serine has been researched along with Diabetes Mellitus, Type 2 in 87 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this clinical study is to examine the association between D-serine and diabetic retinopathy (DR)." | 7.80 | Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy. ( Du, J; He, T; Jiang, H; Qu, J; Song, Z; Wu, S, 2014) |
| "Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease." | 5.33 | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. ( Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P, 2005) |
| "The objective of this clinical study is to examine the association between D-serine and diabetic retinopathy (DR)." | 3.80 | Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy. ( Du, J; He, T; Jiang, H; Qu, J; Song, Z; Wu, S, 2014) |
| "Results showed that E2 influenced on protein levels of insulin receptor substrate-1 (IRS-1) and impaired insulin-induced Ser308 phosphorylation of Akt/PKB and Ser9 phosphorylation of GSK3β in Huh7 cells, leading to an inhibition of glucose uptake and glycogen synthesis, respectively, and eventually insulin resistance." | 3.78 | Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes. ( Chen, TY; Chiou, HL; Hsieh, MJ; Lan, KP; Lin, YF; Liu, HY; Zhang, XZ, 2012) |
| "IRS-1 serine phosphorylation is often elevated in insulin resistance models, but confirmation in vivo in humans is lacking." | 3.77 | Global IRS-1 phosphorylation analysis in insulin resistance. ( De Filippis, E; Finlayson, J; Langlais, P; Luo, M; Mandarino, LJ; Mapes, R; Mattern, M; Meyer, C; Plummer, E; Tongchinsub, P; Yi, Z, 2011) |
| "A promising approach for treating type 2 diabetes mellitus (T2DM) is to target the Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates the expression of proteins critical for T2DM." | 2.72 | The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes. ( Bruning, JB; Frkic, RL; Richter, K, 2021) |
| "To clarify the role of Gly482Ser in type 2 diabetes and related human metabolic phenotypes we genotyped this polymorphism in a case-control study and performed a meta-analysis of relevant published data." | 2.43 | Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. ( Barroso, I; Crowley, V; Franks, PW; Luan, J; O'Rahilly, S; Sandhu, MS; Schafer, AJ; Wareham, NJ, 2006) |
| "Obesity is linked to the development of major metabolic disorders such as type 2 diabetes, cardiovascular disease, and cancer." | 1.91 | Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model. ( , 2023) |
| "The diagnosis of diabetic nephropathy (DN), the major cause of ESKD, requires kidney biopsy." | 1.62 | Identification of Diabetic Nephropathy in Patients Undergoing Kidney Biopsy through Blood and Urinary Profiles of d-Serine. ( Hayashi, T; Hesaka, A; Horio, M; Ikeda, T; Imamura, R; Isaka, Y; Iwata, Y; Kawamura, M; Kimura, T; Mita, M; Nakane, M; Okushima, H; Takahara, S; Tanaka, Y, 2021) |
| "Neither the FCH subjects nor the type 2 diabetes patients were found to have the S323I variant." | 1.37 | S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes. ( Chen, BD; Fu, ZY; Li, XM; Liu, F; Ma, X; Ma, YT; Xie, X; Yang, SJ; Yang, YN; Zheng, YY, 2011) |
