Compounds > serine
Page last updated: 2024-11-08

serine and Disease Models, Animal

serine has been researched along with Disease Models, Animal in 338 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) is essential for normal sympathetic regulation of cardiac myocyte contractility and is responsible for the disturbed Ca(2+) regulation that underlies depressed contractility in heart failure."8.90Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. ( Houser, SR, 2014)
"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis."7.96Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020)
"The purpose of this study was to determine d-Serine and d-Serine synthetase serine racemase (SR) expression and whether decreased d-Serine expression has protective effects on retinal ganglion cells (RGCs) in a glaucomatous animal model."7.88Decreased d-Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model. ( Wu, J; Zhang, R; Zhang, X; Zhou, X, 2018)
" To test whether resveratrol, a polyphenol found in red wine, prevents FFA-induced insulin resistance, we used a hyperinsulinemic-euglycemic clamp with a tracer to assess hepatic and peripheral insulin sensitivity in overnight-fasted Wistar rats infused for 7 h with saline, Intralipid plus 20 U·mL(-1) heparin (IH; triglyceride emulsion that elevates FFA levels in vivo; 5."7.81Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo. ( Breen, DM; Faubert, B; Giacca, A; Kwan, D; Moore, J; Nahle, A; Oprescu, AI; Park, E; Pereira, S; Tsiani, E, 2015)
"Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders."7.79Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. ( Abazyan, B; Abazyan, S; Ma, TM; Nomura, J; Pletnikov, MV; Sawa, A; Seshadri, S; Snyder, SH; Yang, C, 2013)
" We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target."7.78Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012)
" We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels."7.77Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011)
"3) has been proposed to play a main role in the degradation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the human brain, and to be associated with the onset of schizophrenia."7.77Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase. ( Frattini, LF; Molla, G; Piubelli, L; Pollegioni, L; Sacchi, S, 2011)
"Hyperhomocysteinemia (HHcy) has been recognized as a risk factor for developing Alzheimer's disease (AD)."7.76Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. ( Gould, TJ; Kruger, WD; Portugal, GS; Pratico, D; Wang, H; Zhuo, JM, 2010)
"Lewy bodies are found in Parkinson disease and related disorders and are extensively phosphorylated at Ser-129 (S129), but whether S129 phosphorylation mediates alpha-synuclein aggregation and neurotoxicity has been controversial."7.75Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. ( Fan, Z; Feany, MB; Hyman, BT; McFarland, NR; McLean, PJ; Schwarzschild, MA; Xu, K, 2009)
"Behavioral phenotypes relevant to schizophrenia were assessed in Grin1(D481N) mice that have reduced NMDAR glycine affinity."7.74Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. ( Labrie, V; Lipina, T; Roder, JC, 2008)
"Studies have shown that alpha-synuclein (alpha-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129."7.74The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. ( Chen, W; Gorbatyuk, OS; Kondrikova, G; Li, S; Mandel, RJ; Manfredsson, FP; Muzyczka, N; Sullivan, LF, 2008)
"Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated."5.91PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. ( Chen, HN; Dai, L; Dong, L; Fu, S; Huang, C; Luo, L; Nice, EC; Peng, Y; Shen, G; Wang, K; Wang, M; Wang, Z; Wei, X; Wu, X, 2023)
"Schizophrenia is a psychiatric disorder that affects over 20 million people globally."5.72Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia. ( Anisimova, M; Barragan, EV; Gray, JA; Park, DK; Petshow, S; Stein, IS; Zito, K, 2022)
"Limonin has a potential protective function revealed by the metabolic profiling of limonin-treated rats located closer to the normal group."5.42Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis. ( An, N; Meng, X; Sun, H; Wang, H; Wang, X; Yan, G; Zhang, A; Zhang, Y, 2015)
"Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine density, altered neuroplasticity signaling pathways, and cognitive deficits associated with impaired hippocampal function."5.39Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. ( Balu, DT; Basu, AC; Benneyworth, MA; Bolshakov, VY; Coyle, JT; Li, Y; Puhl, MD; Takagi, S, 2013)
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water."5.39Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013)
"Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle."5.39Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013)
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity."5.36Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010)
"Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear."5.35Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009)
"Schizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively."5.33Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. ( Labrie, V; Lipina, T; Roder, J; Weiner, I, 2005)
"Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas."5.25Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975)
"D-amino-acid oxidase (DAAO) degrades D-serine, a co-agonist of the NMDA receptor whose dysfunction is involved in the positive, negative, and cognitive symptoms of schizophrenia."4.98Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies. ( Ferenczy, GG; Keserű, GM; Szilágyi, B, 2018)
"This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) is essential for normal sympathetic regulation of cardiac myocyte contractility and is responsible for the disturbed Ca(2+) regulation that underlies depressed contractility in heart failure."4.90Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. ( Houser, SR, 2014)
" Exposure of L6 myotubes to 25 mmol/L glucose and 100 nmol/L insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/activation of mTOR and p70S6K."4.02Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance. ( MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F, 2021)
"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis."3.96Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020)
"This is the first study to introduce D-serine to a trigeminovascular headache model that demonstrates an antinociceptive-like effect in rats."3.91Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat. ( He, Z; Wang, X; Yu, S; Yu, Z; Zhang, Q, 2019)
"The purpose of this study was to determine d-Serine and d-Serine synthetase serine racemase (SR) expression and whether decreased d-Serine expression has protective effects on retinal ganglion cells (RGCs) in a glaucomatous animal model."3.88Decreased d-Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model. ( Wu, J; Zhang, R; Zhang, X; Zhou, X, 2018)
"In the present study, the effects of both single (6 mmol L-serine/10 ml/kg orally administrated) and chronic (2% L-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression."3.85Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means. ( Furuse, M; Nagasawa, M; Otsuka, T; Teramoto, S; Togo, Y; Uotsu, N; Yamanaga, M; Yasuo, S; Yoshida, J, 2017)
"In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis."3.85Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo. ( Heravi, A; Kass, DA; Keceli, G; Li, Y; Murphy, AM; Okumus, N; Paolocci, N; Ramirez-Correa, G; Takahashi, C; Zhang, P; Zhu, G, 2017)
" Experiments in rats and mice revealed that maladaptive plasticity and hypersensitivity after spinal cord lesion (SCL) are associated with a reduction in the fraction of GluA1 subunits that are phosphorylated at serine 831 (S831) in the hindlimb representation of S1 (S1HL)."3.83Post-translational modification of cortical GluA receptors in rodents following spinal cord lesion. ( Ji, Y; Jiang, L; Masri, R; Voulalas, P, 2016)
" Male Wistar rats (weighing 300-350 g) were assigned to the following groups: (1) sham, (2) myocardial ischemia vehicle-treated (MI-V), and (3) myocardial ischemia clofibrate-treated."3.81PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin-Angiotensin System. ( Cervantes-Pérez, LG; del Valle-Mondragón, L; Hong, E; Ibarra-Lara, L; Pastelín-Hernández, GS; Pérez-Severiano, F; Ramírez-Ortega, M; Sánchez-Aguilar, M; Sánchez-Mendoza, A; Soria-Castro, E; Torres-Narváez, JC, 2015)
" To test whether resveratrol, a polyphenol found in red wine, prevents FFA-induced insulin resistance, we used a hyperinsulinemic-euglycemic clamp with a tracer to assess hepatic and peripheral insulin sensitivity in overnight-fasted Wistar rats infused for 7 h with saline, Intralipid plus 20 U·mL(-1) heparin (IH; triglyceride emulsion that elevates FFA levels in vivo; 5."3.81Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo. ( Breen, DM; Faubert, B; Giacca, A; Kwan, D; Moore, J; Nahle, A; Oprescu, AI; Park, E; Pereira, S; Tsiani, E, 2015)
"The obtained data suggest that stimulation of the glutamate or glycine recognition site of the NMDA receptor complex significantly decreases the antianxiety properties of antagonists of either site."3.79NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice. ( Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A, 2013)
"Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders."3.79Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. ( Abazyan, B; Abazyan, S; Ma, TM; Nomura, J; Pletnikov, MV; Sawa, A; Seshadri, S; Snyder, SH; Yang, C, 2013)
"Effects of systemic injection of the glycine(B) agonist, d-serine, the GlyT-1 glycine transporter inhibitor, ALX-5407, and the glycine(B) antagonist, L-701,324, were tested for the effects on EtOH-induced ataxia, hypothermia, and loss of righting reflex (LORR) duration in C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mice."3.79Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. ( Camp, M; Debrouse, L; Grant, SG; Gunduz-Cinar, O; Holmes, A; Hurd, B; Kiselycznyk, C; Mishina, M; Plitt, A; Todaro, A, 2013)
" Parallel experiments were performed in rat lung sections and PASMCs and in rodent PAH models induced by the HIF-1α activator, cobalt, chronic hypoxia, and monocrotaline."3.78Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. ( Archer, SL; Chen, Y; Fang, YH; Hong, Z; Marsboom, G; Morrow, E; Piao, L; Pogoriler, J; Rehman, J; Ryan, JJ; Thenappan, T; Toth, PT; Weir, EK; Wu, X; Zhang, HJ, 2012)
" We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target."3.78Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012)
" We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels."3.77Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011)
" We investigated the effect of LB1, a small molecule inhibitor of serine/threonine protein phosphatase 2A (PP2A), on its ability to inhibit a low growth fraction and highly drug-resistant solid neuroendocrine tumor, such as metastatic pheochromocytoma (PHEO)."3.77Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy. ( Bernardo, M; Chiang, J; Lonser, R; Lu, J; Martiniova, L; Pacak, K; Zhuang, Z, 2011)
"Glycine inhibitory dysfunction provides a useful experimental model for studying the mechanism of dynamic mechanical allodynia, a widespread and intractable symptom of neuropathic pain."3.77Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. ( Dallel, R; Miraucourt, LS; Peirs, C; Voisin, DL, 2011)
"3) has been proposed to play a main role in the degradation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the human brain, and to be associated with the onset of schizophrenia."3.77Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase. ( Frattini, LF; Molla, G; Piubelli, L; Pollegioni, L; Sacchi, S, 2011)
"Hyperhomocysteinemia (HHcy) has been recognized as a risk factor for developing Alzheimer's disease (AD)."3.76Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. ( Gould, TJ; Kruger, WD; Portugal, GS; Pratico, D; Wang, H; Zhuo, JM, 2010)
"Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease."3.76Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. ( Aebischer, P; Chegini, F; Chiappe, D; Eliezer, D; Fernandez, CO; Gai, WP; Kim, HY; Lamberto, GR; Lashuel, HA; Masliah, E; Moniatte, M; Oueslati, A; Paleologou, KE; Rospigliosi, CC; Schmid, A; Schneider, BL; Shakked, G; Zweckstetter, M, 2010)
"Lewy bodies are found in Parkinson disease and related disorders and are extensively phosphorylated at Ser-129 (S129), but whether S129 phosphorylation mediates alpha-synuclein aggregation and neurotoxicity has been controversial."3.75Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. ( Fan, Z; Feany, MB; Hyman, BT; McFarland, NR; McLean, PJ; Schwarzschild, MA; Xu, K, 2009)
"Mutations in the neuronal protein alpha-synuclein cause familial Parkinson disease."3.75Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. ( Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X, 2009)
"Behavioral phenotypes relevant to schizophrenia were assessed in Grin1(D481N) mice that have reduced NMDAR glycine affinity."3.74Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. ( Labrie, V; Lipina, T; Roder, JC, 2008)
"In Parkinson disease (PD), alpha-synuclein aggregates called Lewy bodies often involve and sequester Septin4 (Sept4), a polymerizing scaffold protein."3.74Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. ( Hagiwara, A; Hattori, N; Hikawa, R; Ihara, M; Kinoshita, M; Kitano, A; Miyakawa, T; Mori, H; Noda, M; Takanashi, M; Tanigaki, A; Tomimoto, H; Yamasaki, N, 2007)
"The activation of JNK elevates the level of IRS-1 phospho-serine 307 and might play a role in insulin resistance after burn in rats."3.74[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn]. ( Ben, DF; Chen, XL; Ge, SD; Tang, HT; Wei, D; Xia, ZF, 2007)
" We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo."3.74The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. ( Atochin, DN; Ayata, C; Critchlow, JD; Dantas, AP; Huang, PL; Liu, VW; Looft-Wilson, R; Michel, T; Moskowitz, MA; Murata, T; Salomone, S; Sessa, WC; Shin, HK; Wang, A, 2007)
"Studies have shown that alpha-synuclein (alpha-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129."3.74The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. ( Chen, W; Gorbatyuk, OS; Kondrikova, G; Li, S; Mandel, RJ; Manfredsson, FP; Muzyczka, N; Sullivan, LF, 2008)
" This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia."3.74Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008)
"alpha-Synuclein (alpha-syn) is the major component of pathologic inclusions that characterize neurodegenerative disorders such as Parkinson disease, dementia with Lewy body disease, and multiple system atrophy."3.74Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. ( Giasson, BI; Waxman, EA, 2008)
"D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules."3.73Sodium benzoate attenuates D-serine induced nephrotoxicity in the rat. ( Lock, EA; Williams, RE, 2005)
"Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures."3.73Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. ( Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M, 2005)
"Normal eyes and eyes at 15 min, 2 and 4 days after retinal detachment in C57Bl6 mice were examined by immunohistochemistry using anti-phosphorylated (p) ERK1/2, anti-cyclin D1, anti-p27(KIP1), anti-p27(KIP1) phosphorylated at serine 10 (S10-phospho-p27), and anti-proliferating cell nuclear antigen (PCNA) antibodies with or without treatment with a specific ERK inhibitor, PD98059."3.73Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment. ( Harada, C; Harada, T; Kase, S; Nakayama, KI; Namekata, K; Ohgami, K; Ohno, S; Shiratori, K; Suzuki, Y; Yoshida, K, 2006)
" Akt activation results in decreased serine phosphorylation of 14-3-3, a cytoplasmic anchor of Bax, and prevents ischemia-induced mitochondrial translocation of Bax, release of cytochrome c, and activation of caspase-3."3.73Ischemic preconditioning negatively regulates plenty of SH3s-mixed lineage kinase 3-Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt. ( Han, D; Lv, Q; Wang, R; Xu, J; Xu, TL; Yin, XH; Zhang, GY; Zhang, QG, 2006)
"The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model."3.69Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994)
"It was investigated whether an increased demand for glycine, as postulated to occur in patients who have suffered from episodic psychoses accompanied by multiple perceptual distortions, could evoke psychotic reactions."3.66Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983)
"The motor impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of α-synuclein (α-syn) called Lewy bodies."2.49The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models. ( Arawaka, S; Kato, T; Sato, H, 2013)
"Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated."1.91PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. ( Chen, HN; Dai, L; Dong, L; Fu, S; Huang, C; Luo, L; Nice, EC; Peng, Y; Shen, G; Wang, K; Wang, M; Wang, Z; Wei, X; Wu, X, 2023)
"Schizophrenia is a psychiatric disorder that affects over 20 million people globally."1.72Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia. ( Anisimova, M; Barragan, EV; Gray, JA; Park, DK; Petshow, S; Stein, IS; Zito, K, 2022)
" Genome-scale metabolic modeling identified phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase (PSAT1) as the synthetic dosage lethal (SDL) partners of IDH2."1.62Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression. ( Barnabas, GD; Beck, L; Erez, N; Geiger, T; Harel, M; Jerby-Arnon, L; Lee, JS; Ruppin, E; Selitrennik, M; Shami, T, 2021)
"Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder characterized by motor incoordination, mild cognitive decline, respiratory dysfunction, and early lethality."1.62Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1. ( Alcala, E; Coffin, SL; Dai, Y; El-Najjar, DB; Liu, Z; Nitschke, L; Orengo, JP; Orr, HT; Wan, YW; Xhako, E; Zoghbi, HY, 2021)
" UHPLC-MS/MS was used to confirm BMAA exposures in dosed vervets."1.56l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND. ( Banack, SA; Beierschmitt, A; Bradley, WG; Cox, PA; Davis, DA; Garamszegi, SP; Hagan, MJ; Lecusay, PD; Mash, DC; Metcalf, JS; Palmour, RM; Powell, JT, 2020)
"Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD)."1.56Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. ( Bell, BM; Chakrabarty, P; Davies, P; Giasson, BI; Gorion, KM; Kim, JD; Manaois, AN; Prokop, S; Sorrentino, ZA; Xia, Y, 2020)
"Parkinson's disease has become one of the most common neurodegenerative diseases."1.56Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry. ( Cao, X; Chen, C; Peng, Q; Tan, Y; Wang, J; Wu, Y; Xu, Y; Yang, X; Zeng, W, 2020)
"The therapeutic index of cytokines in cancer therapy can be increased by targeting strategies based on protein engineering with peptides containing the CNGRC (NGR) motif, a ligand that recognizes CD13-positive tumor vessels."1.56NGR-TNF Engineering with an N-Terminal Serine Reduces Degradation and Post-Translational Modifications and Improves Its Tumor-Targeting Activity. ( Colombo, B; Corti, A; Curnis, F; Ferreri, AJM; Gasparri, AM; Monieri, M; Rrapaj, E; Sacchi, A, 2020)
"Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs."1.56Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway. ( Bice, AR; Bonni, A; Brier, LM; Bumstead, JR; Chen, X; Crowley, JR; Culver, JP; Dikranian, K; Haigis, MC; Ippolito, JE; Oldenborg, A; Papouin, T; Rensing, NR; Ringel, AE; Shin, H; Smith, SE; Wong, M; Zhao, G, 2020)
"Two variants known to cause HSAN1 were identified as causal for macular telangiectasia type 2: of 11 patients with HSAN1, 9 also had macular telangiectasia type 2."1.51Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. ( Allikmets, R; Badur, MG; Bahlo, M; Baldini, M; Bernstein, PS; Bonelli, R; Cai, C; Dorrell, MI; Eade, K; Egan, C; Eichler, F; Fallon, R; Friedlander, M; Fruttiger, M; Gantner, ML; Giles, S; Gillies, M; Guymer, R; Handzlik, MK; Harkins-Perry, S; Hart, BJ; Heeren, TFC; Ideguchi, Y; Kitano, M; Metallo, CM; Nagasaki, T; Okada, M; Sauer, L; Scheppke, L; Trombley, J; Wallace, M; Woods, SM, 2019)
"The NTG injection induced acute migraine-like pain including photophobia and mechanical hypersensitivity as reported previously."1.48AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. ( Liu, S; Shu, H; Tang, Y; Tao, F; Xing, Y, 2018)
" It is well established that reduced vascular endothelial nitric oxide (NO) bioavailability promotes arterial inflammation; however, the role of NO in modulating inflammation in AT remains disputed."1.43Ablation of eNOS does not promote adipose tissue inflammation. ( Gastecki, ML; Jurrissen, TJ; Padilla, J; Rector, RS; Sheldon, RD; Vieira-Potter, VJ; Woodford, ML; Zidon, TM, 2016)
"Our objective was to study hypertension induced by chronic administration of synthetic glucocorticoid, dexamethasone (DEX), under nonstressful conditions and examine the role of catecholamine biosynthesis."1.43A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase. ( Franklin, C; Gottlieb, H; Hinojosa-Laborde, C; Rani, CS; Soto-Piña, AE; Strong, R, 2016)
" We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer."1.43Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016)
"Kainic acid (KA) was microinjected unilaterally into the hippocampal CA3 area in Sprague Dawley rats to induce prolonged seizure activity."1.43Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus. ( Chan, SH; Chen, SD; Chuang, YC; Huang, CW; Lin, JW; Lin, TK; Liou, CW; Zhen, YY, 2016)
"Thus, NE stimulation may prevent memory loss in Ts65Dn mice, and may hold promise for treatment in individuals with DS and dementia."1.42Designer receptors enhance memory in a mouse model of Down syndrome. ( Aston-Jones, G; Boger, HA; Cass, WA; Fortress, AM; Granholm, AC; Hamlett, ED; Vazey, EM, 2015)
"Limonin has a potential protective function revealed by the metabolic profiling of limonin-treated rats located closer to the normal group."1.42Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis. ( An, N; Meng, X; Sun, H; Wang, H; Wang, X; Yan, G; Zhang, A; Zhang, Y, 2015)
"Meanwhile, thermal hyperalgesia was observed from day 2 through day 10 and mechanical allodynia from day 4 through day 10."1.40Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. ( Gao, M; Maixner, DW; Weng, HR, 2014)
"Treatment with telmisartan reversed the abnormalities of PLB amount, coronary flow rate, and -dP/dt in SHRSP fatty rats."1.39Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. ( Kagota, S; Kunitomo, M; Maruyama, K; Nakamura, K; Shinozuka, K; Tada, Y; Wakuda, H, 2013)
"Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine density, altered neuroplasticity signaling pathways, and cognitive deficits associated with impaired hippocampal function."1.39Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. ( Balu, DT; Basu, AC; Benneyworth, MA; Bolshakov, VY; Coyle, JT; Li, Y; Puhl, MD; Takagi, S, 2013)
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water."1.39Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013)
"Depression is usually associated with alterations in the monoaminergic system."1.39Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression. ( De Bundel, D; Gómez-Galán, M; Lindskog, M; Smolders, I; Van Eeckhaut, A, 2013)
"Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle."1.39Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013)
"ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures."1.38Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. ( Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A, 2012)
" Strikingly, overexpression of the phosphomimic mutant S87E did not show any toxic effect on dopaminergic neurons and resulted in significantly less α-syn aggregates, dystrophic fibers, and motor impairment."1.38Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. ( Aebischer, P; Lashuel, HA; Oueslati, A; Paleologou, KE; Schneider, BL, 2012)
"Hyperglycemia and insulin resistance are common findings in critical illness."1.38Injury-induced insulin resistance in adipose tissue. ( Franklin, JL; Hardy, RW; Martin, RE; Messina, JL; Williams, VL, 2012)
"Guanosine is an extracellular signaling molecule implicated in the modulation of glutamatergic transmission and neuroprotection."1.38Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. ( Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2012)
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity."1.36Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010)
"Prolonged seizures cause significant damage to the brain, and cellular damage due to status epilepticus may be related to the pathogenesis of epilepsy."1.36Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death. ( Cho, GJ; Choi, MY; Choi, WS; Jeon, BT; Kang, SS; Kim, HJ; Kim, YH; Kim, YS; Lee, DH; Roh, GS, 2010)
"Morphine withdrawal was precipitated on day 8 by an injection of naloxone (2 mg kg(-1))."1.35The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. ( Almela, P; Laorden, M; Milanés, M, 2008)
"Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear."1.35Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009)
"Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles."1.35Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. ( Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N, 2009)
"We hypothesize that type 1 and type 2 diabetes may contribute to AD through different mechanisms; in type 2 diabetes, hyperglycemia-mediated tau cleavage may be the key feature, whereas insulin deficiency may be the major contributing factor in type 1 diabetes."1.35Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. ( Backus, C; Feldman, EL; Hayes, JM; Kim, B; Oh, S, 2009)
"Familial LPL deficiency is a rare, autosomal-recessive disorder of lipoprotein metabolism that is characterized by severe hypertriglyceridemia with episodes of abdominal pain, acute pancreatitis and eruptive cutaneous xanthomatosis."1.35Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency. ( Burnett, JR; Hooper, AJ, 2009)
" The response of the receptors to inhibitors of polyglutamine toxicity is altered by the amino acid exchanges suggesting that careful consideration is needed in the choice of potential therapies of disorders involving toxic polyQ species."1.35Specific N-terminal mutations in the human androgen receptor induce cytotoxicity. ( Cato, AC; Funderburk, SF; Mink, S; Shatkina, L; Weg-Remers, S; Weis, Q, 2009)
"A primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau)."1.34The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. ( Ash, P; Bailey, RM; Burrows, F; Dickey, CA; Dickson, DW; Dunmore, J; Eckman, CB; Hutton, M; Kamal, A; Klosak, N; Lundgren, K; Nahman, NS; Patterson, C; Petrucelli, L; Shoraka, S; Zlatkovic, J, 2007)
"Propentofylline (PPF) is a synthetic xanthine derivative that inhibits phosphodiesterase and adenosine uptake."1.33Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. ( Chauhan, NB; Feinstein, DL; Siegel, GJ, 2005)
"Schizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively."1.33Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. ( Labrie, V; Lipina, T; Roder, J; Weiner, I, 2005)
"A recent description of dystrophic epidermolysis bullosa (DEB) in Golden Retriever dogs provided details of the principal clinical, morphological and genetic features."1.33[Characterization of a canine model of dystrophic bullous epidermolysis (DBE). Development of a gene therapy protocol]. ( Gache, Y; Lacour, JP; Magnol, JP; Meneguzzi, G; Palazzi, X; Pin, D, 2005)
"Secondary mechanical allodynia resulting from a thermal stimulus (52."1.33Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005)
"Sandhoff disease is a progressive neurodegenerative disorder caused by mutations in the HEXB gene which encodes for the beta-subunit of beta-hexosaminidase A and B, resulting in ganglioside GM(2) accumulation in the brain."1.32Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease. ( Bodennec, J; Buccoliero, R; Futerman, AH; Sandhoff, K; Van Echten-Deckert, G, 2004)
"Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas."1.25Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975)

