serine has been researched along with Hyperglycemia in 22 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Exposure of L6 myotubes to 25 mmol/L glucose and 100 nmol/L insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/activation of mTOR and p70S6K." | 4.02 | Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance. ( MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F, 2021) |
| "703 patients with type 1 diabetes mellitus from one endocrine department were included in the study." | 1.51 | Protective Effect of the ( Catrina, SB; Chatzidionysiou, K; Ekberg, NR; Eliasson, S; Falhammar, H; Gu, HF; Li, YW; Zheng, X, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Malhi, NK | 1 |
| Allen, CL | 1 |
| Stewart, E | 1 |
| Horton, KL | 1 |
| Riu, F | 1 |
| Batson, J | 1 |
| Amoaku, W | 1 |
| Morris, JC | 1 |
| Arkill, KP | 1 |
| Bates, DO | 1 |
| Woznowski, MP | 1 |
| Potthoff, SA | 1 |
| Königshausen, E | 1 |
| Haase, R | 1 |
| Hoch, H | 1 |
| Meyer-Schwesinger, C | 1 |
| Wiech, T | 1 |
| Stegbauer, J | 1 |
| Rump, LC | 1 |
| Sellin, L | 1 |
| Quack, I | 1 |
| Xia, C | 1 |
| Suriyanarayanan, S | 1 |
| Gong, Y | 1 |
| Fridman, V | 1 |
| Selig, M | 1 |
| Li, J | 1 |
| Rutkove, S | 1 |
| Hornemann, T | 1 |
| Eichler, F | 1 |
| Cho, DH | 1 |
| Shamshoum, H | 1 |
| Vlavcheski, F | 1 |
| MacPherson, REK | 1 |
| Tsiani, E | 1 |
| Okuyama, S | 1 |
| Shinoka, W | 1 |
| Nakamura, K | 1 |
| Kotani, M | 1 |
| Sawamoto, A | 1 |
| Sugawara, K | 1 |
| Sudo, M | 1 |
| Nakajima, M | 1 |
| Furukawa, Y | 1 |
| Suwandhi, L | 1 |
| Hausmann, S | 1 |
| Braun, A | 1 |
| Gruber, T | 1 |
| Heinzmann, SS | 1 |
| Gálvez, EJC | 1 |
| Buck, A | 1 |
| Legutko, B | 1 |
| Israel, A | 1 |
| Feuchtinger, A | 1 |
| Haythorne, E | 1 |
| Staiger, H | 1 |
| Heni, M | 1 |
| Häring, HU | 1 |
| Schmitt-Kopplin, P | 1 |
| Walch, A | 1 |
| Cáceres, CG | 1 |
| Tschöp, MH | 1 |
| Rutter, GA | 1 |
| Strowig, T | 1 |
| Elsner, M | 1 |
| Ussar, S | 1 |
| Ekberg, NR | 1 |
| Eliasson, S | 1 |
| Li, YW | 1 |
| Zheng, X | 1 |
| Chatzidionysiou, K | 1 |
| Falhammar, H | 1 |
| Gu, HF | 1 |
| Catrina, SB | 1 |
| Kobayashi, M | 1 |
| Matsuda, Y | 1 |
| Iwai, H | 1 |
| Hiramitsu, M | 1 |
| Inoue, T | 1 |
| Katagiri, T | 1 |
| Yamashita, Y | 1 |
| Ashida, H | 1 |
| Murai, A | 1 |
| Horio, F | 1 |
| Nasu-Kawaharada, R | 1 |
| Nakamura, A | 1 |
| Kakarla, SK | 1 |
| Blough, ER | 1 |
| Kohama, K | 1 |
| Kohama, T | 1 |
| Katsoulieris, EN | 1 |
| Drossopoulou, GI | 1 |
| Kotsopoulou, ES | 1 |
| Vlahakos, DV | 1 |
| Lianos, EA | 1 |
| Tsilibary, EC | 1 |
| Nystoriak, MA | 1 |
| Nieves-Cintrón, M | 1 |
| Patriarchi, T | 1 |
| Buonarati, OR | 1 |
| Prada, MP | 1 |
| Morotti, S | 1 |
| Grandi, E | 1 |
| Fernandes, JD | 1 |
| Forbush, K | 1 |
| Hofmann, F | 1 |
| Sasse, KC | 1 |
| Scott, JD | 1 |
| Ward, SM | 1 |
| Hell, JW | 1 |
| Navedo, MF | 1 |
| Sung, JH | 1 |
| Koh, PO | 1 |
| Kang, ES | 1 |
| Han, D | 1 |
| Park, J | 1 |
| Kwak, TK | 1 |
| Oh, MA | 1 |
| Lee, SA | 1 |
| Choi, S | 1 |
| Park, ZY | 1 |
| Kim, Y | 1 |
| Lee, JW | 1 |
| Park, SY | 1 |
| Kim, HS | 1 |
| Kim, NH | 1 |
| Ji, S | 1 |
| Cha, SY | 1 |
| Kang, JG | 1 |
| Ota, I | 1 |
| Shimada, K | 1 |
| Konishi, N | 1 |
| Nam, HW | 1 |
| Hong, SW | 1 |
| Yang, WH | 1 |
| Roth, J | 1 |
| Yook, JI | 1 |
| Cho, JW | 1 |
| Vind, BF | 1 |
| Birk, JB | 1 |
| Vienberg, SG | 1 |
| Andersen, B | 1 |
| Beck-Nielsen, H | 1 |
| Wojtaszewski, JF | 1 |
| Højlund, K | 1 |
| Le Bacquer, O | 1 |
