serine has been researched along with Hypertension in 50 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy." | 3.74 | [Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats]. ( Faqian, L; Li, ZY; Yi, XP; Zhong, L, 2008) |
| "A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension." | 3.74 | The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes. ( Almgren, P; Berglund, G; Fava, C; Guidi, GC; Melander, O; Montagnana, M; Rosberg, L, 2007) |
| "Clinical evidence suggests a relationship between hypertension and insulin resistance, and cross-talk between angiotensin II (Ang II) and insulin signaling pathways may take place." | 3.73 | ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells. ( Ali, N; Ebina, Y; Fujita, Y; Ishizawa, K; Izawa, Y; Kanematsu, Y; Obata, T; Tamaki, T; Tomita, S; Tsuchiya, K; Yoshizumi, M, 2005) |
| " The other mutation, substituting serine for asparagine at codon 530 (Asn530Ser) of the extracellular loop of ENaC subunit, was found in a 25-year-old man with hypertension, hypokalemia, low plasma renin activity and low serum aldosterone levels." | 3.71 | Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit. ( Gautschi, I; Hannila-Handelberg, T; Hiltunen, TP; Kantola, I; Kontula, K; Petäjäniemi, N; Schild, L; Tikkanen, I; Virtamo, J, 2002) |
| "In order to evaluate the correlation between sulfur amino acids (derived mainly form animal protein in the diet) and blood pressure, free amino acids, including sulfur amino acids such as taurine and methionine, were determined in the plasma and cerebrospinal fluid (CSF) of twelve normotensive subjects and twelve patients with essential hypertension under nutritional control after at least 10 days of standard hospital diet (total calorie and protein content: 2100-2300 Cal per day and 78-83 g per day, respectively)." | 3.67 | Decrease of plasma sulfur amino acids in essential hypertension. ( Ishijima, M; Ogawa, M; Takahara, A; Tazaki, S, 1985) |
| "Hypertension was defined based on blood pressure (BP) values measured on three different occasions according to the BP reference of Chinese children and adolescents." | 1.72 | Serum metabolites of hypertension among Chinese adolescents aged 12-17 years. ( Ding, W; Liu, X; Sun, J; Xi, B; Zhao, M, 2022) |
| "Atherosclerosis is a chronic inflammatory disease of the arteries characterized by the accumulation of inflammatory cells in the arterial wall." | 1.72 | Reducing Proteoglycan Synthesis and NOX Activity by ROCK Inhibitors: Therapeutic Targets in Atherosclerosis. ( Azizi, M; Babaahmadi-Rezaei, H; Beheshti-Nasab, H; Ghaderi-Zefrehi, H; Mehta, JL; Rezaei, M, 2022) |
| "Salt-induced hypertension is one of the major issues worldwide and one of the main factors involved in heart and kidney failure." | 1.72 | Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns. ( Ahmad, H; Ahmad, N; Chen, M; Du, J; Jin, Y; Khan, A; Li, X; Ouyang, Y; Tian, Z; Yang, P; Yang, Z; Zeng, L; Zhao, X; Zheng, X, 2022) |
| "Our objective was to study hypertension induced by chronic administration of synthetic glucocorticoid, dexamethasone (DEX), under nonstressful conditions and examine the role of catecholamine biosynthesis." | 1.43 | A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase. ( Franklin, C; Gottlieb, H; Hinojosa-Laborde, C; Rani, CS; Soto-Piña, AE; Strong, R, 2016) |
| "Mice treated with juglone for 2 weeks, as well as Pin1 knockout mice, exhibited increased aortic endothelial NO synthase serine 116 phosphorylation, endothelial dysfunction, and hypertension." | 1.37 | Pin1 deficiency causes endothelial dysfunction and hypertension. ( Chatterjee, P; Chiasson, VL; Mitchell, BM; Munshi, N; Young, KJ, 2011) |
| "1." | 1.35 | Genetic variants of beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and essential hypertension in a south Indian Tamil population. ( Adithan, C; Balachander, J; Dutta, TK; Rajan, S; Ramu, P; Shewade, DG; Swaminathan, RP, 2009) |
| "Liddle's syndrome is an autosomal dominant form of salt sensitive hypertension caused by mutations in the beta or gamma subunit of the epithelial sodium channel." | 1.30 | A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel. ( Araki, M; Inoue, J; Iwaoka, T; Naomi, S; Takahama, K; Takamune, K; Tokunaga, H; Tomita, K; Yamaguchi, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.00) | 18.7374 |
| 1990's | 4 (8.00) | 18.2507 |
| 2000's | 22 (44.00) | 29.6817 |
| 2010's | 11 (22.00) | 24.3611 |
| 2020's | 7 (14.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, J | 1 |
| Ding, W | 1 |
| Liu, X | 1 |
| Zhao, M | 1 |
| Xi, B | 1 |
| Zhu, X | 1 |
| Li, K | 1 |
| Gao, Y | 1 |
| Shi, M | 1 |
| He, J | 1 |
| Li, C | 1 |
| Lu, X | 1 |
| He, WJ | 1 |
| Cao, J | 1 |
| Chen, J | 1 |
| Chen, JC | 1 |
| Bazzano, LA | 1 |
| Li, JX | 1 |
| He, H | 1 |
| Gu, D | 1 |
| Kelly, TN | 1 |
| Babaahmadi-Rezaei, H | 1 |
| Rezaei, M | 1 |
| Ghaderi-Zefrehi, H | 1 |
| Azizi, M | 1 |
| Beheshti-Nasab, H | 1 |
| Mehta, JL | 1 |
| Strauss-Kruger, M | 1 |
| van Zyl, T | 1 |
| Pieters, M | 1 |
| Kruger, R | 1 |
| Mokwatsi, G | 1 |
| Gafane-Matemane, L | 1 |
| Mbongwa, H | 1 |
| Jacobs, A | 1 |
| Schutte, AE | 1 |
| Louw, R | 1 |
| Mels, C | 1 |
| Ahmad, H | 1 |
| Zhao, X | 1 |
| Ahmad, N | 1 |
| Khan, A | 1 |
| Jin, Y | 1 |
| Du, J | 1 |
| Zheng, X | 1 |
| Zeng, L | 1 |
| Ouyang, Y | 1 |
| Yang, P | 1 |
| Chen, M | 1 |
| Li, X | 1 |
| Yang, Z | 2 |
| Tian, Z | 1 |
| Yu, Z | 1 |
| Wang, L | 2 |
| Wu, S | 1 |
| Zhao, W | 1 |
| Banday, AA | 2 |
| Lokhandwala, MF | 2 |
| Arlier, Z | 1 |
| Basar, M | 1 |
| Kocamaz, E | 1 |
| Kiraz, K | 1 |
| Tanriover, G | 1 |
| Kocer, G | 1 |
| Arlier, S | 1 |
| Giray, S | 1 |
| Nasırcılar, S | 1 |
| Gunduz, F | 1 |
| Senturk, UK | 1 |
| Demir, N | 1 |
| Jablonski, KL | 1 |
| Klawitter, J | 1 |
| Chonchol, M | 1 |
| Bassett, CJ | 1 |
| Racine, ML | 1 |
