serine has been researched along with Huntington Disease in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| " These data predict that the ability of cdk5 phosphorylation to protect against htt cleavage, aggregation, and toxicity is compromised in cells expressing toxic fragments of htt." | 1.33 | Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. ( Davies, JE; Luo, S; Rubinsztein, DC; Vacher, C, 2005) |
| "Here we demonstrate in precise genetic Huntington's disease mouse and striatal cell models that these early phenotypes are associated with activation of the Akt pro-survival signaling pathway." | 1.32 | Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. ( Gines, S; Ivanova, E; MacDonald, ME; Saura, CA; Seong, IS, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cariulo, C | 1 |
| Martufi, P | 1 |
| Verani, M | 1 |
| Toledo-Sherman, L | 1 |
| Lee, R | 1 |
| Dominguez, C | 1 |
| Petricca, L | 1 |
| Caricasole, A | 1 |
| Petrozziello, T | 1 |
| Huntress, SS | 1 |
| Castillo-Torres, AL | 1 |
| Quinn, JP | 1 |
| Connors, TR | 1 |
| Auger, CA | 1 |
| Mills, AN | 1 |
| Kim, SE | 1 |
| Liu, S | 1 |
| Mahmood, F | 1 |
| Boudi, A | 1 |
| Wu, M | 1 |
| Sapp, E | 1 |
| Kivisäkk, P | 1 |
| Sunderesh, SR | 1 |
| Pouladi, MA | 1 |
| Arnold, SE | 1 |
| Hyman, BT | 1 |
| Rosas, HD | 1 |
| DiFiglia, M | 1 |
| Mouro Pinto, R | 1 |
| Kegel-Gleason, K | 1 |
| Sadri-Vakili, G | 1 |
| Watkin, EE | 1 |
| Arbez, N | 1 |
| Waldron-Roby, E | 1 |
| O'Meally, R | 1 |
| Ratovitski, T | 1 |
| Cole, RN | 1 |
| Ross, CA | 2 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 2 |
| Saudou, F | 5 |
| Humbert, S | 5 |
| Yang, XW | 2 |
| Osmand, A | 2 |
| Steffan, JS | 2 |
| Masliah, E | 1 |
| Finkbeiner, S | 2 |
| Zala, D | 1 |
| Colin, E | 3 |
| Rangone, H | 3 |
| Liot, G | 1 |
| Perrin, V | 1 |
| Dufour, N | 1 |
| Raoul, C | 1 |
| Hassig, R | 1 |
| Brouillet, E | 1 |
| Aebischer, P | 2 |
| Luthi-Carter, R | 1 |
| Déglon, N | 2 |
| Xu, EH | 1 |
| Tang, Y | 1 |
| Li, D | 1 |
| Jia, JP | 1 |
| Greiner, ER | 1 |
| Mishra, R | 1 |
| Kodali, R | 1 |
| Thompson, LM | 1 |
| Wetzel, R | 1 |
| Atwal, RS | 1 |
| Desmond, CR | 1 |
| Caron, N | 1 |
| Maiuri, T | 1 |
| Xia, J | 1 |
| Sipione, S | 1 |
| Truant, R | 1 |
| Gines, S | 1 |
| Ivanova, E | 1 |
| Seong, IS | 1 |
| Saura, CA | 1 |
| MacDonald, ME | 2 |
| Poizat, G | 1 |
| Troncoso, J | 1 |
| Pardo, R | 2 |
| Girault, JA | 1 |
| Luo, S | 1 |
| Vacher, C | 1 |
| Davies, JE | 1 |
| Rubinsztein, DC | 1 |
| Régulier, E | 1 |
| Bonilla, E | 1 |
| Prasad, AL | 1 |
| Arrieta, A | 1 |
15 other studies available for serine and Huntington Disease
| Article | Year |
|---|---|
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway.
Topics: Humans; Huntington Disease; I-kappa B Kinase; Phosphorylation; Serine | 2023 |
Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.
Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Phosphorylation | 2023 |
Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.
Topics: Amino Acid Sequence; Animals; Cell Death; Cells, Cultured; HEK293 Cells; Humans; Huntingtin Protein; | 2014 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
Topics: Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cell Line; Cells, Cultured; Genetic Ve | 2008 |
Implication of the JNK pathway in a rat model of Huntington's disease.
Topics: Analysis of Variance; Animals; Cell Line, Transformed; CREB-Binding Protein; Disease Models, Animal; | 2009 |
Polymorphism of HD and UCHL-1 genes in Huntington's disease.
Topics: Adult; Age of Onset; Aged; Alleles; Chi-Square Distribution; Family Health; Female; Gene Frequency; | 2009 |
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode | 2009 |
Kinase inhibitors modulate huntingtin cell localization and toxicity.
Topics: Animals; Blotting, Western; Casein Kinase II; Cell Line; Cell Nucleus; Cell Survival; Disease Models | 2011 |
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.
Topics: Alleles; Animals; beta Catenin; Cell Membrane; Cells, Cultured; Chromones; Corpus Striatum; Cyclin D | 2003 |
The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
Topics: Animals; Brain; Cell Line; Cells, Cultured; Female; Humans; Huntingtin Protein; Huntington Disease; | 2004 |
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Line; COS Cells; Electropho | 2005 |
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
Topics: Amino Acid Sequence; Animals; Brain; Caspases; Cell Death; Cell Membrane; Cyclin-Dependent Kinase 5; | 2005 |
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
Topics: Animals; Brain; Calcineurin; Calcineurin Inhibitors; Female; Humans; Huntingtin Protein; Huntington | 2006 |
Huntington's disease: studies on brain free amino acids.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; | 1988 |