| "We conclude that advanced diabetic nephropathy is associated with increased renal H3K9 and H3K23 acetylation, H3K4 dimethylation and H3 phosphorylation at serine 10 that enhance chromatin unfolding and gene expression." | 1.36 | Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. ( Anders, HJ; Eulberg, D; Gaikwad, AB; Klussmann, S; Kulkarni, O; Lichtnekert, J; Sayyed, SG; Tikoo, K, 2010) |
| "We hypothesize that type 1 and type 2 diabetes may contribute to AD through different mechanisms; in type 2 diabetes, hyperglycemia-mediated tau cleavage may be the key feature, whereas insulin deficiency may be the major contributing factor in type 1 diabetes." | 1.35 | Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. ( Backus, C; Feldman, EL; Hayes, JM; Kim, B; Oh, S, 2009) |
| "In db/db mice at 2 weeks of type 2 diabetes, VEGF expression was increased, which was due not to increase in transcription but to augmented translation of VEGF mRNA." | 1.35 | PKCdelta regulates the stimulation of vascular endothelial factor mRNA translation by angiotensin II through hnRNP K. ( Feliers, D; Lee, MJ; Mariappan, MM; Sataranatarajan, K, 2008) |
| "Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease." | 1.33 | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. ( Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P, 2005) |
| " We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2." | 1.33 | Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. ( Andrulionyte, L; Chiasson, JL; Laakso, M; Peltola, P, 2006) |
| "Insulin resistance was estimated using the homeostasis model assessment (HOMA) index." | 1.31 | Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus. ( Groop, L; Klannemark, M; Orho-Melander, M; Suurinkeroinen, L; Taskinen, MR, 2000) |
| " Finally, glucagon-stimulated insulin secretion by RIN cells expressing the mutant receptor was decreased such that the dose-response curve was shifted to the right in comparison to that obtained with cells expressing the wild type receptor." | 1.29 | The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon. ( Abrahamsen, N; Froguel, P; Hager, J; Hansen, LH; Jelinek, L; Kindsvogel, W; Nishimura, E, 1996) |
| "None of the NIDDM or impaired glucose tolerant patients had this polymorphism." | 1.29 | Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland. ( Groop, L; Huang, X; Lehto, M; Orho, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (17.24) | 18.2507 |
| 2000's | 32 (36.78) | 29.6817 |
| 2010's | 23 (26.44) | 24.3611 |
| 2020's | 17 (19.54) | 2.80 |
| Authors | Studies |
|---|---|
| Iwata, Y | 1 |
| Okushima, H | 1 |
| Hesaka, A | 1 |
| Kawamura, M | 1 |
| Imamura, R | 1 |
| Takahara, S | 1 |
| Horio, M | 1 |
| Tanaka, Y | 1 |
| Ikeda, T | 1 |
| Nakane, M | 1 |
| Mita, M | 1 |
| Hayashi, T | 1 |
| Isaka, Y | 1 |
| Kimura, T | 1 |
| Liu, Y | 2 |
| Liu, B | 1 |
| Qiao, YC | 1 |
| Niu, WY | 1 |
| Zhang, H | 2 |
| Dong, M | 1 |
| Yuan, S | 1 |
| Jin, W | 1 |
| Li, H | 1 |
| Song, D | 1 |
| Liu, Q | 1 |
| Li, L | 1 |
| Sun, X | 1 |
| Guo, J | 1 |
| Li, D | 1 |
| Li, P | 1 |
| Alka, K | 1 |
| Mohammad, G | 1 |
| Kowluru, RA | 1 |
| Yu, M | 1 |
| Sun, Y | 1 |
| Shan, X | 1 |
| Yang, F | 1 |
| Chu, G | 1 |
| Chen, Q | 1 |
| Han, L | 1 |
| Guo, Z | 1 |
| Wang, G | 1 |
| Sakaguchi, M | 1 |
| Okagawa, S | 1 |
| Okubo, Y | 1 |
| Otsuka, Y | 1 |
| Fukuda, K | 1 |
| Igata, M | 1 |
| Kondo, T | 1 |
| Sato, Y | 1 |
| Yoshizawa, T | 1 |