| Seals, DR | 1 |
| Dietrich, S | 1 |
| Floegel, A | 1 |
| Weikert, C | 1 |
| Prehn, C | 1 |
| Adamski, J | 1 |
| Pischon, T | 1 |
| Boeing, H | 1 |
| Drogan, D | 1 |
| Soto-Piña, AE | 1 |
| Franklin, C | 1 |
| Rani, CS | 1 |
| Gottlieb, H | 1 |
| Hinojosa-Laborde, C | 1 |
| Strong, R | 1 |
| Qu, Y | 1 |
| Jin, F | 1 |
| Sun, L | 1 |
| Zhang, C | 1 |
| Ji, L | 1 |
| Sun, H | 1 |
| Wang, B | 1 |
| Zhong, L | 1 |
| Yi, XP | 2 |
| Li, ZY | 1 |
| Faqian, L | 1 |
| Mishra, RC | 2 |
| Tripathy, S | 2 |
| Quest, D | 1 |
| Desai, KM | 2 |
| Akhtar, J | 2 |
| Dattani, ID | 1 |
| Gopalakrishnan, V | 2 |
| Ramu, P | 1 |
| Rajan, S | 1 |
| Shewade, DG | 1 |
| Swaminathan, RP | 1 |
| Dutta, TK | 1 |
| Balachander, J | 1 |
| Adithan, C | 1 |
| Gandhi, JD | 1 |
| Balsevich, J | 1 |
| Yamamoto, F | 1 |
| Yamamoto, H | 1 |
| Tateishi, A | 1 |
| Matsushita, M | 1 |
| Asai, T | 1 |
| Masuda, Z | 1 |
| Kuriyama, M | 1 |
| Kanki, K | 1 |
| Ishino, K | 1 |
| Kawada, M | 1 |
| Sano, S | 1 |
| Matsui, H | 1 |
| Chiasson, VL | 1 |
| Munshi, N | 1 |
| Chatterjee, P | 1 |
| Young, KJ | 1 |
| Mitchell, BM | 1 |
| Kurtz, B | 1 |
| Thibault, HB | 1 |
| Raher, MJ | 1 |
| Popovich, JR | 1 |
| Cawley, S | 1 |
| Atochin, DN | 1 |
| Hayton, S | 1 |
| Shakartzi, HR | 1 |
| Huang, PL | 1 |
| Bloch, KD | 1 |
| Buys, E | 1 |
| Scherrer-Crosbie, M | 1 |
| Zouein, FA | 1 |
| Zgheib, C | 1 |
| Hamza, S | 1 |
| Fuseler, JW | 1 |
| Hall, JE | 1 |
| Soljancic, A | 1 |
| Lopez-Ruiz, A | 1 |
| Kurdi, M | 1 |
| Booz, GW | 1 |
| Hiltunen, TP | 1 |
| Hannila-Handelberg, T | 1 |
| Petäjäniemi, N | 1 |
| Kantola, I | 1 |
| Tikkanen, I | 1 |
| Virtamo, J | 1 |
| Gautschi, I | 1 |
| Schild, L | 1 |
| Kontula, K | 1 |
| Wang, X | 2 |
| Gerdes, AM | 1 |
| Li, F | 1 |
| Ying, WZ | 1 |
| Sanders, PW | 1 |
| Barbato, A | 1 |
| Russo, P | 1 |
| Venezia, A | 1 |
| Strazzullo, V | 1 |
| Siani, A | 1 |
| Cappuccio, FP | 1 |
| FERUGLIO, FS | 1 |
| CAMPUS, S | 1 |
| DE MARTINIS, C | 1 |
| MAXWELL, MH | 2 |
| GONICK, HC | 2 |
| SCADUTO, L | 1 |
| PEARCE, ML | 1 |
| KLEEMAN, CR | 2 |
| ROTH, SI | 1 |
| TEUSCHER, A | 1 |
| LUGINBUEHL, H | 1 |
| Widder, J | 1 |
| Pelzer, T | 1 |
| von Poser-Klein, C | 1 |
| Hu, K | 1 |
| Jazbutyte, V | 1 |
| Fritzemeier, KH | 1 |
| Hegele-Hartung, C | 1 |
| Neyses, L | 1 |
| Bauersachs, J | 1 |
| Pinon, GM | 1 |
| Fagart, J | 1 |
| Souque, A | 1 |
| Auzou, G | 1 |
| Vandewalle, A | 1 |
| Rafestin-Oblin, ME | 1 |
| Fehr, T | 1 |
| Zimmermann, DR | 1 |
| Wüthrich, RP | 1 |
| Ammann, P | 1 |
| Andersen, G | 1 |
| Wegner, L | 1 |
| Jensen, DP | 1 |
| Glümer, C | 1 |
| Tarnow, L | 1 |
| Drivsholm, T | 1 |
| Poulsen, P | 1 |
| Hansen, SK | 1 |
| Nielsen, EM | 1 |
| Ek, J | 1 |
| Mouritzen, P | 1 |
| Vaag, A | 1 |
| Parving, HH | 1 |
| Borch-Johnsen, K | 1 |
| Jørgensen, T | 1 |
| Hansen, T | 1 |
| Pedersen, O | 1 |
| Izawa, Y | 1 |
| Yoshizumi, M | 1 |
| Fujita, Y | 1 |
| Ali, N | 1 |
| Kanematsu, Y | 1 |
