serine has been researched along with Hemophilia B in 4 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mild form of haemophilia B has been known to be underdiagnosed due to mild clinical symptoms and minimally prolonged activated partial thromboplastin time." | 1.39 | Mild haemophilia B from a novel missense mutation Ser350Ala of the F9 gene. ( Kim, HJ; Kim, SH; Koo, HH; Park, CH; Seo, JY, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, G | 1 |
| Sun, J | 1 |
| Li, Z | 1 |
| Chen, Z | 1 |
| Wu, W | 1 |
| Wu, R | 1 |
| Park, CH | 1 |
| Seo, JY | 1 |
| Kim, SH | 1 |
| Koo, HH | 1 |
| Kim, HJ | 1 |
| Jayandharan, G | 1 |
| Shaji, RV | 1 |
| Nair, SC | 1 |
| Chandy, M | 1 |
| Srivastava, A | 1 |
| Wolf, DL | 1 |
| Lin, PH | 1 |
| Hollenbach, S | 1 |
| Wong, A | 1 |
| Phillips, DR | 1 |
| Sinha, U | 1 |
4 other studies available for serine and Hemophilia B
| Article | Year |
|---|---|
F9 mutations causing deletions beyond the serine protease domain confer higher risk for inhibitor development in hemophilia B.
Topics: Factor IX; Hemophilia B; Humans; Mutation; Serine; Serine Endopeptidases; Serine Proteases | 2023 |
Mild haemophilia B from a novel missense mutation Ser350Ala of the F9 gene.
Topics: Alanine; Amino Acid Sequence; Child, Preschool; Factor IX; Female; Hemizygote; Hemophilia B; Heteroz | 2013 |
Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val).
Topics: Child; Codon; DNA Primers; Exons; Factor IX; Factor XI; Factor XI Deficiency; Female; Genotype; Hemo | 2005 |
Procoagulant activity of reversibly acylated human factor Xa.
Topics: Acylation; Animals; Binding Sites; Blood Coagulation; Factor Va; Factor Xa; Hemophilia A; Hemophilia | 1995 |