serine has been researched along with Hypoxia-Ischemia, Brain in 10 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overactivation of the N-methyl-D-aspartate receptor (NMDAr) plays a central role in the pathogenesis of cerebral hypoxia-ischemia, but the role of both endogenous NMDAr co-agonists D-serine and glycine remains largely elusive." | 3.78 | Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia. ( Berger, R; de Barse, MM; de Koning, TJ; Fuchs, SA; Klomp, LW; Peeters-Scholte, CM; Roeleveld, MW, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bardaweel, SK | 1 |
| Alzweiri, M | 1 |
| Ishaqat, AA | 1 |
| Kirschner, DL | 1 |
| Wilson, AL | 1 |
| Drew, KL | 1 |
| Green, TK | 1 |
| Aras, MA | 1 |
| Hara, H | 1 |
| Hartnett, KA | 1 |
| Kandler, K | 1 |
| Aizenman, E | 1 |
| Lee, HT | 2 |
| Chang, YC | 2 |
| Tu, YF | 1 |
| Huang, CC | 2 |
| Fuchs, SA | 1 |
| Peeters-Scholte, CM | 1 |
| de Barse, MM | 1 |
| Roeleveld, MW | 1 |
| Klomp, LW | 1 |
| Berger, R | 1 |
| de Koning, TJ | 1 |
| Fu, XZ | 1 |
| Zhang, QG | 1 |
| Meng, FJ | 1 |
| Zhang, GY | 1 |
| Wang, LY | 1 |
| Wang, ST | 1 |
| Ho, CJ | 1 |
| Hallin, U | 1 |
| Kondo, E | 1 |
| Ozaki, Y | 1 |
| Hagberg, H | 1 |
| Shibasaki, F | 1 |
| Blomgren, K | 1 |
| Lombardi, MS | 1 |
| Vroon, A | 1 |
| Sodaar, P | 1 |
| van Muiswinkel, FL | 1 |
| Heijnen, CJ | 1 |
| Kavelaars, A | 1 |
| Mueller-Burke, D | 1 |
| Koehler, RC | 1 |
| Martin, LJ | 1 |
1 review available for serine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutami | 2014 |
9 other studies available for serine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Simultaneous efflux of endogenous D-ser and L-glu from single acute hippocampus slices during oxygen glucose deprivation.
Topics: Acute Disease; Animals; Diffusion Chambers, Culture; Glucose; Glutamic Acid; Glutamine; Hippocampus; | 2009 |
Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.
Topics: Amino Acid Sequence; Animals; Brain Infarction; Cell Death; Cell Survival; Cells, Cultured; Cytoprot | 2009 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P | 2010 |
Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cell Line, Tumor; Glycine; Humans; Hypoxia; Hypoxia- | 2012 |
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Blotting, Western; Cal | 2004 |
cAMP response element-binding protein activation in ligation preconditioning in neonatal brain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Blotting, Wester | 2004 |
Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic injury.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Blotting, Western; Caspase 3; Caspases; Disease Mo | 2006 |
Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway.
Topics: Animals; Animals, Newborn; beta-Adrenergic Receptor Kinases; Down-Regulation; Enzyme Inhibitors; Ext | 2007 |
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Corpus Striatum; Disease Models, Animal; Hypothermi | 2008 |