1 |
| Matsumoto, Y | 1 |
| Furusawa, Y | 1 |
| Hareyama, M | 1 |
| Fuchs, SA | 1 |
| Peeters-Scholte, CM | 1 |
| de Barse, MM | 1 |
| Roeleveld, MW | 1 |
| Klomp, LW | 1 |
| Berger, R | 1 |
| de Koning, TJ | 1 |
| Stetler, RA | 1 |
| Gao, Y | 1 |
| Zhang, L | 2 |
| Weng, Z | 1 |
| Zhang, F | 1 |
| Hu, X | 1 |
| Wang, S | 1 |
| Vosler, P | 1 |
| Cao, G | 1 |
| Sun, D | 1 |
| Graham, SH | 1 |
| Chen, J | 1 |
| Stein, A | 1 |
| Mao, Z | 1 |
| Morrison, JP | 1 |
| Fanucchi, MV | 1 |
| Postlethwait, EM | 1 |
| Patel, RP | 1 |
| Kraus, DW | 1 |
| Doeller, JE | 1 |
| Bailey, SM | 1 |
| Marsboom, G | 1 |
| Toth, PT | 1 |
| Ryan, JJ | 1 |
| Hong, Z | 1 |
| Wu, X | 1 |
| Fang, YH | 1 |
| Thenappan, T | 1 |
| Piao, L | 1 |
| Zhang, HJ | 1 |
| Pogoriler, J | 1 |
| Chen, Y | 1 |
| Morrow, E | 1 |
| Weir, EK | 1 |
| Rehman, J | 1 |
| Archer, SL | 1 |
| Wojciak-Stothard, B | 1 |
| Zhao, L | 1 |
| Oliver, E | 1 |
| Dubois, O | 1 |
| Wu, Y | 1 |
| Kardassis, D | 1 |
| Vasilaki, E | 1 |
| Huang, M | 1 |
| Mitchell, JA | 1 |
| Harrington, LS | 1 |
| Louise, H | 1 |
| Prendergast, GC | 1 |
| Wilkins, MR | 1 |
| Rakhade, SN | 1 |
| Fitzgerald, EF | 1 |
| Klein, PM | 1 |
| Zhou, C | 1 |
| Sun, H | 1 |
| Huganir, RL | 1 |
| Hunganir, RL | 1 |
| Jensen, FE | 1 |
| Murata, T | 1 |
| Sato, K | 1 |
| Hori, M | 1 |
| Ozaki, H | 1 |
| Karaki, H | 1 |
| Shi, Y | 1 |
| Baker, JE | 1 |
| Zhang, C | 1 |
| Tweddell, JS | 1 |
| Su, J | 1 |
| Pritchard, KA | 1 |
| Koumenis, C | 1 |
| Naczki, C | 1 |
| Koritzinsky, M | 1 |
| Rastani, S | 1 |
| Diehl, A | 1 |
| Sonenberg, N | 1 |
| Koromilas, A | 1 |
| Wouters, BG | 1 |
| Hammond, EM | 1 |
| Dorie, MJ | 1 |
| Giaccia, AJ | 1 |
| Kawasaki, K | 1 |
| Ogawa, S | 1 |
| Kumar, GK | 1 |
| Kim, DK | 1 |
| Lee, MS | 1 |
| Ramachandran, R | 1 |
| Prabhakar, NR | 1 |
| Mahabeleshwar, GH | 1 |
| Kundu, GC | 1 |
| Fritz, KI | 1 |
| Ashraf, QM | 1 |
| Zubrow, AB | 1 |
| Mishra, OP | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Trisciuoglio, D | 1 |
| Iervolino, A | 1 |
| Candiloro, A | 1 |
| Fibbi, G | 1 |
| Fanciulli, M | 1 |
| Zangemeister-Wittke, U | 1 |
| Zupi, G | 1 |
| Del Bufalo, D | 1 |
| Hirai, K | 1 |
| Hayashi, T | 1 |
| Chan, PH | 1 |
| Zeng, J | 1 |
