serine has been researched along with Degenerative Diseases, Central Nervous System in 38 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies have shown that alpha-synuclein (alpha-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129." | 7.74 | The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. ( Chen, W; Gorbatyuk, OS; Kondrikova, G; Li, S; Mandel, RJ; Manfredsson, FP; Muzyczka, N; Sullivan, LF, 2008) |
| "Mefenamic acid treatment provided significant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-α, IL-1β and Bax." | 5.38 | Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. ( Armagan, G; Kanit, L; Turunc, E; Yalcin, A, 2012) |
| "Repeated amino acid sequences in proteins are widely found, and the glycine-serine-alanine repeat is an element with a general propensity to form β-sheet aggregates as found in key pathological factors, in several neurodegenerative diseases." | 4.31 | A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration. ( Chen, S; Gao, XD; Meng, Y; Wang, JF; Xu, Z; Xue, Y; Yang, F; Yao, SY; Yao, WB, 2023) |
| "Alpha-synuclein (aSyn) is a vertebrate protein, normally found within the presynaptic nerve terminal and nucleus, which is known to form somatic and neuritic aggregates in certain neurodegenerative diseases." | 4.12 | Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties. ( Adams, EK; Dent, SE; King, DP; Mackiewicz, MR; Osterberg, VR; Unni, VK; Weissman, TA, 2022) |
| "Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease." | 3.76 | Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. ( Aebischer, P; Chegini, F; Chiappe, D; Eliezer, D; Fernandez, CO; Gai, WP; Kim, HY; Lamberto, GR; Lashuel, HA; Masliah, E; Moniatte, M; Oueslati, A; Paleologou, KE; Rospigliosi, CC; Schmid, A; Schneider, BL; Shakked, G; Zweckstetter, M, 2010) |
| "Studies have shown that alpha-synuclein (alpha-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129." | 3.74 | The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. ( Chen, W; Gorbatyuk, OS; Kondrikova, G; Li, S; Mandel, RJ; Manfredsson, FP; Muzyczka, N; Sullivan, LF, 2008) |
| "MARK4 is associated with various cancer types due to its important role in regulating microtubule dynamics and subsequent cell division." | 2.82 | Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy. ( Anwar, S; Hasan, GM; Hassan, MI; Islam, A; Shahwan, M, 2022) |
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| "Thus, NE stimulation may prevent memory loss in Ts65Dn mice, and may hold promise for treatment in individuals with DS and dementia." | 1.42 | Designer receptors enhance memory in a mouse model of Down syndrome. ( Aston-Jones, G; Boger, HA; Cass, WA; Fortress, AM; Granholm, AC; Hamlett, ED; Vazey, EM, 2015) |
| "Mefenamic acid treatment provided significant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-α, IL-1β and Bax." | 1.38 | Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. ( Armagan, G; Kanit, L; Turunc, E; Yalcin, A, 2012) |
