serine has been researched along with Epilepsy in 24 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genetic disorders of gamma-aminobutyric acid (GABA), glycine, and serine metabolism and of the GABA and glycine receptors are causes of epilepsy with variable responsiveness to treatment." | 8.81 | Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy. ( Jaeken, J, 2002) |
| " The effects of U-54494A and U-50488H on convulsions produced by sound have been studied in genetically epilepsy-prone DBA/2 mice and genetically epilepsy-prone rats." | 7.68 | Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex. ( De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR, 1993) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 7.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 5.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Genetic disorders of gamma-aminobutyric acid (GABA), glycine, and serine metabolism and of the GABA and glycine receptors are causes of epilepsy with variable responsiveness to treatment." | 4.81 | Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy. ( Jaeken, J, 2002) |
| "Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures." | 3.73 | Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. ( Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M, 2005) |
| " The effects of U-54494A and U-50488H on convulsions produced by sound have been studied in genetically epilepsy-prone DBA/2 mice and genetically epilepsy-prone rats." | 3.68 | Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex. ( De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR, 1993) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 3.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Prolonged neonatal febrile seizures (FSs) often lead to cognitive decline and increased risk of psychopathology in adulthood." | 1.72 | Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. ( Griflyuk, AV; Postnikova, TY; Zaitsev, AV, 2022) |
| "ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures." | 1.38 | Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. ( Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A, 2012) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 1.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Griflyuk, AV | 1 |
| Postnikova, TY | 1 |
| Zaitsev, AV | 1 |
| Pujol-Giménez, J | 1 |
| Mirzaa, G | 1 |
| Blue, EE | 1 |
| Albano, G | 1 |
| Miller, DE | 1 |
| Allworth, A | 1 |
| Bennett, JT | 1 |
| Byers, PH | 1 |
| Chanprasert, S | 1 |
| Chen, J | 1 |
| Doherty, D | 1 |
| Folta, AB | 1 |
| Gillentine, MA | 1 |
| Glass, I | 1 |
| Hing, A | 1 |
| Horike-Pyne, M | 1 |
| Leppig, KA | 1 |
| Parhin, A | 1 |
| Ranchalis, J | 1 |
| Raskind, WH | 1 |
| Rosenthal, EA | 1 |
| Schwarze, U | 1 |
| Sheppeard, S | 1 |
| Strohbehn, S | 1 |
| Sybert, VP | 1 |
| Timms, A | 1 |
| Wener, M | 1 |
| Bamshad, MJ | 1 |
| Hisama, FM | 1 |
| Jarvik, GP | 1 |
| Dipple, KM | 1 |
| Hediger, MA | 1 |
| Stergachis, AB | 1 |
| Bettegazzi, B | 1 |
| Bellani, S | 1 |
| Roncon, P | 1 |
| Guarnieri, FC | 1 |
| Bertero, A | 1 |
| Codazzi, F | 1 |
| Valtorta, F | 1 |
| Simonato, M | 1 |
| Grohovaz, F | 1 |
| Zacchetti, D | 1 |
| Almannai, M | 1 |
| El-Hattab, AW | 1 |
| Bardaweel, SK | 1 |
| Alzweiri, M | 1 |
| Ishaqat, AA | 1 |
| Vien, TN | 1 |
| Modgil, A | 1 |
| Abramian, AM | 1 |
| Jurd, R | 1 |
| Walker, J | 1 |
| Brandon, NJ | 1 |
| Terunuma, M | 1 |
| Rudolph, U | 1 |
| Maguire, J | 1 |
| Davies, PA | 1 |
| Moss, SJ | 1 |
| Liu, YH | 1 |
| Wang, L | 1 |
| Wei, LC | 1 |
| Huang, YG | 1 |
| Chen, LW | 1 |
| Ishida, S | 1 |
| Sakamoto, Y | 1 |
| Nishio, T | 1 |
| Baulac, S | 1 |
| Kuwamura, M | 1 |
| Ohno, Y | 1 |
| Takizawa, A | 1 |
| Kaneko, S | 1 |
| Serikawa, T | 1 |
| Mashimo, T | 1 |
| Yamamura, S | 1 |
| Hoshikawa, M | 1 |
| Dai, K | 1 |
| Saito, H | 1 |
| Suzuki, N | 1 |
| Niwa, O | 1 |
| Okada, M | 1 |
| Jaeken, J | 1 |
| de Koning, TJ | 1 |
| Klomp, LW | 1 |
| Belorgey, D | 1 |
| Sharp, LK | 1 |
| Crowther, DC | 1 |
| Onda, M | 1 |
| Johansson, J | 1 |
| Lomas, DA | 1 |
| Sorenson, J | 1 |
| Santhanam, AV | 1 |
| Smith, LA | 1 |
| Akiyama, M | 1 |
| Sessa, WC | 1 |
| Katusic, ZS | 1 |
| Niimura, M | 1 |
| Moussa, R | 1 |
| Bissoon, N | 1 |
