serine has been researched along with Down Syndrome in 13 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dependent on its kinase activity and correlated with the dosage of overexpression, DYRK1A blocked proliferation of SH-SY5Y neuroblastoma cells within 24 h and arrested the cells in G₁ phase." | 5.40 | The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. ( Becker, W; Florencio Ortiz, V; Pasqualon, T; Schumacher, J; Soppa, U; Tejedor, FJ, 2014) |
| "Minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase (Mnb/Dyrk1A) is a proline-directed serine/threonine kinase encoded in the Down syndrome critical region of human chromosome 21." | 3.73 | Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. ( Chen-Hwang, MC; Hwang, YW; Lu, RC; Murakami, N; Wieraszko, A; Xie, W, 2006) |
| "Thus, NE stimulation may prevent memory loss in Ts65Dn mice, and may hold promise for treatment in individuals with DS and dementia." | 1.42 | Designer receptors enhance memory in a mouse model of Down syndrome. ( Aston-Jones, G; Boger, HA; Cass, WA; Fortress, AM; Granholm, AC; Hamlett, ED; Vazey, EM, 2015) |
| " Dependent on its kinase activity and correlated with the dosage of overexpression, DYRK1A blocked proliferation of SH-SY5Y neuroblastoma cells within 24 h and arrested the cells in G₁ phase." | 1.40 | The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. ( Becker, W; Florencio Ortiz, V; Pasqualon, T; Schumacher, J; Soppa, U; Tejedor, FJ, 2014) |
| " The increased dosage of Dyrk1A in DS brain due to trisomy of chromosome 21 correlates to an increase in 3R-tau level, which on abnormal hyperphosphorylation and aggregation of tau results in neurofibrillary degeneration." | 1.35 | Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. ( Chohan, MO; Gong, CX; Grundke-Iqbal, I; Gu, X; Hwang, YW; Iqbal, K; Liu, F; Shi, J; Wegiel, J; Zhang, T; Zhou, C; Zhou, J, 2008) |
| "Down syndrome is the most frequent genetic disorder in humans." | 1.31 | Mutational analyses of the signals involved in the subcellular location of DSCR1. ( Han, SW; Henrique-Silva, F; Machado-Santelli, GM; Pfister, SC, 2002) |
| "A comparative study of the variations of amino acid concentration with age in Down's syndrome subjects aged 0 to 60 years and in control subjects aged 0 to 94 years was made in order to determine whether these impairments could be explained by generalized premature aging, or by a specific gene dosage effect." | 1.30 | [Variation of amino acids in relation to age in Down syndrome subjects]. ( Kamoun, P; Lejeune, J; Mircher, C; Parvy, P; Peeters, MA; Rabier, D; Salabelle, A, 1997) |
| "In contrast, trisomy 21 did not affect the uptake of choline, serine or glucose." | 1.28 | Down's syndrome fibroblasts exhibit enhanced inositol uptake. ( Fruen, BR; Lester, BR, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soundararajan, M | 1 |
| Roos, AK | 1 |
| Savitsky, P | 1 |
| Filippakopoulos, P | 1 |
| Kettenbach, AN | 1 |
| Olsen, JV | 1 |
| Gerber, SA | 1 |
| Eswaran, J | 1 |
| Knapp, S | 1 |
| Elkins, JM | 1 |
| Soppa, U | 1 |
| Schumacher, J | 1 |
| Florencio Ortiz, V | 1 |
| Pasqualon, T | 1 |
| Tejedor, FJ | 1 |
| Becker, W | 1 |
| Fortress, AM | 1 |
| Hamlett, ED | 1 |
| Vazey, EM | 1 |
| Aston-Jones, G | 1 |
| Cass, WA | 1 |
| Boger, HA | 1 |
| Granholm, AC | 1 |
| Dorard, E | 1 |
| Gorisse-Hussonnois, L | 1 |
| Guihenneuc-Jouyaux, C | 1 |
| Albac, C | 1 |
| Potier, MC | 1 |
