Page last updated: 2024-11-08

serine and Folic Acid Deficiency

serine has been researched along with Folic Acid Deficiency in 31 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research Excerpts

ExcerptRelevanceReference
"Experimental hepatoma of the rats was induced by chronic administration of 3'-methyl-dimethylamino-azobenzene."1.26The role of folate deficiency in electrophysiological neuropathy of experimental hepatoma of the rats. ( Chiba, S; Kikuchi, S; Matsumoto, H; Wada, T, 1981)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199025 (80.65)18.7374
1990's0 (0.00)18.2507
2000's4 (12.90)29.6817
2010's2 (6.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morrow, GP1
MacMillan, L1
Lamarre, SG1
Young, SK1
MacFarlane, AJ1
Brosnan, ME1
Brosnan, JT1
Sontag, JM1
Nunbhakdi-Craig, V1
Montgomery, L1
Arning, E1
Bottiglieri, T1
Sontag, E1
Knock, E1
Deng, L1
Krupenko, N1
Mohan, RD1
Wu, Q1
Leclerc, D1
Gupta, S1
Elmore, CL1
Kruger, W1
Tini, M1
Rozen, R1
DOCTOR, VM1
PATTON, TL1
AWAPARA, J1
FATTERPAKER, P1
SREENIVASAN, A1
ARNSTEIN, HR1
Townsend, JH1
Davis, SR2
Mackey, AD1
Gregory, JF3
Quinlivan, EP1
Shelnutt, KP1
Ghandour, H1
Capdevila, A1
Coats, BS1
Wagner, C1
Shane, B2
Selhub, J1
Bailey, LB1
Shuster, JJ1
Stacpoole, PW2
Matsumoto, H1
Chiba, S1
Kikuchi, S1
Wada, T1
Cuskelly, GJ1
Williamson, J1
Baumgartner, TG1
Tikerpae, J1
Chanarin, I2
Anderson, R1
Jackson, N1
Vidal, AJ1
Stokstad, EL2
Robertson, JS1
Hsia, YE1
Scully, KJ1
Featherston, WR1
Deacon, R1
Lumb, M1
Muir, M1
Perry, J1
Battesti, JP1
Thuillier, A1
Ellegaard, J5
Esmann, V5
Poirier, LA1
Rabbani, A1
Akrabawi, S1
Daghir, NJ1
Narisawa, K1
Honda, Y1
Arakawa, T1
Tippett, P1
Danks, DM1
Waxman, S2
Corcino, JJ1
Herbert, V2
Corcino, J1
DeGrazia, JA1
Fish, MB1
Pollycove, M1
Wallerstein, RO1
Hollander, L1
Henriksen, L1
Landi, L1
Pasquali, P1
Marchetti, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029]51 participants (Actual)Observational2011-12-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for serine and Folic Acid Deficiency

ArticleYear
Cobalamin-folate interrelations: a critical review.
    Blood, 1985, Volume: 66, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N

1985
Vitamin B12-folate interrelationships.
    Annual review of nutrition, 1985, Volume: 5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Bone Marrow; Folic

1985
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.
    The American journal of medicine, 1970, Volume: 48, Issue:5

    Topics: Amino Acids; Anemia, Macrocytic; Contraceptives, Oral; Diet; DNA; Ethanol; Folic Acid; Folic Acid An

1970
Aggravation or initiation of megaloblastosis by amino acids in the diet.
    JAMA, 1970, Oct-05, Volume: 214, Issue:1

    Topics: Amino Acids; Anemia, Pernicious; Cell Nucleus; Diet; DNA; Erythrocytes; Folic Acid; Folic Acid Defic

1970

Trials

1 trial available for serine and Folic Acid Deficiency

ArticleYear
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics.
    American journal of physiology. Endocrinology and metabolism, 2001, Volume: 281, Issue:6

    Topics: Adult; Amino Acids; Diet; Folic Acid Deficiency; Homocysteine; Humans; Leucine; Male; Methionine; Me

2001

Other Studies

26 other studies available for serine and Folic Acid Deficiency

ArticleYear
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.
    The Journal of biological chemistry, 2015, Jan-23, Volume: 290, Issue:4

    Topics: Animals; Choline; Dimethylglycine Dehydrogenase; Folic Acid; Folic Acid Deficiency; Formaldehyde; Fo

2015
Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-05, Volume: 28, Issue:45

    Topics: Animals; Brain; Carboxylic Ester Hydrolases; Cell Death; Cell Line, Transformed; Down-Regulation; Fo

2008
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
    The Journal of nutritional biochemistry, 2011, Volume: 22, Issue:11

    Topics: Aminohydrolases; Animals; Colorectal Neoplasms; Diet; DNA Methylation; DNA Polymerase beta; DNA Repa

2011
Incorporation of serine-3-C14 and formaldehyde-C14 into methionine in vitro. I. Role of folic acid.
    Archives of biochemistry and biophysics, 1957, Volume: 67, Issue:2

    Topics: Biochemical Phenomena; Folic Acid; Folic Acid Deficiency; Formaldehyde; Humans; In Vitro Techniques;

1957
Influence of dietary glycine and serine on lipid metabolism in the rat in folic acid deficiency.
    The Indian journal of medical research, 1960, Volume: 48

    Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; Glycine; Lipid Metabolism; Lipids; Nutrition Asses

1960
Biosynthesis of glycine and serine in normal and folic acid-deficient rats.
    The Biochemical journal, 1955, Mar-19, Volume: 60, Issue:Annual Gen