| " The increased dosage of Dyrk1A in DS brain due to trisomy of chromosome 21 correlates to an increase in 3R-tau level, which on abnormal hyperphosphorylation and aggregation of tau results in neurofibrillary degeneration." | 1.35 | Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. ( Chohan, MO; Gong, CX; Grundke-Iqbal, I; Gu, X; Hwang, YW; Iqbal, K; Liu, F; Shi, J; Wegiel, J; Zhang, T; Zhou, C; Zhou, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 15 (39.47) | 29.6817 |
| 2010's | 15 (39.47) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Dent, SE | 1 |
| King, DP | 1 |
| Osterberg, VR | 1 |
| Adams, EK | 1 |
| Mackiewicz, MR | 1 |
| Weissman, TA | 1 |
| Unni, VK | 1 |
| Park, H | 1 |
| Yamanaka, T | 1 |
| Toyama, Y | 1 |
| Fujita, A | 1 |
| Doi, H | 1 |
| Nirasawa, T | 1 |
| Murayama, S | 1 |
| Matsumoto, N | 1 |
| Shimogori, T | 1 |
| Ikegawa, M | 1 |
| Haltia, MJ | 1 |
| Nukina, N | 1 |
| Lone, MA | 1 |
| Aaltonen, MJ | 1 |
| Zidell, A | 1 |
| Pedro, HF | 1 |
| Morales Saute, JA | 1 |
| Mathew, S | 1 |
| Mohassel, P | 1 |
| Bönnemann, CG | 1 |
| Shoubridge, EA | 1 |
| Hornemann, T | 1 |
| Anwar, S | 1 |
| Shahwan, M | 1 |
| Hasan, GM | 1 |
| Islam, A | 1 |
| Hassan, MI | 1 |
| Xu, J | 1 |
| Yang, Z | 1 |
| Wang, R | 1 |
| He, F | 1 |
| Yan, R | 1 |
| Zhang, Y | 1 |
| Yu, L | 1 |
| Deng, W | 1 |
| Nie, Y | 1 |
| Yao, SY | 1 |
| Wang, JF | 1 |
| Xu, Z | 1 |
| Meng, Y | 1 |
| Xue, Y | 1 |
| Yang, F | 1 |
| Yao, WB | 1 |
| Gao, XD | 1 |
| Chen, S | 1 |
| He, Z | 1 |
| Tao, D | 1 |
| Xiong, J | 1 |
| Lou, F | 1 |
| Zhang, J | 1 |
| Chen, J | 1 |
| Dai, W | 1 |
| Sun, J | 1 |
| Wang, Y | 1 |
| Beltrán-Castillo, S | 1 |
| Eugenín, J | 1 |
| von Bernhardi, R | 1 |
| Liachko, NF | 1 |
| McMillan, PJ | 1 |
| Guthrie, CR | 1 |
| Bird, TD | 1 |
| Leverenz, JB | 1 |
| Kraemer, BC | 1 |
| Bardaweel, SK | 1 |
| Alzweiri, M | 1 |
| Ishaqat, AA | 1 |
| Fortress, AM | 1 |
| Hamlett, ED | 1 |
| Vazey, EM | 1 |
| Aston-Jones, G | 1 |
| Cass, WA | 1 |
| Boger, HA | 1 |
| Granholm, AC | 1 |
| Basso, M | 1 |
| Pennuto, M | 1 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 2 |
| Saudou, F | 1 |
| Humbert, S | 1 |
| Yang, XW | 1 |
| Osmand, A | 1 |
| Steffan, JS | 1 |
| Masliah, E | 3 |
| Finkbeiner, S | 1 |
| Wolosker, H | 2 |
| Dumin, E | 1 |
| Balan, L | 1 |
| Foltyn, VN | 1 |
| Shi, J | 1 |
| Zhang, T | 1 |
| Zhou, C | 1 |
| Chohan, MO | 1 |
| Wegiel, J | 1 |
| Zhou, J | 1 |
| Hwang, YW | 1 |
| Iqbal, K | 1 |
| Grundke-Iqbal, I | 1 |
| Gong, CX | 1 |
| Liu, F | 1 |
| Hall, EC | 1 |
| Lee, SY | 1 |
| Mairuae, N | 1 |
| Simmons, Z | 1 |
| Connor, JR | 1 |
| Hugon, J | 1 |
| Paquet, C | 1 |
| Chang, RC | 1 |
| Pollegioni, L | 2 |
| Sacchi, S | 2 |
| Paleologou, KE | 1 |
| Oueslati, A | 1 |
| Shakked, G | 1 |
| Rospigliosi, CC | 1 |
| Kim, HY | 1 |
| Lamberto, GR | 1 |
| Fernandez, CO | 1 |
| Schmid, A | 1 |
| Chegini, F | 1 |
| Gai, WP | 1 |
