serine has been researched along with Disease Exacerbation in 74 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 9.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 5.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 5.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| "O-GlcNAcylation of ribosomal receptor for activated C-kinase 1 at the amino acid serine122 promotes its stability, ribosome localization and interaction with the protein kinase, PKCβII, thus driving the translation of oncogenes and tumorigenesis of hepatocellular carcinoma." | 3.88 | O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis. ( Duan, F; Gu, J; Guo, X; Jia, D; Liu, F; Ren, S; Ruan, Y; Song, S; Wang, L; Wu, H; Wu, W, 2018) |
| "A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension." | 3.74 | The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes. ( Almgren, P; Berglund, G; Fava, C; Guidi, GC; Melander, O; Montagnana, M; Rosberg, L, 2007) |
| " Based on this small study, L-serine appears to be generally safe for patients with ALS." | 2.84 | Phase I clinical trial of safety of L-serine for ALS patients. ( Banack, SA; Bradley, WG; Cox, PA; Flynn, LE; Forshew, DA; Katz, JS; Levine, TD; Metcalf, JS; Miller, RG; Moore, DH; Saperstein, DS, 2017) |
| "Meningiomas are common brain tumours that are usually defined by benign clinical course." | 1.62 | Metabolic alterations in meningioma reflect the clinical course. ( Beck, J; Daka, K; Delev, D; Grauvogel, J; Heiland, DH; Krüger, MT; Masalha, W; Pompe, N; Schnell, O; Weber, S; Woerner, J, 2021) |
| "Alzheimer's disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions." | 1.48 | Phosphorylation of different tau sites during progression of Alzheimer's disease. ( Attems, J; Daum, G; Flunkert, S; Hoeller, C; Hutter-Paier, B; Kerschbaumer, B; Loeffler, T; Neddens, J; Niederkofler, V; Temmel, M, 2018) |
| "The expression of ALX4 in breast cancer cell lines and patients' tissues were detected by RT-PCR, qPCR and western blot." | 1.46 | ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. ( Cao, J; Chen, H; Han, F; Hao, X; Huang, Y; Jiang, X; Liu, J; Liu, W; Yang, J; Yin, L; Zhang, H, 2017) |
| "Melanoma is a disease that primarily arises in the skin but is a derivative of the neural crest." | 1.43 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma. ( Carter, JH; Colligan, BM; Deddens, JA; Douglass, LE; Graff, JR; Hawkins, E; Jones, J; Lewis, TG; Lucas, D; Pemberton, JO; Spaulding, NR, 2016) |
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| "We apply multiple prostate cancer cell models to demonstrate that enzalutamide induces differential activation of protein phosphatase-1 (PP-1) and Akt kinase depending on the gene context of cancer cells." | 1.42 | AR-v7 protein expression is regulated by protein kinase and phosphatase. ( Dong, X; Gleave, ME; Li, Y; Rennie, PS; Xie, N, 2015) |
| "A panel of HNSCC cell lines was determined with anoikis assays, and orthotopic mouse experiments were performed." | 1.39 | Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. ( Brennan, RG; Jasser, SA; Myers, JN; Sano, D; Xie, TX; Zhao, M; Zhou, G, 2013) |