| Ishizawa, K | 1 |
| Tsuchiya, K | 1 |
| Obata, T | 1 |
| Ebina, Y | 1 |
| Tomita, S | 1 |
| Tamaki, T | 1 |
| Moriguchi, T | 1 |
| Urushiyama, S | 1 |
| Hisamoto, N | 1 |
| Iemura, S | 1 |
| Uchida, S | 1 |
| Natsume, T | 1 |
| Matsumoto, K | 1 |
| Shibuya, H | 1 |
| Sanada, H | 1 |
| Yatabe, J | 1 |
| Midorikawa, S | 1 |
| Katoh, T | 1 |
| Hashimoto, S | 1 |
| Watanabe, T | 1 |
| Xu, J | 1 |
| Luo, Y | 1 |
| Zeng, C | 1 |
| Armando, I | 1 |
| Felder, RA | 1 |
| Jose, PA | 1 |
| Vitari, AC | 1 |
| Thastrup, J | 1 |
| Rafiqi, FH | 1 |
| Deak, M | 1 |
| Morrice, NA | 1 |
| Karlsson, HK | 1 |
| Alessi, DR | 1 |
| Fava, C | 1 |
| Montagnana, M | 1 |
| Almgren, P | 1 |
| Rosberg, L | 1 |
| Guidi, GC | 1 |
| Berglund, G | 1 |
| Melander, O | 1 |
| Talmud, PJ | 1 |
| Flavell, DM | 1 |
| Alfakih, K | 1 |
| Cooper, JA | 1 |
| Balmforth, AJ | 1 |
| Sivananthan, M | 1 |
| Montgomery, HE | 1 |
| Hall, AS | 1 |
| Humphries, SE | 1 |
| Chen-Izu, Y | 1 |
| Ward, CW | 1 |
| Stark, W | 1 |
| Banyasz, T | 1 |
| Sumandea, MP | 1 |
| Balke, CW | 1 |
| Izu, LT | 1 |
| Wehrens, XH | 1 |
| Jalil, JE | 1 |
| Kapoor, V | 1 |
| Kapoor, R | 1 |
| Chalmers, JP | 1 |
| Morris, BJ | 2 |
| Chambers, SM | 1 |
| Jeyasingam, CL | 1 |
| Zhang, W | 1 |
| Curtain, RP | 1 |
| Griffiths, LR | 1 |
| Inoue, J | 1 |
| Iwaoka, T | 1 |
| Tokunaga, H | 1 |
| Takamune, K | 1 |
| Naomi, S | 1 |
| Araki, M | 1 |
| Takahama, K | 1 |
| Yamaguchi, K | 1 |
| Tomita, K | 1 |
| Soma, M | 1 |
| Nakayama, K | 1 |
| Rahmutula, D | 1 |
| Uwabo, J | 1 |
| Sato, M | 1 |
| Kunimoto, M | 1 |
| Aoi, N | 1 |
| Kosuge, K | 1 |
| Kanmatsuse, K | 1 |
| Ogawa, M | 1 |
| Takahara, A | 1 |
| Ishijima, M | 1 |
| Tazaki, S | 1 |
| Kew, MC | 1 |
| First, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Non-pharmacological Intervention Study for Prevention of Ischaemic Heart Disease Inter99[NCT00289237] | 61,301 participants (Actual) | Interventional | 1999-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for serine and Hypertension
| Article | Year |
|---|---|
Effect of dietary sodium restriction on human urinary metabolomic profiles.
Topics: Aged; Biomarkers; Blood Pressure; Brachial Artery; Colorado; Cross-Over Studies; Diet, Sodium-Restri | 2015 |
49 other studies available for serine and Hypertension
| Article | Year |
|---|---|
Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
Topics: Acetone; Adolescent; Amino Acids; Biomarkers; Case-Control Studies; Child; China; Chromatography, Hi | 2022 |
Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Chromatography, Liquid; Dependovirus; Hypertension; Neurons; Parave | 2022 |
Metabolomics study of blood pressure salt-sensitivity and hypertension.
Topics: Blood Pressure; Humans; Hypertension; Isoleucine; Metabolomics; Serine; Sodium; Sodium Chloride, Die | 2022 |
Reducing Proteoglycan Synthesis and NOX Activity by ROCK Inhibitors: Therapeutic Targets in Atherosclerosis.