Research

Studies (338)

TimeframeStudies, this research(%)All Research%
pre-19906 (1.78)18.7374
1990's9 (2.66)18.2507
2000's87 (25.74)29.6817
2010's205 (60.65)24.3611
2020's31 (9.17)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Zhang, D2
Xu, S2
Wang, Y5
Bin, P1
Zhu, G3
Nyamsuren, G1
Rapp, G1
Dihazi, H1
Zeisberg, EM1
Tampe, D1
Tampe, B1
Zeisberg, M1
Shindo, T1
Shikanai, H1
Watarai, A1
Hiraide, S1
Iizuka, K1
Izumi, T1
Park, DK1
Petshow, S1
Anisimova, M1
Barragan, EV1
Gray, JA1
Stein, IS1
Zito, K1
Fuchs, C1
Cosentino, L1
Urbinati, C1
Talamo, MC1
Medici, G1
Quattrini, MC1
Mottolese, N1
Pietraforte, D1
Fuso, A1
Ciani, E1
De Filippis, B1
Folorunso, OO1
Harvey, TL1
Brown, SE1
Chelini, G1
Berretta, S1
Balu, DT3
Wang, K1
Luo, L1
Fu, S1
Wang, M2
Wang, Z1
Dong, L1
Wu, X3
Dai, L1
Peng, Y2
Shen, G1
Chen, HN1
Nice, EC1
Wei, X1
Huang, C1
González-Cuesta, M1
Lai, AC1
Chi, PY1
Hsu, IL1
Liu, NT1
Wu, KC1
García Fernández, JM1
Chang, YJ1
Ortiz Mellet, C1
Jian, J1
Li, LG1
Zhao, PJ1
Zheng, RJ1
Dong, XW1
Zhao, YH1
Yin, BQ1
Li, S3
Cheng, H1
Li, HL1
Li, EY1
Petrozziello, T1
Huntress, SS1
Castillo-Torres, AL1
Quinn, JP1
Connors, TR1
Auger, CA1
Mills, AN1
Kim, SE1
Liu, S3
Mahmood, F1
Boudi, A1
Wu, M2
Sapp, E1
Kivisäkk, P1
Sunderesh, SR1
Pouladi, MA1
Arnold, SE1
Hyman, BT4
Rosas, HD1
DiFiglia, M1
Mouro Pinto, R1
Kegel-Gleason, K1
Sadri-Vakili, G2
Gantner, ML1
Eade, K1
Wallace, M1
Handzlik, MK1
Fallon, R1
Trombley, J1
Bonelli, R1
Giles, S1
Harkins-Perry, S1
Heeren, TFC1
Sauer, L1
Ideguchi, Y1
Baldini, M1
Scheppke, L1
Dorrell, MI1
Kitano, M1
Hart, BJ1
Cai, C1
Nagasaki, T1
Badur, MG1
Okada, M2
Woods, SM1
Egan, C1
Gillies, M1
Guymer, R1
Eichler, F1
Bahlo, M1
Fruttiger, M1
Allikmets, R1
Bernstein, PS1
Metallo, CM1
Friedlander, M1
He, F2
Yin, Z1
Wu, C1
Xia, Y3
Li, P1
Zhang, H2
Yin, Y1
Li, N2
Ren, W1
Baraghithy, S1
Smoum, R1
Attar-Namdar, M1
Mechoulam, R1
Bab, I1
Tam, J1
Cho, DH1
Zhang, Z4
Mu, S1
Chen, T1
Sun, Z1
Shu, Z1
Li, Y6
Kang, X1
Davis, DA1
Cox, PA1
Banack, SA1
Lecusay, PD1
Garamszegi, SP1
Hagan, MJ1
Powell, JT1
Metcalf, JS1
Palmour, RM1
Beierschmitt, A1
Bradley, WG1
Mash, DC1
Wu, W1
Sung, CC1
Yu, P1
Li, J3
Chung, KKK1
Qasim, W1
Sun, RM1
Feng, DC1
Wang, ZY1
Liu, DS1
Yao, JH1
Tian, XF1
Chen, R2
Hornemann, T1
Štefanić, S1
Schraner, EM1
Zuellig, R1
Reding, T1
Malagola, E1
Henstridge, DC1
Hills, AP1
Graf, R1
Sonda, S1
Lee, JY2
Han, SH2
Park, MH2
Song, IS2
Choi, MK2
Yu, E1
Park, CM1
Kim, HJ2
Kim, SH2
Schuchman, EH2
Jin, HK2
Bae, JS2
Prokop, S1
Gorion, KM1
Kim, JD1
Sorrentino, ZA1
Bell, BM1
Manaois, AN1
Chakrabarty, P1
Davies, P1
Giasson, BI2
Wang, J1
Tan, Y1
Peng, Q1
Zeng, W1
Yang, X1
Chen, C2
Wu, Y3
Xu, Y1
Cao, X1
Corti, A1
Gasparri, AM1
Sacchi, A1
Colombo, B1
Monieri, M1
Rrapaj, E1
Ferreri, AJM1
Curnis, F1
Smith, SE1
Chen, X3
Brier, LM1
Bumstead, JR1
Rensing, NR1
Ringel, AE1
Shin, H1
Oldenborg, A1
Crowley, JR1
Bice, AR1
Dikranian, K1
Ippolito, JE1
Haigis, MC1
Papouin, T1
Zhao, G1
Wong, M1
Culver, JP1
Bonni, A1
Iwata, Y2
Sakai, N2
Yoneda, I1
Senda, Y1
Sakai-Takemori, Y1
Oshima, M2
Nakagawa-Yoneda, S1
Ogura, H1
Sato, K2
Minami, T1
Kitajima, S2
Toyama, T2
Yamamura, Y2
Miyagawa, T2
Hara, A2
Shimizu, M2
Furuichi, K2
Matsushima, K1
Wada, T2
Lockridge, A1
Gustafson, E1
Wong, A1
Miller, RF1
Alejandro, EU1
Bjelosevic, S1
Gruber, E1
Newbold, A1
Shembrey, C1
Devlin, JR1
Hogg, SJ1
Kats, L1
Todorovski, I1
Fan, Z2
Abrehart, TC1
Pomilio, G1
Wei, A1
Gregory, GP1
Vervoort, SJ1
Brown, KK1
Johnstone, RW1
Shamshoum, H1
Vlavcheski, F1
MacPherson, REK1
Tsiani, E2
Pan, S1
Fan, M1
Liu, Z4
Li, X4
Wang, H4
Barnabas, GD1
Lee, JS1
Shami, T1
Harel, M1
Beck, L1
Selitrennik, M1
Jerby-Arnon, L1
Erez, N1
Ruppin, E1
Geiger, T1
Vaughan, CA1
Singh, S1
Subler, MA1
Windle, JJ1
Inoue, K1
Fry, EA1
Pillappa, R1
Grossman, SR1
Windle, B1
Andrew Yeudall, W1
Deb, SP1
Deb, S1
Nitschke, L1
Coffin, SL1
Xhako, E1
El-Najjar, DB1
Orengo, JP1
Alcala, E1
Dai, Y1
Wan, YW2
Orr, HT3
Zoghbi, HY3
Weston, LJ1
Cook, ZT1
Stackhouse, TL1
Sal, MK1
Schultz, BI1
Tobias, ZJC1
Osterberg, VR1
Brockway, NL1
Pizano, S1
Glover, G1
Weissman, TA1
Unni, VK1
Tseng, YS1
Liao, CH1
Wu, WB1
Ma, MC1
Yasuda, K2
Hirohashi, Y1
Mariya, T1
Murai, A1
Tabuchi, Y1
Kuroda, T1
Kusumoto, H1
Takaya, A1
Yamamoto, E1
Kubo, T1
Nakatsugawa, M1
Kanaseki, T1
Tsukahara, T1
Tamura, Y2
Hirano, H1
Hasegawa, T2
Saito, T2
Sato, N1
Torigoe, T1
Hirt, L1
Price, M1
Mastour, N1
Brunet, JF1
Barrière, G1
Friscourt, F1
Badaut, J1
Maddocks, ODK1
Athineos, D1
Cheung, EC1
Lee, P1
Zhang, T4
van den Broek, NJF1
Mackay, GM1
Labuschagne, CF1
Gay, D1
Kruiswijk, F1
Blagih, J1
Vincent, DF1
Campbell, KJ1
Ceteci, F1
Sansom, OJ1
Blyth, K2
Vousden, KH2
Nagasawa, M1
Otsuka, T2
Togo, Y1
Yamanaga, M1
Yoshida, J3
Uotsu, N2
Teramoto, S1
Yasuo, S2
Furuse, M3
Terrillion, CE1
Abazyan, B2
Yang, Z1
Crawford, J1
Shevelkin, AV1
Jouroukhin, Y1
Yoo, KH1
Cho, CH1
Roychaudhuri, R1
Snyder, SH3
Jang, MH1
Pletnikov, MV2
Wang, ZH1
Liu, P1
Liu, X5
Manfredsson, FP2
Sandoval, IM1
Yu, SP1
Wang, JZ3
Ye, K1
Sun, T1
Qu, Y2
Cui, W1
Yang, L1
Ji, Y2
Yu, W1
Navinduth, R1
Shao, Z1
Yang, H1
Guo, X1
Paolocci, N1
Zhang, P3
Takahashi, C1
Okumus, N1
Heravi, A1
Keceli, G1
Ramirez-Correa, G1
Kass, DA1
Murphy, AM1
Dondelinger, Y1
Delanghe, T1
Rojas-Rivera, D1
Priem, D1
Delvaeye, T1
Bruggeman, I1
Van Herreweghe, F1
Vandenabeele, P1
Bertrand, MJM2
Antón-Fernández, A1
Merchán-Rubira, J1
Avila, J2
Hernández, F1
DeFelipe, J1
Muñoz, A1
Hamanaka, RB1
Nigdelioglu, R1
Meliton, AY1
Tian, Y1
Witt, LJ1
O'Leary, E1
Sun, KA1
Woods, PS1
Wu, D1
Ansbro, B1
Ard, S1
Rohde, JM1
Dulin, NO1
Guzy, RD1
Mutlu, GM1
Qi, GJ1
Jiao, FJ1
Wang, QZ1
Yan, JG1
Zhang, Q2
Lv, ZX1
Peng, X1
Cai, HW1
Sun, N1
Tian, B1
Coyle, JT3
Zhou, H3
Guo, Y1
Liuyang, ZY1
Shentu, YP1
Jing, XP1
Liang, JW1
Zhou, XW2
Wang, XC1
Zeng, J1
Liu, R1
Senthilkumaran, M1
Bobrovskaya, L1
Tao, H1
Zhou, X2
Xie, Q1
Ma, Z1
Sun, F2
Cui, L1
Cai, Y1
Ma, G1
Fu, J1
Zhao, J1
Chen, Y3
Mai, H1
Chen, J4
Qi, W1
Sun, C1
Zhao, B1
Li, K1
Tang, Y1
Shu, H1
Xing, Y3
Tao, F2
Dong, C1
Zhang, JC1
Ren, Q1
Ma, M1
Zhang, K1
Yao, W1
Ishima, T2
Mori, H3
Hashimoto, K3
D'hondt, S1
Guillemyn, B1
Syx, D1
Symoens, S1
De Rycke, R1
Vanhoutte, L1
Toussaint, W1
Lambrecht, BN1
De Paepe, A1
Keene, DR1
Ishikawa, Y1
Bächinger, HP1
Janssens, S1
Malfait, F1
Baek, B1
Takuwa, Y1
Ryu, H1
He, X1
Zhong, C1
Chang, H2
Zhou, L1
Wu, P1
Qi, Z2
Zou, J1
Lin, L2
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Yang, SS2
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Yamamoto, F1
Yamamoto, H1
Tateishi, A1
Matsushita, M1
Asai, T1
Masuda, Z1
Kuriyama, M1
Kanki, K1
Ishino, K1
Kawada, M1
Sano, S1
Matsui, H1
Xin-Long, C1
Zhao-Fan, X1
Dao-Feng, B1
Wei, D2
Devanathan, V1
Jakovcevski, I1
Santuccione, A1
Lee, HJ1
Peles, E1
Leshchyns'ka, I1
Sytnyk, V1
Schachner, M1
Hampton, DW1
Webber, DJ1
Bilican, B1
Chandran, S1
Atianjoh, FE1
Yaster, M1
Zhao, X1
Takamiya, K1
Xia, J2
Gauda, EB1
Huganir, RL2
Tao, YX1
Jang, SH1
Han, TH1
Hwang, IK1
Park, SA1
Kwak, YG1
Park, JB1
Han, SK1
Ryu, PD1
Lee, SY1
Kim, YS1
Choi, MY1
Kim, YH1
Jeon, BT1
Lee, DH1
Roh, GS1
Kang, SS1
Cho, GJ1
Choi, WS1
Lo, YF1
Yu, IS1
Lin, SW1
Chang, TH1
Hsu, YJ1
Chao, TK1
Sytwu, HK1
Uchida, S1
Sasaki, S1
Lin, SH1
Miyoshi, Y1
Okamura, T1
Kasai, N1
Tojo, Y1
Zaitsu, K1
Duvick, L1
Barnes, J1
Ebner, B1
Agrawal, S1
Andresen, M1
Lim, J1
Giesler, GJ1
Xu, J5
Liu, ZA1
Pei, DS1
Xu, TJ1
Yue, X1
Huang, K1
Pu, P1
Jiang, H1
Yan, W1
Jiang, T1
Kang, C1
Grillo, CA1
Piroli, GG1
Evans, AN1
Macht, VA1
Wilson, SP1
Scott, KA1
Sakai, RR1
Mott, DD1
Reagan, LP1
Cuadrado-Tejedor, M1
Ricobaraza, A1
Del Río, J1
Frechilla, D1
Franco, R1
Pérez-Mediavilla, A1
Garcia-Osta, A1
Nishikawa, T1
Hodeify, R1
Tarcsafalvi, A1
Megyesi, J1
Safirstein, RL1
Price, PM1
Martiniova, L1
Lu, J1
Chiang, J1
Bernardo, M1
Lonser, R1
Zhuang, Z1
Pacak, K1
Kiso, M1
Ozawa, M1
Le, MT1
Imai, H1
Kakugawa, S1
Noda, T1
Horimoto, T1
Kawaoka, Y1
Miraucourt, LS1
Peirs, C1
Dallel, R1
Voisin, DL1
Yin, H1
Jiang, Y1
Gui, Y1
Zheng, XL1
Atwal, RS1
Desmond, CR1
Caron, N1
Maiuri, T1
Sipione, S1
Truant, R1
Peterson, LW1
Kim, JS1
Kijek, P1
Mitchell, S1
Hilfinger, J1
Breitenbach, J1
Borysko, K1
Drach, JC1
Kashemirov, BA1
McKenna, CE1
Iovino, M1
Vuono, R1
Nozaki, C1
Vergnano, AM1
Filliol, D1
Ouagazzal, AM1
Le Goff, A1
Carvalho, S1
Reiss, D1
Gaveriaux-Ruff, C1
Neyton, J1
Paoletti, P1