| "Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A syndrome) is caused by mutations in the N-sulfoglucosamine sulfohydrolase (SGSH) gene and the resulting defective lysosomal degradation of the glycosaminoglycan heparan sulfate." | 1.35 | The mutation p.Ser298Pro in the sulphamidase gene (SGSH) is associated with a slowly progressive clinical phenotype in mucopolysaccharidosis type IIIA (Sanfilippo A syndrome). ( Braulke, T; Gal, A; Kossow, K; Meyer, A; Mühlhausen, C; Muschol, N; Steglich, C; Ullrich, K, 2008) |
| "Immunohistochemical staining of primary breast cancer biopsies (n = 290) was carried out using antibodies specific for ER phosphorylated at Ser(167) and for phosphorylated p44/p42 mitogen-activated protein kinase (MAPK), phosphorylated p90RSK, and phosphorylated AKT." | 1.34 | Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients. ( Ali, S; Coombes, RC; Jiang, J; Kulinskaya, E; Peston, D; Sarwar, N; Shousha, S, 2007) |
| " We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2." | 1.33 | Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. ( Andrulionyte, L; Chiasson, JL; Laakso, M; Peltola, P, 2006) |
| "They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures." | 1.31 | Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. ( de Koning, TJ; Jaeken, J; Pineda, M; Poll-The, BT; van der Knaap, MS; Van Maldergem, L, 2000) |
| "Mutation of the adenomatous polyposis coli (APC) gene and the subsequent dysregulation of beta-catenin are well-documented abnormalities in familial adenomatous polyposis (FAP), as well as sporadic polyposis." | 1.31 | Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. ( Dedhar, S; Dupuis, B; Gallinger, S; Gray, V; Malik, S; Marotta, A; Owen, D; Salh, B; Sanghera, J; Tan, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 29 (39.19) | 29.6817 |
| 2010's | 39 (52.70) | 24.3611 |
| 2020's | 6 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Rossi, M | 1 |
| Altea-Manzano, P | 1 |
| Demicco, M | 1 |
| Doglioni, G | 1 |
| Bornes, L | 1 |
| Fukano, M | 1 |
| Vandekeere, A | 1 |
| Cuadros, AM | 1 |
| Fernández-García, J | 1 |
| Riera-Domingo, C | 1 |
| Jauset, C | 1 |
| Planque, M | 1 |
| Alkan, HF | 1 |
| Nittner, D | 1 |
| Zuo, D | 1 |
| Broadfield, LA | 1 |
| Parik, S | 1 |
| Pane, AA | 1 |
| Rizzollo, F | 1 |
| Rinaldi, G | 1 |
| Zhang, T | 1 |
| Teoh, ST | 1 |
| Aurora, AB | 1 |
| Karras, P | 1 |
| Vermeire, I | 1 |
| Broekaert, D | 1 |
| Elsen, JV | 1 |
| Knott, MML | 1 |
| Orth, MF | 1 |
| Demeyer, S | 1 |
| Eelen, G | 1 |
| Dobrolecki, LE | 1 |
| Bassez, A | 1 |
| Brussel, TV | 1 |
| Sotlar, K | 1 |
| Lewis, MT | 1 |
| Bartsch, H | 1 |
| Wuhrer, M | 1 |
| Veelen, PV | 1 |
| Carmeliet, P | 1 |
| Cools, J | 1 |
| Morrison, SJ | 1 |
| Marine, JC | 1 |
| Lambrechts, D | 1 |
| Mazzone, M | 1 |
| Hannon, GJ | 1 |
| Lunt, SY | 1 |
| Grünewald, TGP | 1 |
| Park, M | 1 |
| Rheenen, JV | 1 |
| Fendt, SM | 1 |
| Park, SM | 1 |
| Seo, EH | 1 |
| Bae, DH | 1 |
