serine has been researched along with Diabetes Mellitus, Type 1 in 17 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this clinical study is to examine the association between D-serine and diabetic retinopathy (DR)." | 7.80 | Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy. ( Du, J; He, T; Jiang, H; Qu, J; Song, Z; Wu, S, 2014) |
| "The objective of this clinical study is to examine the association between D-serine and diabetic retinopathy (DR)." | 3.80 | Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy. ( Du, J; He, T; Jiang, H; Qu, J; Song, Z; Wu, S, 2014) |
| "Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell loss in T1D." | 1.91 | Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation. ( Arroba, EN; Bertrand, MJ; Cardozo, AK; Franchimont, M; Gilglioni, EH; Gurzov, EN; Takiishi, T; Xiao, P, 2023) |
| "703 patients with type 1 diabetes mellitus from one endocrine department were included in the study." | 1.51 | Protective Effect of the ( Catrina, SB; Chatzidionysiou, K; Ekberg, NR; Eliasson, S; Falhammar, H; Gu, HF; Li, YW; Zheng, X, 2019) |
| "In this study, experimental autoimmune diabetes (EAD) mice, which subcutaneous immunization of ins1 or 2B:9-23 induced autoimmune diabetes in F1(B7." | 1.35 | One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide. ( Arai, T; Hara, K; Kameno, M; Kishi, M; Kurohara, M; Moriyama, H; Nagata, M; Okumachi, Y; Yamada, K; Yasuda, H; Yokono, K, 2008) |
| "We hypothesize that type 1 and type 2 diabetes may contribute to AD through different mechanisms; in type 2 diabetes, hyperglycemia-mediated tau cleavage may be the key feature, whereas insulin deficiency may be the major contributing factor in type 1 diabetes." | 1.35 | Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. ( Backus, C; Feldman, EL; Hayes, JM; Kim, B; Oh, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Takiishi, T | 1 |
| Xiao, P | 1 |
| Franchimont, M | 1 |
| Gilglioni, EH | 1 |
| Arroba, EN | 1 |
| Gurzov, EN | 1 |
| Bertrand, MJ | 1 |
| Cardozo, AK | 1 |
| Holm, LJ | 2 |
| Haupt-Jorgensen, M | 1 |
| Larsen, J | 1 |
| Giacobini, JD | 1 |
| Bilgin, M | 1 |
| Buschard, K | 2 |
| Ekberg, NR | 1 |
| Eliasson, S | 1 |
| Li, YW | 1 |
| Zheng, X | 1 |
| Chatzidionysiou, K | 1 |
| Falhammar, H | 1 |
| Gu, HF | 1 |
| Catrina, SB | 1 |
| Jiang, H | 1 |
| Du, J | 1 |
| He, T | 1 |
| Qu, J | 1 |
| Song, Z | 1 |
| Wu, S | 1 |
| Okumachi, Y | 1 |
| Moriyama, H | 1 |
| Kameno, M | 1 |
| Arai, T | 1 |
| Kishi, M | 1 |
| Kurohara, M | 1 |
| Yamada, K | 1 |
| Yasuda, H | 1 |
| Hara, K | 1 |
| Yokono, K | 1 |
| Nagata, M | 1 |
| Kim, B | 1 |
| Backus, C | 1 |
| Oh, S | 1 |
| Hayes, JM | 1 |
| Feldman, EL | 1 |
| Bissé, E | 1 |
| Hovasse, A | 1 |
| Preisler-Adams, S | 1 |
| Epting, T | 1 |
| Wagner, O | 1 |
| Kögel, G | 1 |
| Van Dorsselaer, A | 1 |
| Schaeffer-Reiss, C | 1 |
| Suzuki, M | 1 |
| Sasabe, J | 1 |
| Furuya, S | 1 |
| Mita, M | 1 |
| Hamase, K | 1 |
| Aiso, S | 1 |
| Mauvais-Jarvis, F | 1 |
| Boudou, P | 1 |
| Sobngwi, E | 1 |
| Riveline, JP | 1 |
| Kevorkian, JP | 1 |
| Villette, JM | 1 |
| Porcher, R | 1 |
| Vexiau, P | 1 |
| Gautier, JF | 1 |
| Prevost, G | 1 |
| Fajardy, I | 1 |
| Besmond, C | 1 |
| Balkau, B | 1 |
| Tichet, J | 1 |
| Fontaine, P | 1 |
| Danze, PM | 1 |
| Marre, M | 1 |
| Hart, LM | 1 |
| Stolk, RP | 1 |
| Jansen, JJ | 1 |
| Grobbee, DE | 1 |
| Lemkes, HH | 1 |
| Maassen, JA | 1 |
| Boutin, P | 1 |
| Gresh, L | 1 |
| Cisse, A | 1 |
| Hara, M | 1 |
| Bell, G | 1 |