| Yang, GY | 1 |
| Basus, VJ | 1 |
| James, TL | 1 |
| Litt, L | 1 |
| Favetta, LA | 1 |
| Robert, C | 1 |
| King, WA | 1 |
| Betts, DH | 1 |
| Liu, XH | 1 |
| Kirschenbaum, A | 1 |
| Yu, K | 1 |
| Yao, S | 1 |
| Levine, AC | 1 |
| Miller, F | 1 |
| Kentsis, A | 1 |
| Osman, R | 1 |
| Pan, ZQ | 1 |
| Frederich, M | 1 |
| Balschi, JA | 1 |
| Roh, MS | 1 |
| Eom, TY | 1 |
| Zmijewska, AA | 1 |
| De Sarno, P | 1 |
| Roth, KA | 1 |
| Jope, RS | 1 |
| Carrasco-Martín, C | 1 |
| Alonso-Orgaz, S | 1 |
| De la Pinta, JC | 1 |
| Marques, M | 1 |
| Macaya, C | 1 |
| Barrientos, A | 1 |
| González, MM | 1 |
| García-Méndez, A | 1 |
| Mateos-Cáceres, PJ | 1 |
| Porres, JC | 1 |
| Rico, LA | 1 |
| López-Farré, AJ | 1 |
| Nyunoya, T | 1 |
| Monick, MM | 1 |
| Powers, LS | 1 |
| Yarovinsky, TO | 1 |
| Hunninghake, GW | 1 |
| Klein, JB | 1 |
| Barati, MT | 1 |
| Wu, R | 1 |
| Sachleben, LR | 1 |
| Kausar, H | 1 |
| Trent, JO | 1 |
| Gozal, E | 1 |
| Rane, MJ | 1 |
| Chang, NS | 2 |
| Doherty, J | 1 |
| Ensign, A | 1 |
| Schultz, L | 1 |
| Hsu, LJ | 1 |
| Hong, Q | 1 |
| Nakajima, T | 1 |
| Wakasa, T | 1 |
| Okuma, Y | 1 |
| Inanami, O | 1 |
| Nomura, Y | 1 |
| Kuwabara, M | 1 |
| Kawahara, K | 1 |
| John, TA | 1 |
| Ibe, BO | 1 |
| Usha Raj, J | 1 |
| Li, W | 1 |
| Petrimpol, M | 1 |
| Molle, KD | 1 |
| Hall, MN | 1 |
| Battegay, EJ | 1 |
| Humar, R | 1 |
| Chen, WF | 1 |
| Chang, H | 1 |
| Wong, CS | 1 |
| Huang, LT | 1 |
| Yang, CH | 1 |
| Yang, SN | 1 |
| Solan, JL | 1 |
| Marquez-Rosado, L | 1 |
| Sorgen, PL | 1 |
| Thornton, PJ | 1 |
| Gafken, PR | 1 |
| Lampe, PD | 1 |
| Williamson, DH | 1 |
| Lopes-Vieira, O | 1 |
| Walker, B | 1 |
| Hirai, H | 1 |
| Okada, Y | 1 |
| Su, Y | 1 |
| Block, ER | 1 |
| Zhu, Y | 1 |
| Mao, XO | 1 |
| Sun, Y | 1 |
| Xia, Z | 1 |
| Greenberg, DA | 1 |
| Heyman, S | 1 |
| Spokes, K | 1 |
| Rosen, S | 1 |
| Epstein, FH | 1 |
| Van Waarde, A | 1 |
| van den Thillart, G | 1 |
| Verhagen, M | 1 |
| Erkelens, C | 1 |
| Addink, A | 1 |
| Lugtenburg, J | 1 |
| Ballard, FJ | 1 |
Reviews
1 review available for serine and Hypoxia
| Article | Year |
|---|---|
Hypoxia-mediated activation of hypoxia-inducible factor-1α in head and neck squamous cell carcinoma: A review.