Kieffer, BL1
Lim, Y1
Kehm, VM1
Lee, EB1
Soper, JH1
Trojanowski, JQ1
Lee, VM1
Mougenot, AL1
Nicot, S1
Bencsik, A1
Morignat, E1
Verchère, J1
Lakhdar, L1
Legastelois, S1
Baron, T1
Kurtz, B1
Thibault, HB1
Raher, MJ1
Popovich, JR1
Cawley, S1
Atochin, DN2
Hayton, S1
Shakartzi, HR1
Huang, PL2
Bloch, KD1
Buys, E1
Scherrer-Crosbie, M1
Fuster, JJ1
González-Navarro, H1
Vinué, A1
Molina-Sànchez, P1
Andrés-Manzano, MJ1
Nakayama, KI2
Nakayama, K1
Díez-Juan, A1
Bernad, A1
Rodríguez, C1
Martínez-González, J1
Andrés, V1
Malkesman, O1
Austin, DR1
Tragon, T1
Wang, G1
Rompala, G1
Hamidi, AB1
Cui, Z1
Young, WS1
Nakazawa, K1
Zarate, CA1
Manji, HK1
Chen, G1
Frattini, LF1
Piubelli, L1
Sacchi, S1
Molla, G1
Pollegioni, L1
Coffee, RL1
Williamson, AJ1
Adkins, CM1
Gray, MC1
Page, TL1
Broadie, K1
Sato, H2
Arawaka, S2
Hara, S1
Fukushima, S1
Koga, K1
Koyama, S1
Kato, T2
Thompson, M1
Marecki, JC1
Marinesco, S1
Crow, JP1
Llagostera, E1
Álvarez López, MJ1
Scimia, C1
Catalucci, D1
Párrizas, M1
Ruiz-Lozano, P1
Kaliman, P1
Ishida, S1
Sakamoto, Y1
Nishio, T1
Baulac, S1
Kuwamura, M1
Ohno, Y1
Takizawa, A1
Serikawa, T1
Mashimo, T1
Ronesi, JA1
Collins, KA1
Hays, SA1
Tsai, NP1
Guo, W1
Birnbaum, SG1
Hu, JH1
Worley, PF1
Gibson, JR1
Huber, KM1
Troquier, L1
Fernandez-Gomez, FJ1
Zommer, N1
Schraen-Maschke, S1
Stetler, RA1
Gao, Y1
Zhang, L1
Weng, Z1
Zhang, F2
Hu, X1
Wang, S1
Vosler, P1
Cao, G1
Sun, D1
Graham, SH1
de Calignon, A1
Polydoro, M1
Suárez-Calvet, M1
William, C1
Adamowicz, DH1
Kopeikina, KJ1
Pitstick, R1
Sahara, N1
Ashe, KH1
Carlson, GA1
Spires-Jones, TL1
Gómez-Galán, M1
De Bundel, D1
Lindskog, M1
Stein, A1
Mao, Z1
Morrison, JP1
Fanucchi, MV1
Postlethwait, EM1
Patel, RP1
Kraus, DW1
Doeller, JE1
Bailey, SM1
Respress, JL1
van Oort, RJ1
Rolim, N1
Dixit, SS1
deAlmeida, A1
Voigt, N1
Lawrence, WS1
Skapura, DG1
Skårdal, K1
Wisløff, U1
Wieland, T1
Ai, X1
Pogwizd, SM1
Dobrev, D1
Wehrens, XH3
Marsboom, G1
Toth, PT1
Ryan, JJ1
Hong, Z1
Fang, YH1
Thenappan, T1
Piao, L1
Zhang, HJ1
Pogoriler, J1
Morrow, E1
Weir, EK1
Rehman, J1
Archer, SL1
Williams, VL1
Martin, RE1
Franklin, JL1
Hardy, RW1
Messina, JL1
Laurido, C1
Hernández, A1
Pelissier, T1
Constandil, L1
Wojciak-Stothard, B1
Zhao, L1
Oliver, E1
Dubois, O1
Kardassis, D1
Vasilaki, E1
Huang, M1
Mitchell, JA1
Harrington, LS1
Louise, H1
Prendergast, GC1
Wilkins, MR1
Williams, HC1
San Martín, A1
Adamo, CM1
Seidel-Rogol, B1
Pounkova, L1
Datla, SR1
Lassègue, B1
Bear, JE1
Griendling, K1
Hammond, S1
Seymour, CM1
Burger, A1
Wagner, JJ1
Bettio, LE1
Cunha, MP1
Budni, J1
Pazini, FL1
Colla, AR1
Rodrigues, AL1
Ma, TM1
Abazyan, S1
Yang, C2
Seshadri, S1
Yamamura, S1
Hoshikawa, M1
Dai, K1
Saito, H1
Niwa, O2
Ando, K1
Dourlen, P1
Sambo, AV1
Bretteville, A1
Vingtdeux, V1
Eddarkaoui, S1
Drobecq, H1
Ghestem, A1
Bégard, S1
Demey-Thomas, E1
Melnyk, P1
Smet, C1
Lippens, G1
Maurage, CA1
Caillet-Boudin, ML1
Verdier, Y1
Vinh, J1
Landrieu, I1
Galas, MC1
Debrouse, L1
Hurd, B1
Kiselycznyk, C1
Plitt, A1
Todaro, A1
Mishina, M1
Grant, SG1
Camp, M1
Gunduz-Cinar, O1
Holmes, A1
Talukder, MA1
Varadharaj, S1
Velayutham, M1
Zweier, JL1
Rao, J1
Yao, A1
Li, G1
Lu, L1
Nagai, T1
Yu, J1
Kitahara, Y1
Nabeshima, T1
Yamada, K1
Rakhade, SN1
Fitzgerald, EF1
Klein, PM1
Zhou, C1
Hunganir, RL1
Jensen, FE1
Guo, J1
Li, D1
Bai, S1
Xu, T1
Zhou, Z1
Maddocks, OD1
Berkers, CR1
Mason, SM1
Zheng, L1
Gottlieb, E1
Ohno, T1
Kawano, K1
Sasaki, A1
Aramaki, M1
Tahara, K1
Etoh, T1
Kitano, S1
Emamian, ES1
Kaytor, MD1
Duvick, LA1
Zu, T1
Tousey, SK1
Clark, HB1
Caudle, RM1
Perez, FM1
King, C1
Yu, CG1
Yezierski, RP1
Singh, DK1
Griffin, DM1
Pacyniak, E1
Jackson, M1
Werle, MJ1
Wisdom, B1
Hout, DR1
Pinson, DM1
Gunderson, RS1
Powers, MF1
Wong, SW1
Stephens, EB1
Buccoliero, R1
Bodennec, J1
Van Echten-Deckert, G1
Sandhoff, K1
Futerman, AH1
Wang, LY1
Wang, ST1
Ho, CJ1
Maruyama, M1
Mishima, Y1
Fujisawa, H1
Obata, M1
Kodama, Y1
Yoshikai, Y1
Aoyagi, Y1
Schaffner, W1
Kominami, R1
Williams, RE1
Lock, EA1
Khamzina, L1
Veilleux, A1
Bergeron, S1
Marette, A1
Chauhan, NB1
Siegel, GJ1
Feinstein, DL1
Pérez, M1
Ribe, E1
Rubio, A1
Lim, F1
Morán, MA1
Ramos, PG1
Ferrer, I1
Isla, MT1
Niimura, M1
Moussa, R1
Bissoon, N1
Ikeda-Douglas, C1
Milgram, NW1
Gurd, JW1
Weiner, I1
Roder, J1
Shu, E1
Matsuno, H1
Akamastu, S1
Kanno, Y1
Suga, H1
Ishisaki, A1
Takai, S1
Kato, K1
Kitajima, Y1
Kozawa, O1
Kase, S1
Harada, T1
Harada, C1
Namekata, K1
Suzuki, Y1
Ohgami, K1
Shiratori, K1
Ohno, S1
Magnol, JP1
Pin, D1
Palazzi, X1
Lacour, JP1
Gache, Y1
Meneguzzi, G1
Jones, TL1
Sorkin, LS1
Hallin, U1
Kondo, E1
Ozaki, Y1
Hagberg, H1
Shibasaki, F1
Blomgren, K1
Benson, MD1
Kluve-Beckerman, B1
Zeldenrust, SR1
Siesky, AM1
Bodenmiller, DM1
Showalter, AD1
Sloop, KW1
Huang, F1
Shan, J1
Reiken, S1
Marks, AR1
Chen, WF1
Huang, LT1
Lai, MC1
Yang, CH1
Wan, TH1
Yang, SN1
Pietraszek, M1
Nagel, J1
Gravius, A1
Schäfer, D1
Danysz, W1
Sasaki, T1
Han, F1
Shioda, N1
Moriguchi, S1
Kasahara, J1
Ishiguro, K1
Fukunaga, K1
Yamaguchi, K1
Nakatani, A1
Murasawa, H1
Fujimura, K1
Tatsumi, Y1
Tatsumi, M1
Zhang, QG2
Han, D2
Lv, Q1
Wang, R2
Yin, XH2
Xu, TL1
Zhang, GY3
Lü, Q1
Atsuzawa, K1
Aoshima, C1
Yamauchi, K1
Ihara, M1
Yamasaki, N1
Hagiwara, A1
Tanigaki, A1
Kitano, A1
Hikawa, R1
Tomimoto, H1
Noda, M1
Takanashi, M1
Hattori, N1
Miyakawa, T1
Kinoshita, M1
Dickey, CA1
Kamal, A1
Lundgren, K1
Klosak, N1
Bailey, RM1
Dunmore, J1
Ash, P1
Shoraka, S1
Zlatkovic, J1
Eckman, CB1
Patterson, C1
Dickson, DW1
Nahman, NS1
Hutton, M1
Burrows, F1
Petrucelli, L1
Huang, P1
Bu, X1
Zhang, N1
Han, S1
Fang, L1
Chen, XL1
Xia, ZF1
Ben, DF1
Tang, HT1
Ge, SD1
Wang, A1
Liu, VW1
Critchlow, JD1
Dantas, AP1
Looft-Wilson, R1
Murata, T1
Salomone, S1
Shin, HK1
Ayata, C1
Moskowitz, MA1
Sessa, WC1
Chen-Izu, Y1
Ward, CW1
Stark, W1
Banyasz, T1
Sumandea, MP1
Balke, CW1
Izu, LT1
Morimoto, N1
Nagai, M1
Ohta, Y1
Miyazaki, K1
Kurata, T1
Morimoto, M1
Murakami, T1
Takehisa, Y1
Ikeda, Y1
Kamiya, T1
Abe, K1
Inukai, T1
Takagi, T1
Chiba, T1
Yamada, M1
Okamoto, K1
Nishimoto, I1
Matsuoka, M1
Fujita, Y1
Iyo, M1
Rajasingh, J1
Bord, E1
Hamada, H1
Lambers, E1
Qin, G1
Losordo, DW1
Kishore, R1
Rodríguez-Muñoz, M1
de la Torre-Madrid, E1
Gaitán, G1
Sánchez-Blázquez, P1
Garzón, J1
Mueller-Burke, D1
Koehler, RC1
Martin, LJ1
Gorbatyuk, OS1
Sullivan, LF1
Chen, W1
Kondrikova, G1
Mandel, RJ1
Muzyczka, N1
Vithlani, M1
Sieghart, W1
Kittler, J1
Pangalos, M1
Haydon, PG1
Coulter, DA1
Tan, NY1
Midgley, VC1
Kavurma, MM1
Santiago, FS1
Luo, X1
Peden, R1
Fahmy, RG1
Berndt, MC1
Molloy, MP1
Khachigian, LM1
Lu, Y1
Sun, YN1
Sun, Q1
Liu, FY1
Xing, GG1
Wan, Y1
Funderburk, SF1
Shatkina, L1
Mink, S1
Weis, Q1
Weg-Remers, S1
Cato, AC1
Andren, PE1
Chergui, K1
Waxman, EA1
Kwon, YB1
Kim, KW1
Benevenga, NJ1
Steele, RD1
Schouten, MJ1
Bruinvels, J1
Pepplinkhuizen, L1
Wilson, JH1
Glimcher, MJ1
Reit, B1
Kossiva, D1
Stanley, SL2
Blanchard, JL1
Johnson, N1
Foster, L1
Kunz-Jenkins, C1
Tian, K1
Cogswell, FB1
De Sarro, G1
Ongini, E1
Bertorelli, R1
Aguglia, U1
De Sarro, A1
Mori, M1
Nishimura, M1
Whitfield, JF1
Morley, P1
Willick, G1
Langille, R1
Ross, V1
MacLean, S1
Barbier, JR1
Nihei, Y2
Suga, Y1
Morinaga, Y1
Ohishi, K1
Okano, A1
Ohsumi, K1
Hatanaka, T1
Nakagawa, R1
Tsuji, T1
Akiyama, Y1
Saito, S2
Hori, K2
Sato, Y2
Tsuruo, T1
Sawamura, N1
Gong, JS1
Garver, WS1
Heidenreich, RA1
Ninomiya, H1
Ohno, K1
Yanagisawa, K1
Michikawa, M1
Das, J1
Kimball, SD1
Reid, JA1
Wang, TC1
Lau, WF1
Roberts, DG1
Seiler, SM1
Schumacher, WA1
Ogletree, ML1
Longnecker, DS1
Curphey, TJ1
Singh, L1
Oles, RJ1
Vass, CA1
Woodruff, GN1
Gunawan, S1
Walton, NY1
Treiman, DM1
Chanarin, I1
Deacon, R1
Lumb, M1
Muir, M1
Perry, J1
Haycock, JW1
Deadwyler, SA1
Sideroff, SI1
McGaugh, JL1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314]Phase 2/Phase 350 participants (Anticipated)Interventional2019-03-31Not yet recruiting
Curcumin and Yoga Exercise Effects in Veterans at Risk for Alzheimer's Disease[NCT01811381]Phase 280 participants (Anticipated)Interventional2014-01-20Active, not recruiting
A Study to Determine the Safety and Efficacy in Lipoprotein Lipase-Deficient Subjects After Intramuscular Administration of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein LipaseS447X[NCT01109498]Phase 2/Phase 314 participants (Actual)Interventional2007-08-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for serine and Disease Models, Animal

