serine has been researched along with Folic Acid Deficiency in 31 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental hepatoma of the rats was induced by chronic administration of 3'-methyl-dimethylamino-azobenzene." | 1.26 | The role of folate deficiency in electrophysiological neuropathy of experimental hepatoma of the rats. ( Chiba, S; Kikuchi, S; Matsumoto, H; Wada, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (80.65) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrow, GP | 1 |
| MacMillan, L | 1 |
| Lamarre, SG | 1 |
| Young, SK | 1 |
| MacFarlane, AJ | 1 |
| Brosnan, ME | 1 |
| Brosnan, JT | 1 |
| Sontag, JM | 1 |
| Nunbhakdi-Craig, V | 1 |
| Montgomery, L | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Sontag, E | 1 |
| Knock, E | 1 |
| Deng, L | 1 |
| Krupenko, N | 1 |
| Mohan, RD | 1 |
| Wu, Q | 1 |
| Leclerc, D | 1 |
| Gupta, S | 1 |
| Elmore, CL | 1 |
| Kruger, W | 1 |
| Tini, M | 1 |
| Rozen, R | 1 |
| DOCTOR, VM | 1 |
| PATTON, TL | 1 |
| AWAPARA, J | 1 |
| FATTERPAKER, P | 1 |
| SREENIVASAN, A | 1 |
| ARNSTEIN, HR | 1 |
| Townsend, JH | 1 |
| Davis, SR | 2 |
| Mackey, AD | 1 |
| Gregory, JF | 3 |
| Quinlivan, EP | 1 |
| Shelnutt, KP | 1 |
| Ghandour, H | 1 |
| Capdevila, A | 1 |
| Coats, BS | 1 |
| Wagner, C | 1 |
| Shane, B | 2 |
| Selhub, J | 1 |
| Bailey, LB | 1 |
| Shuster, JJ | 1 |
| Stacpoole, PW | 2 |
| Matsumoto, H | 1 |
| Chiba, S | 1 |
| Kikuchi, S | 1 |
| Wada, T | 1 |
| Cuskelly, GJ | 1 |
| Williamson, J | 1 |
| Baumgartner, TG | 1 |
| Tikerpae, J | 1 |
| Chanarin, I | 2 |
| Anderson, R | 1 |
| Jackson, N | 1 |
| Vidal, AJ | 1 |
| Stokstad, EL | 2 |
| Robertson, JS | 1 |
| Hsia, YE | 1 |
| Scully, KJ | 1 |
| Featherston, WR | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Muir, M | 1 |
| Perry, J | 1 |
| Battesti, JP | 1 |
| Thuillier, A | 1 |
| Ellegaard, J | 5 |
| Esmann, V | 5 |
| Poirier, LA | 1 |
| Rabbani, A | 1 |
| Akrabawi, S | 1 |
| Daghir, NJ | 1 |
| Narisawa, K | 1 |
| Honda, Y | 1 |
| Arakawa, T | 1 |
| Tippett, P | 1 |
| Danks, DM | 1 |
| Waxman, S | 2 |
| Corcino, JJ | 1 |
| Herbert, V | 2 |
| Corcino, J | 1 |
| DeGrazia, JA | 1 |
| Fish, MB | 1 |
| Pollycove, M | 1 |
| Wallerstein, RO | 1 |
| Hollander, L | 1 |
| Henriksen, L | 1 |
| Landi, L | 1 |
| Pasquali, P | 1 |
| Marchetti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029] | 51 participants (Actual) | Observational | 2011-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for serine and Folic Acid Deficiency
| Article | Year |
|---|---|
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N | 1985 |
Vitamin B12-folate interrelationships.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Bone Marrow; Folic | 1985 |
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.
Topics: Amino Acids; Anemia, Macrocytic; Contraceptives, Oral; Diet; DNA; Ethanol; Folic Acid; Folic Acid An | 1970 |
Aggravation or initiation of megaloblastosis by amino acids in the diet.
Topics: Amino Acids; Anemia, Pernicious; Cell Nucleus; Diet; DNA; Erythrocytes; Folic Acid; Folic Acid Defic | 1970 |
1 trial available for serine and Folic Acid Deficiency
| Article | Year |
|---|---|
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics.
Topics: Adult; Amino Acids; Diet; Folic Acid Deficiency; Homocysteine; Humans; Leucine; Male; Methionine; Me | 2001 |
26 other studies available for serine and Folic Acid Deficiency
| Article | Year |
|---|---|
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.