Topics: Angiotensin II; Atherosclerosis; Endothelin-1; Humans; Hypertension; Protein Serine-Threonine Kinase | 2022 |
Urinary metabolomics, dietary salt intake and blood pressure: the African-PREDICT study.
Topics: Adult; African People; Amino Acids; Blood Pressure; Cardiovascular Diseases; gamma-Aminobutyric Acid | 2023 |
Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns.
Topics: Alanine; Amino Acids; Animals; Antihypertensive Agents; Antioxidants; Aspartic Acid; Cucurbitaceae; | 2022 |
Dissecting the potential mechanism of antihypertensive effects of RVPSL on spontaneously hypertensive rats via widely targeted kidney metabolomics.
Topics: 3-Hydroxybutyric Acid; Animals; Antihypertensive Agents; Arachidonic Acid; Biomarkers; Blood Pressur | 2023 |
Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation.
Topics: Animals; Antioxidants; Blood Pressure; Buthionine Sulfoximine; Calcium; Cell Adhesion Molecules; Cyc | 2019 |
Hypertension alters phosphorylation of VASP in brain endothelial cells.
Topics: Animals; Blood Pressure; Brain; Case-Control Studies; Cell Adhesion Molecules; Cells, Cultured; Dise | 2015 |
Identification of Serum Metabolites Associated With Incident Hypertension in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study.
Topics: Adult; Biomarkers; Early Diagnosis; Female; Germany; Glycine; Humans; Hypertension; Male; Metabolic | 2016 |
A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.
Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Disease Models, Anima | 2016 |
The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Asian People; Blood Pressure; Case-Control Studies; | 2008 |
[Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats].
Topics: Animals; Cardiomegaly; Cell Nucleus; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinase | 2008 |
L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats.
Topics: Animals; Apamin; Blood Pressure; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Inhibition of natriuretic factors increases blood pressure in rats.
Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-O | 2009 |
Genetic variants of beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and essential hypertension in a south Indian Tamil population.
Topics: Adult; Amino Acid Substitution; Arginine; Case-Control Studies; Female; Gene Frequency; Genetics, Po | 2009 |
Decreases in splanchnic vascular resistance contribute to hypotensive effects of L-serine in hypertensive rats.
Topics: Animals; Apamin; Blood Pressure; Cardiac Output; Charybdotoxin; Disease Models, Animal; Hypertension | 2010 |
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
Topics: Animals; Aorta, Abdominal; Atrial Natriuretic Factor; beta Catenin; Blood Pressure; Cardiovascular A | 2010 |
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
Topics: Animals; Aorta, Abdominal; Atrial Natriuretic Factor; beta Catenin; Blood Pressure; Blotting, Wester | 2010 |
Pin1 deficiency causes endothelial dysfunction and hypertension.
Topics: Amino Acid Substitution; Animals; Aorta; Binding Sites; Blood Pressure; Cells, Cultured; Endothelium | 2011 |
Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance.
Topics: Adenosine Triphosphate; Animals; Dietary Fats; Disease Models, Animal; Energy Metabolism; Enzyme Inh | 2011 |
Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen; Cytokines; Electrocardiography; Fib | 2013 |
Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit.
Topics: Adult; Amino Acid Sequence; Animals; Asparagine; Base Sequence; Epithelial Sodium Channels; Female; | 2002 |
Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium.
Topics: Active Transport, Cell Nucleus; Animals; Cell Membrane; Cell Nucleus; Cytoskeleton; Female; Focal Ad | 2003 |
The interrelationship between TGF-beta1 and nitric oxide is altered in salt-sensitive hypertension.
Topics: Animals; Aorta; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mitogen-Activated Protei | 2003 |
Analysis of Gly40Ser polymorphism of the glucagon receptor (GCGR) gene in different ethnic groups.
Topics: Adult; Asian People; Black People; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus; Female | 2003 |
[On the treatment of arterial hypertension with a drug inhibiting monoamine oxidase (DL-serine-N2-isopropylhydrazide)].
Topics: Hydrazines; Hypertension; Monoamine Oxidase; Oxidoreductases; Serine | 1960 |
Hemodynamic studies of a monoamine oxidase inhibitor, DL-serine-N2-isopropylhydrazide (RO 4-1038). Mechanism of hypotensive action.