ArticleYear
Serine, glycine and one‑carbon metabolism in cancer (Review).
    International journal of oncology, 2021, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents; Carbon; Carcinogenesis; Disease Models, Animal; Glycine; Humans; Met

2021
Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies.
    Expert opinion on drug discovery, 2018, Volume: 13, Issue:10

    Topics: Animals; Antipsychotic Agents; D-Amino-Acid Oxidase; Disease Models, Animal; Drug Development; Drug

2018
L-serine: a neglected amino acid with a potential therapeutic role in diabetes.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2019, Volume: 127, Issue:10

    Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supple

2019
Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias.
    Circulation research, 2014, Apr-11, Volume: 114, Issue:8

    Topics: Animals; Arrhythmias, Cardiac; Calcium; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal

2014
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.
    Reviews in the neurosciences, 2013, Volume: 24, Issue:2

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Humans; Nerve Degeneration; Parkinson Disease; Pho

2013
The role of group I metabotropic glutamate receptors in schizophrenia.
    Amino acids, 2007, Volume: 32, Issue:2

    Topics: Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Glycine; Humans; Mice; Mice, Knockout;

2007
[Update on the animal models of schizophrenia].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 128, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Drug Design; Excitatory Amino Acid Antagon

2006
Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival.
    Progress in lipid research, 2008, Volume: 47, Issue:3

    Topics: Animals; Brain; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Hereditary Sensory and Aut

2008
Adverse effects of excessive consumption of amino acids.
    Annual review of nutrition, 1984, Volume: 4

    Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Ani

1984
Cobalamin-folate interrelations: a critical review.
    Blood, 1985, Volume: 66, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N

1985

Other Studies

328 other studies available for serine and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
The Amino Acid-mTORC1 Pathway Mediates APEC TW-XM-Induced Inflammation in bEnd.3 Cells.
    International journal of molecular sciences, 2021, Aug-26, Volume: 22, Issue:17

    Topics: Amino Acid Transport Systems; Amino Acids; Animals; Bird Diseases; Blood-Brain Barrier; Cell Line; D

2021
PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.
    Scientific reports, 2021, 12-15, Volume: 11, Issue:1

    Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Biomarkers; Disease Mo

2021
D-serine metabolism in the medial prefrontal cortex, but not the hippocampus, is involved in AD/HD-like behaviors in SHRSP/Ezo.
    European journal of pharmacology, 2022, May-15, Volume: 923

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Hippocampus; Prefron

2022
Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia.
    Neurobiology of disease, 2022, Volume: 170

    Topics: Animals; Dendritic Spines; Disease Models, Animal; Humans; Mice; Mice, Knockout; Neuronal Plasticity

2022
Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Epileptic Syndromes; Female; Glucose

2022
The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease.
    Neuroscience letters, 2023, 01-01, Volume: 792

    Topics: Alzheimer Disease; Amygdala; Animals; Astrocytes; Disease Models, Animal; Humans; Mice; Plaque, Amyl

2023
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.
    Nature communications, 2023, 02-23, Volume: 14, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Humans; Liver Neoplasm

2023
Serine-/Cysteine-Based sp
    Journal of medicinal chemistry, 2023, 04-13, Volume: 66, Issue:7

    Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Animals; Asthma; CD8-Positive T-Lymphocytes; Cystei

2023
Mouse nerve growth factor suppresses neuronal apoptosis in valproic acid-induced autism spectrum disorder rats by regulating the phosphoinositide-3-kinase/serine/threonine kinase signaling pathway.
    Pharmacogenetics and genomics, 2023, 07-01, Volume: 33, Issue:5

    Topics: Animals; Apoptosis; Autism Spectrum Disorder; Disease Models, Animal; Humans; Mice; Phosphatidylinos

2023
Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.
    Journal of Huntington's disease, 2023, Volume: 12, Issue:3

    Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Phosphorylation

2023
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
    The New England journal of medicine, 2019, 10-10, Volume: 381, Issue:15

    Topics: Adult; Aged; Animals; Disease Models, Animal; DNA Mutational Analysis; Exome; Female; Hereditary Sen

2019
l-Serine Lowers the Inflammatory Responses during Pasteurella multocida Infection.
    Infection and immunity, 2019, Volume: 87, Issue:12

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Host-Pathogen Interactions; Inflammation;

2019
HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity.
    Molecules (Basel, Switzerland), 2019, Oct-16, Volume: 24, Issue:20

    Topics: Adipocytes; Adiposity; Animals; Bone Marrow; Disease Models, Animal; Female; Mice; Oleic Acids; Oste

2019
Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser
    Journal of Korean medical science, 2019, Nov-04, Volume: 34, Issue:42

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Cat

2019
H4S1ph, an alternative epigenetic marker for sperm maturity.
    Andrologia, 2020, Volume: 52, Issue:1

    Topics: Animals; Brachyura; Cell Nucleus; Disease Models, Animal; Epigenesis, Genetic; Fertility; Histones;

2020
l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND.
    Journal of neuropathology and experimental neurology, 2020, 04-01, Volume: 79, Issue:4

    Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chlorocebus aethiops; Cyanobacteria To

2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
    PloS one, 2020, Volume: 15, Issue:4

    Topics: Age Factors; alpha-Synuclein; Animals; Casein Kinase II; Disease Models, Animal; G-Protein-Coupled R

2020
PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury.
    World journal of gastroenterology, 2020, Apr-21, Volume: 26, Issue:15

    Topics: Animals; Apoptosis; Caco-2 Cells; Cell Hypoxia; Disease Models, Animal; Dynamins; Gene Knockdown Tec

2020
Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.
    Diabetologia, 2020, Volume: 63, Issue:9

    Topics: Acinar Cells; Animals; Apoptosis; Ceruletide; Diabetes Mellitus, Experimental; Disease Models, Anima

2020
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
    Nature communications, 2020, 05-12, Volume: 11, Issue:1

    Topics: Acetyl Coenzyme A; Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Brain; Cell Li

2020
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies.
    Acta neuropathologica communications, 2020, 06-22, Volume: 8, Issue:1

    Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; HEK293 Cells; Humans; Mice, Inb

2020
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.
    Behavioural brain research, 2020, 09-01, Volume: 393

    Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Male; Medial Forebrain Bundle; Parkinson Di

2020
NGR-TNF Engineering with an N-Terminal Serine Reduces Degradation and Post-Translational Modifications and Improves Its Tumor-Targeting Activity.
    Molecular pharmaceutics, 2020, 10-05, Volume: 17, Issue:10

    Topics: Amino Acid Motifs; Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Disease Models,

2020
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
    Nature communications, 2020, 12-02, Volume: 11, Issue:1

    Topics: Animals; Astrocytes; Ataxia; Brain; Disease Models, Animal; Electroencephalography; Female; Function

2020
D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus.
    Biochemical and biophysical research communications, 2021, 01-22, Volume: 537

    Topics: Animals; Bacterial Adhesion; Biofilms; Catheters; Disease Models, Animal; Down-Regulation; Gene Expr

2021
Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity.
    Cells, 2021, 01-07, Volume: 10, Issue:1

    Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Glucose; Glucose Intolerance; Homeostasis; I

2021
Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.
    Cancer discovery, 2021, Volume: 11, Issue:6

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Mye

2021
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2021, Volume: 46, Issue:7

    Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models

2021
Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
    Cancer research, 2021, 03-15, Volume: 81, Issue:6

    Topics: Animals; Breast; Cell Line, Tumor; Cell Proliferation; CRISPR-Cas Systems; Datasets as Topic; Diseas

2021
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
    Nature communications, 2021, 01-29, Volume: 12, Issue:1

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Disease Models, Animal; Female; Gain of Function Mutation

2021
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
    JCI insight, 2021, 02-08, Volume: 6, Issue:3

    Topics: Alleles; Animals; Ataxin-1; Behavior, Animal; Brain; Disease Models, Animal; Humans; Mice; Mice, Inb

2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.
    Neurobiology of disease, 2021, Volume: 152

    Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Humans; Parkinson D

2021
    American journal of physiology. Renal physiology, 2021, 05-01, Volume: 320, Issue:5

    Topics: Animals; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Kidney Tubules, Proxima

2021
Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.
    Oncotarget, 2017, May-09, Volume: 8, Issue:19

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expressio

2017
Increase of aquaporin 9 expression in astrocytes participates in astrogliosis.
    Journal of neuroscience research, 2018, Volume: 96, Issue:2

    Topics: Animals; Aquaporin 4; Aquaporins; Astrocytes; Cells, Cultured; Disease Models, Animal; Embryo, Mamma

2018
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
    Nature, 2017, 04-19, Volume: 544, Issue:7650

    Topics: Animals; Antioxidants; Biguanides; Cell Line, Tumor; Diet; Disease Models, Animal; Female; Food Depr

2017
Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means.
    Amino acids, 2017, Volume: 49, Issue:9

    Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Cystathionine; Depression; D

2017
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:11

    Topics: Animals; Animals, Newborn; Anxiety; Astrocytes; Behavior, Animal; Cell Proliferation; Disease Models

2017
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
    Molecular cell, 2017, Sep-07, Volume: 67, Issue:5

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Brain; Cognition

2017
Evaluation of osteogenic inductivity of a novel BMP2-mimicking peptide P28 and P28-containing bone composite.
    Journal of biomedical materials research. Part A, 2018, Volume: 106, Issue:1

    Topics: Animals; Aspartic Acid; Biomimetic Materials; Bone and Bones; Bone Morphogenetic Protein 2; Bone Reg

2018
Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.
    Circulation. Heart failure, 2017, Volume: 10, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Calpain; Disease Models, Animal; Genetic Predisposition to Diseas

2017
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.
    Nature cell biology, 2017, Volume: 19, Issue:10

    Topics: Animals; Apoptosis; Cell Line; Cytosol; Disease Models, Animal; Enzyme Activation; Female; Fibroblas

2017
Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2

    Topics: Animals; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Golgi Apparatus; Humans; Intrace

2017
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
    American journal of respiratory cell and molecular biology, 2018, Volume: 58, Issue:5

    Topics: Airway Remodeling; Animals; Bleomycin; Collagen; Disease Models, Animal; Enzyme Inhibitors; Fibrobla

2018
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Active Transport, Cell Nucleus; Amygdala; Animals; Behavior, Animal; Cyclin-Dependent Kinase 5; Depr

2018
Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia.
    ACS chemical neuroscience, 2018, 09-19, Volume: 9, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Cytoskeleta

2018
Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2017, Volume: 37, Issue:6

    Topics: Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Female; Gene Expression Reg

2017
The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF.
    Autonomic neuroscience : basic & clinical, 2018, Volume: 210

    Topics: Animals; Blood Glucose; Disease Models, Animal; Epinephrine; Hypoglycemia; Hypoglycemic Agents; Insu

2018
SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:3

    Topics: Animals; Case-Control Studies; Cohort Studies; Computational Biology; Disease Models, Animal; Epilep

2018
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain.
    Neuropharmacology, 2018, 05-01, Volume: 133

    Topics: Animals; Avoidance Learning; Calcium; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Locomot

2018
Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress.
    Neurochemistry international, 2018, Volume: 116

    Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal;

2018
Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.
    Matrix biology : journal of the International Society for Matrix Biology, 2018, Volume: 70

    Topics: Amino Acid Substitution; Animals; Arteries; Collagen Type III; Disease Models, Animal; Ehlers-Danlos

2018
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
    Nature communications, 2018, 04-16, Volume: 9, Issue:1

    Topics: Acetyl Coenzyme A; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Pre

2018
Up-regulated Cx43 phosphorylation at Ser368 prolongs QRS duration in myocarditis.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:7

    Topics: Animals; Cell Communication; Connexin 43; Disease Models, Animal; Electrocardiography; Heart; Interl

2018
Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:7

    Topics: Activating Transcription Factor 6; Alzheimer Disease; Animals; Brain; Cyclic AMP Response Element-Bi

2018
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
    Alzheimer's research & therapy, 2018, 06-19, Volume: 10, Issue:1

    Topics: Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship,

2018
Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Mal

2018
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.
    Molecular and cellular biology, 2018, 09-15, Volume: 38, Issue:18

    Topics: Aging; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Knock

2018
PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons.
    Cell death & disease, 2018, 08-29, Volume: 9, Issue:9

    Topics: Animals; Cysteine; Disease Models, Animal; Dynamins; Male; Mitochondria; Mitochondrial Dynamics; Neu

2018
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 09-18, Volume: 115, Issue:38

    Topics: Amino Acid Transport System ASC; Animals; Astrocytes; Brain; Cell Communication; Disease Models, Ani

2018
Monitoring α-synuclein multimerization in vivo.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:2

    Topics: alpha-Synuclein; Amyloid; Animals; Disease Models, Animal; Drosophila melanogaster; Male; Phosphoryl

2019
Gut microbiota-derived D-serine protects against acute kidney injury.
    JCI insight, 2018, 10-18, Volume: 3, Issue:20

    Topics: Acute Kidney Injury; Administration, Oral; Animals; Biomarkers; Disease Models, Animal; Dysbiosis; F

2018
Decreased d-Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model.
    Investigative ophthalmology & visual science, 2018, 10-01, Volume: 59, Issue:12

    Topics: Animals; Apoptosis; Aqueous Humor; Blotting, Western; Cell Count; Cell Survival; Chromatography, Hig

2018
Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat.
    Neurological research, 2019, Volume: 41, Issue:3

    Topics: Analgesics; Animals; Disease Models, Animal; Dura Mater; Electric Stimulation; Female; Grooming; Hea

2019
Serine Metabolism Supports Macrophage IL-1β Production.
    Cell metabolism, 2019, 04-02, Volume: 29, Issue:4

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Interleukin-1beta; Lipopolysaccharides; Ma

2019
Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.
    Current medical science, 2019, Volume: 39, Issue:1

