Page last updated: 2024-11-08

serine and Experimental Mammary Neoplasms

serine has been researched along with Experimental Mammary Neoplasms in 16 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, an understanding of the underlying molecular mechanisms would be highly valuable."5.37Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. ( Edgren, H; Guise, T; Käkönen, SM; Kallioniemi, O; Kohonen, P; Nees, M; Pollari, S; Sara, H; Wolf, M, 2011)
" The plasma levels of QLT0267 were determined by LC-MS/MS methods following oral dosing of QLT0267 (200 mg/kg)."1.42Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Ca ( Bally, MB; Dragowska, WH; Kalra, J, 2015)
"Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, an understanding of the underlying molecular mechanisms would be highly valuable."1.37Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. ( Edgren, H; Guise, T; Käkönen, SM; Kallioniemi, O; Kohonen, P; Nees, M; Pollari, S; Sara, H; Wolf, M, 2011)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's1 (6.25)18.2507
2000's1 (6.25)29.6817
2010's5 (31.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Rinaldi, G1
Pranzini, E1
Van Elsen, J1
Broekaert, D1
Funk, CM1
Planque, M1
Doglioni, G1
Altea-Manzano, P1
Rossi, M1
Geldhof, V1
Teoh, ST1
Ross, C1
Hunter, KW1
Lunt, SY1
Grünewald, TGP1
Fendt, SM1
Meiser, J1
Schuster, A1
Pietzke, M1
Vande Voorde, J1
Athineos, D1
Oizel, K1
Burgos-Barragan, G1
Wit, N1
Dhayade, S1
Morton, JP1
Dornier, E1
Sumpton, D1
Mackay, GM1
Blyth, K1
Patel, KJ1
Niclou, SP1
Vazquez, A1
Kalra, J1
Dragowska, WH1
Bally, MB1
Pacold, ME1
Brimacombe, KR1
Chan, SH1
Rohde, JM1
Lewis, CA1
Swier, LJ1
Possemato, R1
Chen, WW1
Sullivan, LB1
Fiske, BP1
Cho, S1
Freinkman, E1
Birsoy, K1
Abu-Remaileh, M1
Shaul, YD1
Liu, CM1
Zhou, M1
Koh, MJ1
Chung, H1
Davidson, SM1
Luengo, A1
Wang, AQ1
Xu, X1
Yasgar, A1
Liu, L1
Rai, G1
Westover, KD1
Vander Heiden, MG1
Shen, M1
Gray, NS1
Boxer, MB1
Sabatini, DM1
Barbash, O1
Zamfirova, P1
Lin, DI1
Chen, X1
Yang, K1
Nakagawa, H1
Lu, F1
Rustgi, AK1
Diehl, JA1
Pollari, S1
Käkönen, SM1
Edgren, H1
Wolf, M1
Kohonen, P1
Sara, H1
Guise, T1
Nees, M1
Kallioniemi, O1
Du, WW1
Yang, BB1
Shatseva, TA1
Yang, BL1
Deng, Z1
Shan, SW1
Lee, DY1
Seth, A1
Yee, AJ1
TARNOWSKI, GS1
STOCK, CC1
Ando, S1
Tsujimura, K1
Matsuoka, Y1
Tokui, T1
Hisanaga, S1
Okumura, E1
Uchiyama, M1
Kishimoto, T1
Yasuda, H1
Inagaki, M1
Lee, BJ1
Worland, PJ1
Davis, JN1
Stadtman, TC1
Hatfield, DL1
Nishimura, M1
Nakada, H1
Kawamura, I1
Mizota, T1
Shimomura, K1
Nakahara, K1
Goto, T1
Yamaguchi, I1
Okuhara, M1
Kano-Sueoka, T1
King, DM1
Morrison, DG1
Dishart, MK1
Medina, D1
Knox, WE1
Herzfeld, A1
Hudson, J1
Korytnyk, W1
Ahrens, H1
Codington, JF1
Sanford, BH1
Jeanloz, RW1

Other Studies

16 other studies available for serine and Experimental Mammary Neoplasms

ArticleYear
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
    Molecular cell, 2021, 01-21, Volume: 81, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prolif

2021
Increased formate overflow is a hallmark of oxidative cancer.
    Nature communications, 2018, 04-10, Volume: 9, Issue:1

    Topics: Adenoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Female; Formates; Gene Expressi

2018
Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Ca
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2015, Volume: 63, Issue:9

    Topics: Animals; Azo Compounds; bcl-Associated Death Protein; Caspase 3; Cell Line, Tumor; Drug Screening As

2015
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
    Nature chemical biology, 2016, Volume: 12, Issue:6

    Topics: Animals; Carbon; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gl

2016
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.
    Cancer cell, 2008, Jul-08, Volume: 14, Issue:1

    Topics: Animals; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin D; Cyclins; Dimerization;

2008
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:2

    Topics: Animals; Blotting, Western; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Differentiation;

2011
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.
    PloS one, 2010, Nov-05, Volume: 5, Issue:11

    Topics: Animals; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cycl

2010
Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas.
    Cancer research, 1957, Volume: 17, Issue:10

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Breast; Breast Neoplasms; Diazooxonorleu

1957
Phosphorylation of synthetic vimentin peptides by cdc2 kinase.
    Biochemical and biophysical research communications, 1993, Sep-15, Volume: 195, Issue:2

    Topics: Animals; CDC2 Protein Kinase; Desmin; Electrophoresis, Polyacrylamide Gel; Kinetics; Mammary Neoplas

1993
Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA.
    The Journal of biological chemistry, 1989, Jun-15, Volume: 264, Issue:17

    Topics: Animals; Base Sequence; Cell Line; Codon; Mammary Neoplasms, Experimental; Rats; Ribosomes; RNA, Mes

1989
A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.
    The Journal of antibiotics, 1989, Volume: 42, Issue:4

    Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Carcinoma, Squamous Cel

1989
Phosphatidylethanolamine biosynthesis in rat mammary carcinoma cells that require and do not require ethanolamine for proliferation.
    The Journal of biological chemistry, 1987, May-05, Volume: 262, Issue:13

    Topics: Animals; Cell Division; Cell Line; Epithelium; Ethanolamine; Ethanolamines; Mammary Neoplasms, Exper

1987
Serine and methionine enhancement of selenite inhibition of DNA synthesis in a mouse mammary epithelial cell line.
    Carcinogenesis, 1988, Volume: 9, Issue:10

    Topics: Animals; Cell Line; DNA Replication; Drug Synergism; Kinetics; Mammary Neoplasms, Experimental; Meth

1988
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues.
    Archives of biochemistry and biophysics, 1969, Volume: 132, Issue:2

    Topics: Adenocarcinoma; Animals; Brain; Carcinoma, Hepatocellular; Female; Fetus; Fibrosarcoma; Kidney; Kine

1969
5-homopyridoxals, 5-thiopyridoxal, and related compounds. Synthesis, tautomerism, and biological properties.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:10

    Topics: Adenocarcinoma; Animals; Deuterium; Female; Hydro-Lyases; Infrared Rays; Liver; Lymphoid Tissue; Mag

1971
Glycoprotein coat of the TA3 cell. Isolation and partial characterization of a sialic acid containing glycoprotein fraction.
    Biochemistry, 1972, Jul-04, Volume: 11, Issue:14

    Topics: Acetates; Adenocarcinoma; Amino Acids; Animals; Cell Membrane; Chromatography, Gel; Galactosamine; G

1972