| Chiappe, D | 1 |
| Moniatte, M | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Eliezer, D | 1 |
| Zweckstetter, M | 1 |
| Lashuel, HA | 1 |
| Bech, S | 1 |
| Nørremølle, A | 1 |
| Winge, K | 1 |
| Hasholt, L | 1 |
| Tommerup, N | 1 |
| Svenstrup, K | 1 |
| Nielsen, JE | 1 |
| Hjermind, LE | 1 |
| Sato, H | 1 |
| Arawaka, S | 1 |
| Hara, S | 1 |
| Fukushima, S | 1 |
| Koga, K | 1 |
| Koyama, S | 1 |
| Kato, T | 1 |
| Armagan, G | 1 |
| Turunc, E | 1 |
| Kanit, L | 1 |
| Yalcin, A | 1 |
| Velázquez-Delgado, EM | 1 |
| Hardy, JA | 1 |
| Mori, H | 1 |
| Caldinelli, L | 1 |
| Cappelletti, P | 1 |
| Molla, G | 1 |
| Takahashi, M | 1 |
| Kanuka, H | 1 |
| Fujiwara, H | 2 |
| Koyama, A | 1 |
| Hasegawa, M | 2 |
| Miura, M | 1 |
| Iwatsubo, T | 2 |
| Maurage, CA | 2 |
| Sergeant, N | 2 |
| Ruchoux, MM | 2 |
| Hauw, JJ | 2 |
| Delacourte, A | 3 |
| Yamashita, S | 1 |
| Maeda, Y | 1 |
| Ohmori, H | 1 |
| Uchida, Y | 1 |
| Hirano, T | 1 |
| Yonemura, K | 1 |
| Uyama, E | 1 |
| Uchino, M | 1 |
| D'Souza, I | 1 |
| Schellenberg, GD | 1 |
| Lee, JW | 1 |
| Beebe, K | 1 |
| Nangle, LA | 1 |
| Jang, J | 1 |
| Longo-Guess, CM | 1 |
| Cook, SA | 1 |
| Davisson, MT | 1 |
| Sundberg, JP | 1 |
| Schimmel, P | 1 |
| Ackerman, SL | 1 |
| Roy, H | 1 |
| Ibba, M | 1 |
| Windisch, M | 1 |
| Wolf, HJ | 1 |
| Hutter-Paier, B | 1 |
| Hofmeister, A | 1 |
| Wronski, R | 1 |
| Mueller-Burke, D | 1 |
| Koehler, RC | 1 |
| Martin, LJ | 1 |
| Gorbatyuk, OS | 1 |
| Li, S | 1 |
| Sullivan, LF | 1 |
| Chen, W | 1 |
| Kondrikova, G | 1 |
| Manfredsson, FP | 1 |
| Mandel, RJ | 1 |
| Muzyczka, N | 1 |
| Bussière, T | 1 |
| Hof, PR | 1 |
| Mailliot, C | 1 |
| Brown, CD | 1 |
| Caillet-Boudin, ML | 1 |
| Perl, DP | 1 |
| Buée, L | 1 |
| Mothet, JP | 1 |
| Dohmae, N | 1 |
| Kawashima, A | 1 |
| Goldberg, MS | 1 |
| Shen, J | 1 |
| Takio, K | 1 |
11 reviews available for serine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Humans; Microtubules; Neoplasms; Neurodegener | 2022 |
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Brain Injuries; Humans; Inflammation; Lipoxygenase Inhi | 2020 |
Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS.
Topics: Aging; Animals; Central Nervous System; Humans; Microglia; Neurodegenerative Diseases; Serine | 2018 |
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutami | 2014 |
Serine phosphorylation and arginine methylation at the crossroads to neurodegeneration.
Topics: Animals; Arginine; Humans; Methylation; Neurodegenerative Diseases; Phosphorylation; Serine | 2015 |
D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.
Topics: Animals; Brain; Isomerism; Neurodegenerative Diseases; Neuroglia; Neurons; Rats; Receptors, N-Methyl | 2008 |
Metabolism of the neuromodulator D-serine.
Topics: Brain; D-Amino-Acid Oxidase; Gene Expression Regulation, Enzymologic; Humans; Mental Disorders; Neur | 2010 |
Serine racemase: an unconventional enzyme for an unconventional transmitter.