| Fukuda, T | 1 |
| Yamagata, K | 3 |
| Cai, W | 1 |
| Tseng, YH | 1 |
| Sakaguchi, N | 1 |
| Kahn, CR | 1 |
| Araki, E | 1 |
| Holeček, M | 1 |
| Lallement, J | 1 |
| Raho, I | 1 |
| Merlen, G | 1 |
| Rainteau, D | 1 |
| Croyal, M | 1 |
| Schiffano, M | 1 |
| Kassis, N | 1 |
| Doignon, I | 1 |
| Soty, M | 1 |
| Lachkar, F | 1 |
| Krempf, M | 1 |
| Van Hul, M | 1 |
| Cani, PD | 1 |
| Foufelle, F | 1 |
| Amouyal, C | 1 |
| Le Stunff, H | 1 |
| Magnan, C | 1 |
| Tordjmann, T | 1 |
| Cruciani-Guglielmacci, C | 1 |
| Keller, LJ | 1 |
| Nguyen, TH | 1 |
| Liu, LJ | 1 |
| Hurysz, BM | 1 |
| Lakemeyer, M | 1 |
| Guerra, M | 1 |
| Gelsinger, DJ | 1 |
| Chanin, R | 1 |
| Ngo, N | 1 |
| Lum, KM | 1 |
| Faucher, F | 1 |
| Ipock, P | 1 |
| Niphakis, MJ | 1 |
| Bhatt, AS | 1 |
| O'Donoghue, AJ | 1 |
| Huang, KC | 1 |
| Bogyo, M | 1 |
| Wang, W | 1 |
| Tanokashira, D | 1 |
| Fukui, Y | 1 |
| Maruyama, M | 1 |
| Kuroiwa, C | 1 |
| Saito, T | 1 |
| Saido, TC | 1 |
| Taguchi, A | 1 |
| Liu, PJ | 1 |
| Yao, A | 1 |
| Chen, XY | 1 |
| Ma, L | 1 |
| Hou, YX | 1 |
| Bonelli, R | 3 |
| Woods, SM | 1 |
| Ansell, BRE | 2 |
| Heeren, TFC | 1 |
| Egan, CA | 1 |
| Khan, KN | 1 |
| Guymer, R | 1 |
| Trombley, J | 1 |
| Friedlander, M | 1 |
| Bahlo, M | 3 |
| Fruttiger, M | 1 |
| Lotta, LA | 1 |
| Pietzner, M | 1 |
| Stewart, ID | 1 |
| Wittemans, LBL | 1 |
| Li, C | 1 |
| Raffler, J | 1 |
| Biggs, EK | 1 |
| Oliver-Williams, C | 1 |
| Auyeung, VPW | 1 |
| Luan, J | 2 |
| Wheeler, E | 1 |
| Paige, E | 1 |
| Surendran, P | 1 |
| Michelotti, GA | 1 |
| Scott, RA | 1 |
| Burgess, S | 1 |
| Zuber, V | 1 |
| Sanderson, E | 1 |
| Koulman, A | 1 |
| Imamura, F | 1 |
| Forouhi, NG | 1 |
| Khaw, KT | 1 |
| Griffin, JL | 1 |
| Wood, AM | 1 |
| Kastenmüller, G | 1 |
| Danesh, J | 1 |
| Butterworth, AS | 1 |
| Gribble, FM | 1 |
| Reimann, F | 1 |
| Fauman, E | 1 |
| Wareham, NJ | 2 |
| Langenberg, C | 2 |
| Fridman, V | 1 |
| Zarini, S | 1 |
| Sillau, S | 1 |
| Harrison, K | 1 |
| Bergman, BC | 1 |
| Feldman, EL | 2 |
| Reusch, JEB | 1 |
| Callaghan, BC | 1 |
| Lotta, L | 1 |
| Scerri, T | 1 |
| Clemons, TE | 1 |
| Leung, I | 1 |
| Peto, T | 1 |
| Bird, AC | 1 |
| Sallo, FB | 1 |
| Frkic, RL | 1 |
| Richter, K | 1 |
| Bruning, JB | 1 |
| Vandenbeek, R | 1 |
| Khan, NP | 1 |
| Estall, JL | 1 |
| Okuyama, S | 1 |
| Shinoka, W | 1 |
| Nakamura, K | 1 |
| Kotani, M | 1 |
| Sawamoto, A | 1 |
| Sugawara, K | 1 |
| Sudo, M | 1 |
| Nakajima, M | 1 |
| Furukawa, Y | 1 |
| Bathina, S | 1 |
| Das, UN | 1 |
| Holm, LJ | 1 |
| Buschard, K | 1 |
| Shibata, T | 1 |
| Takaguri, A | 1 |
| Ichihara, K | 1 |
| Satoh, K | 1 |
| Thewissen, MM | 1 |
| van de Gaar, J | 1 |
| den Boer, AT | 1 |
| Munsters, MJ | 1 |
| Blaak, EE | 1 |
| Duijvestijn, A | 1 |
| Jiang, H | 1 |
| Du, J | 1 |
| He, T | 1 |
| Qu, J | 1 |
| Song, Z | 1 |
| Wu, S | 1 |
| Li, J | 1 |
| Bi, L | 1 |
| Hulke, M | 1 |
| Li, T | 1 |
| Xie, X | 2 |
| Zhou, X | 1 |
| Chen, W | 1 |
| Long, L | 1 |
| Li, W | 1 |
| Yang, X | 1 |
| Li, S | 1 |
| Wang, L | 3 |
| Pichu, S | 1 |
| Sathiyamoorthy, J | 1 |
| Krishnamoorthy, E | 1 |
| Umapathy, D | 1 |
| Viswanathan, V | 1 |
| Simon-Szabó, L | 1 |
| Kokas, M | 1 |
| Greff, Z | 1 |
| Boros, S | 1 |
| Bánhegyi, P | 1 |
| Zsákai, L | 1 |
| Szántai-Kis, C | 1 |
| Vantus, T | 1 |
| Mandl, J | 1 |
