Page last updated: 2024-11-08

serine and Depressive Disorder, Major

serine has been researched along with Depressive Disorder, Major in 9 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity."7.88Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018)
" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity."3.88Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018)
" Recent evidence has suggested that acute and chronic administration of antidepressants led to inhibition of GSK-3β via phosphorylation of Serine9 residue."1.39Effects of acute and chronic electroconvulsive shocks on glycogen synthase kinase 3β level and phosphorylation in mice. ( Basar, K; Eren-Kocak, E; Ertugrul, A; Ozdemir, H, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Murtas, G1
Pollegioni, L1
Ishiwata, S1
Hattori, K1
Sasayama, D1
Teraishi, T1
Miyakawa, T1
Yokota, Y1
Matsumura, R1
Nishikawa, T1
Kunugi, H1
Zhang, Z1
Zhang, P1
Qi, GJ1
Jiao, FJ1
Wang, QZ1
Yan, JG1
He, F1
Zhang, Q1
Lv, ZX1
Peng, X1
Cai, HW1
Chen, X1
Sun, N1
Tian, B1
Basar, K1
Eren-Kocak, E1
Ozdemir, H1
Ertugrul, A1
Madeira, C1
Lourenco, MV1
Vargas-Lopes, C1
Suemoto, CK1
Brandão, CO1
Reis, T1
Leite, RE1
Laks, J1
Jacob-Filho, W1
Pasqualucci, CA1
Grinberg, LT1
Ferreira, ST1
Panizzutti, R1
Sumiyoshi, T1
Anil, AE1
Jin, D1
Jayathilake, K1
Lee, M1
Meltzer, HY1
van Rossum, EF1
Binder, EB1
Majer, M1
Koper, JW1
Ising, M1
Modell, S1
Salyakina, D1
Lamberts, SW1
Holsboer, F1
Hashimoto, K1
Sawa, A1
Iyo, M1
Maes, M1
Verkerk, R1
Vandoolaeghe, E1
Lin, A1
Scharpé, S1

Trials

2 trials available for serine and Depressive Disorder, Major

ArticleYear
Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms.
    The international journal of neuropsychopharmacology, 2004, Volume: 7, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Female; Glycine; Humans; Ma

2004
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.
    Acta psychiatrica Scandinavica, 1998, Volume: 97, Issue:4

    Topics: Adult; Aged; Alanine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine; Asparagine;

1998

Other Studies

7 other studies available for serine and Depressive Disorder, Major

ArticleYear
D-amino Acids as Novel Blood-based Biomarkers.
    Current medicinal chemistry, 2022, Volume: 29, Issue:24

    Topics: Amino Acids; Biomarkers; D-Aspartic Acid; Depressive Disorder, Major; Humans; Receptors, N-Methyl-D-

2022
Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity.
    Journal of affective disorders, 2018, 01-15, Volume: 226

    Topics: Adult; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans;

2018
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Active Transport, Cell Nucleus; Amygdala; Animals; Behavior, Animal; Cyclin-Dependent Kinase 5; Depr

2018
Effects of acute and chronic electroconvulsive shocks on glycogen synthase kinase 3β level and phosphorylation in mice.
    The journal of ECT, 2013, Volume: 29, Issue:4

    Topics: Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroshock; Frontal Lobe; Glycogen

2013
d-serine levels in Alzheimer's disease: implications for novel biomarker development.
    Translational psychiatry, 2015, May-05, Volume: 5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A

2015
Polymorphisms of the glucocorticoid receptor gene and major depression.
    Biological psychiatry, 2006, Apr-15, Volume: 59, Issue:8

    Topics: Adult; Analysis of Variance; Antidepressive Agents; Asparagine; Case-Control Studies; Corticotropin-

2006
Increased levels of glutamate in brains from patients with mood disorders.
    Biological psychiatry, 2007, Dec-01, Volume: 62, Issue:11

    Topics: Adult; Aged; Amino Acids; Animals; Autopsy; Brain Chemistry; Depressive Disorder, Major; Female; Glu

2007