    Topics: Animals; Apoptosis; Dexamethasone; Disease Models, Animal; Femur Head Necrosis; Gene Knockdown Techn

2019
Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury.
    Scientific reports, 2019, 05-10, Volume: 9, Issue:1

    Topics: Animals; Disease Models, Animal; Gene Knock-In Techniques; Intercellular Signaling Peptides and Prot

2019
Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus.
    Schizophrenia research, 2019, Volume: 210

    Topics: Animals; Cuprizone; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Hippocampus; Male; Met

2019
Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity.
    JCI insight, 2019, 07-25, Volume: 4, Issue:14

    Topics: Animals; Carbon; Disease Models, Animal; Glycine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, al

2019
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
    Annals of neurology, 2013, Volume: 74, Issue:1

    Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cel

2013
Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:2

    Topics: Animals; Benzimidazoles; Benzoates; Blood Glucose; Body Weight; Calcium; Calcium-Binding Proteins; C

2013
Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase Cγ-dependent mechanism.
    Neuroscience, 2013, Jun-14, Volume: 240

    Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Pain Threshold; Pain, Postoperative; Phosphoryl

2013
Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway.
    Glia, 2013, Volume: 61, Issue:7

    Topics: Animals; Axotomy; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Glial Cell Line-Derive

2013
Pentylenetetrazol-induced seizures are associated with Na⁺,K⁺-ATPase activity decrease and alpha subunit phosphorylation state in the mice cerebral cortex.
    Epilepsy research, 2013, Volume: 105, Issue:3

    Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Mal

2013
(-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus.
    Molecular and cellular biochemistry, 2013, Volume: 380, Issue:1-2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western

2013
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-15, Volume: 33, Issue:20

    Topics: Analysis of Variance; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Depres

2013
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
    Neuropharmacology, 2013, Volume: 75

    Topics: Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Death; Cells, Cultured; Connexin 43; Cra

2013
Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Jun-25, Volume: 110, Issue:26

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Dendritic Spines; Disease Models, A

2013
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Anxiety Disorders; Behavior, Animal; Depression; Disease Models, Animal; Glial Fibrillary A

2013
Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
    Brain research, 2013, Sep-05, Volume: 1529

    Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Electroacupuncture; Functional Laterality; In

2013
Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Aug-07, Volume: 33, Issue:32

    Topics: Allosteric Regulation; Animals; Binding Sites; Cognition Disorders; D-Amino-Acid Oxidase; Disease Mo

2013
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
    British journal of pharmacology, 2013, Volume: 170, Issue:5

    Topics: Analgesics; Animals; Benzamides; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line; Dise

2013
Phosphatidylethanolamine-binding protein 1 (PEBP1) as a potential target for the treatment for depression.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:12

    Topics: Animals; Depression; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression

2013
Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis.
    Scientific reports, 2013, Oct-31, Volume: 3

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Mutational Analys

2013
Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration.
    Neuroreport, 2014, Jan-22, Volume: 25, Issue:2

    Topics: Animals; Brain; Conditioning, Operant; Disease Models, Animal; Drug-Seeking Behavior; Gene Expressio

2014
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.
    Experimental neurology, 2014, Volume: 252

    Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Disease Models, Animal; Drug Administration R

2014
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites;

2013
Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²⁺ channel due to a familial hemiplegic migraine mutation.
    Neuron, 2014, Jan-08, Volume: 81, Issue:1

    Topics: Animals; Animals, Genetically Modified; Biophysical Phenomena; Biophysics; Calcium; Calcium Channels

2014
Thromboxane receptor hyper-responsiveness in hypoxic pulmonary hypertension requires serine 324.
    British journal of pharmacology, 2014, Volume: 171, Issue:3

    Topics: Amino Acid Substitution; Animals; Animals, Newborn; Calcium Signaling; Cell Hypoxia; Cells, Cultured

2014
Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.
    Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:5

    Topics: Animals; Binding Sites; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CX3CL1; Diseas

2014
Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization.
    The Journal of infectious diseases, 2014, Sep-15, Volume: 210, Issue:6

    Topics: Adhesins, Bacterial; Animals; Bacterial Adhesion; Cell Line; Disease Models, Animal; Epithelium; Fem

2014
Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-30, Volume: 34, Issue:18

    Topics: Animals; Antipsychotic Agents; Clozapine; CREB-Binding Protein; Cyclic AMP; Cyclin-Dependent Kinase

2014
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
    American journal of physiology. Endocrinology and metabolism, 2014, Jun-15, Volume: 306, Issue:12

    Topics: Animals; Carrier Proteins; Cumulative Trauma Disorders; Disease Models, Animal; HEK293 Cells; Humans

2014
Hypertension alters phosphorylation of VASP in brain endothelial cells.
    The International journal of neuroscience, 2015, Volume: 125, Issue:4

    Topics: Animals; Blood Pressure; Brain; Case-Control Studies; Cell Adhesion Molecules; Cells, Cultured; Dise

2015
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014, Volume: 9, Issue:7

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem

2014
The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice.
    Anesthesia and analgesia, 2014, Volume: 119, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cognition; Cognition D

2014
D-serine prevents cognitive deficits induced by acute stress.
    Neuropharmacology, 2014, Volume: 86

    Topics: Acute Disease; Animals; Cognition Disorders; Corticosterone; Disease Models, Animal; Glycine; Hippoc

2014
A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
    Endocrinology, 2014, Volume: 155, Issue:11

    Topics: Alopecia; Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Familial Hypoph

2014
Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice.
    Behavioural brain research, 2014, Nov-01, Volume: 274

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Gene Expression

2014
Serine catabolism regulates mitochondrial redox control during hypoxia.
    Cancer discovery, 2014, Volume: 4, Issue:12

    Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Gene Amplification;

2014
Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015, Volume: 33, Issue:1

    Topics: Animals; Anterior Cruciate Ligament Reconstruction; Asparagine; Biomarkers; Disease Models, Animal;

2015
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:12

    Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Disease Models, Animal; Female; Humans; Infar

2014
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
    Behavioural brain research, 2015, Feb-01, Volume: 278

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine

2015
Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis.
    Neurosurgical focus, 2014, Volume: 37, Issue:6

    Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; DNA-Activated Protein Kin

2014
Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 130

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine Plasma Membra

2015
Regulation of nonclassical renin-angiotensin system receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Mar-15, Volume: 308, Issue:6

    Topics: Adrenal Medulla; Animals; Catecholamines; Disease Models, Animal; Gene Expression Regulation; Immobi

2015
Suppression of PKCε-mediated mitochondrial connexin 43 phosphorylation at serine 368 is involved in myocardial mitochondrial dysfunction in a rat model of dilated cardiomyopathy.
    Molecular medicine reports, 2015, Volume: 11, Issue:6

    Topics: Administration, Oral; Animals; Cardiomyopathy, Dilated; Cells, Cultured; Connexin 43; Disease Models

2015
Designer receptors enhance memory in a mouse model of Down syndrome.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jan-28, Volume: 35, Issue:4

    Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Cross-Over Studies; Designer Drugs; Disease Mo

2015
PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin-Angiotensin System.
    Journal of cardiovascular pharmacology, 2015, Volume: 65, Issue:5

    Topics: Angiotensin-Converting Enzyme 2; Animals; Bradykinin; Clofibrate; Disease Models, Animal; Enzyme Act

2015
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
    Neurobiology of disease, 2015, Volume: 77

    Topics: Adenoviridae; alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Female; Forelimb; G

2015
Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Apoptosis; Astrocytes; Brain; Brain Edema; Brain Injuries; Cytokines; Disease Models, Anima

2015
Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.
    BMC neuroscience, 2015, Mar-14, Volume: 16

    Topics: Anhedonia; Animals; Anti-Anxiety Agents; Anxiety; Dietary Sucrose; Disease Models, Animal; Hippocamp

2015
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
    Journal of Crohn's & colitis, 2015, Volume: 9, Issue:7

    Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogenesis; Colitis; Colorectal Neoplasm

2015
Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser⁸⁴⁷ in the hippocampus immediately after subarachnoid hemorrhage.
    Brain research, 2015, Aug-07, Volume: 1616

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gene Expression

2015
d-serine levels in Alzheimer's disease: implications for novel biomarker development.
    Translational psychiatry, 2015, May-05, Volume: 5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A

2015
Cardiac Nitric Oxide Synthases and Na⁺/K⁺-ATPase in the Rat Model of Polycystic Ovary Syndrome Induced by Dihydrotestosterone.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2015, Volume: 123, Issue:5

    Topics: Animals; Cell Membrane; Dihydrotestosterone; Disease Models, Animal; Down-Regulation; Female; Myocar

2015
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.
    Molecular psychiatry, 2016, Volume: 21, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Age Factors; Animals;

2016
A novel phosphorylation site of N-methyl-D-aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia.
    Experimental neurology, 2015, Volume: 271

    Topics: Animals; Carotid Artery Diseases; Cells, Cultured; Central Nervous System Stimulants; Cyclin-Depende

2015
Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.
    Neurochemistry international, 2015, Volume: 88

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Male; Motor Cortex; Oxidopamine; Pa

2015
Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis.
    Food & function, 2015, Volume: 6, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Capsaicin; Disease Models, Animal; Glycerophospholipi

2015
Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.
    Experimental neurology, 2015, Volume: 273

    Topics: Analysis of Variance; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Disease Models, Animal;

2015
Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
    Pharmacological research, 2015, Volume: 100

    Topics: Animals; Astrocytes; Disease Models, Animal; Ethylenediamines; Hyperalgesia; Male; Mice; Mice, Inbre

2015
Antidepressant-like effect of bright light is potentiated by L-serine administration in a mouse model of seasonal affective disorder.
    Brain research bulletin, 2015, Volume: 118

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Light;

2015
dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Escherichia coli Proteins; Female; Hum

2015
Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 47, Issue:1

    Topics: Animals; Antidepressive Agents, Second-Generation; Citalopram; Colforsin; Disease Models, Animal; En

2015
Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2015, Volume: 40, Issue:11

    Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Dyslipidemias; Emulsions; Fatty Acids, N

2015
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Dec-01, Volume: 112, Issue:48

    Topics: Alanine; Animals; Autism Spectrum Disorder; Behavior, Animal; Biotinylation; Cell Membrane; Dendriti

2015
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman.
    The Journal of biological chemistry, 2016, Feb-26, Volume: 291, Issue:9

    Topics: Animals; Animals, Newborn; Cells, Cultured; Computational Biology; Disease Models, Animal; Heart Fai

2016
Post-translational modification of cortical GluA receptors in rodents following spinal cord lesion.
    Neuroscience, 2016, Mar-01, Volume: 316

    Topics: Animals; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Female; Gene Expression Reg

2016
pSer40 tyrosine hydroxylase immunohistochemistry identifies the anatomical location of C1 neurons in rat RVLM that are activated by hypotension.
    Neuroscience, 2016, Mar-11, Volume: 317

    Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hybrido

2016
Ablation of eNOS does not promote adipose tissue inflammation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2016, Apr-15, Volume: 310, Issue:8

    Topics: Adipose Tissue, Brown; Adiposity; Animals; Diet, High-Fat; Disease Models, Animal; Genetic Predispos

2016
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
    Acta neuropathologica, 2016, Volume: 131, Issue:4

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai

2016
Antipsychotic-like effects of a neurotensin receptor type 1 agonist.
    Behavioural brain research, 2016, May-15, Volume: 305

    Topics: Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Central Nervous System Stim

2016
Effects of CC-chemokine receptor 5 on ROCK2 and P-MLC2 expression after focal cerebral ischaemia-reperfusion injury in rats.
    Brain injury, 2016, Volume: 30, Issue:4

    Topics: Analysis of Variance; Animals; Brain Infarction; Cardiac Myosins; Disease Models, Animal; In Situ Ni

2016
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
    Oncogene, 2016, 11-17, Volume: 35, Issue:46

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Mode

2016
A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:3

    Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Disease Models, Anima

2016
Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
    Neurobiology of aging, 2016, Volume: 46

    Topics: Amyloid beta-Protein Precursor; Animals; Brain; CA1 Region, Hippocampal; Cytoplasm; Disease Models,

2016
Restoration of visual performance by d-serine in models of inner and outer retinal dysfunction assessed using sweep VEP measurements in the conscious rat and rabbit.
    Vision research, 2016, Volume: 127

    Topics: Animals; Contrast Sensitivity; Disease Models, Animal; Evoked Potentials, Visual; Male; Rabbits; Rat

2016
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
    The Journal of clinical investigation, 2016, 09-01, Volume: 126, Issue:9

    Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model

2016
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.
    Scientific reports, 2016, 08-25, Volume: 6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Disease Models, Animal; H

2016
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:12

    Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Dynamins; Excitatory Amino Acid Agonists; Fun

2016
Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:3

    Topics: Amino Alcohols; Animals; Apolipoproteins E; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal

2017
A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway.
    Journal of medicinal chemistry, 2016, 10-13, Volume: 59, Issue:19

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Ani

2016
Effects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain.
    Neuroscience letters, 2017, 01-01, Volume: 636

    Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Male;

2017
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
    The journal of pain, 2017, Volume: 18, Issue:4

    Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitato

2017
Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1
    Molecular neurobiology, 2018, Volume: 55, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; D-Amino-Acid Oxidase; Dependovirus; Disease Model

2018
Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility.
    Molecular immunology, 2017, Volume: 82

    Topics: Animals; Autoimmune Diseases; Cell Separation; Diabetes Mellitus, Experimental; Disease Models, Anim

2017
Dysregulated Glycine Signaling Contributes to Increased Impulsivity during Protracted Alcohol Abstinence.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 02-15, Volume: 37, Issue:7

    Topics: Alcohol Abstinence; Alcohol Drinking; Animals; Central Nervous System Depressants; Choice Behavior;