| Bánhegyi, G | 1 |
| Vályi-Nagy, I | 1 |
| Őrfi, L | 1 |
| Ullrich, A | 1 |
| Csala, M | 1 |
| Kéri, G | 1 |
| Nystoriak, MA | 1 |
| Nieves-Cintrón, M | 1 |
| Patriarchi, T | 1 |
| Buonarati, OR | 1 |
| Prada, MP | 1 |
| Morotti, S | 1 |
| Grandi, E | 1 |
| Fernandes, JD | 1 |
| Forbush, K | 1 |
| Hofmann, F | 1 |
| Sasse, KC | 1 |
| Scott, JD | 1 |
| Ward, SM | 1 |
| Hell, JW | 1 |
| Navedo, MF | 1 |
| Okauchi, Y | 1 |
| Iwahashi, H | 1 |
| Okita, K | 1 |
| Yuan, M | 1 |
| Matsuda, M | 1 |
| Tanaka, T | 1 |
| Miyagawa, J | 1 |
| Funahashi, T | 1 |
| Horikawa, Y | 1 |
| Shimomura, I | 1 |
| Qu, Y | 1 |
| Yang, Z | 1 |
| Jin, F | 1 |
| Sun, L | 1 |
| Zhang, C | 2 |
| Ji, L | 1 |
| Sun, H | 1 |
| Wang, B | 1 |
| Sparks, SM | 1 |
| Banker, P | 1 |
| Bickett, DM | 1 |
| Clancy, DC | 1 |
| Dickerson, SH | 1 |
| Garrido, DM | 1 |
| Golden, PL | 1 |
| Peat, AJ | 1 |
| Sheckler, LR | 1 |
| Tavares, FX | 1 |
| Thomson, SA | 1 |
| Weiel, JE | 1 |
| Daimon, M | 1 |
| Oizumi, T | 1 |
| Toriyama, S | 1 |
| Karasawa, S | 1 |
| Jimbu, Y | 1 |
| Wada, K | 1 |
| Kameda, W | 1 |
| Susa, S | 1 |
| Muramatsu, M | 1 |
| Kubota, I | 1 |
| Kawata, S | 1 |
| Kato, T | 1 |
| Zhang, HM | 1 |
| Chen, LL | 1 |
| Liao, YF | 1 |
| Wu, ZH | 1 |
| Ye, F | 1 |
| Xu, S | 1 |
| Yi, LL | 1 |
| Yang, J | 1 |
| Park, Y | 1 |
| Gao, X | 1 |
| Wilson, E | 1 |
| Zimmer, W | 1 |
| Abbott, L | 1 |
| Kim, B | 1 |
| Backus, C | 1 |
| Oh, S | 1 |
| Hayes, JM | 1 |
| Liu, S | 1 |
| Okada, T | 1 |
| Assmann, A | 1 |
| Soto, J | 1 |
| Liew, CW | 1 |
| Bugger, H | 1 |
| Shirihai, OS | 1 |
| Abel, ED | 1 |
| Kulkarni, RN | 1 |
| Király, MA | 1 |
| Campbell, J | 1 |
| Park, E | 1 |
| Bates, HE | 1 |
| Yue, JT | 1 |
| Rao, V | 1 |
| Matthews, SG | 1 |
| Bikopoulos, G | 1 |
| Rozakis-Adcock, M | 1 |
| Giacca, A | 1 |
| Vranic, M | 1 |
| Riddell, MC | 1 |
| Sayyed, SG | 1 |
| Gaikwad, AB | 1 |
| Lichtnekert, J | 1 |
| Kulkarni, O | 1 |
| Eulberg, D | 1 |
| Klussmann, S | 1 |
| Tikoo, K | 1 |
| Anders, HJ | 1 |
| Bertea, M | 1 |
| Rütti, MF | 1 |
| Othman, A | 1 |
| Marti-Jaun, J | 1 |
| Hersberger, M | 1 |
| von Eckardstein, A | 1 |
| Hornemann, T | 1 |
| Langlais, P | 1 |
| Yi, Z | 1 |
| Finlayson, J | 1 |
| Luo, M | 1 |
| Mapes, R | 1 |
| De Filippis, E | 1 |
| Meyer, C | 1 |
| Plummer, E | 1 |
| Tongchinsub, P | 1 |
| Mattern, M | 1 |
| Mandarino, LJ | 1 |
| Fatehi, M | 1 |
| Raja, M | 1 |
| Carter, C | 1 |
| Soliman, D | 1 |
| Holt, A | 1 |
| Light, PE | 1 |
| Zheng, YY | 1 |
| Ma, YT | 1 |
| Yang, YN | 1 |
| Fu, ZY | 1 |
| Li, XM | 1 |
| Liu, F | 1 |
| Yang, SJ | 1 |
| Ma, X | 1 |
| Chen, BD | 1 |
| Vind, BF | 1 |
| Birk, JB | 1 |
| Vienberg, SG | 1 |
| Andersen, B | 1 |
| Beck-Nielsen, H | 1 |
| Wojtaszewski, JF | 1 |
| Højlund, K | 1 |
| Hsieh, MJ | 1 |
| Lan, KP | 1 |
| Liu, HY | 1 |
| Zhang, XZ | 1 |
| Lin, YF | 1 |
| Chen, TY | 1 |
| Chiou, HL | 1 |
| Tokuda, H | 1 |
| Kato, K | 1 |
| Kasahara, S | 1 |
| Matsushima-Nishiwaki, R | 1 |
| Mizuno, T | 1 |
| Sakakibara, S | 1 |
| Kozawa, O | 1 |
| Xie, W | 1 |
| Wood, AR | 1 |
| Lyssenko, V | 1 |
| Weedon, MN | 1 |
| Knowles, JW | 1 |
| Alkayyali, S | 1 |
| Assimes, TL | 1 |
| Quertermous, T | 1 |
| Abbasi, F | 1 |
| Paananen, J | 1 |
| Häring, H | 1 |
| Hansen, T | 3 |
| Pedersen, O | 4 |
| Smith, U | 1 |
| Laakso, M | 3 |
