serine has been researched along with Ewing Sarcoma in 6 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes." | 5.48 | Menin regulates the serine biosynthetic pathway in Ewing sarcoma. ( Bankhead, AR; Cierpicki, T; Grembecka, J; Halbrook, CJ; Kerk, S; Klossowski, S; Kremer, D; Lawlor, ER; Lee, HJ; Ljungman, M; Lyssiotis, CA; Magnuson, B; Sud, S; Svoboda, LK; Teh, SSK; Thomas, D; Treichel, S; Zebolsky, A; Zhang, L, 2018) |
| "Ewing sarcomas are driven by EWS-ETS fusions, most commonly EWS-FLI1, which promotes widespread metabolic reprogramming, including activation of serine biosynthesis." | 4.02 | EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma. ( Apfelbaum, AA; Bradin, J; Chen, D; Cierpicki, T; Garcia, AX; Grembecka, J; Haarer, E; Hawkins, AG; Jiménez, JA; Kumar, A; Lawlor, ER; Lyssiotis, CA; Nwosu, ZC; Purohit, T; Ruiz, RO; Svoboda, LK, 2021) |
| "We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes." | 1.48 | Menin regulates the serine biosynthetic pathway in Ewing sarcoma. ( Bankhead, AR; Cierpicki, T; Grembecka, J; Halbrook, CJ; Kerk, S; Klossowski, S; Kremer, D; Lawlor, ER; Lee, HJ; Ljungman, M; Lyssiotis, CA; Magnuson, B; Sud, S; Svoboda, LK; Teh, SSK; Thomas, D; Treichel, S; Zebolsky, A; Zhang, L, 2018) |
| "Four human cell lines derived from Ewing's sarcoma, EW-7, EW-1, COH and ORS, were investigated to establish the effects of human recombinant interferon-alpha2a and human recombinant interferon-beta on cell proliferation and apoptosis." | 1.31 | IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. ( Delattre, O; Hiscott, J; Sancéau, J; Wietzerbin, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Issaq, SH | 1 |
| Mendoza, A | 1 |
| Kidner, R | 1 |
| Rosales, TI | 1 |
| Duveau, DY | 1 |
| Heske, CM | 1 |
| Rohde, JM | 1 |
| Boxer, MB | 1 |
| Thomas, CJ | 1 |
| DeBerardinis, RJ | 1 |
| Helman, LJ | 1 |
| Jiménez, JA | 1 |
| Apfelbaum, AA | 1 |
| Hawkins, AG | 1 |
| Svoboda, LK | 2 |
| Kumar, A | 1 |
| Ruiz, RO | 1 |
| Garcia, AX | 1 |
| Haarer, E | 1 |
| Nwosu, ZC | 1 |
| Bradin, J | 1 |
| Purohit, T | 1 |
| Chen, D | 1 |
| Cierpicki, T | 2 |
| Grembecka, J | 2 |
| Lyssiotis, CA | 2 |
| Lawlor, ER | 2 |
| Teh, SSK | 1 |
| Sud, S | 1 |
| Kerk, S | 1 |
| Zebolsky, A | 1 |
| Treichel, S | 1 |
| Thomas, D | 1 |
| Halbrook, CJ | 1 |
| Lee, HJ | 1 |
| Kremer, D | 1 |
| Zhang, L | 1 |
| Klossowski, S | 1 |
| Bankhead, AR | 1 |
| Magnuson, B | 1 |
| Ljungman, M | 1 |
| Sen, N | 1 |
| Cross, AM | 1 |
| Lorenzi, PL | 1 |
| Khan, J | 1 |
| Gryder, BE | 1 |
| Kim, S | 1 |
| Caplen, NJ | 1 |
| Sancéau, J | 1 |
| Hiscott, J | 1 |
| Delattre, O | 1 |
| Wietzerbin, J | 1 |
| Olsen, RJ | 1 |
| Hinrichs, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients With Relapsed or Refractory Acute Myeloid Leukemia[NCT04067336] | Phase 1/Phase 2 | 199 participants (Anticipated) | Interventional | 2019-09-12 | Recruiting | ||
| A Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in Patients With Relapsed/Refractory Leukemias, Including Those Harboring an MLL/KMT2A Gene Rearrangement or Nucleophosmin 1 (NPM1) Mutation[NCT04065399] | Phase 1/Phase 2 | 440 participants (Anticipated) | Interventional | 2019-11-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for serine and Ewing Sarcoma
| Article | Year |
|---|---|
EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplast | 2020 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Bone Neoplasms; Cell Line, Tumor; Cell Pro | 2021 |
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Energy Metabol | 2018 |
EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
Topics: Amino Acid Transport System ASC; Aminohydrolases; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell | 2018 |
IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7.
Topics: 2',5'-Oligoadenylate Synthetase; Apoptosis; Caspase 7; Caspases; Cell Division; DNA-Binding Proteins | 2000 |
Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins.
Topics: 3T3 Cells; Animals; DNA; Exons; Heterogeneous-Nuclear Ribonucleoproteins; Mice; Oncogene Proteins, F | 2001 |