Topics: Animals; Behavior, Animal; Brain; Enzyme Inhibitors; Gene Expression; Humans; Mice; Mice, Knockout; | 2012 |
Structure-function relationships in human D-amino acid oxidase.
Topics: Brain; D-Amino-Acid Oxidase; Enzyme Stability; Gene Expression; Humans; Kinetics; Models, Molecular; | 2012 |
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?
Topics: alpha-Synuclein; Animals; Enzyme Inhibitors; Humans; Neurodegenerative Diseases; Serine | 2007 |
Physiological relevance of endogenous free D-serine in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?
Topics: Animals; Astrocytes; Brain Chemistry; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Di | 2001 |
27 other studies available for serine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties.
Topics: alpha-Synuclein; DNA; Neurodegenerative Diseases; Phosphorylation; Serine; Structure-Activity Relati | 2022 |
Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions.
Topics: Amino Acids; Animals; Intranuclear Inclusion Bodies; Mice; Neurodegenerative Diseases; Proteins; Ser | 2022 |
SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins.
Topics: Amyotrophic Lateral Sclerosis; Hereditary Sensory and Autonomic Neuropathies; Humans; Membrane Prote | 2022 |
Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA.
Topics: Alanine; Humans; Induced Pluripotent Stem Cells; Neurodegenerative Diseases; Oligodendrocyte Transcr | 2022 |
A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Humans; Mice; Mice, Trans | 2023 |
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cel | 2013 |
Designer receptors enhance memory in a mouse model of Down syndrome.
Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Cross-Over Studies; Designer Drugs; Disease Mo | 2015 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.
Topics: Alternative Splicing; Animals; Brain; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Down Syndro | 2008 |
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
Topics: Alleles; Antioxidants; Cell Line, Tumor; Chromans; Genetic Variation; Glycogen Synthase Kinase 3; Gl | 2011 |
Could PKR inhibition modulate human neurodegeneration?
Topics: Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Humans; Neurodegenerative Dise | 2009 |
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cell Membrane; Creatine Kin | 2010 |
The lrrk2 p.Gly2019Ser mutation is uncommon in a Danish cohort with various neurodegenerative disorders.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Denmark; Female; Genome-Wide Association Study; Glyc | 2011 |
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cell Count; Cell Line, Transformed; Disease Models, Animal; Dopamine Plasm | 2011 |
Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Inflammation; Mefenamic Acid; Ne | 2012 |
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Topics: Apoptosis; Binding Sites; Caspase 6; Crystallography, X-Ray; Escherichia coli; Humans; Models, Molec | 2012 |
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.
Topics: alpha-Synuclein; Animals; Drosophila; Immunohistochemistry; Mutation; Nerve Tissue Proteins; Neurode | 2003 |
Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Child | 2003 |
Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.
Topics: Acanthocytes; Adult; Anticonvulsants; Asian People; Asparagine; Basal Ganglia; Brain Mapping; Clonaz | 2004 |
Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K.
Topics: Alternative Splicing; Animals; Arginine; Binding Sites; Enhancer Elements, Genetic; Exons; HeLa Cell | 2006 |
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.
Topics: Acetylation; Alanine; Alanine-tRNA Ligase; Animals; Catalysis; Escherichia coli; Fibroblasts; Humans | 2006 |
Molecular biology: sticky end in protein synthesis.
Topics: Alanine; Alanine-tRNA Ligase; Animals; Genetic Code; Humans; Mice; Mutation; Neurodegenerative Disea | 2006 |
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Corpus Striatum; Disease Models, Animal; Hypothermi | 2008 |
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.
Topics: alpha-Synuclein; Animals; Brain; Dependovirus; Disease Models, Animal; Dopamine; Humans; Lewy Bodies | 2008 |
Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration.
Topics: Adult; Aged; Aged, 80 and over; Antibody Specificity; Brain; Humans; Immunoblotting; Immunohistochem | 1999 |
Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Child; Fe | 2001 |
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Topics: Aged; alpha-Synuclein; Amino Acid Sequence; Brain Chemistry; Cerebral Cortex; Humans; Lewy Bodies; M | 2002 |