| Babu, S | 1 |
| Eisenbarth, G | 1 |
| Froguel, P | 1 |
| Fountain, WC | 1 |
| Requena, JR | 1 |
| Jenkins, AJ | 1 |
| Lyons, TJ | 1 |
| Smyth, B | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Miyazaki, T | 1 |
| Uno, M | 1 |
| Uehira, M | 1 |
| Kikutani, H | 1 |
| Kishimoto, T | 1 |
| Kimoto, M | 1 |
| Nishimoto, H | 1 |
| Miyazaki, J | 1 |
| Yamamura, K | 1 |
| Sasaki, M | 1 |
| Sato, K | 1 |
| Maruhama, Y | 1 |
| Nordöy, A | 1 |
| Rödset, JM | 1 |
1 review available for serine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
L-serine: a neglected amino acid with a potential therapeutic role in diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supple | 2019 |
16 other studies available for serine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation.
Topics: Animals; Diabetes Mellitus, Type 1; Humans; Inflammation; Mice; Obesity; Protein Kinases; Receptor-I | 2023 |
L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Dietary Supplements; Female; Glucose Tolerance Te | 2018 |
Protective Effect of the
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Di | 2019 |
Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy.
Topics: Aged; Aqueous Humor; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, | 2014 |
One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.
Topics: Amino Acid Sequence; Animals; CD4 Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2008 |
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
Topics: Age Factors; Animals; Blood Glucose; Brain; Cerebral Cortex; Diabetes Mellitus, Type 1; Diabetes Mel | 2009 |
Hb Riesa or β93 (F9) Cys→Ser, a new electrophoretically silent haemoglobin variant interfering with haemoglobin A1c measurement.
Topics: Amino Acid Sequence; Amino Acid Substitution; beta-Globins; Chromatography, High Pressure Liquid; Cy | 2011 |
Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hippocampus; M | 2012 |
The polymorphism Gly574Ser in the transcription factor HNF-1alpha is not a marker of adult-onset ketosis-prone atypical diabetes in Afro-Caribbean patients.
Topics: Adult; Africa; Amino Acid Substitution; Black People; Caribbean Region; Diabetes Mellitus, Type 1; D | 2003 |
Polymorphisms of the receptor of advanced glycation endproducts (RAGE) and the development of nephropathy in type 1 diabetic patients.
Topics: Amino Acid Substitution; Arginine; Cross-Sectional Studies; Cysteine; Diabetes Mellitus, Type 1; Dia | 2005 |
Absence of the Gly40-Ser mutation in the glucagon receptor among diabetic patients in the Netherlands.
Topics: Aged; Cohort Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Frequency; Glycine; | 1995 |
Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children.
Topics: Adult; Amino Acid Substitution; Black People; Child; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1999 |
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry | 1999 |
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Topics: Animals; Aspartic Acid; Base Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; F | 1990 |
Rapid changes in urinary serine and branched-chain amino acid excretion among diabetic patients during insulin treatment.
Topics: Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus, Type 1; Energy Intake; F | 1988 |
Platelet phospholipids and their function in patients with juvenile diabetes and maturity onset diabetes.
Topics: Adult; Aged; Amino Alcohols; Blood Platelets; Blood Proteins; Cholesterol; Choline; Chromatography, | 1970 |