| Ikeda-Douglas, C | 1 |
| Milgram, NW | 1 |
| Gurd, JW | 1 |
| van Gelder, NM | 3 |
| Janjua, NA | 1 |
| Metrakos, K | 1 |
| MacGibbon, B | 1 |
| Metrakos, JD | 1 |
| De Sarro, G | 1 |
| Trimarchi, GR | 1 |
| Sinopoli, S | 1 |
| Masuda, Y | 1 |
| De Sarro, A | 1 |
| Feldman, JD | 1 |
| Vician, L | 1 |
| Crispino, M | 1 |
| Hoe, W | 1 |
| Baudry, M | 1 |
| Herschman, HR | 1 |
| Ronne Engström, E | 1 |
| Hillered, L | 1 |
| Flink, R | 1 |
| Kihlström, L | 1 |
| Lindquist, C | 1 |
| Nie, JX | 1 |
| Olsson, Y | 1 |
| Silander, HC | 1 |
| Sherwin, AL | 1 |
| Sacks, C | 1 |
| Anderman, F | 1 |
| Gunawan, S | 1 |
| Walton, NY | 1 |
| Treiman, DM | 1 |
| Allen, IC | 1 |
| Grieve, A | 1 |
| Griffiths, R | 1 |
| Courtois, A | 1 |
| Ionasescu, V | 1 |
| Stegink, L | 1 |
| Mueller, S | 1 |
| Weinstein, M | 1 |
| Ellegaard, J | 1 |
| Esmann, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001] | Phase 1 | 4 participants (Actual) | Interventional | 2006-02-28 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for serine and Epilepsy
| Article | Year |
|---|---|
Inborn Errors of Metabolism with Seizures: Defects of Glycine and Serine Metabolism and Cofactor-Related Disorders.
Topics: Child; Child, Preschool; Coenzymes; Diagnosis, Differential; Epilepsy; Glycine; Humans; Infant; Infa | 2018 |
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutami | 2014 |
Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy.
Topics: Amino Acid Metabolism, Inborn Errors; Epilepsy; Female; gamma-Aminobutyric Acid; Glycine; Humans; In | 2002 |
Serine-deficiency syndromes.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Brain; Brain Diseases, Metabolic, Inborn; Carbohydrate | 2004 |
20 other studies available for serine and Epilepsy
| Article | Year |
|---|---|
Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.
Topics: Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Glycine; Hippocampus; Neuronal Plast | 2022 |
Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome.
Topics: Amino Acid Transport System ASC; Child; Epilepsy; Epileptic Syndromes; Heterozygote; Humans; Microce | 2023 |
eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology.
Topics: Animals; Casein Kinases; Cells, Cultured; Epilepsy; Eukaryotic Initiation Factors; HEK293 Cells; Hum | 2017 |
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.
Topics: Alanine; Animals; Autism Spectrum Disorder; Behavior, Animal; Biotinylation; Cell Membrane; Dendriti | 2015 |
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner | 2009 |
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultu | 2012 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim | 2013 |
Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.
Topics: Amino Acid Substitution; Arginine; Biopolymers; Catalysis; Circular Dichroism; Dementia; Epilepsy; H | 2004 |
Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries.
Topics: Adult; Aspartic Acid; Cerebral Arteries; Cyclic GMP; Endothelium, Vascular; Epilepsy; Female; Gene E | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Foc | 2005 |
Plasma amino acids in 3/sec spike-wave epilepsy.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aspartic Acid; Child; Child, Preschool; Epilepsy; Female; G | 1980 |
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 1993 |
The salt-inducible kinase, SIK, is induced by depolarization in brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Colforsin; Cycloheximide; Epilepsy; Excitatory Amino A | 2000 |
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Craniocerebral Trauma; Electroencephalo | 2001 |
Biochemical observations following administration of taurine to patients with epilepsy.
Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool | 1975 |
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D | 1990 |
Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Corpus Striatum; Epilepsy; gamma-Aminobutyric A | 1986 |
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro | 1972 |
Amino acid abnormality in Sjögren-Larsson syndrome.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Dental Enamel Hypoplasia; Epilepsy; Ethylamines; G | 1973 |
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficie | 1972 |