serine has been researched along with Fatty Liver, Nonalcoholic in 13 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD)." | 8.12 | Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. ( Hanessian, S; Hocine, S; Kiyeleko, S; Kotschy, A; Kuenemann, M; Mautino, G; Miallau, L; Mirguet, O; Nawrotek, A; Vuillard, LM, 2022) |
| "Although the involvement of chronic overnutrition, systemic inflammation, and insulin resistance in the development of NAFLD is well-established, however, the associations among these remain to be elucidated." | 5.91 | Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation. ( Dehury, B; Dogra, S; Jaswal, K; Mondal, P; Rawat, P; Thakur, S, 2023) |
| "We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD)." | 4.12 | Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. ( Hanessian, S; Hocine, S; Kiyeleko, S; Kotschy, A; Kuenemann, M; Mautino, G; Miallau, L; Mirguet, O; Nawrotek, A; Vuillard, LM, 2022) |
| "Although the involvement of chronic overnutrition, systemic inflammation, and insulin resistance in the development of NAFLD is well-established, however, the associations among these remain to be elucidated." | 1.91 | Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation. ( Dehury, B; Dogra, S; Jaswal, K; Mondal, P; Rawat, P; Thakur, S, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is becoming one of the most common liver diseases worldwide." | 1.72 | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice. ( Araujo, LCC; Carvalho, CRO; Matos, SL; Moreira, GV; Murata, GM, 2022) |
| "NAFLD is regarded unquestionably as one of the components of the metabolic syndrome." | 1.40 | NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids. ( Pirola, CJ; Sookoian, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 9 (69.23) | 2.80 |
| Authors | Studies |
|---|---|
| Kiyeleko, S | 1 |
| Hocine, S | 1 |
| Mautino, G | 1 |
| Kuenemann, M | 1 |
| Nawrotek, A | 1 |
| Miallau, L | 1 |
| Vuillard, LM | 1 |
| Mirguet, O | 1 |
| Kotschy, A | 1 |
| Hanessian, S | 1 |
| Moreira, GV | 1 |
| Araujo, LCC | 1 |
| Murata, GM | 1 |
| Matos, SL | 1 |
| Carvalho, CRO | 1 |
| Su, W | 1 |
| Wu, S | 1 |
| Yang, Y | 1 |
| Guo, Y | 1 |
| Zhang, H | 1 |
| Su, J | 1 |
| Chen, L | 1 |
| Mao, Z | 1 |
| Lan, R | 1 |
| Cao, R | 1 |
| Wang, C | 1 |
| Xu, H | 1 |
| Zhang, C | 4 |
| Li, S | 1 |
| Gao, M | 1 |
| Chen, X | 1 |
| Zheng, Z | 1 |
| Wang, B | 1 |
| Liu, Y | 1 |
| Liu, Z | 1 |
| Wang, Z | 1 |
| Liu, B | 1 |
| Fan, X | 1 |
| Zhang, X | 1 |
| Guan, Y | 1 |
| Rawat, P | 1 |
| Thakur, S | 1 |
| Dogra, S | 1 |
| Jaswal, K | 1 |
| Dehury, B | 1 |
| Mondal, P | 1 |
| Yang, H | 1 |
| Turkez, H | 2 |
| Uhlen, M | 4 |
| Boren, J | 3 |
| Mardinoglu, A | 4 |
| Zhang, Z | 1 |
| TeSlaa, T | 1 |
| Rabinowitz, JD | 1 |
| Sim, WC | 1 |
| Lee, W | 1 |
| Sim, H | 1 |
| Lee, KY | 1 |
| Jung, SH | 1 |
| Choi, YJ | 2 |
| Kim, HY | 1 |
| Kang, KW | 1 |
| Lee, JY | 1 |
| Kim, SK | 1 |
| Jun, DW | 1 |
| Kim, W | 2 |
| Lee, BH | 1 |
| Bjornson, E | 2 |
| Arif, M | 1 |
| Tebani, A | 1 |
| Lovric, A | 1 |
| Benfeitas, R | 1 |
| Ozcan, M | 1 |
| Juszczak, K | 1 |
| Kim, JT | 1 |
| Bidkhori, G | 1 |
| Ståhlman, M | 2 |
| Bergh, PO | 1 |
| Adiels, M | 2 |
| Taskinen, MR | 2 |
| Bosley, J | 1 |
| Marschall, HU | 2 |
| Nielsen, J | 3 |
| Gao, SS | 1 |
| Sun, JJ | 1 |
| Wang, X | 1 |
| Hu, YY | 1 |
| Feng, Q | 1 |
| Gou, XJ | 1 |
| Zhou, X | 1 |
| He, L | 1 |
| Zuo, S | 1 |
| Zhang, Y | 1 |
| Wan, D | 1 |
| Long, C | 1 |
| Huang, P | 1 |
| Wu, X | 1 |
| Wu, C | 1 |
| Liu, G | 1 |
| Yin, Y | 1 |
| Agren, R | 1 |
| Kampf, C | 1 |
| Asplund, A | 1 |
| Sookoian, S | 1 |
| Pirola, CJ | 1 |
| Klevstig, M | 1 |
| Söderlund, S | 1 |
| Hakkarainen, A | 1 |
| Lundbom, N | 1 |
| Kilicarslan, M | 1 |
| Hallström, BM | 1 |
| Lundbom, J | 1 |
| Vergès, B | 1 |
| Barrett, PH | 1 |
| Watts, GF | 1 |
| Serlie, MJ | 1 |
| Smith, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2019-03-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for serine and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.
Topics: Humans; Intracellular Signaling Peptides and Proteins; Molecular Docking Simulation; Non-alcoholic F | 2022 |
Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice.
Topics: Animals; Bile Acids and Salts; Carbohydrates; Citrate (si)-Synthase; Collagen; Diet, High-Fat; Farne | 2022 |
Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Hepatocytes; Liver; Mice; Non-alcoholic Fatty Liver Disea | 2022 |
Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
Topics: Animals; Diet, High-Fat; Inflammation; Insulin Resistance; Lipids; Lipogenesis; Liver; Mice; Mice, I | 2023 |
Revisiting the role of serine metabolism in hepatic lipogenesis.
Topics: Humans; Lipogenesis; Non-alcoholic Fatty Liver Disease; Serine | 2023 |
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis.
Topics: Humans; Lipogenesis; Non-alcoholic Fatty Liver Disease; Serine | 2023 |
Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease.
Topics: Animals; Cells, Cultured; Cohort Studies; Diet, High-Fat; Down-Regulation; Embryo, Mammalian; Female | 2020 |
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Topics: Acetylcysteine; Adult; Animals; Carnitine; Dietary Supplements; Drug Therapy, Combination; Healthy V | 2020 |
Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology.
Topics: Drugs, Chinese Herbal; Gene Ontology; Glycogen Synthase Kinase 3 beta; Humans; Molecular Docking Sim | 2020 |
Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diet, High-Fat; Dietary Fats; Dietary Suppleme | 2018 |
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Biomarkers; Chondroitin; Databases, Genetic; Female; Genome; Glycine Hydrox | 2014 |
NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids.
Topics: Female; Genome; Hepatocytes; Humans; Male; Models, Biological; Models, Genetic; Non-alcoholic Fatty | 2014 |
Personal model-assisted identification of NAD
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Genome; Glutathion | 2017 |