serine has been researched along with Dementia in 21 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frontotemporal dementia with parkinsonism linked to chromosome 17q21-22 (FTDP-17) is an autosomal dominant tauopathy manifested by a variable combination of personality changes, cognitive decline and hypokinetic-rigid movement disorder." | 1.32 | Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family. ( Abramsky, O; Biran, I; Boher, M; Ekstein, D; Gal, A; Gomori, JM; Lossos, A; Meiner, Z; Newman, JP; Reches, A; Rosenmann, H; Soffer, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 16 (76.19) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ashby, EL | 1 |
| Miners, JS | 1 |
| Kumar, S | 1 |
| Walter, J | 1 |
| Love, S | 1 |
| Kehoe, PG | 1 |
| Biemans, EA | 1 |
| Verhoeven-Duif, NM | 1 |
| Gerrits, J | 1 |
| Claassen, JA | 1 |
| Kuiperij, HB | 1 |
| Verbeek, MM | 1 |
| Inukai, Y | 1 |
| Nonaka, T | 2 |
| Arai, T | 2 |
| Yoshida, M | 1 |
| Hashizume, Y | 1 |
| Beach, TG | 1 |
| Buratti, E | 1 |
| Baralle, FE | 1 |
| Akiyama, H | 2 |
| Hisanaga, S | 1 |
| Hasegawa, M | 2 |
| Nesgaard, L | 1 |
| Vad, B | 1 |
| Christiansen, G | 1 |
| Otzen, D | 1 |
| Kametani, F | 1 |
| Suzuki, T | 1 |
| Dohmae, N | 1 |
| Lossos, A | 1 |
| Reches, A | 1 |
| Gal, A | 1 |
| Newman, JP | 1 |
| Soffer, D | 1 |
| Gomori, JM | 1 |
| Boher, M | 1 |
| Ekstein, D | 1 |
| Biran, I | 1 |
| Meiner, Z | 1 |
| Abramsky, O | 1 |
| Rosenmann, H | 1 |
| Kobayashi, K | 2 |
| Kidani, T | 2 |
| Ujike, H | 2 |
| Hayashi, M | 2 |
| Ishihara, T | 2 |
| Miyazu, K | 1 |
| Kuroda, S | 2 |
| Koshino, Y | 2 |
| Iijima, M | 1 |
| Nakano, H | 1 |
| Sugimori, K | 1 |
| Shimazaki, M | 1 |
| Alonso, Adel C | 1 |
| Mederlyova, A | 1 |
| Novak, M | 1 |
| Grundke-Iqbal, I | 1 |
| Iqbal, K | 1 |
| Belorgey, D | 1 |
| Sharp, LK | 1 |
| Crowther, DC | 1 |
| Onda, M | 1 |
| Johansson, J | 1 |
| Lomas, DA | 2 |
| Pérez, M | 2 |
| Ribe, E | 1 |
| Rubio, A | 1 |
| Lim, F | 2 |
| Morán, MA | 1 |
| Ramos, PG | 1 |
| Ferrer, I | 1 |
| Isla, MT | 1 |
| Avila, J | 2 |
| Saunders-Pullman, R | 1 |
| Lipton, RB | 1 |
| Senthil, G | 1 |
| Katz, M | 1 |
| Costan-Toth, C | 1 |
| Derby, C | 1 |
| Bressman, S | 1 |
| Verghese, J | 1 |
| Ozelius, LJ | 1 |
| Dächsel, JC | 1 |
| Ross, OA | 1 |
| Mata, IF | 1 |
| Kachergus, J | 1 |
| Toft, M | 1 |
| Cannon, A | 1 |
| Baker, M | 1 |
| Adamson, J | 1 |
| Hutton, M | 1 |
| Dickson, DW | 1 |
| Farrer, MJ | 1 |
| Spina, S | 1 |
| Murrell, JR | 1 |
| Yoshida, H | 1 |
| Ghetti, B | 1 |
| Bermingham, N | 1 |
| Sweeney, B | 1 |
| Dlouhy, SR | 1 |
| Crowther, RA | 1 |
| Goedert, M | 1 |
| Keohane, C | 1 |
| van Swieten, JC | 1 |
| Bronner, IF | 1 |
| Azmani, A | 1 |
| Severijnen, LA | 1 |
| Kamphorst, W | 1 |
| Ravid, R | 1 |
| Rizzu, P | 1 |
| Willemsen, R | 1 |
| Heutink, P | 1 |
| Gaig, C | 1 |
| Ezquerra, M | 1 |
| Martí, MJ | 1 |
| Valldeoriola, F | 1 |
| Muñoz, E | 1 |
| Lladó, A | 1 |
| Rey, MJ | 1 |
| Cardozo, A | 1 |
| Molinuevo, JL | 1 |
| Tolosa, E | 1 |
| Van Deerlin, VM | 1 |
| Leverenz, JB | 1 |
| Bekris, LM | 1 |
| Bird, TD | 1 |
| Yuan, W | 1 |
| Elman, LB | 1 |
| Clay, D | 1 |
| Wood, EM | 1 |
| Chen-Plotkin, AS | 1 |
| Martinez-Lage, M | 1 |
| Steinbart, E | 1 |
| McCluskey, L | 1 |
| Grossman, M | 1 |
| Neumann, M | 1 |
| Wu, IL | 1 |
| Yang, WS | 1 |
| Kalb, R | 1 |
| Galasko, DR | 1 |
| Montine, TJ | 1 |
| Trojanowski, JQ | 2 |
| Lee, VM | 2 |
| Schellenberg, GD | 1 |
| Yu, CE | 1 |
| Mawal-Dewan, M | 1 |
| Schmidt, ML | 1 |
| Balin, B | 1 |
| Perl, DP | 1 |
| Davis, RL | 1 |
| Shrimpton, AE | 1 |
| Holohan, PD | 1 |
| Bradshaw, C | 1 |
| Feiglin, D | 1 |
| Collins, GH | 1 |
| Sonderegger, P | 1 |
| Kinter, J | 1 |
| Becker, LM | 1 |
| Lacbawan, F | 1 |
| Krasnewich, D | 1 |
| Muenke, M | 1 |
| Lawrence, DA | 1 |
| Yerby, MS | 1 |
| Shaw, CM | 1 |
| Gooptu, B | 1 |
| Elliott, PR | 1 |
| Finch, JT | 1 |
| Carrell, RW | 1 |
| Arrasate, M | 1 |
| Komiya, T | 1 |
| Narabayashi, H | 1 |
| Kondo, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genetic Disease Gene Identification[NCT00916903] | 200 participants (Anticipated) | Observational | 2005-10-31 | Enrolling by invitation | |||
| Clinical, Molecular and Biochemical Characterization of Familial Encephalopathy With Neuroserpin Inclusion Bodies[NCT00006176] | 100 participants | Observational | 2000-08-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 other studies available for serine and Dementia
| Article | Year |
|---|---|
Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Dementia; Deme | 2015 |
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; | 2016 |
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antibodies, Monoclonal; Brain; Dementia; DNA-Binding Protein | 2008 |
Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amyloid; Circular Dichroism; Cysteine; De | 2009 |
Identification of casein kinase-1 phosphorylation sites on TDP-43.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Brain; Casein Kinase I; Dementia; DNA-Binding Pr | 2009 |
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family.
Topics: Adult; Algeria; Cerebral Cortex; Dementia; DNA Mutational Analysis; Family Health; Female; Humans; I | 2003 |
Another phenotype of frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17) with a missense mutation of S305N closely resembling Pick's disease.
Topics: Asparagine; Chromosomes, Human, Pair 17; Dementia; Dentate Gyrus; Genetic Linkage; Humans; Immunohis | 2003 |
Pick's disease pathology of a missense mutation of S305N of frontotemporal dementia and parkinsonism linked to chromosome 17: another phenotype of S305N.
Topics: Asparagine; Base Sequence; Brain; Dementia; DNA Mutational Analysis; Genetic Linkage; Heterozygote; | 2004 |
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations.
Topics: Brain; Chromosomes, Human, Pair 17; Dementia; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Immu | 2004 |
Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.
Topics: Amino Acid Substitution; Arginine; Biopolymers; Catalysis; Circular Dichroism; Dementia; Epilepsy; H | 2004 |
Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Chromosomes, Human, Pair 17; | 2005 |
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Topics: Aged, 80 and over; Aging; Dementia; DNA Mutational Analysis; Female; Glycine; Humans; Jews; Leucine- | 2006 |
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Topics: Aged; Amino Acid Substitution; Dementia; Female; Glycine; Humans; Inclusion Bodies; Leucine-Rich Rep | 2007 |
The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.
Topics: Adult; Dementia; DNA Mutational Analysis; Glycine; Humans; Male; Microscopy, Electron, Transmission; | 2007 |
The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.
Topics: Alzheimer Disease; Blotting, Western; Brain; Dementia; Exons; Female; Humans; Immunohistochemistry; | 2007 |
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Topics: Dementia; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Testing; Glyci | 2008 |
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Amyotrophic Lateral Sclerosis; Brain; Child; De | 2008 |
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex.
Topics: Aged; Amyotrophic Lateral Sclerosis; Binding Sites, Antibody; Blotting, Western; Brain Chemistry; De | 1996 |
Familial dementia caused by polymerization of mutant neuroserpin.
Topics: Biopolymers; Cerebral Cortex; Dementia; Female; Humans; Inclusion Bodies; Male; Neuropeptides; Neuro | 1999 |
Familial dementia caused by polymerization of mutant neuroserpin.
Topics: Biopolymers; Cerebral Cortex; Dementia; Female; Humans; Inclusion Bodies; Male; Neuropeptides; Neuro | 1999 |
Familial dementia caused by polymerization of mutant neuroserpin.
Topics: Biopolymers; Cerebral Cortex; Dementia; Female; Humans; Inclusion Bodies; Male; Neuropeptides; Neuro | 1999 |
Familial dementia caused by polymerization of mutant neuroserpin.
Topics: Biopolymers; Cerebral Cortex; Dementia; Female; Humans; Inclusion Bodies; Male; Neuropeptides; Neuro | 1999 |
The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Chromosomes, Human, Pai | 2000 |
[The effective of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) in hypersomnia and subcortical dementia caused by bilateral medial thalamic and midbrain infarcts].
Topics: Aged; Cerebral Infarction; Dementia; Disorders of Excessive Somnolence; Droxidopa; Female; Humans; M | 1988 |