2017
Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome.
    The Journal of biological chemistry, 2017, 04-21, Volume: 292, Issue:16

    Topics: Aged; Aged, 80 and over; Animals; Behavior, Animal; Disease Models, Animal; Fragile X Mental Retarda

2017
Personal model-assisted identification of NAD
    Molecular systems biology, 2017, 03-02, Volume: 13, Issue:3

    Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Genome; Glutathion

2017
L-Gln and L-Ser suppress the D-galactosamine-induced IL-18 expression and hepatitis.
    Biochemical and biophysical research communications, 2008, Aug-08, Volume: 372, Issue:4

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Diet; Disease Models, Animal;

2008
The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.
    British journal of pharmacology, 2008, Volume: 155, Issue:1

    Topics: Aminoacetonitrile; Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Impla

2008
Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
    Psychopharmacology, 2008, Volume: 200, Issue:2

    Topics: Animals; Behavior, Animal; Carrier Proteins; Clozapine; Disease Models, Animal; Glycine; Male; Mice;

2008
Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation.
    Neuropharmacology, 2009, Volume: 56, Issue:1

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electric

2009
Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.
    Neuroscience letters, 2008, Nov-21, Volume: 445, Issue:3

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Glycine Pl

2008
l-Serine induces sedative and hypnotic effects acting at GABA(A) receptors in neonatal chicks.
    European journal of pharmacology, 2008, Dec-03, Volume: 599, Issue:1-3

    Topics: Acute Disease; Animals; Animals, Newborn; Chickens; Disease Models, Animal; Glycine; Hypnotics and S

2008
Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Oct-22, Volume: 28, Issue:43

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Coca

2008
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antimanic Agents; Brain; Citrates; Disease Mode

2009
Implication of the JNK pathway in a rat model of Huntington's disease.
    Experimental neurology, 2009, Volume: 215, Issue:1

    Topics: Analysis of Variance; Animals; Cell Line, Transformed; CREB-Binding Protein; Disease Models, Animal;

2009
L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats.
    Journal of hypertension, 2008, Volume: 26, Issue:12

    Topics: Animals; Apamin; Blood Pressure; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship,

2008
Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice.
    Neuroscience letters, 2009, Jan-30, Volume: 450, Issue:2

    Topics: Animals; Catechin; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Dr

2009
Cytosolic phospholipase A2-{alpha} is an early apoptotic activator in PEDF-induced endothelial cell apoptosis.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Arachidonic Acid; Burns, Chemical; Caspase 3; Ce

2009
Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.
    Neuroscience research, 2009, Volume: 63, Issue:3

    Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Transporter 1; Gene Expres

2009
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Dec-31, Volume: 28, Issue:53

    Topics: Amyloid beta-Peptides; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal;

2008
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
    Neurochemical research, 2009, Volume: 34, Issue:7

    Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner

2009
Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy.
    Journal of pharmacological sciences, 2009, Volume: 109, Issue:3

    Topics: Animals; Binding Sites; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycin

2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.
    Neuroscience, 2009, Jun-02, Volume: 160, Issue:4

    Topics: Aging; alpha-Synuclein; Amygdala; Animals; Brain; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Co

2009
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
    Current Alzheimer research, 2009, Volume: 6, Issue:2

    Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus

2009
Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.
    Neurobiology of aging, 2011, Volume: 32, Issue:3

    Topics: Analysis of Variance; Animals; Axons; Bacterial Proteins; Disease Models, Animal; Humans; Inclusion

2011
Inhibition of natriuretic factors increases blood pressure in rats.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:2

    Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-O

2009
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
    Human molecular genetics, 2009, Sep-01, Volume: 18, Issue:17

    Topics: Animals; Case-Control Studies; Disease Models, Animal; Disease Susceptibility; Female; Humans; Male;

2009
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
    Experimental neurology, 2009, Volume: 219, Issue:1

    Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins;

2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
    Journal of neuropathology and experimental neurology, 2009, Volume: 68, Issue:5

    Topics: Alanine; alpha-Synuclein; Animals; Aspartic Acid; Basal Ganglia; Cell Count; Dependovirus; Disease M

2009
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
    Neuroscience research, 2009, Volume: 65, Issue:2

    Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Catalytic Domain; Central Nervous Syste

2009
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-15, Volume: 29, Issue:28

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A

2009
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:4

    Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabet

2009
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.
    Neuron, 2009, Aug-13, Volume: 63, Issue:3

    Topics: Animals; Behavior, Animal; Cell Line, Transformed; Chlorocebus aethiops; Class I Phosphatidylinosito

2009
Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Calcium-Binding Proteins; Card

2009
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell A

2009
Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism.
    Journal of neuroimmunology, 2009, Dec-10, Volume: 217, Issue:1-2

    Topics: Analysis of Variance; Animals; Autistic Disorder; Brain; Cells, Cultured; Cerebral Cortex; Cytokines

2009
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.
    Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:6

    Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Hemodynamics; Mice; Myocardi

2010
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
    Endocrinology, 2009, Volume: 150, Issue:12

    Topics: Age Factors; Animals; Blood Glucose; Brain; Cerebral Cortex; Diabetes Mellitus, Type 1; Diabetes Mel

2009
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.
    Circulation research, 2009, Dec-04, Volume: 105, Issue:12

    Topics: Alanine; Animals; Apoptosis; Autophagy; Base Sequence; Disease Models, Animal; Heart Failure; HSP20

2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:11

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila m

2009
Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease.
    Current Alzheimer research, 2010, Volume: 7, Issue:2

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; CHO Cells; Cricetinae

2010
Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits.
    Journal of neurochemistry, 2010, Volume: 112, Issue:4

    Topics: Animals; Aromatase; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cognition Disorders; Disease

2010
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
    Journal of cellular physiology, 2010, Volume: 222, Issue:3

    Topics: Animals; Cardiomegaly; Cell Line; Cell Size; Chromones; Deferoxamine; Disease Models, Animal; Fibrob

2010
Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:3

    Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Exercise Therapy; Glu

2010
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum.
    Journal of neurochemistry, 2010, Volume: 112, Issue:4

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebellum; Cyclic GMP; Disease Models,

2010
Early behavioural markers of disease in P301S tau transgenic mice.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Cues; Disease Mode

2010
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Apr-16, Volume: 34, Issue:3

    Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; D

2010
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus

2010
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
    Neuron, 2009, Dec-24, Volume: 64, Issue:6

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode

2009
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
    Journal of neurochemistry, 2010, Volume: 113, Issue:1

    Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P

2010
Dysregulation of mTOR signaling in fragile X syndrome.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-13, Volume: 30, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Animals; CA1 Region, Hippocampal; Carrier Proteins; Cell Cycle

2010
Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency.
    Current opinion in molecular therapeutics, 2009, Volume: 11, Issue:6

    Topics: Animals; Clinical Trials as Topic; Dependovirus; Disease Models, Animal; Drug Evaluation, Preclinica

2009
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-20, Volume: 30, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Death; Cycloheximi

2010
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-27, Volume: 30, Issue:4

    Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Cytoprotection; Disease Models, A

2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Mar-03, Volume: 30, Issue:9

    Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cell Membrane; Creatine Kin

2010
Decreases in splanchnic vascular resistance contribute to hypotensive effects of L-serine in hypertensive rats.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6

    Topics: Animals; Apamin; Blood Pressure; Cardiac Output; Charybdotoxin; Disease Models, Animal; Hypertension

2010
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:8

    Topics: Adult; Aged; Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Electro

2010
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
    Biochemical and biophysical research communications, 2010, Apr-30, Volume: 395, Issue:2

    Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3; Gly

2010
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
    General thoracic and cardiovascular surgery, 2010, Volume: 58, Issue:6

    Topics: Animals; Aorta, Abdominal; Atrial Natriuretic Factor; beta Catenin; Blood Pressure; Cardiovascular A

2010
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
    General thoracic and cardiovascular surgery, 2010, Volume: 58, Issue:6

    Topics: Animals; Aorta, Abdominal; Atrial Natriuretic Factor; beta Catenin; Blood Pressure; Blotting, Wester

2010
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn.
    Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Burns; C-Peptide; Disease Models, Animal; Glucose

2011
Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.
    Biochimica et biophysica acta, 2010, Volume: 1802, Issue:11

    Topics: Animals; Astrocytes; Brain; Cytokines; Disease Models, Animal; Female; Fragile X Mental Retardation

2010
Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jul-07, Volume: 30, Issue:27

    Topics: Animals; Biotinylation; Brain; Catecholamines; Cell Adhesion Molecules; Cell Adhesion Molecules, Neu

2010
Cell-mediated neuroprotection in a mouse model of human tauopathy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jul-28, Volume: 30, Issue:30

    Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Trans

2010
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.
    Pain, 2010, Volume: 151, Issue:1

    Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Disease Models, Animal; Freund's Adjuvant; Gene Expr

2010
Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction.
    Neuroscience letters, 2010, Oct-29, Volume: 484, Issue:2

    Topics: Animals; Crystallins; Disease Models, Animal; Gene Expression Regulation; Male; Microtubule-Associat

2010
Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death.
    Epilepsy research, 2010, Volume: 92, Issue:1

    Topics: 14-3-3 Proteins; Animals; bcl-Associated Death Protein; Caspase 3; Cell Death; Disease Models, Anima

2010
Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome.
    Human mutation, 2010, Volume: 31, Issue:12

    Topics: Animals; Base Sequence; Calcium Channels; Cell Size; Codon, Nonsense; Diet; Disease Models, Animal;

2010
Simultaneous two-dimensional HPLC determination of free D-serine and D-alanine in the brain and periphery of mutant rats lacking D-amino-acid oxidase.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Nov-01, Volume: 879, Issue:29

    Topics: Alanine; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Disea

2011
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
    Neuron, 2010, Sep-23, Volume: 67, Issue:6

    Topics: Animals; Aspartic Acid; Ataxin-1; Ataxins; Calbindins; Cerebellum; Dendrites; Disease Models, Animal

2010
Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.
    Brain research, 2010, Dec-17, Volume: 1366

    Topics: Analysis of Variance; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dis

2010
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.
    Brain research, 2010, Dec-17, Volume: 1366

    Topics: Animals; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models,

2010
Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction.
    Physiology & behavior, 2011, Aug-03, Volume: 104, Issue:2

    Topics: Adiposity; Animals; Area Under Curve; Autoradiography; Body Weight; Corticosterone; Disease Models,

2011
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
    Behavioural brain research, 2011, Jul-07, Volume: 220, Issue:2

    Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases;

2011
[Development of psychotropic agents for schizophrenia based on the glutamate hypothesis].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2010, Volume: 30, Issue:5-6

    Topics: Animals; Disease Models, Animal; Drug Discovery; Glutamic Acid; Humans; Phencyclidine; Receptors, N-

2010
Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity.
    American journal of physiology. Renal physiology, 2011, Volume: 300, Issue:5

    Topics: Acute Kidney Injury; Adenoviridae; Amino Acid Sequence; Animals; Antineoplastic Agents; Cisplatin; C

2011
Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy.
    PloS one, 2011, Feb-14, Volume: 6, Issue:2

    Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor;

2011
Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus.
    Journal of virology, 2011, Volume: 85, Issue:10

    Topics: Amino Acid Substitution; Animals; Antiviral Agents; Asparagine; Disease Models, Animal; Drug Resista

2011
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Citrates; Disease Models, Animal; Enzyme I

2011
Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.
    Journal of cellular physiology, 2011, Volume: 226, Issue:7

    Topics: Acetylcysteine; Actins; Animals; Binding Sites; Carotid Artery Injuries; Cells, Cultured; Chromatin

2011
Kinase inhibitors modulate huntingtin cell localization and toxicity.
    Nature chemical biology, 2011, May-29, Volume: 7, Issue:7

    Topics: Animals; Blotting, Western; Casein Kinase II; Cell Line; Cell Nucleus; Cell Survival; Disease Models

2011
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytomegaloviru

2011
Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology.
    Archives italiennes de biologie, 2011, Volume: 149, Issue:2

    Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Disease Mode

2011
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.
    Nature neuroscience, 2011, Jul-03, Volume: 14, Issue:8

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Disease Models, Animal; DNA Mutational Analysis

2011
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jul-06, Volume: 31, Issue:27

    Topics: Acoustic Stimulation; Age Factors; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn;

2011
Prion-like acceleration of a synucleinopathy in a transgenic mouse model.
    Neurobiology of aging, 2012, Volume: 33, Issue:9

    Topics: Age Factors; Animals; Disease Models, Animal; Humans; Intermediate Filament Proteins; Mice; Mice, In

2012
Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:5

    Topics: Adenosine Triphosphate; Animals; Dietary Fats; Disease Models, Animal; Energy Metabolism; Enzyme Inh

2011
Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:11

    Topics: Animals; Apolipoproteins E; Arteries; Atherosclerosis; Case-Control Studies; Cell Proliferation; Cyc

2011
Acute D-serine treatment produces antidepressant-like effects in rodents.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:8

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Ty

2012
Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase.
    The FEBS journal, 2011, Volume: 278, Issue:22

    Topics: Animals; Carrier Proteins; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Flavin-A

2011
In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation.
    Human molecular genetics, 2012, Feb-15, Volume: 21, Issue:4

    Topics: Animals; Animals, Genetically Modified; Brain; Cytoskeleton; Disease Models, Animal; Drosophila mela

2012
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: alpha-Synuclein; Animals; Cell Count; Cell Line, Transformed; Disease Models, Animal; Dopamine Plasm

2011
Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
    Journal of neurochemistry, 2012, Volume: 120, Issue:4

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Female; Humans;

2012
Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase.
    Muscle & nerve, 2012, Volume: 45, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cell Membrane; Disease Models, Animal; Dose-Response Relationship

2012
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
    Brain research, 2012, Jan-30, Volume: 1435

    Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultu

2012
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.
    Nature neuroscience, 2012, Jan-22, Volume: 15, Issue:3

    Topics: Analysis of Variance; Animals; Carrier Proteins; Cycloheximide; Disease Models, Animal; Electric Sti

2012
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
    Current Alzheimer research, 2012, Volume: 9, Issue:4

    Topics: Age Factors; Alzheimer Disease; Animals; Antibodies; Cognition Disorders; Disease Models, Animal; En

2012
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Feb-01, Volume: 32, Issue:5

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Gene Transfer Techniques; Humans;

2012
Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Feb-22, Volume: 32, Issue:8

    Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Disease Models, Anim

2012
Propagation of tau pathology in a model of early Alzheimer's disease.
    Neuron, 2012, Feb-23, Volume: 73, Issue:4

    Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Entorhinal Cor

2012
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression.
    Molecular psychiatry, 2013, Volume: 18, Issue:5

    Topics: Animals; Astrocytes; Depression; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Po

2013
Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:10

    Topics: Administration, Inhalation; Animals; Body Temperature Regulation; Creatine Kinase, MB Form; Disease

2012
Role of RyR2 phosphorylation at S2814 during heart failure progression.
    Circulation research, 2012, May-25, Volume: 110, Issue:11

    Topics: Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Di

2012
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
    Circulation research, 2012, May-25, Volume: 110, Issue:11

    Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints;

2012
Injury-induced insulin resistance in adipose tissue.
    Biochemical and biophysical research communications, 2012, May-11, Volume: 421, Issue:3

    Topics: Adipose Tissue; Animals; Critical Illness; Diabetes Mellitus; Disease Models, Animal; Glycogen Synth

2012
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Ep

2012
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.
    Circulation research, 2012, May-25, Volume: 110, Issue:11

    Topics: Actomyosin; Animals; Capillary Permeability; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells,

2012
Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.
    Circulation research, 2012, Jun-22, Volume: 111, Issue:1

    Topics: Actin-Related Protein 2-3 Complex; Animals; Becaplermin; Carotid Artery Injuries; Cell Movement; Cel

2012
D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference.
    Neuropharmacology, 2013, Volume: 64

    Topics: Animals; Antimetabolites; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral

2013
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
    Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Mode

2012
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
    Molecular psychiatry, 2013, Volume: 18, Issue:5

    Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Astrocytes; Brain; Cell Line, Tran

2013
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
    British journal of pharmacology, 2013, Volume: 168, Issue:5

    Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim

2013
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
    Neurobiology of aging, 2013, Volume: 34, Issue:3

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; Cell Lin

2013
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
    Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:2

    Topics: Alcoholic Intoxication; Animals; Ataxia; Cycloserine; Disease Models, Animal; Disks Large Homolog 4

2013
Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation.
    Cardiovascular research, 2013, Jan-01, Volume: 97, Issue:1

    Topics: Animals; Blotting, Western; Coronary Vessels; Cyclic AMP-Dependent Protein Kinases; Disease Models,

2013
Lithium exacerbates hepatic ischemia/reperfusion injury by inhibiting GSK-3β/NF-κB-mediated protective signaling in mice.
    European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3

    Topics: Animals; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Disease Models, Ani

2012
D-Serine ameliorates neonatal PolyI:C treatment-induced emotional and cognitive impairments in adult mice.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:3

    Topics: Affective Symptoms; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; Central Nervou

2012
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Dec-05, Volume: 32, Issue:49

    Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La

2012
Detecting DNA synthesis of neointimal formation after catheter balloon injury in GK and in Wistar rats: using 5-ethynyl-2'-deoxyuridine.
    Cardiovascular diabetology, 2012, Dec-13, Volume: 11

    Topics: Angioplasty, Balloon; Animals; Biomarkers; Blotting, Western; Carotid Artery Injuries; Carotid Arter

2012
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
    Nature, 2013, Jan-24, Volume: 493, Issue:7433

    Topics: Aerobiosis; Animals; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cel

2013
Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer.
    International journal of clinical oncology, 2002, Volume: 7, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Disease Models, Animal; Liver Neoplasms, Ex

2002
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
    Neuron, 2003, May-08, Volume: 38, Issue:3

    Topics: Amino Acid Sequence; Animals; Ataxin-1; Ataxins; Cell Nucleus; CHO Cells; COS Cells; Cricetinae; Dis

2003
N-methyl-D-aspartate receptor subunit expression and phosphorylation following excitotoxic spinal cord injury in rats.
    Neuroscience letters, 2003, Sep-25, Volume: 349, Issue:1

    Topics: Animals; Disease Models, Animal; Endocytosis; Grooming; Neurons; Neurotoxins; Phosphorylation; Prote

2003
The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.
    Virology, 2003, Sep-01, Volume: 313, Issue:2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Casein Kinase II; CD4 Lymphocyte Count; CD4-P

2003
Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease.
    Journal of neurochemistry, 2004, Volume: 90, Issue:1

    Topics: Animals; beta-N-Acetylhexosaminidases; Brain; Carbon Radioisotopes; CDPdiacylglycerol-Serine O-Phosp

2004
cAMP response element-binding protein activation in ligation preconditioning in neonatal brain.
    Annals of neurology, 2004, Volume: 56, Issue:5

    Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Blotting, Wester

2004
Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1).
    Oncogene, 2005, Jan-13, Volume: 24, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Line, Tumor; Disease Mode

2005
Sodium benzoate attenuates D-serine induced nephrotoxicity in the rat.
    Toxicology, 2005, Feb-01, Volume: 207, Issue:1

    Topics: Animals; Creatinine; D-Amino-Acid Oxidase; Disease Models, Animal; Dose-Response Relationship, Drug;

2005
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
    Endocrinology, 2005, Volume: 146, Issue:3

    Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Activation; Food Deprivation; Humans; Immunoblott

2005
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.
    Neuropharmacology, 2005, Volume: 48, Issue:1

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Blotting,

2005
Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.
    Neuroscience, 2005, Volume: 130, Issue:2

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Chromosomes, Human, Pair 17;

2005
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
    Journal of neurochemistry, 2005, Volume: 92, Issue:6

    Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Foc

2005
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
    Psychopharmacology, 2005, Volume: 179, Issue:1

    Topics: Amino Acid Transport Systems, Neutral; Animals; Attention; Clozapine; Conditioning, Psychological; D

2005
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
    Nature neuroscience, 2005, Volume: 8, Issue:5

    Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; bet

2005
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
    Archives of biochemistry and biophysics, 2005, Jun-15, Volume: 438, Issue:2

    Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme In

2005
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:3

    Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; C

2006
[Characterization of a canine model of dystrophic bullous epidermolysis (DBE). Development of a gene therapy protocol].
    Bulletin de l'Academie nationale de medecine, 2005, Volume: 189, Issue:1

    Topics: Animals; Disease Models, Animal; Dogs; Epidermolysis Bullosa Dystrophica; Female; Genetic Therapy; G

2005
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
    Pain, 2005, Volume: 117, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area

2005
Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic injury.
    Neurobiology of disease, 2006, Volume: 21, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Blotting, Western; Caspase 3; Caspases; Disease Mo

2006
Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides.
    Muscle & nerve, 2006, Volume: 33, Issue:5

    Topics: Alanine Transaminase; Amyloidosis, Familial; Animals; Aspartate Aminotransferases; Carcinoma, Hepato

2006
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Feb-28, Volume: 103, Issue:9

    Topics: Animals; Aspartic Acid; Catalysis; Disease Models, Animal; Electrophysiology; Gene Expression Regula

2006
Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia.
    Epilepsia, 2006, Volume: 47, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease M

2006
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
    Brain research, 2006, Sep-07, Volume: 1108, Issue:1

    Topics: Animals; Antimanic Agents; Brain Infarction; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Ki

2006
Ischemic preconditioning negatively regulates plenty of SH3s-mixed lineage kinase 3-Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt.
    Neuroscience, 2006, Dec-01, Volume: 143, Issue:2

    Topics: 14-3-3 Proteins; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Enzyme Ac

2006
Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.
    Journal of neurochemistry, 2006, Volume: 99, Issue:6

    Topics: Animals; Blotting, Western; Chromones; Disease Models, Animal; Drug Interactions; Enzyme Activation;

2006
Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice.
    Neuroscience, 2007, Mar-02, Volume: 145, Issue:1

    Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-D

2007
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
    Neuron, 2007, Feb-15, Volume: 53, Issue:4

    Topics: Acoustic Stimulation; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Brain; Cytoskeletal Protein

2007
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blood-Brain Barrier; Disease Models, Animal; DN

2007
Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice.
    Journal of neuroscience research, 2007, May-01, Volume: 85, Issue:6

    Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Hypoxia, Brain; Immunohistochemistry; Isc

2007
[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2007, Jan-01, Volume: 45, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western;

2007
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:7

    Topics: Alanine; Animals; Aspartic Acid; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Gene Exp

2007
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4

    Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein

2007
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene.
    Brain research, 2007, Sep-05, Volume: 1167

    Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Central Nervous System; Disease Models, Animal; F

2007
Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage.
    Neuroscience letters, 2007, Sep-13, Volume: 424, Issue:3

    Topics: Animals; Basilar Artery; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzy

2007
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.
    The EMBO journal, 2007, Sep-19, Volume: 26, Issue:18

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Activation; Enzyme Induction;

2007
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and D-serine.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:6

    Topics: Animals; Brain; Brain Chemistry; Cognition Disorders; Disease Models, Animal; Drug Administration Sc

2008
STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
    Circulation research, 2007, Oct-26, Volume: 101, Issue:9

    Topics: Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Butadienes; Capillar

2007
RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.
    Cellular signalling, 2007, Volume: 19, Issue:12

    Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2

2007
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2008, Volume: 26, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Corpus Striatum; Disease Models, Animal; Hypothermi

2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Jan-15, Volume: 105, Issue:2

    Topics: alpha-Synuclein; Animals; Brain; Dependovirus; Disease Models, Animal; Dopamine; Humans; Lewy Bodies

2008
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jan-09, Volume: 28, Issue:2

    Topics: Animals; Biotinylation; Disease Models, Animal; Endocytosis; Enzyme Inhibitors; Hippocampus; Immunop

2008
Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.
    Circulation research, 2008, Feb-29, Volume: 102, Issue:4

    Topics: Angiotensin II; Animals; Antibodies; Carotid Artery Diseases; Catheterization; Cells, Cultured; Dise

2008
Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat.
    Brain research, 2008, Mar-20, Volume: 1200

    Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation;

2008
Specific N-terminal mutations in the human androgen receptor induce cytotoxicity.
    Neurobiology of aging, 2009, Volume: 30, Issue:11

    Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Behavioral Symptoms; Butyrates; Chloroc

2009
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
    Neuropharmacology, 2008, Volume: 54, Issue:7

    Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat

2008
Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.
    Neuropharmacology, 2008, Volume: 54, Issue:7

    Topics: Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Calcium-Calmodulin-Dependent Prote

2008
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Binding Sites; Casein Kinase II; Cell Line

2008
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; D

2008
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; H

1983
Serine phosphate, threonine phosphate and gamma-carboxyglutamic acid in normal and experimentally induced, pathologically calcified rat skin (topical cutaneous calciphylaxis).
    Calcified tissue international, 1981, Volume: 33, Issue:2

    Topics: 1-Carboxyglutamic Acid; Animals; Calciphylaxis; Dihydrotachysterol; Disease Models, Animal; Female;

1981
Immunogenicity of the recombinant serine rich Entamoeba histolytica protein (SREHP) amebiasis vaccine in the African green monkey.
    Vaccine, 1995, Volume: 13, Issue:10

    Topics: Animals; Antibodies, Protozoan; Chlorocebus aethiops; Disease Models, Animal; Entamoeba histolytica;

1995
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls

1994
A serine-to-proline mutation in the copper-transporting P-type ATPase gene of the macular mouse.
    Mammalian genome : official journal of the International Mammalian Genome Society, 1997, Volume: 8, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Carrier Proteins; Cation Transport Proteins; Copper-Transporting

1997
Cyclization by a specific lactam increases the ability of human parathyroid hormone (hPTH)-(1-31)NH2 to stimulate bone growth in ovariectomized rats.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1997, Volume: 12, Issue:8

    Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bone Development; Bone Neoplasms; Disease Models,

1997
A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:9

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Hu

1999
Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:9

    Topics: Animals; Antineoplastic Agents; Blood Pressure; Body Weight; Disease Models, Animal; Drug Screening

1999
DNA vaccination with the serine rich Entamoeba histolytica protein (SREHP) prevents amebic liver abscess in rodent models of disease.
    Vaccine, 1999, Dec-10, Volume: 18, Issue:9-10

    Topics: Animals; Antibodies, Protozoan; Cell Division; Disease Models, Animal; Entamoeba histolytica; Enzyme

1999
Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Age Factors; Alkaline Phosphatase; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cel

2001
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.
    Bioorganic & medicinal chemistry letters, 2002, Jan-07, Volume: 12, Issue:1

    Topics: Animals; Binding Sites; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug

2002
Adenocarcinoma of the pancreas in azaserine-treated rats.
    Cancer research, 1975, Volume: 35, Issue:8

    Topics: Adenocarcinoma; Adenoma; Animals; Azaserine; Dipeptides; Disease Models, Animal; Hyperplasia; Inject

1975
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
    Journal of neuroscience methods, 1991, Volume: 37, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intra

1991
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
    Journal of chromatography, 1990, Mar-09, Volume: 503, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D

1990
Retrograde amnesia and cholinergic systems in the caudate-putamen complex and dorsal hippocampus of the rat.
    Experimental neurology, 1973, Volume: 41, Issue:1

    Topics: Amnesia; Animals; Avoidance Learning; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; Elec

1973