serine has been researched along with Demyelinating Diseases in 5 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After establishing FDL, l-serine treatment: 1) improved spatial learning, memory and cognitive ability in mice, and relieved anxiety for 4 weeks post-FDL induction; 2) reduced abnormally dephosphorylated neurofilament proteins, increased myelin basic protein, and preserved anatomic myelinated axons; 3) inhibited microglia activation and reduced the release of inflammatory factors; 4) promoted recruitment and proliferation of oligodendrocyte progenitor cells, and the efficiency of subsequent remyelination on day twenty-eight post-FDL induction." | 7.91 | Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. ( Ding, L; Gan, D; Gao, C; Jiang, Z; Luo, Q; Sun, Y; Wang, G; Xu, L; Zhang, N, 2019) |
| " After establishing FDL, l-serine treatment: 1) improved spatial learning, memory and cognitive ability in mice, and relieved anxiety for 4 weeks post-FDL induction; 2) reduced abnormally dephosphorylated neurofilament proteins, increased myelin basic protein, and preserved anatomic myelinated axons; 3) inhibited microglia activation and reduced the release of inflammatory factors; 4) promoted recruitment and proliferation of oligodendrocyte progenitor cells, and the efficiency of subsequent remyelination on day twenty-eight post-FDL induction." | 3.91 | Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. ( Ding, L; Gan, D; Gao, C; Jiang, Z; Luo, Q; Sun, Y; Wang, G; Xu, L; Zhang, N, 2019) |
| "Using this preclinical murine demyelination model, we discover that application of metformin, an FDA-approved drug, in this model promotes oligodendrocyte regeneration and remyelination and improves the social interaction." | 1.56 | Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation. ( De Repentigny, Y; Gouveia, A; He, L; Ilin, J; Kosaraju, J; Kothary, R; Lagace, D; Lu, KJ; Sarma, SN; Seegobin, M; Syal, C; Wang, J; Wondisford, FE, 2020) |
| "They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures." | 1.31 | Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency. ( de Koning, TJ; Jaeken, J; Pineda, M; Poll-The, BT; van der Knaap, MS; Van Maldergem, L, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kosaraju, J | 1 |
| Seegobin, M | 1 |
| Gouveia, A | 1 |
| Syal, C | 1 |
| Sarma, SN | 1 |
| Lu, KJ | 1 |
| Ilin, J | 1 |
| He, L | 1 |
| Wondisford, FE | 1 |
| Lagace, D | 1 |
| De Repentigny, Y | 1 |
| Kothary, R | 1 |
| Wang, J | 1 |
| Wang, G | 1 |
| Ding, L | 1 |
| Gao, C | 1 |
| Zhang, N | 1 |
| Gan, D | 1 |
| Sun, Y | 1 |
| Xu, L | 1 |
| Luo, Q | 1 |
| Jiang, Z | 1 |
| Bhagavati, S | 1 |
| Maccabee, PJ | 1 |
| Xu, W | 1 |
| Vallat, JM | 1 |
| Magy, L | 1 |
| Lagrange, E | 1 |
| Sturtz, F | 1 |
| Magdelaine, C | 1 |
| Grid, D | 1 |
| Tazir, M | 1 |
| de Koning, TJ | 1 |
| Jaeken, J | 1 |
| Pineda, M | 1 |
| Van Maldergem, L | 1 |
| Poll-The, BT | 1 |
| van der Knaap, MS | 1 |
5 other studies available for serine and Demyelinating Diseases
| Article | Year |
|---|---|
Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation.
Topics: Animals; Demyelinating Diseases; Female; Histone Acetyltransferases; Hypoglycemic Agents; Male; Metf | 2020 |
Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice.
Topics: Animals; Anxiety; Axons; Calcium-Binding Proteins; Corpus Callosum; Demyelinating Diseases; Explorat | 2019 |
The neurofilament light chain gene (NEFL) mutation Pro22Ser can be associated with mixed axonal and demyelinating neuropathy.
Topics: Adolescent; Amino Acid Sequence; Amino Acid Substitution; Axons; Charcot-Marie-Tooth Disease; Demyel | 2009 |
Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance.
Topics: Adult; Asparagine; Charcot-Marie-Tooth Disease; Child; Consanguinity; Demyelinating Diseases; DNA Mu | 2007 |
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Amino Acids; Carbohydrate Dehydrogenases; Cerebral Cortex; Child; Child, Preschool; Choline; Demyeli | 2000 |