Page last updated: 2024-11-08

serine and Diabetes Mellitus

serine has been researched along with Diabetes Mellitus in 26 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia due to a variety of etiological factors."3.01RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications. ( Chen, P; Chu, Y; Dai, Y; Ke, D; Li, L; Liu, J; Sun, X; Zhang, Z, 2023)
"Hyperglycemia and insulin resistance are common findings in critical illness."1.38Injury-induced insulin resistance in adipose tissue. ( Franklin, JL; Hardy, RW; Martin, RE; Messina, JL; Williams, VL, 2012)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.69)18.7374
1990's1 (3.85)18.2507
2000's9 (34.62)29.6817
2010's7 (26.92)24.3611
2020's7 (26.92)2.80

Authors

AuthorsStudies
Elshorbagy, AK1
Turner, C1
Bastani, N1
Refsum, H1
Kwok, T1
Xia, C1
Suriyanarayanan, S1
Gong, Y1
Fridman, V1
Selig, M1
Li, J1
Rutkove, S1
Hornemann, T2
Eichler, F1
Starling, S1
Mizukami, H1
Chen, JX1
Fang, QJ1
Wan, YG1
Liu, YL1
Wang, Y1
Wu, W1
Tu, Y1
Wang, MZ1
Wang, DG1
Ge, HT1
Ke, D1
Zhang, Z1
Liu, J1
Chen, P1
Dai, Y1
Sun, X1
Chu, Y1
Li, L1
Finamore, F1
Reny, JL1
Malacarne, S1
Fontana, P1
Sanchez, JC1
Takaguri, A1
Sartoretto, JL1
Jin, BY1
Bauer, M1
Gertler, FB1
Liao, R1
Michel, T1
Uebi, T1
Tamura, M1
Horike, N1
Hashimoto, YK1
Takemori, H1
Panjala, SR1
Jiang, Y1
Kern, TS1
Thomas, SA1
Steinle, JJ1
Fingar, DC1
Inoki, K1
Williams, VL1
Martin, RE1
Franklin, JL1
Hardy, RW1
Messina, JL1
Copps, KD1
White, MF1
Gum, RJ1
Gaede, LL1
Koterski, SL1
Heindel, M1
Clampit, JE1
Zinker, BA1
Trevillyan, JM1
Ulrich, RG1
Jirousek, MR1
Rondinone, CM1
Barbato, A1
Russo, P1
Venezia, A1
Strazzullo, V1
Siani, A1
Cappuccio, FP1
Chadarevian, R1
Foubert, L1
Beucler, I1
Kottler, ML1
Raisonnier, A1
Ajlouni, A1
Giral, P1
Turpin, G1
Bruckert, E1
Stumvoll, M1
Fritsche, A1
t'Hart, LM1
Machann, J1
Thamer, C1
Tschritter, O1
Van Haeften, TW1
Jacob, S1
Dekker, JM1
Maassen, JA1
Machicao, F1
Schick, F1
Heine, RJ1
Häring, H1
Oxombre, B1
Kouach, M1
Moerman, E1
Formstecher, P1
Laine, B1
Wang, C1
Fang, Q1
Zhang, R1
Lin, X1
Xiang, K1
Levkovitz, Y1
Ben-Shushan, G1
Hershkovitz, A1
Isaac, R1
Gil-Ad, I1
Shvartsman, D1
Ronen, D1
Weizman, A1
Zick, Y1
Parker, PJ1
Caudwell, FB1
Cohen, P1
Akimoto, Y1
Hirano, H1
Hart, GW1
Kreppel, LK1
Lewis, S1
Karrer, J1
Saleh, S1
Chan, X1
Tan, Z1
Hua, D1
McGill, J1
Pang, YP1
Fenwick, B1
Brightman, A1
Takemoto, D1
Nordöy, A1
Rödset, JM1

Reviews

4 reviews available for serine and Diabetes Mellitus

ArticleYear
RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Humans; Inflammation; Receptor-In

2023
[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2018, Volume: 138, Issue:11

    Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Atorvastatin; Diabetes Mellitus; Dual-Specificit

2018
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
    Diabetologia, 2012, Volume: 55, Issue:10

    Topics: Animals; Diabetes Mellitus; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; M

2012
[O-GlcNAc and its function].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1998, Volume: 43, Issue:16 Suppl

    Topics: Acetylglucosamine; Animals; Cell Nucleus; Cloning, Molecular; Diabetes Mellitus; Glycosylation; Hexo

1998

Trials

1 trial available for serine and Diabetes Mellitus

ArticleYear
A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study.
    Journal of proteomics, 2019, 02-10, Volume: 192