| Kim, SS | 1 |
| Kim, J | 1 |
| Lin, W | 1 |
| Kim, KH | 1 |
| Park, JB | 1 |
| Kim, YS | 1 |
| Yin, J | 1 |
| Kim, SY | 1 |
| Padilla-Mendoza, JR | 1 |
| Contis-Montes de Oca, A | 1 |
| Rodríguez, MA | 1 |
| López-Casamichana, M | 1 |
| Bolaños, J | 1 |
| Quintas-Granados, LI | 1 |
| Reyes-Hernández, OD | 1 |
| Fragozo-Sandoval, F | 1 |
| Reséndiz-Albor, AA | 1 |
| Arellano-Gutiérrez, CV | 1 |
| López-Reyes, I | 1 |
| Esposito, M | 1 |
| Akman, HB | 1 |
| Giron, P | 1 |
| Ceregido, MA | 1 |
| Schepers, R | 1 |
| Ramos Paez, LC | 1 |
| La Monaca, E | 1 |
| De Greve, J | 1 |
| Coux, O | 1 |
| De Trez, C | 1 |
| Lindon, C | 1 |
| Gutierrez, GJ | 1 |
| Masalha, W | 1 |
| Daka, K | 1 |
| Woerner, J | 1 |
| Pompe, N | 1 |
| Weber, S | 1 |
| Delev, D | 1 |
| Krüger, MT | 1 |
| Schnell, O | 1 |
| Beck, J | 1 |
| Heiland, DH | 1 |
| Grauvogel, J | 1 |
| Bonelli, R | 1 |
| Ansell, BRE | 1 |
| Lotta, L | 1 |
| Scerri, T | 1 |
| Clemons, TE | 1 |
| Leung, I | 1 |
| Peto, T | 1 |
| Bird, AC | 1 |
| Sallo, FB | 1 |
| Langenberg, C | 1 |
| Bahlo, M | 1 |
| Tsai, CL | 1 |
| Jung, SM | 1 |
| Chi, LM | 1 |
| Tsai, CN | 1 |
| Lin, CY | 1 |
| Chao, A | 1 |
| Lee, YS | 1 |
| Wu, Q | 1 |
| Li, J | 1 |
| Sun, S | 2 |
| Chen, X | 2 |
| Zhang, H | 2 |
| Li, B | 1 |
| Zeng, S | 1 |
| Xie, X | 2 |
| Xiao, YF | 1 |
| Tang, B | 1 |
| Hu, CJ | 1 |
| Wang, SM | 1 |
| Wu, YY | 1 |
| Dong, H | 1 |
| Li, BS | 1 |
| Yang, SM | 1 |
| Bui, NL | 1 |
| Pandey, V | 1 |
| Zhu, T | 1 |
| Ma, L | 1 |
| Lobie, PE | 1 |
| Yang, J | 1 |
| Han, F | 1 |
| Liu, W | 1 |
| Chen, H | 1 |
| Hao, X | 1 |
| Jiang, X | 1 |
| Yin, L | 1 |
| Huang, Y | 3 |
| Cao, J | 1 |
| Liu, J | 1 |
| Duan, F | 1 |
| Wu, H | 1 |
| Jia, D | 1 |
| Wu, W | 1 |
| Ren, S | 1 |
| Wang, L | 3 |
| Song, S | 1 |
| Guo, X | 1 |
| Liu, F | 1 |
| Ruan, Y | 1 |
| Gu, J | 1 |
| Neddens, J | 1 |
| Temmel, M | 1 |
| Flunkert, S | 1 |
| Kerschbaumer, B | 1 |
| Hoeller, C | 1 |
| Loeffler, T | 1 |
| Niederkofler, V | 1 |
| Daum, G | 1 |
| Attems, J | 1 |
| Hutter-Paier, B | 1 |
| Ranek, MJ | 1 |
| Kokkonen-Simon, KM | 1 |
| Chen, A | 1 |
| Dunkerly-Eyring, BL | 1 |
| Vera, MP | 1 |
| Oeing, CU | 1 |
| Patel, CH | 1 |
| Nakamura, T | 3 |
| Zhu, G | 1 |
| Bedja, D | 1 |
| Sasaki, M | 1 |
| Holewinski, RJ | 1 |
| Van Eyk, JE | 1 |
| Powell, JD | 1 |
| Lee, DI | 1 |
| Kass, DA | 1 |
| Szybowska, P | 1 |
| Kostas, M | 1 |
| Wesche, J | 1 |
| Wiedlocha, A | 1 |
| Haugsten, EM | 1 |
| Hesaka, A | 1 |
| Yasuda, K | 1 |
| Sakai, S | 1 |
| Yonishi, H | 1 |
| Namba-Hamano, T | 1 |
| Takahashi, A | 1 |
| Mizui, M | 1 |
| Hamase, K | 1 |
| Matsui, R | 1 |
| Mita, M | 1 |
| Horio, M | 1 |
| Isaka, Y | 1 |
| Kimura, T | 1 |
| Xie, TX | 1 |
| Zhou, G | 1 |
| Zhao, M | 1 |
| Sano, D | 1 |
| Jasser, SA | 1 |
| Brennan, RG | 1 |
| Myers, JN | 1 |
| Li, Y | 2 |
| Xu, S | 1 |
| Jiang, B | 1 |
| Cohen, RA | 1 |
| Zang, M | 1 |
| Onishi, T | 1 |
| Matsumoto, Y | 1 |
| Hattori, M | 1 |
| Obayashi, Y | 1 |
| Nakamura, K | 1 |
| Yano, T | 1 |
| Horiguchi, T | 1 |
| Iwashita, H | 1 |
| Bian, Y | 1 |