| Dekker, JM | 1 |
| Nolan, JJ | 1 |
| Groop, L | 3 |
| Ferrannini, E | 1 |
| Adam, KP | 1 |
| Gall, WE | 1 |
| Frayling, TM | 1 |
| Walker, M | 1 |
| Muller, YL | 1 |
| Bogardus, C | 1 |
| Baier, L | 1 |
| Cho, YM | 1 |
| Kim, M | 1 |
| Park, KS | 1 |
| Kim, SY | 1 |
| Lee, HK | 1 |
| Bouzakri, K | 1 |
| Roques, M | 1 |
| Gual, P | 1 |
| Espinosa, S | 1 |
| Guebre-Egziabher, F | 1 |
| Riou, JP | 1 |
| Laville, M | 1 |
| Le Marchand-Brustel, Y | 1 |
| Tanti, JF | 1 |
| Vidal, H | 1 |
| Schmitz-Peiffer, C | 1 |
| Whitehead, JP | 1 |
| Fehmann, HC | 1 |
| Gross, U | 1 |
| Epe, M | 1 |
| Hartman, ME | 1 |
| O'Connor, JC | 1 |
| Godbout, JP | 1 |
| Minor, KD | 1 |
| Mazzocco, VR | 1 |
| Freund, GG | 1 |
| Kunej, T | 1 |
| Globocnik Petrovic, M | 1 |
| Dovc, P | 1 |
| Peterlin, B | 1 |
| Petrovic, D | 1 |
| Sanke, T | 1 |
| Sakagashira, S | 1 |
| Danielsson, A | 1 |
| Ost, A | 1 |
| Nystrom, FH | 1 |
| Strålfors, P | 1 |
| Yao, K | 1 |
| Xu, B | 1 |
| Gao, L | 1 |
| Ge, JB | 1 |
| Morino, K | 1 |
| Petersen, KF | 1 |
| Dufour, S | 1 |
| Befroy, D | 1 |
| Frattini, J | 1 |
| Shatzkes, N | 1 |
| Neschen, S | 1 |
| White, MF | 1 |
| Bilz, S | 1 |
| Sono, S | 1 |
| Pypaert, M | 1 |
| Shulman, GI | 1 |
| Tzatsos, A | 1 |
| Kandror, KV | 1 |
| Barroso, I | 1 |
| Sandhu, MS | 1 |
| Franks, PW | 1 |
| Crowley, V | 1 |
| Schafer, AJ | 1 |
| O'Rahilly, S | 1 |
| Radha, V | 1 |
| Mohan, V | 1 |
| Vidya, R | 1 |
| Ashok, AK | 1 |
| Deepa, R | 1 |
| Mathias, RA | 1 |
| Hu, Y | 1 |
| Liu, W | 1 |
| Huang, R | 1 |
| Zhang, X | 1 |
| Andrulionyte, L | 1 |
| Peltola, P | 1 |
| Chiasson, JL | 1 |
| Gao, JX | 1 |
| Xu, DL | 1 |
| Shao, YH | 1 |
| Lao, WY | 1 |
| Lin, S | 1 |
| Zhang, B | 1 |
| Sataranatarajan, K | 1 |
| Lee, MJ | 1 |
| Mariappan, MM | 1 |
| Feliers, D | 1 |
| Fujisawa, T | 1 |
| Ikegami, H | 1 |
| Yamato, E | 1 |
| Takekawa, K | 1 |
| Nakagawa, Y | 1 |
| Hamada, Y | 1 |
| Ueda, H | 1 |
| Fukuda, M | 1 |
| Ogihara, T | 1 |
| Kellerer, M | 1 |
| Coghlan, M | 1 |
| Capp, E | 1 |
| Mühlhöfer, A | 1 |
| Kroder, G | 1 |
| Mosthaf, L | 1 |
| Galante, P | 1 |
| Siddle, K | 1 |
| Häring, HU | 1 |
| Orho, M | 2 |
| Nikula-Ijäs, P | 1 |
| Schalin-Jäntti, C | 1 |
| Permutt, MA | 1 |
| Groop, LC | 1 |
| Hua, QX | 1 |
| Shoelson, SE | 1 |
| Inouye, K | 1 |
| Weiss, MA | 1 |
| Hansen, LH | 1 |
| Abrahamsen, N | 1 |
| Hager, J | 1 |
| Jelinek, L | 1 |
| Kindsvogel, W | 1 |
| Froguel, P | 2 |
| Nishimura, E | 1 |
| Huang, X | 1 |
| Lehto, M | 1 |
| Hart, LM | 1 |
| Stolk, RP | 1 |
| Jansen, JJ | 1 |
| Grobbee, DE | 1 |
| Lemkes, HH | 1 |
| Maassen, JA | 1 |
| Odawara, M | 2 |
| Matsunuma, A | 1 |
| Yamashita, K | 2 |
| Tachi, Y | 1 |
| Arai, K | 1 |
| Kajimoto, Y | 1 |
| Yamasaki, Y | 1 |
| Urhammer, SA | 1 |
| Møller, AM | 1 |
| Nyholm, B | 1 |
| Ekstrøm, CT | 1 |
| Eiberg, H | 1 |
| Clausen, JO | 1 |
| Schmitz, O | 1 |
| Boutin, P | 1 |
| Gresh, L | 1 |
| Cisse, A | 1 |
| Hara, M | 1 |
| Bell, G | 1 |
| Babu, S | 1 |
| Eisenbarth, G | 1 |
| Liu, L | 1 |
| Xiang, K | 1 |
| Mammarella, S | 1 |
| Creati, B | 1 |
| Esposito, DL | 1 |
| Arcuri, P | 1 |
| Della Loggia, F | 1 |
| Capani, F | 1 |
| Mariani-Costantini, R | 1 |
| Caramia, FG | 1 |
| Battista, P | 1 |
| Cama, A | 1 |
| Ambrosch, A | 1 |
| Lobmann, R | 1 |
| Dierkes, J | 1 |
| König, W | 1 |