| Queniat, G | 1 |
| Gmyr, V | 1 |
| Kerr-Conte, J | 1 |
| Lefebvre, B | 1 |
| Pattou, F | 1 |
| Bhuvaneswari, S | 1 |
| Anuradha, CV | 1 |
| Pillay, TS | 1 |
| Xiao, S | 1 |
| Keranen, L | 1 |
| Olefsky, JM | 1 |
| Oyama, K | 1 |
| Minami, K | 1 |
| Ishizaki, K | 1 |
| Fuse, M | 1 |
| Miki, T | 1 |
| Seino, S | 1 |
| Song, P | 1 |
| Wu, Y | 1 |
| Xu, J | 1 |
| Xie, Z | 1 |
| Dong, Y | 1 |
| Zhang, M | 1 |
| Zou, MH | 1 |
| Li, PA | 1 |
| Shuaib, A | 1 |
| Miyashita, H | 1 |
| He, QP | 1 |
| Siesjö, BK | 1 |
| Warner, DS | 1 |
22 other studies available for serine and Hyperglycemia
| Article | Year |
|---|---|
Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Hyperglycemia; Mac | 2022 |
Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria.
Topics: Albuminuria; Endocytosis; Humans; Hyperglycemia; Membrane Proteins; p38 Mitogen-Activated Protein Ki | 2022 |
Long-term effects of l-serine supplementation upon a mouse model of diabetic neuropathy.
Topics: Animals; Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements; Hyperglycemia; Mice; Serine; | 2023 |
Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Cat | 2019 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models | 2021 |
Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hippocam | 2018 |
Chronic d-serine supplementation impairs insulin secretion.
Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Glucose | 2018 |
Protective Effect of the
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Di | 2019 |
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperg | 2012 |
A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats.
Topics: Animals; Animals, Newborn; Diet, High-Fat; Female; Fish Oils; Hyperglycemia; Hypertriglyceridemia; H | 2013 |
High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach.
Topics: Animals; Apoptosis; Cell Line, Transformed; Forkhead Box Protein O1; Forkhead Box Protein O3; Gene E | 2016 |
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Topics: Acute Disease; Adult; Aged; Animals; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinases; | 2017 |
Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Diabetes Mellitus, Experimental; Diabetic Ne | 2017 |
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.
Topics: Acetylglucosamine; Alloxan; Animals; Apoptosis; Cell Line; Glucosamine; Glucose; Humans; Hyperglycem | 2008 |
Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition.
Topics: Acetylglucosamine; Amino Acid Sequence; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial-Mesen | 2010 |
Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Female; Glucose; Glucose Clamp Technique; Glycogen Synthase; Humans; Hype | 2012 |
mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Carrier Proteins; Cell Line; Humans; | 2013 |
Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice.
Topics: Animals; Antioxidants; Dietary Supplements; Hyperglycemia; Hypoglycemic Agents; Insulin Receptor Sub | 2012 |
Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII.
Topics: Animals; Catalytic Domain; Glucose; Hyperglycemia; Insulin; Isoenzymes; Mice; NIH 3T3 Cells; Peptide | 2004 |
Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice.
Topics: Amino Acid Substitution; Animals; Apoptosis; Blood Glucose; Glucose Tolerance Test; Glycine; Hypergl | 2006 |
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experi | 2007 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |