Page last updated: 2024-11-08

serine and Fetal Growth Retardation

serine has been researched along with Fetal Growth Retardation in 15 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Fetal Growth Retardation: Failure of a FETUS to attain expected GROWTH.

Research Excerpts

ExcerptRelevanceReference
" Uteroplacental insufficiency significantly decreased serine-15-phosphorylated (serine-15P) p53, an active form of p53, in IUGR rat lung."7.74Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. ( Albertine, KH; Barnes, V; Callaway, CW; Dahl, MJ; Lane, RH; McIntyre, TM; McKnight, RA; O'Brien, EA; Sun, JC; Wang, L; Wang, Z; Wint, A; Yu, X; Zhao, L, 2007)
"A woman with ichthyosis, contractures, and progressive neuropathy represents the first case of phosphoserine aminotransferase deficiency diagnosed and treated in an adult."4.02Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy. ( Brown, LH; Cowen, EW; Debs, S; Ferreira, CR; Gahl, WA; Groden, C; Kim, HJ; King, KA; King, MC; Lehky, T; Macnamara, E; Merideth, M; Owen, CM; Soldatos, A; Toro, C, 2021)
"Serine biosynthesis defects can present in a broad phenotypic spectrum ranging from Neu-Laxova syndrome, a lethal disease with multiple congenital anomalies at the severe end, to an infantile disease with severe psychomotor retardation and seizures as an intermediate phenotype, to a childhood disease with intellectual disability at the mild end."3.85Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges. ( Benke, PJ; Braffman, BH; El-Hattab, AW; Gassen, KLIV; Hidalgo, RJ; Jans, J; Sunbul, R, 2017)
" Uteroplacental insufficiency significantly decreased serine-15-phosphorylated (serine-15P) p53, an active form of p53, in IUGR rat lung."3.74Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. ( Albertine, KH; Barnes, V; Callaway, CW; Dahl, MJ; Lane, RH; McIntyre, TM; McKnight, RA; O'Brien, EA; Sun, JC; Wang, L; Wang, Z; Wint, A; Yu, X; Zhao, L, 2007)
"During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained, yet fetal glucose and amino acid supply is decreased and fetal lactate concentrations are increased."1.91Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. ( Brown, LD; Julian, CG; Kyllo, HM; Lorca, RA; Moore, LG; Rozance, PJ; Wang, D; Wesolowski, SR; Wilkening, RB, 2023)
"Phosphorylation enhances IGFBP-1 binding to IGF-I, thereby limiting the bioavailability of IGF-I that may be important in fetal growth."1.36Site-specific IGFBP-1 hyper-phosphorylation in fetal growth restriction: clinical and functional relevance. ( Abu Shehab, M; Gupta, MB; Han, VK; Khosravi, J; Shilton, BH, 2010)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (13.33)29.6817
2010's7 (46.67)24.3611
2020's6 (40.00)2.80

Authors

AuthorsStudies
Huang, C1
Wu, D1
Zhang, K1
Khan, FA1
Pandupuspitasari, NS1
Wang, Y1
Huo, L1
Sun, F1
Kyllo, HM1
Wang, D1
Lorca, RA1
Julian, CG1
Moore, LG1
Wilkening, RB1
Rozance, PJ1
Brown, LD1
Wesolowski, SR1
Cuinat, S1
Quélin, C1
Pasquier, L1
Loget, P1
Aussel, D1
Odent, S1
Laquerrière, A1
Proisy, M1
Mazoyer, S1
Delous, M1
Edery, P1
Chatron, N1
Lesca, G1
Putoux, A1
Sirr, A1
Lo, RS1
Cromie, GA1
Scott, AC1
Ashmead, J1
Heyesus, M1
Dudley, AM1
Abdelfattah, F1
Kariminejad, A2
Kahlert, AK1
Morrison, PJ1
Gumus, E1
Mathews, KD1
Darbro, BW1
Amor, DJ1
Walsh, M1
Sznajer, Y1
Weiß, L1
Weidensee, S1
Chitayat, D1
Shannon, P1
Bermejo-Sánchez, E1
Riaño-Galán, I1
Hayes, I1
Poke, G1
Rooryck, C1
Pennamen, P1
Khung-Savatovsky, S1
Toutain, A1
Vuillaume, ML1
Ghaderi-Sohi, S2
Kariminejad, MH2
Weinert, S1
Sticht, H1
Zenker, M2
Schanze, D2
Debs, S1
Ferreira, CR1
Groden, C1
Kim, HJ1
King, KA1
King, MC1
Lehky, T1
Cowen, EW1
Brown, LH1
Merideth, M1
Owen, CM1
Macnamara, E1
Toro, C1
Gahl, WA1
Soldatos, A1
de Koning, TJ1
Shaheen, R2
Rahbeeni, Z1
Alhashem, A1
Faqeih, E1
Zhao, Q1
Xiong, Y1
Almoisheer, A1
Al-Qattan, SM1
Almadani, HA1
Al-Onazi, N1
Al-Baqawi, BS1
Saleh, MA1
Alkuraya, FS2
Acuna-Hidalgo, R1
Nordgren, A1
Conner, P1
Grigelioniene, G1
Nilsson, D1
Nordenskjöld, M1
Wedell, A1
Freyer, C1
Wredenberg, A1
Wieczorek, D1
Gillessen-Kaesbach, G1
Kayserili, H1
Elcioglu, N1
Goodarzi, P1
Setayesh, H1
van de Vorst, M1
Steehouwer, M1
Pfundt, R1
Krabichler, B1
Curry, C1
MacKenzie, MG1
Boycott, KM1
Gilissen, C1
Janecke, AR1
Hoischen, A1
El-Hattab, AW3
Hertecant, J1
Galadari, HI1
Albaqawi, BS1
Nabil, A1
Benke, PJ1
Hidalgo, RJ1
Braffman, BH1
Jans, J1
Gassen, KLIV1
Sunbul, R1
Abu Shehab, M1
Khosravi, J1
Han, VK1
Shilton, BH1
Gupta, MB1
Baserga, M1
Hale, MA1
McKnight, RA2
Yu, X2
Callaway, CW2
Lane, RH2
O'Brien, EA1
Barnes, V1
Zhao, L1
Wang, L1
Sun, JC1
Dahl, MJ1
Wint, A1
Wang, Z1
McIntyre, TM1
Albertine, KH1

Reviews

2 reviews available for serine and Fetal Growth Retardation

ArticleYear
Amino acid synthesis deficiencies.
    Journal of inherited metabolic disease, 2017, Volume: 40, Issue:4

    Topics: Abnormalities, Multiple; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Asparagine; Bra

2017
Serine biosynthesis and transport defects.
    Molecular genetics and metabolism, 2016, Volume: 118, Issue:3

    Topics: Abnormalities, Multiple; Amino Acid Transport System ASC; Brain Diseases; Child; Fetal Growth Retard

2016

Other Studies

13 other studies available for serine and Fetal Growth Retardation

ArticleYear
Perfluorooctanoic acid alters the developmental trajectory of female germ cells and embryos in rodents and its potential mechanism.
    Ecotoxicology and environmental safety, 2022, May-01, Volume: 236

    Topics: Animals; Caprylates; Female; Fetal Growth Retardation; Fluorocarbons; Germ Cells; Humans; Melatonin;

2022
Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
    American journal of physiology. Endocrinology and metabolism, 2023, 06-01, Volume: 324, Issue:6

    Topics: Amino Acids; AMP-Activated Protein Kinases; Animals; Female; Fetal Growth Retardation; Fetus; Glucos

2023
PHGDH-related microcephalic dwarfism in two fetuses: Expanding the phenotypical spectrum of L-serine biosynthesis defect.
    European journal of medical genetics, 2023, Volume: 66, Issue:11

    Topics: Dwarfism; Female; Fetal Growth Retardation; Fetus; Humans; Microcephaly; Serine

2023
A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1.
    Journal of inherited metabolic disease, 2020, Volume: 43, Issue:4

    Topics: Abnormalities, Multiple; Brain Diseases; Fetal Growth Retardation; Humans; Ichthyosis; Limb Deformit

2020
Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders.
    Human mutation, 2020, Volume: 41, Issue:9

    Topics: Abnormalities, Multiple; Brain Diseases; Female; Fetal Growth Retardation; Fetus; Genetic Associatio

2020
Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy.
    American journal of medical genetics. Part A, 2021, Volume: 185, Issue:7

    Topics: Adult; Child, Preschool; Congenital Abnormalities; Exome Sequencing; Female; Fetal Growth Retardatio

2021
Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH.
    American journal of human genetics, 2014, Jun-05, Volume: 94, Issue:6

    Topics: Abnormalities, Multiple; Alleles; Amino Acid Sequence; Animals; Brain Diseases; Carbohydrate Metabol

2014
Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.
    American journal of human genetics, 2014, Sep-04, Volume: 95, Issue:3

    Topics: Abnormalities, Multiple; Amino Acid Sequence; Brain Diseases; Consanguinity; Family; Female; Fetal G

2014
On the phenotypic spectrum of serine biosynthesis defects.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:3

    Topics: Abnormalities, Multiple; Brain Diseases; Fetal Growth Retardation; Humans; Ichthyosis; Infant; Infan

2016
Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges.
    Journal of child neurology, 2017, Volume: 32, Issue:6

    Topics: Abnormalities, Multiple; Adolescent; Brain Diseases; Carbohydrate Metabolism, Inborn Errors; Child,

2017
Site-specific IGFBP-1 hyper-phosphorylation in fetal growth restriction: clinical and functional relevance.
    Journal of proteome research, 2010, Apr-05, Volume: 9, Issue:4

    Topics: Amniotic Fluid; Biological Availability; Female; Fetal Growth Retardation; Humans; Insulin-Like Grow

2010
Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 289, Issue:5

    Topics: Animals; Chromatin; Corticosterone; Cyclin A; Female; Fetal Growth Retardation; Gene Expression Regu

2005
Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:1

    Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Cycle; Female; Fetal Growth Retardatio

2007
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