    Topics: Animals; Fabaceae; Folic Acid; Folic Acid Deficiency; Glycine; Rats; Serine

1955
Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:4

    Topics: Amino Acids; Caco-2 Cells; Culture Media; Epithelial Cells; Folic Acid Deficiency; Homocysteine; Hum

2004
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
    The Journal of nutrition, 2005, Volume: 135, Issue:5

    Topics: Adult; Amino Acids; Female; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry;

2005
The role of folate deficiency in electrophysiological neuropathy of experimental hepatoma of the rats.
    Acta neurologica Scandinavica, 1981, Volume: 64, Issue:6

    Topics: Animals; Folic Acid Deficiency; Glycine; Liver Neoplasms, Experimental; Male; Neural Conduction; Per

1981
Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of therapy.
    British journal of haematology, 1978, Volume: 38, Issue:3

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Folic Acid Deficiency; Fo

1978
A study on the effect of folate deficiency on the incorporation of 14-C labelled glycine, serine and leucine into the oviduct protein of the oestrogen-treated, immature female domestic fowl.
    The International journal of biochemistry, 1975, Volume: 6, Issue:1

    Topics: Animals; Chickens; Estradiol; Female; Folic Acid; Folic Acid Deficiency; Glycine; Leucine; Organ Siz

1975
The effect of methionine on the metabolism of serine and glycine in vitamin B-12-deficient rats.
    Biochimica et biophysica acta, 1975, Aug-13, Volume: 399, Issue:2

    Topics: Animals; Folic Acid Deficiency; Glycine; Liver; Male; Methionine; Perfusion; Rats; Serine; Vitamin B

1975
Defective leukocyte metabolism in human cobalamin deficiency: impaired propionate oxidation and serine biosynthesis reversible by cyanocobalamin therapy.
    The Journal of laboratory and clinical medicine, 1976, Volume: 87, Issue:1

    Topics: Adult; Aged; Anemia, Pernicious; Female; Folic Acid; Folic Acid Deficiency; Humans; Leukocyte Count;

1976
Glycine-serine interrelations in the chick.
    Federation proceedings, 1976, Volume: 35, Issue:8

    Topics: Animals; Chickens; Folic Acid Deficiency; Glycine; Liver; Nutritional Requirements; Serine; Uric Aci

1976
[Folic acid deficiencies. Etiology and biological diagnosis].
    La Presse medicale, 1968, Nov-30, Volume: 76, Issue:47

    Topics: Alcoholic Intoxication; Anticonvulsants; Antimetabolites; Celiac Disease; Chromatography; Enterococc

1968
A sensitive test for folic-acid deficiency.
    Lancet (London, England), 1970, Feb-07, Volume: 1, Issue:7641

    Topics: Carbon Isotopes; Folic Acid Deficiency; Formates; Humans; Lymphocytes; Methods; Serine

1970
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
    Cancer research, 1973, Volume: 33, Issue:9

    Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic

1973
Folate activity of human lymphocytes determined by measurement of serine synthesis.
    Scandinavian journal of clinical and laboratory investigation, 1973, Volume: 31, Issue:1

    Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Folic Acid; Folic Ac

1973
Folated deficiency in pernicious anemia measured by determination of decreased serine synthesis in lymphocytes.
    British journal of haematology, 1973, Volume: 24, Issue:5

    Topics: Adolescent; Adult; Aged; Anemia, Pernicious; Blood Proteins; Carbon Isotopes; Female; Folic Acid; Fo

1973
Effect of dietary folic acid deficiency on serine-glycine interconversion and the activity of liver serine hydroxymethyl transferase in the chick.
    Poultry science, 1973, Volume: 52, Issue:5

    Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Folic Acid; Folic Acid Deficiency; Glycine; In Vi

1973
Effect of diphenylhydantoin administration on single carbon metabolism in folate deficient rats.
    The Tohoku journal of experimental medicine, 1973, Volume: 110, Issue:4

    Topics: Acrylates; Animals; Azo Compounds; Carbon; Carbon Dioxide; Carbon Radioisotopes; Folic Acid Deficien

1973
The clinical and biochemical findings in three cases of hypersarcosinemia and one case of transient hypersarcosinuria associated with folic acid deficiency.
    Helvetica paediatrica acta, 1974, Volume: 29, Issue:3

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anemia, Macrocytic; Electrophoresis; Female; Folic

1974
The oxidation of the beta carbon of serine in human folate and vitamin B 12 deficiency.
    The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:3

    Topics: Anemia, Macrocytic; Carbon; Carbon Dioxide; Carbon Isotopes; Diet; Erythrocyte Count; Folic Acid; Fo

1972
Deficient folate activity during treatment of psoriasis with methotrexate diagnosed by determination of serine synthesis in lymphocytes.
    The British journal of dermatology, 1972, Volume: 87, Issue:3

    Topics: Adult; Aged; Carbon Isotopes; Female; Folic Acid Deficiency; Formates; Humans; In Vitro Techniques;

1972
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
    European journal of clinical investigation, 1972, Volume: 2, Issue:5

    Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficie

1972
Folic acid and biotin on the metabolism of 1 carbon unit: utilization of beta-carbon of serine for the synthesis of methionine.
    Experientia, 1966, Jun-15, Volume: 22, Issue:6

    Topics: Animals; Biotin; Folic Acid Deficiency; Homocysteine; In Vitro Techniques; Liver; Methionine; Rats;

1966