serine and Glycosuria
serine has been researched along with Glycosuria in 6 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of D-serine to rats induced acute necrosis of the proximal straight tubules, proteinuria, glucosuria, and aminoaciduria." | 7.65 | D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. ( Carone, FA; Ganote, CE, 1975) |
| "Administration of D-serine to rats induced acute necrosis of the proximal straight tubules, proteinuria, glucosuria, and aminoaciduria." | 3.65 | D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. ( Carone, FA; Ganote, CE, 1975) |
| " Alderely Park (Wistar-derived) rats were dosed with either D-serine (250 mg/kg ip) or vehicle (deionised water) and urine was collected at 0-12, 12-24, 24-36 and 36-48 h post-dosing." | 1.33 | D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach. ( Lenz, EM; Lock, EA; Major, H; Williams, RE; Wilson, ID, 2005) |
| "In maleic acid-treated rats the site and extent of tubular necrosis and the nature of urinary loss of solutes were studied." | 1.27 | Urinary loss of glucose, phosphate, and protein by diffusion into proximal straight tubules injured by D-serine and maleic acid. ( Carone, FA; Goldman, B; Nakamura, S, 1985) |
| "In similarly treated rats, proteinuria and glucosuria developed at the onset of tubular necrosis and disappeared when the tubules were completely relined by epithelium suggesting that they are due to diffusion of protein and glucose from interstitium into tubular fluid across the denuded basement membranes and that epithelial cells, under normal conditions, act as a barrier to diffusion of certain substances between the interstitium and tubular fluid." | 1.25 | The nature of D-serine--induced nephrotoxicity. ( Carone, FA; Ganote, CE; Peterson, DR, 1974) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Williams, RE | 1 |
| Major, H | 1 |
| Lock, EA | 1 |
| Lenz, EM | 1 |
| Wilson, ID | 1 |
| Maekawa, M | 1 |
| Okamura, T | 1 |
| Kasai, N | 1 |
| Hori, Y | 1 |
| Summer, KH | 1 |
| Konno, R | 1 |
| Krug, AW | 1 |
| Völker, K | 1 |
| Dantzler, WH | 1 |
| Silbernagl, S | 1 |
| Carone, FA | 3 |
| Ganote, CE | 2 |
| Nakamura, S | 1 |
| Goldman, B | 1 |
| Peterson, DR | 1 |
Other Studies
6 other studies available for serine and Glycosuria
| Article | Year |
|---|---|
D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.
Topics: Animals; Chromatography, High Pressure Liquid; Glycosuria; Kidney; Kidney Tubular Necrosis, Acute; M | 2005 |
D-amino-acid oxidase is involved in D-serine-induced nephrotoxicity.
Topics: Alkynes; Animals; D-Amino-Acid Oxidase; Glycine; Glycosuria; Kidney; Male; Rats; Rats, Inbred F344; | 2005 |
Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective?
Topics: Amino Acids; Aminoisobutyric Acids; Animals; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; | 2007 |
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis.
Topics: Acute Kidney Injury; Animals; Glycosuria; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Pota | 1975 |
Urinary loss of glucose, phosphate, and protein by diffusion into proximal straight tubules injured by D-serine and maleic acid.
Topics: Acute Kidney Injury; Animals; Carbon Radioisotopes; Glomerular Filtration Rate; Glucose; Glycosuria; | 1985 |
The nature of D-serine--induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Cytoplasm; Diffusion; Epithelial Cells; Epithelium; Glycosuria; Kidney | 1974 |