Topics: Animals; Choline; Dimethylglycine Dehydrogenase; Folic Acid; Folic Acid Deficiency; Formaldehyde; Fo | 2015 |
Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Cell Death; Cell Line, Transformed; Down-Regulation; Fo | 2008 |
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
Topics: Aminohydrolases; Animals; Colorectal Neoplasms; Diet; DNA Methylation; DNA Polymerase beta; DNA Repa | 2011 |
Incorporation of serine-3-C14 and formaldehyde-C14 into methionine in vitro. I. Role of folic acid.
Topics: Biochemical Phenomena; Folic Acid; Folic Acid Deficiency; Formaldehyde; Humans; In Vitro Techniques; | 1957 |
Influence of dietary glycine and serine on lipid metabolism in the rat in folic acid deficiency.
Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; Glycine; Lipid Metabolism; Lipids; Nutrition Asses | 1960 |
Biosynthesis of glycine and serine in normal and folic acid-deficient rats.
Topics: Animals; Fabaceae; Folic Acid; Folic Acid Deficiency; Glycine; Rats; Serine | 1955 |
Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation.
Topics: Amino Acids; Caco-2 Cells; Culture Media; Epithelial Cells; Folic Acid Deficiency; Homocysteine; Hum | 2004 |
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
Topics: Adult; Amino Acids; Female; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; | 2005 |
The role of folate deficiency in electrophysiological neuropathy of experimental hepatoma of the rats.
Topics: Animals; Folic Acid Deficiency; Glycine; Liver Neoplasms, Experimental; Male; Neural Conduction; Per | 1981 |
Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of therapy.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Folic Acid Deficiency; Fo | 1978 |
A study on the effect of folate deficiency on the incorporation of 14-C labelled glycine, serine and leucine into the oviduct protein of the oestrogen-treated, immature female domestic fowl.
Topics: Animals; Chickens; Estradiol; Female; Folic Acid; Folic Acid Deficiency; Glycine; Leucine; Organ Siz | 1975 |
The effect of methionine on the metabolism of serine and glycine in vitamin B-12-deficient rats.
Topics: Animals; Folic Acid Deficiency; Glycine; Liver; Male; Methionine; Perfusion; Rats; Serine; Vitamin B | 1975 |
Defective leukocyte metabolism in human cobalamin deficiency: impaired propionate oxidation and serine biosynthesis reversible by cyanocobalamin therapy.
Topics: Adult; Aged; Anemia, Pernicious; Female; Folic Acid; Folic Acid Deficiency; Humans; Leukocyte Count; | 1976 |
Glycine-serine interrelations in the chick.
Topics: Animals; Chickens; Folic Acid Deficiency; Glycine; Liver; Nutritional Requirements; Serine; Uric Aci | 1976 |
[Folic acid deficiencies. Etiology and biological diagnosis].
Topics: Alcoholic Intoxication; Anticonvulsants; Antimetabolites; Celiac Disease; Chromatography; Enterococc | 1968 |
A sensitive test for folic-acid deficiency.
Topics: Carbon Isotopes; Folic Acid Deficiency; Formates; Humans; Lymphocytes; Methods; Serine | 1970 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic | 1973 |
Folate activity of human lymphocytes determined by measurement of serine synthesis.
Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Folic Acid; Folic Ac | 1973 |
Folated deficiency in pernicious anemia measured by determination of decreased serine synthesis in lymphocytes.
Topics: Adolescent; Adult; Aged; Anemia, Pernicious; Blood Proteins; Carbon Isotopes; Female; Folic Acid; Fo | 1973 |
Effect of dietary folic acid deficiency on serine-glycine interconversion and the activity of liver serine hydroxymethyl transferase in the chick.
Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Folic Acid; Folic Acid Deficiency; Glycine; In Vi | 1973 |
Effect of diphenylhydantoin administration on single carbon metabolism in folate deficient rats.
Topics: Acrylates; Animals; Azo Compounds; Carbon; Carbon Dioxide; Carbon Radioisotopes; Folic Acid Deficien | 1973 |
The clinical and biochemical findings in three cases of hypersarcosinemia and one case of transient hypersarcosinuria associated with folic acid deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anemia, Macrocytic; Electrophoresis; Female; Folic | 1974 |
The oxidation of the beta carbon of serine in human folate and vitamin B 12 deficiency.
Topics: Anemia, Macrocytic; Carbon; Carbon Dioxide; Carbon Isotopes; Diet; Erythrocyte Count; Folic Acid; Fo | 1972 |
Deficient folate activity during treatment of psoriasis with methotrexate diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Carbon Isotopes; Female; Folic Acid Deficiency; Formates; Humans; In Vitro Techniques; | 1972 |
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficie | 1972 |
Folic acid and biotin on the metabolism of 1 carbon unit: utilization of beta-carbon of serine for the synthesis of methionine.
Topics: Animals; Biotin; Folic Acid Deficiency; Homocysteine; In Vitro Techniques; Liver; Methionine; Rats; | 1966 |