serine has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 13 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Genome-scale metabolic modeling identified phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase (PSAT1) as the synthetic dosage lethal (SDL) partners of IDH2." | 1.62 | Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression. ( Barnabas, GD; Beck, L; Erez, N; Geiger, T; Harel, M; Jerby-Arnon, L; Lee, JS; Ruppin, E; Selitrennik, M; Shami, T, 2021) |
| "Sanguinarine could inhibit the nuclear colocalization and interaction of HIF-1α with p-STAT3-Tyr and p-STAT3-Ser in vivo and in vitro." | 1.56 | Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer. ( Dai, B; Fan, M; Ghauri, MA; Su, Q; Ullah, A; Wang, B; Wang, J; Zhan, Y; Zhang, D; Zhang, Y, 2020) |
| "However, treatments for triple negative breast cancer (TNBC) are lacking." | 1.46 | Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer. ( Edwards, J; Liew, B; Lim, Z; Mallon, EA; McCall, P; Roseweir, AK; Scott, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, Y | 1 |
| Kim, S | 1 |
| Kim, HS | 1 |
| DO, SI | 1 |
| Daulat, AM | 1 |
| Wagner, MS | 1 |
| Audebert, S | 1 |
| Kowalczewska, M | 1 |
| Ariey-Bonnet, J | 1 |
| Finetti, P | 1 |
| Bertucci, F | 1 |
| Camoin, L | 1 |
| Borg, JP | 1 |
| Stenckova, M | 1 |
| Nenutil, R | 1 |
| Vojtesek, B | 1 |
| Coates, PJ | 1 |
| Ritter, JL | 1 |
| Zhu, Z | 1 |
| Thai, TC | 1 |
| Mahadevan, NR | 1 |
| Mertins, P | 1 |
| Knelson, EH | 1 |
| Piel, BP | 1 |
| Han, S | 1 |
| Jaffe, JD | 1 |
| Carr, SA | 1 |
| Barbie, DA | 1 |
| Barbie, TU | 1 |
| Su, Q | 1 |
| Wang, J | 1 |
| Fan, M | 1 |
| Ghauri, MA | 1 |
| Ullah, A | 1 |
| Wang, B | 1 |
| Dai, B | 1 |
| Zhan, Y | 1 |
| Zhang, D | 1 |
| Zhang, Y | 2 |
| Barnabas, GD | 1 |
| Lee, JS | 1 |
| Shami, T | 1 |
| Harel, M | 1 |
| Beck, L | 1 |
| Selitrennik, M | 1 |
| Jerby-Arnon, L | 1 |
| Erez, N | 1 |
| Ruppin, E | 1 |
| Geiger, T | 1 |
| Roseweir, AK | 1 |
| McCall, P | 1 |
| Scott, A | 1 |
| Liew, B | 1 |
| Lim, Z | 1 |
| Mallon, EA | 1 |
| Edwards, J | 1 |
| Suyama, K | 1 |
| Yao, J | 1 |
| Liang, H | 2 |
| Benard, O | 1 |
| Loudig, OD | 1 |
| Amgalan, D | 1 |
| McKimpson, WM | 1 |
| Phillips, GR | 1 |
| Segall, J | 1 |
| Wang, Y | 1 |
| Fineberg, S | 1 |
| Norton, L | 1 |
| Kitsis, RN | 1 |
| Hazan, RB | 1 |
| Tsai, HY | 1 |
| Fu, SL | 1 |
| Tseng, LM | 1 |
| Chiu, JH | 1 |
| Lin, CH | 1 |
| Noh, S | 1 |
| Kim, DH | 1 |
| Jung, WH | 1 |
| Koo, JS | 1 |
| Fagan-Solis, KD | 1 |
| Pentecost, BT | 1 |
| Gozgit, JM | 1 |
| Bentley, BA | 1 |
| Marconi, SM | 1 |
| Otis, CN | 1 |
| Anderton, DL | 1 |
| Schneider, SS | 1 |
| Arcaro, KF | 1 |
| Lin, A | 1 |
| Li, C | 1 |
| Xing, Z | 1 |
| Hu, Q | 1 |
| Liang, K | 1 |
| Han, L | 1 |
| Wang, C | 1 |
| Hawke, DH | 1 |
| Wang, S | 1 |
| Wei, Y | 1 |
| Ma, G | 1 |
| Park, PK | 1 |
| Zhou, J | 1 |
| Zhou, Y | 2 |
| Hu, Z | 1 |
| Marks, JR | 1 |
| Hung, MC | 1 |
| Lin, C | 1 |
| Yang, L | 1 |
| Zhang, X | 1 |
| Bai, W | 1 |
13 other studies available for serine and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
High Receptor-interacting Serine/Threonine-protein Kinase 3 (RIP3) Expression Serves as an Independent Poor Prognostic Factor for Triple-negative Breast Carcinoma.
Topics: Breast; Humans; Prognosis; Serine; Threonine; Triple Negative Breast Neoplasms | 2022 |
The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins.
Topics: Cell Line, Tumor; Cell Movement; Humans; Microtubules; Protein Serine-Threonine Kinases; Serine; Tri | 2022 |
Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer.
Topics: Cell Line, Tumor; Humans; Phenotype; Phosphorylation; Serine; STAT3 Transcription Factor; Triple Neg | 2022 |
Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.
Topics: Breast; Cell Line, Tumor; Female; HEK293 Cells; Humans; I-kappa B Kinase; Immunity, Innate; Membrane | 2020 |
Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer.
Topics: Benzophenanthridines; Cell Line, Tumor; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; I | 2020 |
Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
Topics: Animals; Breast; Cell Line, Tumor; Cell Proliferation; CRISPR-Cas Systems; Datasets as Topic; Diseas | 2021 |
Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer.
Topics: Biomarkers, Tumor; Carcinoma, Ductal, Breast; CDC2 Protein Kinase; Cohort Studies; Extracellular Sig | 2017 |
An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Caspase 3; Cell Line, Tumor; | 2018 |
hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Down-Regulation; Epithelial-Mesenchymal Transition; F | 2019 |
Expression levels of serine/glycine metabolism-related proteins in triple negative breast cancer tissues.
Topics: Adult; Aged; Female; Glycine; Glycine Hydroxymethyltransferase; Humans; Middle Aged; Phosphoglycerat | 2014 |
SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Cycl | 2014 |
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
Topics: Animals; Cell Line, Tumor; Cytoplasm; E1A-Associated p300 Protein; ErbB Receptors; Female; Gene Expr | 2016 |
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; | 2016 |