Page last updated: 2024-11-08

serine and Hemophilia B

serine has been researched along with Hemophilia B in 4 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)

Research Excerpts

ExcerptRelevanceReference
"The mild form of haemophilia B has been known to be underdiagnosed due to mild clinical symptoms and minimally prolonged activated partial thromboplastin time."1.39Mild haemophilia B from a novel missense mutation Ser350Ala of the F9 gene. ( Kim, HJ; Kim, SH; Koo, HH; Park, CH; Seo, JY, 2013)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Liu, G1
Sun, J1
Li, Z1
Chen, Z1
Wu, W1
Wu, R1
Park, CH1
Seo, JY1
Kim, SH1
Koo, HH1
Kim, HJ1
Jayandharan, G1
Shaji, RV1
Nair, SC1
Chandy, M1
Srivastava, A1
Wolf, DL1
Lin, PH1
Hollenbach, S1
Wong, A1
Phillips, DR1
Sinha, U1

Other Studies

4 other studies available for serine and Hemophilia B

ArticleYear
F9 mutations causing deletions beyond the serine protease domain confer higher risk for inhibitor development in hemophilia B.
    Blood, 2023, 02-09, Volume: 141, Issue:6

    Topics: Factor IX; Hemophilia B; Humans; Mutation; Serine; Serine Endopeptidases; Serine Proteases

2023
Mild haemophilia B from a novel missense mutation Ser350Ala of the F9 gene.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:5

    Topics: Alanine; Amino Acid Sequence; Child, Preschool; Factor IX; Female; Hemizygote; Hemophilia B; Heteroz

2013
Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val).
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:4

    Topics: Child; Codon; DNA Primers; Exons; Factor IX; Factor XI; Factor XI Deficiency; Female; Genotype; Hemo

2005
Procoagulant activity of reversibly acylated human factor Xa.
    Blood, 1995, Dec-01, Volume: 86, Issue:11

    Topics: Acylation; Animals; Binding Sites; Blood Coagulation; Factor Va; Factor Xa; Hemophilia A; Hemophilia

1995