Topics: Heart Function Tests; Hemodynamics; Hypertension; Hypotension; Kidney Function Tests; Monoamine Oxid | 1962 |
CLINICAL EXPERIENCE WITH THE MONOAMINE OXIDASE INHIBITOR, DL-SERINE-N-ISOPROPYLHYDRAZIDE (RO 4-1038), IN THE TREATMENT OF HYPERTENSION.
Topics: Antihypertensive Agents; Chlorothiazide; Drug Tolerance; Geriatrics; Humans; Hypertension; Hypertens | 1963 |
[ANTIHYPERTENSIVE PROPERTIES OF A MONOAMINE OXIDASE INHIBITOR (DL-SERINE-N2-ISOPROPYLHYDRAZIDE: RO 4-1038). CLINICAL RESULTS AND EFFECT ON RENAL FUNCTION].
Topics: Antihypertensive Agents; Blood Pressure Determination; Chemical and Drug Induced Liver Injury; Chlor | 1964 |
Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR.
Topics: Animals; Aorta; Cell Adhesion Molecules; Culture Techniques; Endothelium, Vascular; Estrogen Antagon | 2003 |
Identification of steroid ligands able to inactivate the mineralocorticoid receptor harboring the S810L mutation responsible for a severe form of hypertension.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Humans; Hypertension; Leucine; Ligands; Mineralocor | 2004 |
A young renal transplant recipient with unexplained resting sinus tachycardia, hypertension and beta-blocker resistance.
Topics: Adult; Arginine; Glycine; Homozygote; Humans; Hypertension; Kidney Diseases; Kidney Transplantation; | 2004 |
PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites.
Topics: Adult; Aged; Blood Pressure; Denmark; Female; Genetic Predisposition to Disease; Genotype; Glycine; | 2005 |
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blood Vessels; Cell Membrane; Cytoplasm; Enzyme Activation; Enzyme Inhibito | 2005 |
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Biological Transport; Cations; Cell Line; Chlorides | 2005 |
Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.
Topics: Animals; Blood Pressure; Diuresis; G-Protein-Coupled Receptor Kinase 4; Hypertension; Immunohistoche | 2006 |
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Topics: Binding Sites; Cells, Cultured; Enzyme Activation; Humans; Hyperkalemia; Hypertension; Intracellular | 2006 |
The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes.
Topics: Adult; Blood Pressure; Chloride Channels; Cohort Studies; Cross-Sectional Studies; Disease Progressi | 2007 |
The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.
Topics: Adult; Apolipoproteins; Coronary Disease; Fatty Acids; Female; Gene Frequency; Genotype; Homozygote; | 2007 |
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein | 2007 |
Blood pressure reduction, potassium channels, and the endothelium: insights from L-serine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Endothelium, Vascular; Heart Rate; Hypertension; N | 2008 |
Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats.
Topics: Animals; Blood Pressure; Glutamic Acid; Hypertension; Kynurenic Acid; Medulla Oblongata; Microinject | 1996 |
Hypothesis: glucagon receptor glycine to serine missense mutation contributes to one in 20 cases of essential hypertension.
Topics: Adult; Female; Glycine; Humans; Hypertension; Male; Middle Aged; Mutation; Receptors, Glucagon; Seri | 1996 |
Influence of family history on frequency of glucagon receptor Gly40Ser mutation in hypertensive subjects.
Topics: Adult; Age of Onset; Female; Gene Frequency; Glycine; Humans; Hypertension; Male; Middle Aged; Nucle | 1997 |
A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel.
Topics: Adult; Alleles; Base Sequence; Codon; DNA; Epithelium; Female; Humans; Hypertension; Male; Mutagenes | 1998 |
Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese.
Topics: Adult; Aged; Alleles; Female; Genotype; Glycine; Humans; Hypertension; Japan; Leukocytes; Male; Midd | 2002 |
Decrease of plasma sulfur amino acids in essential hypertension.
Topics: Adult; Aged; Amino Acids, Sulfur; Blood Pressure; Female; Humans; Hypertension; Male; Methionine; Mi | 1985 |
A trial of Ro 4-2137 in the treatment of hypertension.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Synergis | 1972 |