| Wang, Z | 1 |
| Xu, J | 1 |
| Zhao, W | 1 |
| Cao, H | 1 |
| Zhang, Z | 2 |
| Zhang, N | 1 |
| Döppler, H | 1 |
| Bastea, L | 1 |
| Borges, S | 1 |
| Geiger, X | 1 |
| Storz, P | 1 |
| Xie, N | 1 |
| Gleave, ME | 1 |
| Rennie, PS | 1 |
| Dong, X | 1 |
| Carter, JH | 1 |
| Deddens, JA | 1 |
| Spaulding, NR | 1 |
| Lucas, D | 1 |
| Colligan, BM | 1 |
| Lewis, TG | 1 |
| Hawkins, E | 1 |
| Jones, J | 1 |
| Pemberton, JO | 1 |
| Douglass, LE | 1 |
| Graff, JR | 1 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 1 |
| Saudou, F | 1 |
| Humbert, S | 1 |
| Yang, XW | 1 |
| Osmand, A | 1 |
| Steffan, JS | 1 |
| Masliah, E | 1 |
| Finkbeiner, S | 1 |
| Levine, TD | 1 |
| Miller, RG | 2 |
| Bradley, WG | 1 |
| Moore, DH | 1 |
| Saperstein, DS | 1 |
| Flynn, LE | 1 |
| Katz, JS | 1 |
| Forshew, DA | 1 |
| Metcalf, JS | 1 |
| Banack, SA | 1 |
| Cox, PA | 1 |
| Samanta, D | 1 |
| Semenza, GL | 1 |
| Patek, S | 1 |
| Willder, J | 1 |
| Heng, J | 1 |
| Taylor, B | 1 |
| Horgan, P | 1 |
| Leung, H | 1 |
| Underwood, M | 1 |
| Edwards, J | 1 |
| Lin, H | 1 |
| Hu, H | 1 |
| Duan, W | 1 |
| Liu, Y | 3 |
| Tan, G | 1 |
| Li, Z | 1 |
| Deng, B | 1 |
| Song, X | 1 |
| Wang, W | 1 |
| Wen, D | 1 |
| Wang, Y | 3 |
| Li, C | 2 |
| Liu, P | 2 |
| Li, R | 1 |
| Antonov, AA | 1 |
| Li, W | 1 |
| Hua, Y | 1 |
| Guo, H | 1 |
| Chen, L | 1 |
| Tian, Y | 1 |
| Xu, F | 1 |
| Zhu, Y | 1 |
| Sakurai, H | 1 |
| Cheng, C | 2 |
| Ji, Y | 1 |
| Zhao, Y | 1 |
| Zou, L | 1 |
| Shen, A | 2 |
| Kang, HJ | 1 |
| Lee, H | 1 |
| Choi, HJ | 1 |
| Youn, JH | 1 |
| Shin, JS | 1 |
| Ahn, YH | 1 |
| Yoo, JS | 1 |
| Paik, YK | 1 |
| Kim, H | 1 |
| Kadoyama, K | 1 |
| Funakoshi, H | 1 |
| Ohya-Shimada, W | 1 |
| Matsumoto, K | 1 |
| Matsuyama, S | 1 |
| Teofili, L | 1 |
| Giona, F | 1 |
| Torti, L | 1 |
| Cenci, T | 1 |
| Ricerca, BM | 1 |
| Rumi, C | 1 |
| Nunes, V | 1 |
| Foà, R | 1 |
| Leone, G | 1 |
| Martini, M | 1 |
| Larocca, LM | 1 |
| Walker, LA | 1 |
| Walker, JS | 1 |
| Ambler, SK | 1 |
| Buttrick, PM | 1 |
| Doi, H | 1 |
| Koyano, S | 1 |
| Miyatake, S | 1 |
| Matsumoto, N | 1 |
| Kameda, T | 1 |
| Tomita, A | 1 |
| Miyaji, Y | 1 |
| Suzuki, Y | 1 |
| Sawaishi, Y | 1 |
| Kuroiwa, Y | 1 |
| Xu, YM | 1 |
| Zhu, F | 1 |
| Cho, YY | 1 |
| Carper, A | 1 |
| Peng, C | 1 |
| Zheng, D | 1 |
| Yao, K | 1 |
| Lau, AT | 1 |
| Zykova, TA | 1 |
| Kim, HG | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Zheng, HC | 1 |
| Xu, XY | 1 |
| Xia, P | 1 |
| Yu, M | 1 |
| Takahashi, H | 1 |
| Takano, Y | 1 |
| Bertea, M | 1 |
| Rütti, MF | 1 |
| Othman, A | 1 |
| Marti-Jaun, J | 1 |
| Hersberger, M | 1 |
| von Eckardstein, A | 1 |
| Hornemann, T | 1 |
| Argyriou, P | 1 |
| Papageorgiou, SG | 1 |
| Panteleon, V | 1 |
| Psyrri, A | 1 |
| Bakou, V | 1 |
| Pappa, V | 1 |
| Spathis, A | 1 |
| Economopoulou, P | 1 |
| Papageorgiou, E | 1 |
| Economopoulos, T | 1 |
| Rontogianni, D | 1 |
| Zhou, J | 1 |
| Broe, M | 1 |
| Anderson, JP | 1 |
| Gai, WP | 1 |
| Milward, EA | 1 |
| Porritt, M | 1 |
| Howells, D | 1 |
| Hughes, AJ | 1 |
| Wang, X | 1 |