| Luley, C | 1 |
| Lehnert, H | 1 |
| Pulkkinen, A | 1 |
| Viitanen, L | 1 |
| Kareinen, A | 1 |
| Lehto, S | 1 |
| Hayakawa, T | 1 |
| Nagai, Y | 1 |
| Ando, H | 1 |
| Yamashita, H | 1 |
| Takamura, T | 1 |
| Abe, T | 1 |
| Nomura, G | 1 |
| Kobayashi, KI | 1 |
| Klannemark, M | 1 |
| Suurinkeroinen, L | 1 |
| Orho-Melander, M | 1 |
| Taskinen, MR | 1 |
| Frame, S | 1 |
| Cohen, P | 1 |
| Biondi, RM | 1 |
| Echwald, SM | 1 |
| Bach, H | 1 |
| Vestergaard, H | 1 |
| Richelsen, B | 1 |
| Kristensen, K | 1 |
| Drivsholm, T | 1 |
| Borch-Johnsen, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in Pulmonary Arterial Hypertension[NCT03979482] | 30 participants (Actual) | Observational | 2019-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for serine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Role of Impaired Glycolysis in Perturbations of Amino Acid Metabolism in Diabetes Mellitus.
Topics: Amino Acids; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Glycine; Glycolysis; Humans; Py | 2023 |
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Ligands; Phosphorylation; PPAR gamma; Protein | 2021 |
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea | 2018 |
L-serine: a neglected amino acid with a potential therapeutic role in diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supple | 2019 |
IRS-1 regulation in health and disease.
Topics: Animals; Cysteine Endopeptidases; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Ins | 2003 |
[S20G mutation of amylin gene--amyloid diabetes due to S20G amylin gene mutation].
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Diabetes Mellitus, Type 2; Genetic P | 2005 |
[HNF-1alpha G319S mutation in Oji-Cree type 2 diabetes].
Topics: Amino Acid Substitution; Canada; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Genetic Predisposi | 2005 |
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
Topics: Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Glycine; Heat-Shock Proteins; Hu | 2006 |
A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases.
Topics: Amino Acid Substitution; Asparagine; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hum | 2006 |
1 trial available for serine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Rarity of the Asn291Ser mutation of lipoprotein lipase gene in Japanese NIDDM patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asparagine; Diabetes Mellitus, Type 2; Female; Gene Freq | 1997 |
77 other studies available for serine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Identification of Diabetic Nephropathy in Patients Undergoing Kidney Biopsy through Blood and Urinary Profiles of d-Serine.
Topics: Biopsy; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Kidney; Serine | 2021 |
A New Case of Hb Headington (
Topics: Aged; Arginine; beta-Globins; Diabetes Mellitus, Type 2; DNA; Female; Glycated Hemoglobin; Hemoglobi | 2022 |
Oral glucagon-like peptide 1 analogue ameliorates glucose intolerance in db/db mice.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon-Like Pe | 2022 |
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation.
Topics: Animals; Atherosclerosis; Azo Compounds; C-Reactive Protein; Cholesterol, LDL; Diabetes Mellitus, Ex | 2022 |
Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy.
