serine has been researched along with Depressive Disorder, Major in 9 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 7.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
| " We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 3.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
| " Recent evidence has suggested that acute and chronic administration of antidepressants led to inhibition of GSK-3β via phosphorylation of Serine9 residue." | 1.39 | Effects of acute and chronic electroconvulsive shocks on glycogen synthase kinase 3β level and phosphorylation in mice. ( Basar, K; Eren-Kocak, E; Ertugrul, A; Ozdemir, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Murtas, G | 1 |
| Pollegioni, L | 1 |
| Ishiwata, S | 1 |
| Hattori, K | 1 |
| Sasayama, D | 1 |
| Teraishi, T | 1 |
| Miyakawa, T | 1 |
| Yokota, Y | 1 |
| Matsumura, R | 1 |
| Nishikawa, T | 1 |
| Kunugi, H | 1 |
| Zhang, Z | 1 |
| Zhang, P | 1 |
| Qi, GJ | 1 |
| Jiao, FJ | 1 |
| Wang, QZ | 1 |
| Yan, JG | 1 |
| He, F | 1 |
| Zhang, Q | 1 |
| Lv, ZX | 1 |
| Peng, X | 1 |
| Cai, HW | 1 |
| Chen, X | 1 |
| Sun, N | 1 |
| Tian, B | 1 |
| Basar, K | 1 |
| Eren-Kocak, E | 1 |
| Ozdemir, H | 1 |
| Ertugrul, A | 1 |
| Madeira, C | 1 |
| Lourenco, MV | 1 |
| Vargas-Lopes, C | 1 |
| Suemoto, CK | 1 |
| Brandão, CO | 1 |
| Reis, T | 1 |
| Leite, RE | 1 |
| Laks, J | 1 |
| Jacob-Filho, W | 1 |
| Pasqualucci, CA | 1 |
| Grinberg, LT | 1 |
| Ferreira, ST | 1 |
| Panizzutti, R | 1 |
| Sumiyoshi, T | 1 |
| Anil, AE | 1 |
| Jin, D | 1 |
| Jayathilake, K | 1 |
| Lee, M | 1 |
| Meltzer, HY | 1 |
| van Rossum, EF | 1 |
| Binder, EB | 1 |
| Majer, M | 1 |
| Koper, JW | 1 |
| Ising, M | 1 |
| Modell, S | 1 |
| Salyakina, D | 1 |
| Lamberts, SW | 1 |
| Holsboer, F | 1 |
| Hashimoto, K | 1 |
| Sawa, A | 1 |
| Iyo, M | 1 |
| Maes, M | 1 |
| Verkerk, R | 1 |
| Vandoolaeghe, E | 1 |
| Lin, A | 1 |
| Scharpé, S | 1 |
2 trials available for serine and Depressive Disorder, Major
| Article | Year |
|---|---|
Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Female; Glycine; Humans; Ma | 2004 |
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine; Asparagine; | 1998 |
7 other studies available for serine and Depressive Disorder, Major
| Article | Year |
|---|---|
D-amino Acids as Novel Blood-based Biomarkers.
Topics: Amino Acids; Biomarkers; D-Aspartic Acid; Depressive Disorder, Major; Humans; Receptors, N-Methyl-D- | 2022 |
Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity.
Topics: Adult; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans; | 2018 |
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
Topics: Active Transport, Cell Nucleus; Amygdala; Animals; Behavior, Animal; Cyclin-Dependent Kinase 5; Depr | 2018 |
Effects of acute and chronic electroconvulsive shocks on glycogen synthase kinase 3β level and phosphorylation in mice.
Topics: Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroshock; Frontal Lobe; Glycogen | 2013 |
d-serine levels in Alzheimer's disease: implications for novel biomarker development.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2015 |
Polymorphisms of the glucocorticoid receptor gene and major depression.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Asparagine; Case-Control Studies; Corticotropin- | 2006 |
Increased levels of glutamate in brains from patients with mood disorders.
Topics: Adult; Aged; Amino Acids; Animals; Autopsy; Brain Chemistry; Depressive Disorder, Major; Female; Glu | 2007 |