Topics: Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Phosphatidylino | 2023 |
Other Studies
60 other studies available for serine and Hypoxia
| Article | Year |
|---|---|
PrrA modulates Mycobacterium tuberculosis response to multiple environmental cues and is critically regulated by serine/threonine protein kinases.
Topics: Bacterial Proteins; Cues; Gene Expression Regulation, Bacterial; Humans; Hypoxia; Mycobacterium tube | 2022 |
Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner.
Topics: Cell Hypoxia; Cell Line, Tumor; Endoribonucleases; Gene Expression Regulation, Neoplastic; Glioblast | 2023 |
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.
Topics: Alanine; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cell Division; Chaperonins; | 2019 |
Hypoxia induced phosphorylation of estrogen receptor at serine 118 in the absence of ligand.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Estrogen Receptor alpha; HEK293 Cells; Humans; | 2017 |
Oxygen and Glucose Deprivation Alter Synaptic Distribution of Tau Protein: The Role of Phosphorylation.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Glucose; Glucose Transp | 2017 |
Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women.
Topics: Acclimatization; Adult; Altitude; Bradykinin; Estrogens; Female; Heart Rate; Humans; Hypoxia; India; | 2018 |
Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Ki | 2019 |
Protective Effect of the
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Di | 2019 |
Hypertension alters phosphorylation of VASP in brain endothelial cells.
Topics: Animals; Blood Pressure; Brain; Case-Control Studies; Cell Adhesion Molecules; Cells, Cultured; Dise | 2015 |
Serine catabolism regulates mitochondrial redox control during hypoxia.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Gene Amplification; | 2014 |
Mitochondrial one-carbon metabolism maintains redox balance during hypoxia.
Topics: Animals; Humans; Hypoxia; Mitochondria; Oxidation-Reduction; Serine | 2014 |
Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia.
Topics: Alternative Splicing; Arginine; Cell Hypoxia; Gene Expression Regulation, Enzymologic; HeLa Cells; H | 2015 |
A novel phosphorylation site of N-methyl-D-aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia.
Topics: Animals; Carotid Artery Diseases; Cells, Cultured; Central Nervous System Stimulants; Cyclin-Depende | 2015 |
Hypoxic preconditioning decreases nuclear factor κB activity via Disrupted in Schizophrenia-1.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Hypoxia; Cell Line, Tumor; Epithelial Cells; G | 2016 |
The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.
Topics: ATPase Inhibitory Protein; Cell Transformation, Neoplastic; Cellular Reprogramming; Cyclic AMP-Depen | 2016 |
Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries.
Topics: Animals; Blotting, Western; Class Ia Phosphatidylinositol 3-Kinase; Coronary Vessels; Dose-Response | 2017 |
Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex.
Topics: Animals; Carrier Proteins; Cullin Proteins; Gene Expression Regulation; Hippocampus; Hypoxia; Learni | 2009 |
Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.
Topics: Aconitate Hydratase; Cytosol; Electron Spin Resonance Spectroscopy; Humans; Hypoxia; Iron; Iron Chel | 2009 |
Coagulation factor Xa activates thrombin in ischemic neural tissue.
Topics: Animals; Animals, Newborn; Anticoagulants; Cell Death; Factor Xa; Fondaparinux; Gene Expression Regu | 2009 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P | 2010 |
Homology modeling and in silico screening of inhibitors for the substrate binding domain of human Siah2: implications for hypoxia-induced cancers.
Topics: Binding Sites; Drug Design; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Hydrogen Bo | 2011 |
Gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia, and reoxygenation.
Topics: Cell Line, Tumor; DNA-Activated Protein Kinase; Gene Expression Profiling; Gene Expression Regulatio | 2011 |
Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cell Line, Tumor; Glycine; Humans; Hypoxia; Hypoxia- | 2012 |
Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Disease Models, Anim | 2012 |
Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats.