Topics: Animals; Ceramides; Cytosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic R | 2022 |
Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy.
Topics: Animals; Apoptosis; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Glucose; Glutathione; Malo | 2022 |
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Homeostasis; Insulin; Insulin Resistance; Male; Mice | 2022 |
Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model.
Topics: Animals; Antioxidants; CCAAT-Enhancer-Binding Protein-alpha; Diabetes Mellitus, Type 2; Lipid Metabo | 2023 |
Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice.
Topics: Animals; Bile Acids and Salts; Ceramides; Diabetes Mellitus, Type 2; Glucose; Homeostasis; Liver; Mi | 2023 |
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron.
Topics: Bacteroides thetaiotaomicron; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Humans; Serine | 2023 |
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dia | 2019 |
Associations of TMPRSS6 Polymorphisms with Gestational Diabetes Mellitus in Chinese Han Pregnant Women: a Preliminary Cohort Study.
Topics: China; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Membrane Pr | 2021 |
Systemic lipid dysregulation is a risk factor for macular neurodegenerative disease.
Topics: Aged; Carbamoyl-Phosphate Synthase (Ammonia); Case-Control Studies; Diabetes Mellitus, Type 2; Femal | 2020 |
A cross-platform approach identifies genetic regulators of human metabolism and health.
Topics: Diabetes Mellitus, Type 2; Eye Diseases; Gene Frequency; Genetic Loci; Genetic Pleiotropy; Genome, H | 2021 |
Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Obesity; Serine; Tandem Mass Spectrometry | 2021 |
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression.
Topics: Biosynthetic Pathways; Diabetes Mellitus, Type 2; Disease Progression; Endophenotypes; Genetic Loci; | 2021 |
Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hippocam | 2018 |
Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Line; Diabetes Mellitus, Experimental; Diabe | 2018 |
Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR.
Topics: 3T3-L1 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; D | 2013 |
Monocytes, but not T cells, respond to insulin with Akt(S473) phosphorylation independent of the donor glucometabolic state.
Topics: Aged; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Female; Glu | 2014 |
Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy.
Topics: Aged; Aqueous Humor; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, | 2014 |
Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diabetes Mellitus, Type 2; Diet, Western; Fenofibrat | 2014 |
L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation.
Topics: 3T3-L1 Cells; Adipose Tissue, White; Animals; Binding, Competitive; Blotting, Western; Cyclin-Depend | 2015 |
Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers.
Topics: Adult; Aged; Amino Acid Substitution; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Foot | 2015 |
Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes.
Topics: Diabetes Mellitus, Type 2; HEK293 Cells; Humans; Hypoglycemic Agents; Insulin Receptor Substrate Pro | 2016 |
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Topics: Acute Disease; Adult; Aged; Animals; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinases; | 2017 |
PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Topics: Adiponectin; Aged; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glycine; Heat-Shock Proteins; | 2008 |
The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Asian People; Blood Pressure; Case-Control Studies; | 2008 |
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemistry, Pharmaceutical; Crystallography, X-Ray; Cytochrom | 2009 |
Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.
Topics: Aged; Amino Acid Substitution; Asian People; Cysteine; Diabetes Mellitus, Type 2; DNA Glycosylases; | 2009 |
Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese population.
Topics: Adult; Aged; Amino Acid Substitution; Case-Control Studies; China; Diabetes Mellitus, Type 2; Diabet | 2009 |
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabet | 2009 |
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
Topics: Age Factors; Animals; Blood Glucose; Brain; Cerebral Cortex; Diabetes Mellitus, Type 1; Diabetes Mel | 2009 |
Insulin signaling regulates mitochondrial function in pancreatic beta-cells.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diabetes Mellitus, Type 2; Glucokinase; Huma | 2009 |
Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Exercise Therapy; Glu | 2010 |
Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.
Topics: Acetylation; Animals; Base Sequence; Chemokine CCL2; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 2010 |
Deoxysphingoid bases as plasma markers in diabetes mellitus.
Topics: Aged; Alanine; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Diabeti | 2010 |
Global IRS-1 phosphorylation analysis in insulin resistance.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2011 |
The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; Amino Acid Substitution; ATP-Binding Cas | 2012 |
S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes.
Topics: Adult; Aged; Alleles; Asian People; Cardiovascular Diseases; Case-Control Studies; China; Diabetes M | 2011 |
Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Female; Glucose; Glucose Clamp Technique; Glycogen Synthase; Humans; Hype | 2012 |
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes.
Topics: Cell Line; Diabetes Mellitus, Type 2; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycogen Syntha | 2012 |
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; CD40 Ligand; Diabetes Mellitus, | 2012 |
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Topics: Adult; Betaine; Diabetes Mellitus, Type 2; Female; Glycine; Humans; Insulin Resistance; Male; Middle | 2013 |
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.