    Topics: Acetylation; Adult; Aspirin; Blood Glucose; Blood Platelets; Cyclooxygenase 1; Diabetes Mellitus; Fe

2019

Other Studies

21 other studies available for serine and Diabetes Mellitus

ArticleYear
The association of serum sulfur amino acids and related metabolites with incident diabetes: a prospective cohort study.
    European journal of nutrition, 2022, Volume: 61, Issue:6

    Topics: Amino Acids; Amino Acids, Sulfur; Cystathionine; Cysteine; Diabetes Mellitus; Glutamates; Glutamine;

2022
Long-term effects of l-serine supplementation upon a mouse model of diabetic neuropathy.
    Journal of diabetes and its complications, 2023, Volume: 37, Issue:2

    Topics: Animals; Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements; Hyperglycemia; Mice; Serine;

2023
Serine deficiency causes complications in diabetes.
    Nature, 2023, Volume: 614, Issue:7946

    Topics: Diabetes Mellitus; Humans; Serine

2023
Serine slows diabetic neuropathy in mice.
    Nature reviews. Endocrinology, 2023, Volume: 19, Issue:4

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Humans; Mice; Serine

2023
Serine supplementation: Is it a new option for the treatment of diabetic polyneuropathy?
    Journal of diabetes investigation, 2023, Volume: 14, Issue:10

    Topics: Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements; Humans; Serine

2023
[Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:15

    Topics: Abelmoschus; Animals; Collagen; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Flavones; Human

2023
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell A

2009
Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 299, Issue:3

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP Response Element-Binding Protein; Cyclosporine;

2010
Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse.
    Molecular vision, 2011, Volume: 17

    Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Caspase 3; Cell Extracts; Diabetes Complications

2011
Deconvolution of mTORC2 "in Silico".
    Science signaling, 2012, Mar-27, Volume: 5, Issue:217

    Topics: Animals; Cardiovascular Diseases; Computer Simulation; Diabetes Mellitus; HeLa Cells; Humans; Insuli

2012
Injury-induced insulin resistance in adipose tissue.
    Biochemical and biophysical research communications, 2012, May-11, Volume: 421, Issue:3

    Topics: Adipose Tissue; Animals; Critical Illness; Diabetes Mellitus; Disease Models, Animal; Glycogen Synth

2012
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
    Diabetes, 2003, Volume: 52, Issue:1

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 be

2003
Analysis of Gly40Ser polymorphism of the glucagon receptor (GCGR) gene in different ethnic groups.
    Journal of human hypertension, 2003, Volume: 17, Issue:8

    Topics: Adult; Asian People; Black People; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus; Female

2003
Lipoprotein lipase activity and common gene variants in severely hypertriglyceridemic patients with and without diabetes.
    Hormone research, 2003, Volume: 60, Issue:2

    Topics: Adult; Apolipoproteins; Asparagine; Aspartic Acid; Diabetes Complications; Diabetes Mellitus; Female

2003
The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2004, Volume: 112, Issue:5

    Topics: Adult; Amino Acid Substitution; Diabetes Mellitus; Female; Genotype; Germany; Glucose Clamp Techniqu

2004
The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain.
    The Biochemical journal, 2004, Nov-01, Volume: 383, Issue:Pt. 3

    Topics: Age of Onset; Amino Acid Substitution; Binding Sites; Carcinoma, Hepatocellular; Cell Line, Tumor; C

2004
Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigrees.
    Acta diabetologica, 2004, Volume: 41, Issue:4

    Topics: Adenine; Adult; Aged; Amino Acid Substitution; Asian People; Base Sequence; Case-Control Studies; Di

2004
Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.
    Molecular and cellular neurosciences, 2007, Volume: 36, Issue:3

    Topics: Animals; Cell Line, Tumor; Diabetes Mellitus; Enzyme Activation; Insulin; Insulin Receptor Substrate

2007
Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo.
    European journal of biochemistry, 1983, Jan-17, Volume: 130, Issue:1

    Topics: Animals; Carrier Proteins; Diabetes Mellitus; Glycogen Synthase; Insulin; Intracellular Signaling Pe

1983
Synthesis and evaluation of novel aldose reductase inhibitors: Effects on lens protein kinase Cgamma.
    Molecular vision, 2001, Jul-18, Volume: 7

    Topics: Acetates; Aldehyde Reductase; Animals; Benzopyrans; Blotting, Western; Connexins; Diabetes Mellitus;

2001
Platelet phospholipids and their function in patients with juvenile diabetes and maturity onset diabetes.
    Diabetes, 1970, Volume: 19, Issue:10

    Topics: Adult; Aged; Amino Alcohols; Blood Platelets; Blood Proteins; Cholesterol; Choline; Chromatography,

1970