| Halliday, GM | 1 |
| Lim, Y | 1 |
| Kehm, VM | 1 |
| Lee, EB | 1 |
| Soper, JH | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Fuster, JJ | 1 |
| González-Navarro, H | 1 |
| Vinué, A | 1 |
| Molina-Sànchez, P | 1 |
| Andrés-Manzano, MJ | 1 |
| Nakayama, KI | 1 |
| Nakayama, K | 1 |
| Díez-Juan, A | 1 |
| Bernad, A | 1 |
| Rodríguez, C | 1 |
| Martínez-González, J | 1 |
| Andrés, V | 1 |
| Thompson, M | 1 |
| Marecki, JC | 1 |
| Marinesco, S | 1 |
| Labrie, V | 1 |
| Roder, JC | 1 |
| Barger, SW | 1 |
| Crow, JP | 1 |
| de Calignon, A | 1 |
| Polydoro, M | 1 |
| Suárez-Calvet, M | 1 |
| William, C | 1 |
| Adamowicz, DH | 1 |
| Kopeikina, KJ | 1 |
| Pitstick, R | 1 |
| Sahara, N | 1 |
| Ashe, KH | 1 |
| Carlson, GA | 1 |
| Spires-Jones, TL | 1 |
| Hyman, BT | 1 |
| Respress, JL | 1 |
| van Oort, RJ | 1 |
| Li, N | 1 |
| Rolim, N | 1 |
| Dixit, SS | 1 |
| deAlmeida, A | 1 |
| Voigt, N | 1 |
| Lawrence, WS | 1 |
| Skapura, DG | 1 |
| Skårdal, K | 1 |
| Wisløff, U | 1 |
| Wieland, T | 1 |
| Ai, X | 1 |
| Pogwizd, SM | 1 |
| Dobrev, D | 1 |
| Wehrens, XH | 2 |
| Paul, P | 1 |
| de Belleroche, J | 1 |
| Azzedine, H | 1 |
| Ruberg, M | 1 |
| Ente, D | 1 |
| Gilardeau, C | 1 |
| Périé, S | 1 |
| Wechsler, B | 1 |
| Brice, A | 1 |
| LeGuern, E | 1 |
| Dubourg, O | 1 |
| Dowjat, WK | 1 |
| Kuchna, I | 1 |
| Wisniewski, T | 1 |
| Wegiel, J | 1 |
| Verhoeven, K | 1 |
| Coen, K | 1 |
| De Vriendt, E | 1 |
| Jacobs, A | 1 |
| Van Gerwen, V | 1 |
| Smouts, I | 1 |
| Pou-Serradell, A | 1 |
| Martin, JJ | 1 |
| Timmerman, V | 1 |
| De Jonghe, P | 1 |
| Skildum, A | 1 |
| Faivre, E | 1 |
| Lange, CA | 1 |
| Roesch, A | 1 |
| Becker, B | 1 |
| Meyer, S | 1 |
| Hafner, C | 1 |
| Wild, PJ | 1 |
| Landthaler, M | 1 |
| Vogt, T | 1 |
| Matsumoto, M | 1 |
| Furihata, M | 1 |
| Kurabayashi, A | 1 |
| Sasaguri, S | 1 |
| Araki, K | 1 |
| Hayashi, H | 1 |
| Ohtsuki, Y | 1 |
| Yanagawa, T | 1 |
| Funasaka, T | 1 |
| Tsutsumi, S | 1 |
| Raz, T | 1 |
| Tanaka, N | 1 |
| Raz, A | 1 |
| Cardone, RA | 1 |
| Bagorda, A | 1 |
| Bellizzi, A | 1 |
| Busco, G | 1 |
| Guerra, L | 1 |
| Paradiso, A | 1 |
| Casavola, V | 1 |
| Zaccolo, M | 1 |
| Reshkin, SJ | 1 |
| Yang, SF | 1 |
| Yuan, SS | 1 |
| Yeh, YT | 1 |
| Wu, MT | 1 |
| Su, JH | 1 |
| Hung, SC | 1 |
| Chai, CY | 1 |
| Mackay, H | 1 |
| Hedley, D | 1 |
| Major, P | 1 |
| Townsley, C | 1 |
| Mackenzie, M | 1 |
| Vincent, M | 1 |
| Degendorfer, P | 1 |
| Tsao, MS | 1 |
| Nicklee, T | 1 |
| Birle, D | 1 |
| Wright, J | 1 |
| Siu, L | 1 |
| Moore, M | 1 |
| Oza, A | 1 |
| Koul, D | 1 |
| Shen, R | 1 |
| Bergh, S | 1 |
| Lu, Y | 1 |
| de Groot, JF | 1 |
| Liu, TJ | 1 |
| Mills, GB | 1 |
| Yung, WK | 1 |
| Matsuzaki, K | 1 |
| Andrulionyte, L | 1 |
| Peltola, P | 1 |
| Chiasson, JL | 1 |
| Laakso, M | 1 |
| Rajput, A | 1 |
| Dickson, DW | 1 |
| Robinson, CA | 1 |
| Ross, OA | 1 |
| Dächsel, JC | 1 |
| Lincoln, SJ | 1 |
| Cobb, SA | 1 |
| Rajput, ML | 1 |
| Farrer, MJ | 1 |
| Ammosova, T | 1 |
| Berro, R | 1 |
| Jerebtsova, M | 1 |
| Jackson, A | 1 |
| Charles, S | 1 |
| Klase, Z | 1 |