Topics: Adipocytes; Adipose Tissue; Adult; Alleles; Blood Glucose; Body Composition; Body Mass Index; Cell S | 2003 |
S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients.
Topics: Age of Onset; Amino Acid Substitution; Amyloid; Asian People; Body Mass Index; Diabetes Mellitus, Ty | 2003 |
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
Topics: Biopsy; Cells, Cultured; Diabetes Mellitus, Type 2; Gene Expression Regulation, Enzymologic; Hexokin | 2003 |
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear | 2004 |
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.
Topics: Amino Acid Motifs; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Type 2; | 2004 |
A Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with type 2 diabetes in Caucasians.
Topics: Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to D | 2004 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, | 2005 |
Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation.
Topics: Blood Platelets; Diabetes Mellitus, Type 2; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Red | 2005 |
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Topics: Biopsy; Blood Glucose; Blotting, Western; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; D | 2005 |
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Glucose; | 2006 |
Association of lipoprotein lipase Hind III and Ser 447 Ter polymorphisms with dyslipidemia in Asian Indians.
Topics: Asian People; Cholesterol, HDL; Deoxyribonuclease HindIII; Diabetes Mellitus, Type 2; Dyslipidemias; | 2006 |
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Disease Progression; Female; Glucose Intolerance | 2006 |
[Association of Gly82Ser polymorphism of receptor for advanced glycation end products gene in a type 2 diabetic Chinese population].
Topics: Aged; Amino Acid Substitution; Asian People; China; Diabetes Mellitus, Type 2; Female; Gene Frequenc | 2007 |
PKCdelta regulates the stimulation of vascular endothelial factor mRNA translation by angiotensin II through hnRNP K.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Cell Line; Diabetes Mellitus, Type 2; Diabetic Nep | 2008 |
A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.
Topics: Adolescent; Adult; Age of Onset; Aged; Diabetes Mellitus, Type 2; France; Genetic Linkage; Glycine; | 1995 |
Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.
Topics: Aged; Aged, 80 and over; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Middle Aged | 1995 |
Isolation and characterization of the human muscle glycogen synthase gene.
Topics: Adult; Amino Acid Sequence; Animals; Base Sequence; Deoxyribonucleases, Type II Site-Specific; Diabe | 1995 |
Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Topics: Amino Acid Sequence; Diabetes Mellitus, Type 2; Humans; Insulin; Magnetic Resonance Spectroscopy; Mo | 1993 |
The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Exons; G | 1996 |
Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Finland; France | 1995 |
Absence of the Gly40-Ser mutation in the glucagon receptor among diabetic patients in the Netherlands.
Topics: Aged; Cohort Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Frequency; Glycine; | 1995 |
Gly40Ser substitution in the glucagon receptor is rarely involved in the pathogenesis of NIDDM in Japanese patients.
Topics: Base Sequence; Codon; Diabetes Mellitus, Type 2; DNA Primers; Female; Glycine; Humans; Japan; Male; | 1996 |
Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance.
Topics: Adult; Aged; Asian People; Codon; Diabetes Mellitus, Type 2; Exons; Female; Glucose Intolerance; Gly | 1996 |
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
Topics: Adult; Amino Acid Substitution; Asparagine; C-Peptide; Diabetes Mellitus, Type 2; DNA-Binding Protei | 1998 |
Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children.
Topics: Adult; Amino Acid Substitution; Black People; Child; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1999 |
RAGE Gly82Ser polymorphism in diabetic microangiopathy.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Gene Frequency; Genotype; | 1999 |
Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus. Mutations in brief no. 130. Online.
Topics: Alleles; Amino Acid Substitution; Diabetes Mellitus, Type 2; Humans; Insulin Receptor Substrate Prot | 1998 |
Analysis of the Gly40Ser polymorphism in the glucagon receptor gene in a German non-insulin-dependent diabetes mellitus population.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Europe; Gene Frequency; Germany; Glycine; Humans; Japan; Mid | 1999 |
Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes.
Topics: Amino Acid Substitution; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; | 2000 |
S20G mutation of the amylin gene in Japanese patients with type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyloid; Asian People; Blood Glucose; Diabe | 2000 |
Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.
Topics: Aged; Amino Acid Substitution; Apolipoproteins; Asparagine; Blood Pressure; Cholesterol; Cholesterol | 2000 |
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
Topics: Amino Acid Sequence; Arginine; Axin Protein; beta Catenin; Binding Sites; Calcium-Calmodulin-Depende | 2001 |
A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.
Topics: Amino Acid Substitution; Animals; Diabetes Mellitus, Type 2; Female; Genetic Variation; Genotype; Hu | 2002 |