| Allinquant, B | 1 |
| Shi, J | 1 |
| Zhang, T | 1 |
| Zhou, C | 1 |
| Chohan, MO | 1 |
| Gu, X | 1 |
| Wegiel, J | 1 |
| Zhou, J | 1 |
| Hwang, YW | 2 |
| Iqbal, K | 1 |
| Grundke-Iqbal, I | 1 |
| Gong, CX | 1 |
| Liu, F | 1 |
| Palminiello, S | 2 |
| Jarząbek, K | 2 |
| Kaur, K | 2 |
| Walus, M | 2 |
| Rabe, A | 1 |
| Albertini, G | 2 |
| Golabek, AA | 2 |
| Kida, E | 2 |
| Wierzba-Bobrowicz, T | 1 |
| Pfister, SC | 1 |
| Machado-Santelli, GM | 1 |
| Han, SW | 1 |
| Henrique-Silva, F | 1 |
| Jong, YJ | 1 |
| Ford, SR | 1 |
| Seehra, K | 1 |
| Malave, VB | 1 |
| Baenziger, NL | 1 |
| Murakami, N | 1 |
| Xie, W | 1 |
| Lu, RC | 1 |
| Chen-Hwang, MC | 1 |
| Wieraszko, A | 1 |
| Ryoo, SR | 1 |
| Jeong, HK | 1 |
| Radnaabazar, C | 1 |
| Yoo, JJ | 1 |
| Cho, HJ | 1 |
| Lee, HW | 1 |
| Kim, IS | 1 |
| Cheon, YH | 1 |
| Ahn, YS | 1 |
| Chung, SH | 1 |
| Song, WJ | 1 |
| Mircher, C | 1 |
| Salabelle, A | 1 |
| Peeters, MA | 1 |
| Rabier, D | 1 |
| Parvy, P | 1 |
| Kamoun, P | 1 |
| Lejeune, J | 1 |
| Fruen, BR | 1 |
| Lester, BR | 1 |
13 other studies available for serine and Down Syndrome
| Article | Year |
|---|---|
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
Topics: Amino Acid Sequence; Catalytic Domain; Down Syndrome; Dyrk Kinases; Enzyme Activation; Humans; Model | 2013 |
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation.
Topics: Animals; Brain; Cell Cycle; Cell Differentiation; Cell Line; Cyclin D1; Cyclin-Dependent Kinase Inhi | 2014 |
Designer receptors enhance memory in a mouse model of Down syndrome.
Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Cross-Over Studies; Designer Drugs; Disease Mo | 2015 |
Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; CA1 Region, Hippocampal; Cytoplasm; Disease Models, | 2016 |
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.
Topics: Alternative Splicing; Animals; Brain; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Down Syndro | 2008 |
Upregulation of phosphorylated alphaB-crystallin in the brain of children and young adults with Down syndrome.
Topics: Adolescent; alpha-Crystallin B Chain; Astrocytes; Brain; Child; Child, Preschool; Down Syndrome; Epe | 2009 |
Molecular chaperone alphaB-crystallin is expressed in the human fetal telencephalon at midgestation by a subset of progenitor cells.
Topics: Age Factors; alpha-Crystallin B Chain; Down Syndrome; Embryonic Stem Cells; Fetus; Gene Expression R | 2010 |
Mutational analyses of the signals involved in the subcellular location of DSCR1.
Topics: Amino Acid Motifs; Animals; Calcineurin; Calcineurin Inhibitors; Cell Line; Chlorocebus aethiops; CH | 2002 |
Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation.
Topics: Adult; Alzheimer Disease; Bradykinin; Cell Line; Down Syndrome; Fibroblasts; Humans; Membrane Protei | 2003 |
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Binding Sites, Antibody; CHO | 2006 |
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
Topics: Alzheimer Disease; Animals; Brain; Cell Line; DNA, Complementary; Down Syndrome; Dyrk Kinases; Human | 2007 |
[Variation of amino acids in relation to age in Down syndrome subjects].
Topics: Adolescent; Adult; Age Factors; Amino Acids; Child; Child, Preschool; Down Syndrome; Female; Humans; | 1997 |
Down's syndrome fibroblasts exhibit enhanced inositol uptake.
Topics: Alzheimer Disease; Biological Transport; Cell Line; Choline; Chromosome Mapping; Chromosomes, Human, | 1990 |