| Southerland, W | 1 |
| Gordeuk, VR | 1 |
| Kashanchi, F | 1 |
| Nekhai, S | 1 |
| Fava, C | 1 |
| Montagnana, M | 1 |
| Almgren, P | 1 |
| Rosberg, L | 1 |
| Guidi, GC | 1 |
| Berglund, G | 1 |
| Melander, O | 1 |
| Tumini, E | 1 |
| Porcellini, E | 1 |
| Chiappelli, M | 1 |
| Conti, CM | 1 |
| Beraudi, A | 1 |
| Poli, A | 1 |
| Caciagli, F | 1 |
| Doyle, R | 1 |
| Conti, P | 1 |
| Licastro, F | 1 |
| Coppedè, F | 1 |
| Mancuso, M | 1 |
| Lo Gerfo, A | 1 |
| Carlesi, C | 1 |
| Piazza, S | 1 |
| Rocchi, A | 1 |
| Petrozzi, L | 1 |
| Nesti, C | 1 |
| Micheli, D | 1 |
| Bacci, A | 1 |
| Migliore, L | 1 |
| Murri, L | 1 |
| Siciliano, G | 1 |
| Chen-Izu, Y | 1 |
| Ward, CW | 1 |
| Stark, W | 1 |
| Banyasz, T | 1 |
| Sumandea, MP | 1 |
| Balke, CW | 1 |
| Izu, LT | 1 |
| Jiang, J | 1 |
| Sarwar, N | 1 |
| Peston, D | 1 |
| Kulinskaya, E | 1 |
| Shousha, S | 1 |
| Coombes, RC | 1 |
| Ali, S | 1 |
| Al-Kateb, H | 1 |
| Boright, AP | 1 |
| Mirea, L | 1 |
| Sutradhar, R | 1 |
| Mowjoodi, A | 1 |
| Bharaj, B | 1 |
| Liu, M | 1 |
| Bucksa, JM | 1 |
| Arends, VL | 1 |
| Steffes, MW | 1 |
| Cleary, PA | 1 |
| Sun, W | 1 |
| Lachin, JM | 1 |
| Thorner, PS | 1 |
| Ho, M | 1 |
| McKnight, AJ | 1 |
| Maxwell, AP | 1 |
| Savage, DA | 1 |
| Kidd, KK | 1 |
| Kidd, JR | 1 |
| Speed, WC | 1 |
| Orchard, TJ | 1 |
| Sun, L | 1 |
| Bull, SB | 1 |
| Paterson, AD | 1 |
| Golan, MP | 1 |
| Styczyńska, M | 1 |
| Jóźwiak, K | 1 |
| Walecki, J | 1 |
| Maruszak, A | 1 |
| Pniewski, J | 1 |
| Lugiewicz, R | 1 |
| Filipek, S | 1 |
| Zekanowski, C | 1 |
| Barcikowska, M | 1 |
| Zhao, J | 1 |
| Qin, J | 1 |
| Shi, S | 1 |
| Chen, M | 1 |
| Gao, S | 1 |
| Xiao, F | 1 |
| Lu, Q | 1 |
| Meyer, A | 1 |
| Kossow, K | 1 |
| Gal, A | 1 |
| Steglich, C | 1 |
| Mühlhausen, C | 1 |
| Ullrich, K | 1 |
| Braulke, T | 1 |
| Muschol, N | 1 |
| de Koning, TJ | 1 |
| Jaeken, J | 1 |
| Pineda, M | 1 |
| Van Maldergem, L | 1 |
| Poll-The, BT | 1 |
| van der Knaap, MS | 1 |
| Marotta, A | 1 |
| Tan, C | 1 |
| Gray, V | 1 |
| Malik, S | 1 |
| Gallinger, S | 1 |
| Sanghera, J | 1 |
| Dupuis, B | 1 |
| Owen, D | 1 |
| Dedhar, S | 1 |
| Salh, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study[NCT03580616] | Phase 2 | 43 participants (Actual) | Interventional | 2018-10-24 | Terminated (stopped due to Study was terminated by the IRB due to continued noncompliance.) | ||
| A Phase II Study Of PS-341 In Patients With Metastatic Colorectal Cancer[NCT00052507] | Phase 2 | 0 participants | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for serine and Disease Exacerbation
| Article | Year |
|---|---|
YAP/TAZ-mediated activation of serine metabolism and methylation regulation is critical for LKB1-deficient breast cancer progression.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Breast Neoplasms; Diseas | 2017 |
Bad phosphorylation as a target of inhibition in oncology.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Survival; Disease Progression; Humans; Neoplasms; Phos | 2018 |
Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression.
Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Disease Progression; Drug Resistance, Neop | 2017 |
The role of D-amino acids in amyotrophic lateral sclerosis pathogenesis: a review.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; D-Amino-Acid Oxidase; Disease Progression; Gene Expre | 2012 |
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Colorec | 2006 |
3 trials available for serine and Disease Exacerbation
| Article | Year |
|---|---|
Phase I clinical trial of safety of L-serine for ALS patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Disease Progression; Dose | 2017 |
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer.
Topics: Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomi | 2005 |
Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications G
Topics: Alanine; Albuminuria; Amino Acid Substitution; Diabetic Nephropathies; Diabetic Retinopathy; Disease | 2008 |
66 other studies available for serine and Disease Exacerbation
| Article | Year |
|---|---|
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; | 2022 |
Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.
Topics: A549 Cells; Animals; Disease Progression; Humans; Insulin Receptor Substrate Proteins; Lung Neoplasm | 2019 |
Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients.
Topics: Adult; Cervix Uteri; Clusterin; Disease Progression; Female; Heat-Shock Proteins; Humans; Keratin-19 | 2020 |
USP13 controls the stability of Aurora B impacting progression through the cell cycle.
Topics: Aurora Kinase B; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Progression; Endopept | 2020 |
Metabolic alterations in meningioma reflect the clinical course.
Topics: Aged; Algorithms; Biomarkers, Tumor; Choline; Cluster Analysis; Disease Progression; Female; Glycine | 2021 |
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression.
Topics: Biosynthetic Pathways; Diabetes Mellitus, Type 2; Disease Progression; Endophenotypes; Genetic Loci; | 2021 |
Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Movement; Disease Progression; Female; Glycogen | 2021 |
Long noncoding RNA LINC00675 enhances phosphorylation of vimentin on Ser83 to suppress gastric cancer progression.
Topics: Adult; Aged; Animals; Cell Movement; Disease Progression; Female; Genes, Tumor Suppressor; Humans; M | 2018 |
ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway.
Topics: beta Catenin; Breast Neoplasms; Disease Progression; DNA-Binding Proteins; Down-Regulation; Epigenes | 2017 |
O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis.
Topics: Amino Acid Substitution; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease | 2018 |
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Male; Middle | 2018 |
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Topics: Animals; Autophagy; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Disease Progression; Enzy | 2019 |
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway.
Topics: Amino Acid Sequence; Cell Line, Tumor; Disease Progression; Epidermal Growth Factor; Feedback, Physi | 2019 |
Dynamics of D-serine reflected the recovery course of a patient with rapidly progressive glomerulonephritis.
Topics: Acute Kidney Injury; Adult; Antibodies, Antineutrophil Cytoplasmic; Creatinine; Cyclophosphamide; Di | 2019 |
Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.
Topics: Animals; Anoikis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Codon; Disease Prog | 2013 |
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Aorta; Atherosclerosis; Biomarkers; Carrier Pro | 2013 |
Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.
Topics: Age Factors; Animals; Axonal Transport; Cognition Disorders; Disease Progression; Exploratory Behavi | 2014 |
Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer.
Topics: Biomarkers, Tumor; Carrier Proteins; Disease Progression; Female; Humans; Male; Middle Aged; Prognos | 2015 |
Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2016 |
The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.
Topics: Breast Neoplasms; Carcinoma, Ductal; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Move | 2015 |
AR-v7 protein expression is regulated by protein kinase and phosphatase.
Topics: Alternative Splicing; Benzamides; Cell Line, Tumor; Cytoplasm; Disease Progression; Gene Expression | 2015 |
Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.
Topics: Adult; Biomarkers, Tumor; Disease Progression; Eukaryotic Initiation Factor-4E; Female; Humans; Immu | 2016 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Disease Progression; Humans; Neoplastic Stem Cel | 2016 |
Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients.
Topics: Cell Line, Tumor; Cell Nucleus; Cytoplasm; Disease Progression; Humans; Male; Phosphorylation; Progn | 2017 |
Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; D-Amino-Acid Oxidase; Dependovirus; Disease Model | 2018 |
Discovery of Metabolite Biomarkers for Acute Ischemic Stroke Progression.