Topics: Administration, Inhalation; Animals; Body Temperature Regulation; Creatine Kinase, MB Form; Disease | 2012 |
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; | 2012 |
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.
Topics: Actomyosin; Animals; Capillary Permeability; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, | 2012 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La | 2012 |
Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension.
Topics: Animals; Blotting, Western; Body Weight; Calcium; Carbachol; Cell Membrane; Cyclic GMP; Electrophore | 2002 |
Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation.
Topics: Animals; Animals, Newborn; Benzoquinones; Blotting, Western; Chronic Disease; Enzyme Activation; Enz | 2002 |
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.
Topics: 3T3 Cells; Animals; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initi | 2002 |
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; DNA Damage; DNA-Activated Pr | 2003 |
[The role of glycine binding site in NMDA receptor--interactions between NMDA and D-serine in artificial anoxia/agycemia rat hippocampus].
Topics: Animals; Binding Sites; Glycine; Hippocampus; Hypoxia; In Vitro Techniques; N-Methylaspartate; Norep | 2003 |
Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Catecholamines; Cell Survival; Cyclic AMP-Dep | 2003 |
Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; DNA | 2003 |
Expression of phosphorylation of N-methyl-D-aspartate receptor subunits during graded hypoxia in the cerebral cortex of newborn piglets.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Hypoxia; Phosphocreatine; Phosphorylation; Receptors, N- | 2004 |
bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity.
Topics: Blotting, Northern; Blotting, Western; Butadienes; Cell Line, Tumor; Cell Nucleus; DNA; Dose-Respons | 2004 |
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-Associated Death Protein; Brain; Carrier Proteins; Chapero | 2004 |
Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cattle; Cell D | 2004 |
Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic | 2005 |
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcr | 2005 |
Hypoxia and AMP independently regulate AMP-activated protein kinase activity in heart.
Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; AMP-Activated Protein Kinases; Animals; Cytosol; En | 2005 |
Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Carbon Dioxide; Dose-Response Rel | 2005 |
Endothelial hypoxic preconditioning in rat hypoxic isolated aortic segments.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; HSP90 Heat-Shock | 2005 |
Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; | 2005 |
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins.
Topics: Adenosine Triphosphatases; Animals; Brain; Cell Cycle Proteins; Hypoxia; Isoelectric Point; Male; PC | 2005 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cyto | 2005 |
Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death.
Topics: Animals; Blotting, Western; Calpain; Cell Differentiation; CREB-Binding Protein; Dose-Response Relat | 2006 |
Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells.
Topics: Animals; Antibody Specificity; Caveolin 1; Cells, Cultured; Down-Regulation; Endocytosis; Endothelia | 2006 |
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.
Topics: Animals; Biological Transport; Cell Nucleus; Cell Proliferation; Cells, Cultured; Embryo, Mammalian; | 2007 |
Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia.
Topics: Animals; Animals, Newborn; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Disks Lar | 2007 |
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC.
Topics: Amino Acid Substitution; Animals; Blotting, Western; Cell Line; Connexin 43; Connexins; Dogs; Down-R | 2007 |
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut | 1967 |
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Aci | 1993 |
Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells.
Topics: Animals; Calpain; Caveolin 1; Caveolins; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides | 2000 |
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression.
Topics: Animals; Ankyrins; Apoptosis; Cell Division; Cell Line; Cell Nucleus; COS Cells; Cytosol; DNA Damage | 2002 |
p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Dow | 2002 |
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic | 1992 |
Direct observation of the phosphate acceptor and phosphagen pool sizes in vivo.
Topics: Adenosine Diphosphate; Animals; Electric Stimulation; Energy Metabolism; Hypoxia; Magnetic Resonance | 1990 |
Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions.
Topics: Acetoacetates; Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartic Acid; Gluconeogenesis; | 1971 |