Topics: Aged; Betaine; Biomarkers; Disease Progression; Early Diagnosis; Female; Humans; Isoleucine; Male; M | 2017 |
Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma.
Topics: Adult; Aged; Carcinoma in Situ; COP9 Signalosome Complex; Cyclin-Dependent Kinase 2; Cyclin-Dependen | 2009 |
Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.
Topics: Adenocarcinoma; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Nucleus; Colonic Neoplasms; | 2009 |
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Catalytic Domain; Central Nervous Syste | 2009 |
Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Asparagine; Child; Child, Presc | 2010 |
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.
Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Hemodynamics; Mice; Myocardi | 2010 |
Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.
Topics: Age of Onset; Amino Acid Substitution; Brain; Cerebrovascular Circulation; Disease Progression; DNA | 2010 |
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; D | 2010 |
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Line, Tumor; Disease Progres | 2010 |
Deoxysphingoid bases as plasma markers in diabetes mellitus.
Topics: Aged; Alanine; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Diabeti | 2010 |
Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway.
Topics: Basic Helix-Loop-Helix Transcription Factors; Disease Progression; Female; Humans; Hypoxia-Inducible | 2011 |
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Analysis of Variance; Disease Progression; Female; Frontal | 2011 |
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
Topics: Acoustic Stimulation; Age Factors; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; | 2011 |
Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.
Topics: Animals; Apolipoproteins E; Arteries; Atherosclerosis; Case-Control Studies; Cell Proliferation; Cyc | 2011 |
Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Female; Humans; | 2012 |
Propagation of tau pathology in a model of early Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Entorhinal Cor | 2012 |
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Topics: Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Di | 2012 |
Variability of disease progression in a family with autosomal recessive CMT associated with a S194X and new R310Q mutation in the GDAP1 gene.
Topics: Adult; Arginine; Charcot-Marie-Tooth Disease; Disease Progression; DNA Mutational Analysis; Electrop | 2003 |
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; C | 2004 |
SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I.
Topics: Acyl Coenzyme A; Acyltransferases; Belgium; Chromosome Mapping; Chromosomes, Human, Pair 9; Disease | 2004 |
Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases.
Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Culture Media, S | 2005 |
Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Topics: Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Melanocyt | 2005 |
Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Proli | 2004 |
Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.
Topics: Amino Acid Sequence; Binding Sites; Casein Kinase II; Cell Line, Tumor; Cross-Linking Reagents; Cyto | 2005 |
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Topics: Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Collagen; Culture Media, Serum-Free; | 2005 |
The role of p-STAT3 (ser727) revealed by its association with Ki-67 in cervical intraepithelial neoplasia.
Topics: Biomarkers, Tumor; Disease Progression; DNA-Binding Proteins; Female; Humans; Ki-67 Antigen; Phospho | 2005 |
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Topics: Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; C | 2005 |
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Disease Progression; Female; Glucose Intolerance | 2006 |
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.
Topics: Aged; alpha-Synuclein; Brain; Cell Line; Disability Evaluation; Disease Progression; Female; Glycine | 2006 |
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.
Topics: Cyclin-Dependent Kinase 2; Disease Progression; Gene Expression Regulation, Viral; Gene Products, ta | 2006 |
The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes.
Topics: Adult; Blood Pressure; Chloride Channels; Cohort Studies; Cross-Sectional Studies; Disease Progressi | 2007 |
The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
Topics: Alleles; Alzheimer Disease; Apolipoprotein E4; Cognition Disorders; Disease Progression; Follow-Up S | 2007 |
Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis.
Topics: Age Factors; Aged; Amino Acid Sequence; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Cyst | 2007 |
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein | 2007 |
Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients.
Topics: Breast Neoplasms; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Estrogen Receptor al | 2007 |
Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene.
Topics: Adult; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Mo | 2007 |
Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation.
Topics: Active Transport, Cell Nucleus; Acute Disease; Amino Acid Sequence; Animals; Astrocytes; Cell Prolif | 2008 |
The mutation p.Ser298Pro in the sulphamidase gene (SGSH) is associated with a slowly progressive clinical phenotype in mucopolysaccharidosis type IIIA (Sanfilippo A syndrome).
Topics: Adolescent; Adult; Child; Child, Preschool; Disease Progression; Female; Genotype; Humans; Hydrolase | 2008 |
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Amino Acids; Carbohydrate Dehydrogenases; Cerebral Cortex; Child; Child, Preschool; Choline; Demyeli | 2000 |
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis.
Topics: Adenomatous Polyposis Coli; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Polyps; Diseas | 2001 |